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The RNA Pol Ⅱ sub-complex hsRpb4/7 is required for viability of multiple human cell lines

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Protein & Cell 2012年第11期3卷 846-854页

作者： Yang Zhao Kim K.C.Li King Pan Ng Chi Ho Ng Kevin A.W.lee Division of Life Science The Hong Kong University of Science and TechnologySai KungHong Kong S.A.R.China

The evolutionarily conserved RNA Polymerase Ⅱ Rpb4/7 sub-complex has been thoroughly studied in yeast and impacts gene expression at multiple levels including transcription,mRNA processing and *** addition Rpb4/7 exerts differential effects on gene expression in yeast and Rpb4 is not obligatory for yeast(***)*** roles for human(hs)Rpb4/7 have not been extensively described and we have probed this question by depleting hsRpb4/7 in established human cell lines using RNA *** find that Rpb4/7 protein levels are inter-dependent and accordingly,the functional effects of depleting either protein are ***4/7 exhibits gene-specific effects and cells initially remain viable upon hsRpb4/7 *** prolonged hsRpb4/7 depletion is cytotoxic in the range of cell lines *** cell death occurs by an unknown mechanism and in some cases is accompanied by a pronounced elongated cell *** conclusion we provide evidence for a gene-specific role of hsRpb4/7 in human cell viability.

关键词： RNA PolymeraseⅡ hsRpb4/7 sub-complex gene expression cell viability cell shape

Ursolic acid: An overview on its cytotoxic activities against breast and colorectal cancer cells

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Journal of Integrative Medicine 2019年第3期17卷 155-160页

作者： Eric Wei Chiang Chan Chu Yong Soon Joash Ban lee Tan Siu Kuin Wong Yew Woh Hui Faculty of Applied Sciences UCSI University School of Science Monash University Sunway Xiamen University Malaysia Bandar Sunsuria

Ursolic acid(UA) is a pentacyclic triterpene of the ursane type. As a common chemical constituent among species of the family Lamiaceae, UA possesses a broad spectrum of pharmacological properties. This overview focuses on the anticancer properties of UA against breast cancer(BC) and colorectal cancer(CRC)that are most common among women and men, respectively. In vitro studies have shown that UA inhibited the growth of BC and CRC cell lines through various molecular targets and signaling *** are several in vivo studies on the cytotoxic activity of UA against BC and CRC. UA also inhibits the growth of other types of cancer. Studies on structural modifications of UA have shown that the –OH groups at C3 and at C28 are critical factors influencing the cytotoxic activity of UA and its *** needs for future research are suggested. Sources of information were from ScienceDirect, Google Scholar and PubMed.

关键词： Ursolic acid Cytotoxic Molecular targets Signaling pathways

Schlieren techniques for observations of long positive sparks:Review and application

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High Voltage 2022年第5期7卷 825-839页

作者： Junjia He Xiankang Wang Xiangen Zhao Juhyeong lee Yaping Du Xiaopeng Liu Quan Gan Yang Liu Yuqin Liao State Key Laboratory of Advanced Electromagnetic Engineering and Technology Huazhong University of Science and TechnologyWuhanChina Department of Building Environment and Energy Engineering Hong Kong Polytechnic UniversityKowloonChina Department of Mechanical and Aerospace Engineering Utah State UniversityLoganUtahUSA

Understanding the mechanism of positive leader discharge is important in lightning protection engineering and the external insulation design in high voltage power transmission *** the propagation of a positive leader,some processes without light-emitting,for example,the insulation recovery process after the breakdown,cannot be observed by optical photography *** the combination of the digital high-speed imaging system,the conventional Schlieren techniques offer new vistas in the long air gap discharge *** important features of high spatial resolution,high sensitivity,and easy arrangement make Schlieren techniques powerful and effective tools for characterising the discharge processes without *** work presents a brief review of current Schlieren techniques and discusses the design of the Schlieren optics system for long spark *** interesting phenomena discovered at different phases of long sparks with high-speed Schlieren techniques are also presented.

关键词： insulation system positive

Ameliorative effects of human adipose tissue-derived mesenchymal stem cells on myelin basic protein-induced experimental autoimmune encephalomyelitis in Lewis rats

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Neural Regeneration Research 2011年第16期6卷 1205-1210页

作者： Myung-Soon Ko Hyeong-geun Park Young-Min Yun Jeong Chan Ra Taekyun Shin Kyoung-Kap lee College of Veterinary Medicine Jeju National University Stem Cell Research Center RNL BIO Co.Ltd.

Mesenchymal stem cells have been previously shown to exert an immunomodulatory function. The present study sought to investigate the effects of multipotential human adipose tissue-derived mesenchymal stem cells （hAdMSCs） on disease progression and cytokine expression in Lewis rats with experimental autoimmune encephalomyelitis （EAE） induced by myelin basic protein. The duration of EAE paralysis in the group treated on day 7 posfimmunization with 5 × 10^6 hAdMSCs was significantly reduced compared with the vehicle-treated controls and the 1 x 106 hAdMSC- treated group. The duration of EAE paralysis in the groups treated with 5 × 10^6 hAdMSCs on both day 1 and day 7 postimmunization was significantly reduced compared with the vehicle-treated controls and the groups treated with 5 × 10^6 hAdMSCs on both day 7 and day 10 postimmunization. The mRNA expression of interleukin-10 and indoleamine 2, 3-dioxygenase was significantly decreased in the hAdMSC-treated group compared with the vehicle-treated group. These findings suggest that the ameliorative effects of hAdMSCs on EAE symptoms operate in a dose- and time-dependent manner and can be mediated in part by the ample production of anti-inflammatory cytokines.

关键词： experimental autoimmune encephalomyelitis human adipose tissue mesenchymal stem cells intedeukin-10 interferon-gamma indoleamine 2, 3-dioxygenase neural regeneration

A Review of the Enforcement of HKSAR Award in China's Mainland after the Promulgation of "The Arrangement"

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武汉仲裁 2009年第1期 78-87页

作者： James lee Wuhan University of PRC

Hong Kong’s first architect-turned barrister Dr James lee gives a concise review of how China's Mainland courts approach the enforcement of the arbitral awards published in Hong Kong Special Administrative *** attent...

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MICROSTRUCTURE AND PROPERTIES OF ANNEALED ZnO THIN FILMS DEPOSITED BY MAGNETRON SPUTTERING

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Acta Metallurgica Sinica(English Letters) 2005年第3期18卷 177-183页

作者： J.lee W.Gao Z.Li M.Hodgson A.Asadov J.Metson DepartmentofMechanicalEngineering TheUniversityofAucklandAuckland1004NewZealand DepartmentofChemicalandMaterialsEngineering TheUniversityofAucklandAuckland1004NewZealand DepartmentofChemistry TheUniversityofAucklandPrivateBag92019Auckland1004NewZealand

ZnO thin films were deposited on a glass substrate by dc (direct current) and rf (radio frequency) magnetron sputtering. Post-deposition annealing was performed in different atmospheres and at different temperatures. The correlation of the annealing conditions with the microstructure and properties of the ZnO films wer e investigated by ultraviolet-visible spectroscopy, X-ray diffraction, conductiv ity measurement and scanning electron microscopy. Only the strong 002 peak could be observed by X-ray diffraction. The post-deposition annealing of ZnO films wa s found to alter the film's microstructure and properties, including crystallini ty, porosity, grain size, internal stress level and resistivity. It was also fou nd that after annealing, the conductivity of poorly conductive samples often imp roved. However, annealing does not improve the conductivity of samples with high conductivity prior to annealing. The resistivity of as-grown films can be decre ased from 102 to 10-4Ω·cm after annealing in nitrogen. To explain the effects of annealing on the conductivity of ZnO, it is believed that annealing may alter the presence and distribution of oxygen defects, reduce the lattice stress, cau se diffusion, grain coarsening and recrystallization. Annealing will reduce the density of grain boundaries in less dense films, which may decrease the resistiv ity of the films. On the other hand, annealing may also increase the porosity of thin films, leading to an increase in resistivity.

关键词： zinc oxide thin films microstructure magnetron sputtering post-deposition annealing electrical conductivity

Taking the ＂Local＂ out of Local News： Implications for an Informed Public

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Journalism and Mass Communication 2013年第9期3卷 549-562页

作者： lee Hood Loyola University Chicago Chicago USA

The meaning of ＂local＂ in TV news is not as straightforward as one might imagine. ＂Local＂ newscasts in several U.S. markets are outsourced to an independent company located hundreds of miles from the communities served. What are the implications of such a delivery system for coverage of local issues and the Jeffersonian ideal of an informed citizenry？ This study employs a content analysis of outsourced and local newscasts, using a data set of more than 1,000 stories from more than 30 hours of newscasts to determine if differences exist on story topics and source types. Does one type of station cover more public affairs stories than the other？ Does one type use more official sources, or more perspective from private individuals？ Even with the wide array of news sources currently available, local TV news still ranks as the most widely used information source. How well that source delivers information to local audiences is an important question to ask, particularly when the information may be coming from a great distance.

关键词： TV news content analysis local news news outsourcing public affairs coverage

Yancheng Lvye Chemical:Green Agrochemicals

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China Chemical Reporter 2010年第5期21卷 42-42页

作者： Amy lee

Yancheng Lvve Chemical Co.,Ltd was established in 1997 and is located in LonggangChemical Park of Yancheng,Jiangsu province,the northeast of Yangtze Delta,It is engagedin the production and sales of fine chemicals,commodity chemicals and *** products mainly include climbazote,propyzamide and thiazide,whichare in great demand in Europe and the Southeast Asia.

关键词： chemicals Jiangsu commodity Southeast Yangtze frie

ENDOFEM INTEGRATED METHODOLOGY FOR FATIGUE CRACK GROWTH

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Acta Mechanica Sinica 2002年第2期18卷 89-94页

作者： C.F.lee L.T.Hsiao DepartmentofEngineeringScienceNationalCheng-KungUniversityTainan Taiwan10617R.O.C. Nan-JongInst.ofTechnology

In this paper, the FEM with the incremental endochronic cyclic plasticity (EndoFEM) and the rc controlled node-released strategy are employed to study the fatigue crack opened/closed load (Pop) of A1 2024-T3 CCT specimens provided by Mageed and Pandey under several crack lengths and the constant amplitude with various load ratio (R). After statisfactory results are achieved by comparisons of computed Pop values and cited experimental data, the simulations will be extended to the crack lengths with significant bending effect due to short ligaments or high peak (Pmax) or high positive or very low negative R cyclic loads. Through these simulations, the complete map of Pop/Pmax vs. Kmax and R can be constructed and thereafter its correspondant empirical formulae can be proposed. Using these formulae and selecting the traditional fatigue crack growth parameter ΔKeff, the A1 2024-T3 fatigue crack growth rate da/dN vs. ΔK and R data, provided by Hiroshi and Schijve, can be employed to proposed empirical formulae of da/dN vs. ΔKeff and R. After integration, fatigue-crack-growth length a vs. N curves computed by EndoFEM can be obtained. The results are agreed very well with the existing experimental curves. According to the above procedures of simulation and steps of comparions with experiment, this paper may provides an integrate methodology of numerical simulation in the studies of fatigue crack growth for academic and industrial researches and design analysis.

关键词：疲劳裂缝 FEM 可塑性挠曲效应闭合模型