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Gender differences in clinical outcomes of acute myocardial infarction undergoing percutaneous coronary intervention: insights from the KAMIR-NIH Registry

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Journal of Geriatric Cardiology 2020年第11期17卷 680-693页

作者： Myunhee Lee Dae-won Kim Mahn-won Park Kyusup Lee Kiyuk Chang Wook Sung Chung Tae Hoon Ahn Myung Ho Jeong Seung-Woon Rha Hyo-Soo Kim Hyeon Cheol Gwon In Whan Seong Kyung Kuk Hwang Shung Chull Chae kwon-Bae Kim Young Jo Kim Kwang Soo Cha Seok Kyu Oh Jei Keon Chae Ji-Hoon jung 无 KAMIR-NIH registry investigators Division of Cardiology Daejeon St.Mary’s hospitalCollege of MedicineThe Catholic University of KoreaSeoulSouth Korea Division of Cardiology Seoul St.Mary’s hospitalCollege of MedicineThe Catholic University of KoreaSeoulSouth Korea Gachon University Gil Medical CenterIncheonSouth Korea Chonnam National University Hospital GwangjuSouth Korea d Korea University Korea University Guro Hospital SeoulSouth Korea Seoul National University Hospital SeoulSouth Korea Sungkyunkwan Universtiy Samsung Medical CenterSeoulSouth Korea Chungnam National University Hospital DaejeonSouth Korea Chungbuk National University Hospital CheongjuSouth Korea Kyungpook National University Hospital DaeguSouth Korea Keimyung University Dongsan Medical Center DaeguSouth Korea Yeungnam University Hospital DaeguSouth Korea Pusan National University Hospital BusanSouth Korea wonkwang University Hospital IksanSouth Korea Chonbuk National University Hospital JeonjuSouth Korea Institute of Toxicology DaejeonSouth Korea 不详

Background There are numerous but conflicting data regarding gender differences in outcomes following percutaneous coronary intervention(PCI). Furthermore, gender differences in clinical outcomes with acute myocardial infarction(AMI) following PCI in Asian population remain uncertain because of the under-representation of Asian in previous trials. Methods A total of 13,104 AMI patients from Korea Acute Myocardial Infarction Registry-National Institute of Health(KAMIR-NIH) between November 2011 and December 2015 were classified into male(n = 8021, 75.9%) and female(n = 2547, 24.1%). We compared the demographic, clinical and angiographic characteristics, 30-days and 1-year major adverse cardiac and cerebrovascular events(MACCE) in women with those in men after AMI by using propensity score(PS) matching. Results Compared with men, women were older, had more comorbidities and more often presented with non-ST segment elevation myocardial infarction(NSTEMI) and reduced left ventricular systolic function. Over the median follow-up of 363 days, gender differences in both 30-days and 1-year MACCE as well as thrombolysis in myocardial infarction minor bleeding risk were not observed in the PS matched population(30-days MACCE: 5.3% vs. 4.7%, log-rank P = 0.494, HR = 1.126, 95% CI: 0.800-1.585;1-year MACCE: 9.3% vs. 9.0%, log-rank P = 0.803, HR = 1.032, 95% CI: 0.802-1.328;TIMI minor bleeding: 4.9% vs. 3.9%, log-rank P = 0.215, HR = 1.255, 95% CI: 0.869-1.814). Conclusions Among Korean AMI population undergoing contemporary PCI, women, as compared with men, had different clinical and angiographic characteristics but showed similar 30-days and 1-year clinical outcomes. The risk of bleeding after PCI was comparable between men and women during one-year follow up.

关键词： Acute myocardial infarction Asian population Gender difference Percutaneous coronary intervention

Silver-palladium alloy deposited by DC magnetron sputtering method as lubricant for high temperature application

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中国有色金属学会会刊：英文版 2009年第4期19卷 1001-1004页

作者： jung-Dae kwon Sung-Hun LEE Koo-Hyun LEE Jong-Joo RHA Kee-Seok NAM Sang-Hoon CHOI Dong-Min LEE Dong-Il KIM Materials Processing Division Korea Institute of Materials Science Technology Research & Development Institute Korea Plant Service and Engineering

The silver-palladium(Ag-Pd) alloy coating as a solid lubricant was investigated for its application to the high temperature stud bolts used in nuclear power plants.A hex bolt sample was prepared in the following steps:1) bolt surface treatment using alumina grit blasting for cleaning and increasing the surface area;2) nickel(Ni) film coating as a glue layer on the surface of the bolt;and 3) Ag-Pd alloy coating on the Ni *** films were deposited by using a direct current(DC) magnetron sputtering *** thickness and composition of the Ag-Pd alloy film have effect on the friction coefficient,which was determined using axial force measurement.A 500 nm-thick Ag-Pd(80-20,molar ratio) alloy film has the lowest friction coefficient of 0.109.A cyclic test was conducted to evaluate the durability of bolts coated with either the Ag-Pd(80-20) alloy film or N-5000 *** a cycle,the bolts were inserted into a block using a torque wrench,which was followed by heating and *** only one cycle,it was not possible to remove the bolts coated with the N-5000 oil from the ***,the bolts coated with the Ag-Pd(80-20) alloy could be easily removed up until 15 cycles.

关键词：银钯合金直流电高温润滑剂沉积磁控溅射法固体润滑涂层高温螺栓

Reduction of gastrointestinal motility by unilateral thyroparathyroidectomy plus subdiaphragmatic vagotomy in rats

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World Journal of Gastroenterology 2012年第33期18卷 4570-4577页

作者： Jun Ho Lee Oh Deog kwon Seon Ho Ahn Keun Han Choi Ji Hye Park Seoul Lee Bong Kyu Choi Kyu Yong jung Department of Pharmacology Wonkwang University School of Medicine Jeonbuk 570-749 South Korea Department of Clinical Pathology College of Veterinary Medicine Kyungpook National University Daegu 702-701 South Korea Department of Internal Medicine Wonkwang University School of Medicine Jeonbuk 570-749 South Korea

AIM: To investigate whether the combined methods of unilateral thyroparathyroidectomy (TPX) and subdiaphragmatic vagotomy (VAX) can be adapted for rats and used as a reliable method to produce a rat model of long-term reduction of gastrointestinal (GI) motor function. METHODS: Male Sprague-Dawley rats were randomly divided into 3 groups, normal, sham-operated and unilateral TPX plus VAX. The TPX plus VAX rats received VAX 7 d after application of TPX, and dietary intake and fecal output were then measured daily for 1 *** completion of the experiments, gastric emptying and small bowel transit were measured in vivo, and the contractile responses of colonic strips to excitatory and inhibitory neurotransmitters were estimated using isometric force transducers in vitro. RESULTS: In comparison with normal and sham-operated rats, rats which received unilateral TPX plus VAX showed a significant decrease in body weight and in fecal pellet number and weight throughout the entire week. Application of TPX plus VAX to rats markedly delayed gastric emptying and small bowel transit. In TPX plus VAX rats, the longitudinal muscles of the proximal colon showed a significant reduction in contractile responses to acetylcholine (5 × 10-6 mol/L), and a dramatic attenuation of contractile responses was also observed in both the longitudinal and circular muscles of the distal colon. However, the spontaneous contractility of the colonic strips from TPX plus VAX rats was not significantly affected by treatment with N-nitro-Larginine-methyl ester (0.1 mol/L). CONCLUSION: The results indicate that unilateral TPX plus VAX reduced the motor function of the GI tract in rats, and the reduced gut motility is likely mediated, at least in part, by inhibition of the excitatory neurotransmitter system.

关键词： Unilateral thyroparathyroidectomy Subdiaphragmatic vagotomy Gastric emptying Small bowel transit Rat

Characterization of Birefringence and Dispersion Properties in an Arrayed Waveguide Grating

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光学学报 2003年第S1期23卷 293-294页

作者： Jeong Hwan Song Oh Dal kwon Dong-Su Kim Sun Tae jung Kyung Shik Lee Network Research Team Telecomm R&D Center Samsung Electronics Suwon KoreaNetwork Research Team Telecomm R&D Center Samsung Electronics Suwon KoreaNetwork Research Team Telecomm R&D Center Samsung Electronics Suwon KoreaNetwork Research Team Telecomm R&D Center Samsung Electronics Suwon KoreaDepartment of Electrical and Electronics Engineering SungKyunKwan University Suwon Korea

We have characterized polarization dependent loss(PDL), differential group delay(DGD), and chromatic dispersion of an AWG and a simple method was proposed to estimate the chromatic dispersion from the measured DGD of ... 详细信息

关键词： of as AWG Characterization of Birefringence and Dispersion Properties in an Arrayed Waveguide Grating PDL in

Stomach cancer screening and preventive behaviors in relatives of gastric cancer patients

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World Journal of Gastroenterology 2011年第30期17卷 3518-3525页

作者： jung Min Kang Dong Wook Shin Young Min kwon Sang Min Park Min Sun Park Jin Ho Park Ki Young Son Be Long Cho Department of Family Medicine Seoul National University Hospital101 DaehangnoJongno-Gu110-744 SeoulSouth Korea

AIM:To investigate gastric cancer screening and preventive behaviors among the relatives of patients with gastric cancer[i.e.,gastric cancer relatives(GCRs)].METHODS:We examined the Korean National Health and Nutrition Examination Survey 2005(KNHANESⅢ) database and compared the gastric cancer screening and preventive behaviors of GCRs(n=261)with those of non-GCRs(n=454)and controls without a family history of cancer(n=2842).RESULTS:The GCRs were more likely to undergo gastric cancer screening compared with the control group(39.2%vs 32.3%,adjusted odds ratio:1.43,CI:1.05-1.95),although the absolute screening rate was *** patterns and smoking rates did not differ significantly between the groups,and a high proportion of GCRs reported inappropriate dietary habits(i.e.,approximately 95%consumed excessive sodium,30% were deficient in vitamin C,and 85%were deficient in dietary fiber).CONCLUSION:The gastric cancer screening and preventive behaviors of GCRs have yet to be *** increase awareness among GCRs,systematic family education programs should be implemented.

关键词： Family history of cancer Cancer relatives Gastric cancer screening Preventive behaviors Cancerprevention

Reconstruction of Rabbit Corneal Layer Composed of Corneal Fibroblasts and Corneal Epithelium on the Lyophilized Amniotic Membrane

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Chemical Research in Chinese Universities 2006年第2期22卷 150-156页

作者： AHN Jae-il JANG In-keun YOON Mun-young SEO Young-kwon YOON Hee-hun KIN Jae-chan SONG Kye-yong YANG Eun-kyung PARK jung-keug Department of Chemical and Biochemical Engineering Dongguk University Seoul Korea Department of Ophthalmology Chung-Ang University Hospital Seoul Korea Department of Pathology College of Medicine Chung-Ang University Seoul Korea R & D Center Bioland Ltd. Chun-An Korea

Many researchers have employed the cryopreserved amniotic membrane（CAM） and corneal epithelial cells in the treatment of a severely damaged burned cornea, with corneal epithelial cells cultured on an amniotic membrane （AM）. The lyophilized amniotic membrane（LAM） has a higher graft take and a longer shelf life; it is easier to store and safer because of gamma irradiation. Two Teflon rings（ Ahn＇s supporter） were made for culturing the cells on the LAM, and were then used to support the LAM. To reconstruct a corneal layer composed of corneal fibroblasts and epithelium, the corneal fibroblasts were first cultivated on the stromal side of LAM for five days, foUowed by epithelial cells culture on the epithelial side, by using the air-liquid interface culture. The reconstructed corneal layer composed of corneal fibroblasts and corneal epithelial cells has a much healthier basal layer of corneal epithelium than the reconstructed corneal epithelium, which was got by using only corneal epithelial cells, and resembles the epithelium of normal corneas, without the horny layer. Thus, the reconstruction of the corneal layer by using a LAM is considered to be a good in vitro model, not only for its application in toxicological test kits, but also for transplantation in patients with a severely damaged cornea.

关键词： Lyophilized amniotic membrane Corneal layer Corneal fibroblast Corneal epithelium

Renal cell carcionoma with synchronous metastases to the bladder and lung

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Case Reports in Clinical Medicine 2013年第2期2卷 97-99页

作者： won Seok Jang In Sang Hwang Eu Chang Hwang Seung Il jung Dong Deuk kwon Chan Choi Departments of Pathology Chonnam National University Medical School Gwangju South Korea Departments of Urology Chonnam National University Medical School Gwangju South Korea

Renal cell carcinoma can metastasize to virtually any organ, yet synchronous metastasis to the bladder is extremely rare. A 77-year-old woman presented with gross hematuria. Abdominal and chest computed tomography showed a bilateral renal masses, bladder dome mass, and multiple lung metastasis. Transurethral resection of the bladder tumor and sonography guided renal biopsy were performed. Both pathology diagnoses were clear cell renal cell carcinoma. Targeted therapy using pazopanib was administered to the patient without surgical resection of primary tumors and metastatic lung lesions. Herein, we report the synchronous metastasis of renal cell carcinoma to the bladder and lung.

关键词： Carcinoma Renal Cell Urinary Bladder Lung Neoplasm Metastasis

Extremely low-frequency magnetic field exposure level for Koreans by occupational code

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Emerging Contaminants 2018年第1期4卷 40-46页

作者： Joon Sig jung Mailan Arachchige Don Rajitha Kawshalya In Keun Shim jung Min Ryu Myung Hee kwon Duck Shin Park Seung Cheol Hong National Indoor Environment&Noise Research Division National Institute of Environmental Research42 Hwankyeong-RoSeo-KuIncheonSouth Korea Dept.of Emergency and Disaster Management Inje University197 Inje-roGimhae-siGyungnamSouth Korea Transportation Environment Research Team Korea Railroad Research Institute176 Cheoldobagmulgwan-RoUiwang-siGyeonggi-doSouth Korea Dept.of Occupational Health&Safety Engineering Inje University197 Inje-roGimhae-siGyungnamSouth Korea

This study attempted to identify the level of exposure of 350 subjects to the extremely low-frequency magnetic field(ELF-MF).The occupational group showed significantly high levels of ELF-MF in every exposure indicator during work and transportation(p<0.05).About 11%and 6%of the members of the occupational group were exposed to over 2mG and 4 mG,respectively,of ELF-MF during"all"*** 24-h ELF-MF exposure levels of the subjects in both groups were *** the occupational group,for every activity,the percentile for less than 2mG corresponded to 100%of C-4(agriculture),95%of C-1(professional),97%of C-2(engineer,office/sales),81%of C-3(services),85%of C-5(technician,labor management),and 50%of C-6(electrician).In the non-occupational group,the percentile for less than 2mG corresponded to 92%of students,83%of homemakers,81%of the elderly,and 88%of the *** percentile for over 4mG was 5%for students,homemakers,and the elderly and 13%of the *** and the unemployed had the highest ELF-MF levels in both groups,*** were exposed to ELF-MF mostly at work,while the unemployed subjects were most affected by the activities classified under sleep and transportation.

关键词： ELF-MF EMF Exposure assessment Occupational code Occupational exposure

Gastric angiodysplasia in a hereditary hemorrhagic telangiectasia type 2 patient

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World Journal of Gastroenterology 2012年第15期18卷 1840-1844页

作者： Minsu Ha Yoon Jae Kim Kwang An kwon Ki Baik Hahm Mi-jung Kim Dong Kyu Kim Young Jae Lee S Paul Oh Department of Gastroenterology Gachon University Gil Medical CenterIncheon 402-751South Korea World Class University program Lee Gil Ya Cancer and Diabetes InstituteGachon University of Medicine and ScienceIncheon 402-751South Korea Lee Gil Ya Cancer and Diabetes Institute Gachon University of Medicine and ScienceIncheon 402-751South Korea

Hereditary hemorrhagic telangiectasia(HHT)is a rare autosomal-dominantly inherited disease that occurs in approximately one in 5000 to 8000 *** diagnosis of HHT is made when a person presents three of the following four criteria:family history,recurrent nosebleeds,mucocutaneous telangiectasis,and arteriovenous malformations(AVM)in the brain,lung,liver and gastrointestinal(GI)*** epistaxis is themost common presenting symptom,AVMs affecting the lungs,brain and GI tract provoke a more serious *** mutations in endoglin,activin receptor-like kinase 1(ACVRL1;ALK1),and SMAD4,the genes involved in the transforming growth factor-βfamily signaling cascade,cause *** report here the case of a 63 year-old male patient who presented melena and GI bleeding episodes,proven to be caused by bleeding from multiple gastric *** revealed multiple angiodysplasia throughout the *** argon plasma coagulation was performed to control bleeding from a gastric *** patient has been admitted several times with episodes of hemoptysis and *** year ago,the patient was hospitalized due to right-sided weakness,which was caused by left basal ganglia hemorrhage as the part of HHT *** family history,the patient's mother and elder sister had died,due to intracranial hemorrhage,and his eldest son has been suffered from recurrent epistaxis for 20 years.A genetic study revealed a mutation in exon 3 of ALK1(c.199C>T;***67Trp)in the proband and his eldest son presenting epistaxis.

关键词： Hereditary hemorrhagic telangiectasia Angiodysplasia Intracranial hemorrhage Epistaxis Activin receptor-like kinase 1