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journal of Energy Chemistry 2025年第2期101卷 298-323页

作者： Bonghyun jo Wenning Chen hyun Suk jung School of Advanced Materials Science and Engineering Sungkyunkwan University SKKU Institute of Energy Science and Technology (SIEST) Sungkyunkwan University Department of Future Energy Engineering Sungkyunkwan University

Perovskite solar cells(PSCs) have developed rapidly,positioning them as potential candidates for nextgeneration renewable energy ***,conventional trial-and-error approaches and the vast compositional parameter space continue to pose challenges in the pursuit of exceptional performance and high stability of perovskite-based *** increasing demand for novel materials in optoelectronic devices and establishment of substantial databases has enabled data-driven machinelearning(ML) approaches to swiftly advance in the materials *** review succinctly outlines the fundamental ML procedures,techniques,and recent breakthroughs,particularly in predicting the physical characteristics of perovskite ***,it highlights research endeavors aimed at optimizing and screening materials to enhance the efficiency and stability of ***,this review highlights recent efforts in using characterization data for ML,exploring their correlations with material properties and device performance,which are actively being researched,but they have yet to receive significant ***,we provide future perspectives,such as leveraging Large Language Models(LLMs) and text-mining,to expedite the discovery of novel perovskite materials and expand their utilization across various optoelectronic fields.

关键词： Characterization Data-driven machine learning Perovskite materials Perovskite solar cell

Benefit of neoadjuvant concurrent chemoradiotherapy for locally advanced perihilar cholangiocarcinoma

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World journal of Gastroenterology 2017年第18期23卷 3301-3308页

作者： Jang Han jung hyun Jik Lee Hee Seung Lee jung hyun jo In Rae Cho Moon Jae Chung Jeong Youp Park Seung Woo Park Si Young Song Seungmin Bang Division of Gastroenterology Department of Internal Medicine Hallym University Dongtan Sacred Heart Hospital Division of Gastroenterology Department of Internal Medicine and Yonsei Institute of Gastroenterology Yonsei University College of Medicine

To clarify the role of neoadjuvant concurrent chemoradiotherapy (NACCRT) followed by surgical resection for localized or locally advanced perihilar cholangiocarcinoma (CCA).METHODSWe retrospectively reviewed 57 patients who underwent surgical resection with or without NACCRT for perihilar CCA; 12 patients received NACCRT and 45 patients did not received NACCRT. Patients with locally advanced perihilar CCA requiring NACCRT were defined as follows: (1) a mass involving unilateral branches of the portal vein or hepatic artery with insufficient volume of the anticipated remnant lobe; or (2) an infiltrating mass in the main portal vein that was too long for reconstruction, identified at preoperative *** median disease-free survival (DFS) durations of the neoadjuvant and non-neoadjuvant CCRT groups were 26.0 and 15.1 mo, respectively (P = 0.91). The median overall survival (OS) durations of the neoadjuvant and non-neoadjuvant CCRT groups were 32.9 and 27.1 mo, respectively (P = 0.26). The NACCRT group showed a downstaging tendency compared to the non-NACCRT group as compared with the tumor stage confirmed by histological examination after surgery and the tumor stage confirmed by imaging test at the time of diagnosis (P = 0.01).CONCLUSIONNACCRT does not prolong DFS and OS in localized or locally advanced perihilar CCA. However, NACCRT may allow tumor downstaging and improve tumor resectability.

关键词： Klatskin tumor Locally advanced Survival rate Neoadjuvant therapy Chemoradiotherapy

KML001, an arsenic compound, as salvage chemotherapy in refractory biliary tract cancers: A prospective study

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Hepatobiliary & Pancreatic Diseases International 2019年第1期18卷 62-66页

作者： jung hyun jo Huapyong Kang Hee Seung Lee Moon Jae Chung Jeong Youp Park Seungmin Bang Seung Woo Park Si Young Song Division of Gastroenterology Department of Internal Medicine Severance Hospital Yonsei University College of Medicine

Background: Sodium meta-arsenite(NaAsO_2, KML001) is a potential oral anticancer agent acting on telomerase and telomere length. This prospective study evaluated its safety, tolerability, and effectiveness as salvage chemotherapy in patients with advanced biliary tract cancer(BTC) resistant to gemcitabinebased chemotherapy. Methods: Forty-four patients(21 women and 23 men) with advanced BTC and failure history of gemcitabine-based chemotherapy, performance status(PS) 0–2, normal cardiac, hepatic, and renal function were enrolled. Daily dose of KML001(7.5 mg. p.o.) was administered to eligible subjects for 24 weeks divided into six treatment cycles. Response was evaluated bimonthly using CT. Results: After an average of 1.5 months of treatment(range: 0.5–10.0), 3 patients(6.8%) obtained progression-free status, 23 patients(52.3%) had disease progression, and 18 patients(40.9%) dropped out before evaluation. One patient(2.3%) completed six treatment cycles without progression. During the treatment, morphine dosage kept the same or decreased in 20 patients(47.6%). Nine patients(20.5%) experienced grade-3 adverse events(AEs), while no patient experienced grade-4 AEs. The most common AEs were liver enzyme elevation(11/44, 25%) and anemia(10/44, 22.7%). KML001 was discontinued in six patients(13.6%) due to AEs, including liver toxicity( n = 3), QTc prolongation( n = 2), and abdominal pain( n = 1). Conclusions: KML001 did not have enough anticancer effect on patients with advanced BTC resistant to gemcitabine. However, KML001 was safe and well-tolerable in terms of AEs and pain control when used as salvage therapy. Further studies are needed to establish arsenic agents as a reliable treatment option in patients with BTC.

关键词： Biliary tract neoplasms Cholangiocarcinoma Gallbladder neoplasms KML001 Sodium meta-arsenite

Comparison of efficacy and safety between standard-dose and modified-dose FOLFIRINOX as a first-line treatment of pancreatic cancer

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World journal of Gastrointestinal Oncology 2018年第11期10卷 421-430页

作者： Huapyong Kang jung hyun jo Hee Seung Lee Moon Jae Chung Seungmin Bang Seung Woo Park Si Young Song Jeong Youp Park Division of Gastroenterology Department of Internal Medicine Yonsei University College of Medicine

AIM To directly compare the efficacy and toxicity of standarddose FOLFIRINOX(sFOLFIRINOX) and modified-dose FOLFIRINOX(mFOLFIRINOX, 75% of standard-dose) for pancreatic *** One hundred and thirty pancreatic cancer patients who received sFOLFIRINOX(n = 88) or mFOLFIRINOX(n = 42) as their first-line chemotherapy from January 2013 to July 2017 were retrospectively reviewed. For efficacy analysis, the objective response rate(ORR),disease control rate(DCR), progression-free survival(PFS), and overall survival(OS) were evaluated and compared using Pearson's chi-square test, Kaplan-Meier plot and log-rank test. The adverse events(AEs) were evaluated, and severe(≥ grade 3) AEs rates of the two groups were compared for toxicity *** The mFOLFIRINOX group included more female patients(30.7% vs 57.1%; P = 0.004) and older patients [age(median), 57 vs 63.5; P = 0.018] than the sFOLFIRINOX group. In the efficacy analysis, the ORR and DCR were not significantly different between the two groups(ORR: 39.8% vs 35.7%; P = 0.656; DCR: 80.7% vs 83.3%; P = 0.716). The median PFS and OS were also not different between the groups(PFS: 8.7 mo vs 8.1 mo, P = 0.272; OS: 13.9 mo vs 13.7 mo, P = 0.476). In the safety analysis with severe AEs, the rates of neutropenia(83.0% vs 66.7%; P = 0.044), anorexia(48.9% vs 28.6%; P = 0.029) and diarrhea(13.6% vs 0.0%; P = 0.009) were markedly lower in the mFOLFIRINOX *** m FOLFIRINOX showed comparable efficacy but better safety compared to sFOLFIRINOX. If clinically necessary, initiating FOLFIRINOX with 75% of the standard-dose can alleviate toxicity concerns without compromising efficacy.

关键词： Dose modification Adverse event Pancreatic cancer Adenocarcinoma FOLFIRINOX Chemotherapy

FOLFIRINOX vs gemcitabine/nab-paclitaxel for treatment of metastatic pancreatic cancer: Single-center cohort study

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World journal of Gastrointestinal Oncology 2020年第2期12卷 182-194页

作者： In Rae Cho Huapyong Kang jung hyun jo Hee Seung Lee Moon Jae Chung Jeong Youp Park Seung Woo Park Si Young Song Chansik An Mi-Suk Park Seungmin Bang Department of Internal Medicine International Saint Mary’s HospitalCatholic Kwandong University College of MedicineIncheon 22711South Korea Department of Medicine Yonsei University Graduate School50-1 Yonsei-roSeoul 03722South Korea Division of Gastroenterology Department of Internal MedicineYonsei University College of Medicine50-1 Yonsei-roSeoul 03722South Korea Department of Radiology Yonsei University College of Medicine50-1 Yonsei-roSeoul 03722South Korea

BACKGROUND FOLFIRINOX and gemcitabine plus nab-paclitaxel(Gem+nabPTX)were recently introduced for metastatic pancreatic cancer ***,studies that compared these two regimens and studies in Asian populations are *** To compare the treatment outcomes of FOLFIRINOX and Gem+nabPTX regimen for metastatic pancreatic cancer treatment in Korean *** Patients with metastatic or recurrent pancreatic cancer treated with FOLFIRINOX(n=86)or Gem+nabPTX(n=81)as the first-line since January 2015 were identified using the Severance Hospital Pancreatic Cancer Cohort *** efficacy,treatment-related adverse events and economic aspects were *** Patients in the FOLFIRINOX group were significantly younger(54 vs 65 years;P<0.001)and had better performance statuses at *** median overall survival(10.7 vs 12.1 mo;P=0.157),progression-free survival(8.0 vs 8.4 mo;P=0.134),and objective response rates(33.7%vs 46.9%;P=0.067)were not significantly different when compared with Gem+nabPTX ***≥3 neutropenia and gastrointestinal adverse events were more common in the FOLFIRINOX *** drug costs of both regimens were *** Treatment efficacy and economic burdens were comparable between the two ***,the details of adverse event were ***+nabPTX regimen might be considered preferentially in certain conditions.

关键词： Pancreatic cancer Chemotherapy FOLFIRINOX Gemcitabine Nabpaclitaxel Survival

TMEM39A and TMEM131 facilitate bulk transport of ECM proteins through large COPII vesicle formation

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journal of Genetics and Genomics 2025年第2期52卷 189-203页

作者： Jee Young Sung Ga-Eun Lim Jarim Goo Kyung Jin jung Jeong Min Chung hyun Suk jung Yong-Nyun Kim Jaegal Shim Cancer Metastasis Branch Research InstituteNational Cancer Center323 Ilsan-roGoyang-siGyeonggi-do10408Republic of Korea Experimental Clinical Research Center Biomedical Research InstituteSeoul National University Bundang HospitalSeongnamGyeonggi-do13620Republic of Korea Department of Biochemistry College of Natural SciencesKangwon National UniversityChuncheonKangwon-do24341Republic of Korea

The growth of Caenorhabditis elegans involves multiple molting processes,during which old cuticles are shed and new cuticles are rapidly *** process requires the regulated bulk secretion of cuticle *** transmembrane protein-39(TMEM-39)mutant exhibits distinct dumpy and ruptured phenotypes characterized by notably thin ***-39 primarily co-localizes with the coat protein II complex(COPII)in large vesicles rather than small COPII *** TMEM-39-associated large vesicles(TMEM-39-LVs)form robustly during the molting period and co-localize with various extracellular matrix components,including BLI-1 collagen,BLI-3 dual oxidase,and *** immunoprecipitation using TMEM39A-FLAG and proteomics analysis in human sarcoma cells,we identify TMEM39A-associated proteins,including *** of TMEM131 results in reduced TMEM39A-LV formation and collagen secretion in both *** and human sarcoma cells,indicating a cooperative role between TMEM39A and TMEM131 in the secretion of extracellular components through the formation of large COPII *** the conservation of TMEM39A and its associated proteins between *** and humans,TMEM39A-LVs may represent a fundamental machinery for rapid and extensive secretion across metazoans.

关键词： Bulk secretion Collagen COPII ECM TMEM39A TMEM131

Extended protective effects of three dimensional cultured human mesenchymal stromal cells in a neuroinflammation model

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World journal of Stem Cells 2025年第1期17卷 53-65页

作者： Ok-Hyeon Kim Hana Kang Eun Seo Chang Younghyun Lim Young-Jin Seo hyun jung Lee Department of Anatomy and Cell Biology College of MedicineChung-Ang UniversitySeoul 06974South Korea Department of Global Innovative Drugs Graduate School of Chung-Ang UniversitySeoul 06974South Korea Department of Life Science Chung-Ang UniversitySeoul 06974South Korea

BACKGROUND Human mesenchymal stromal cells(MSCs)possess regenerative potential due to pluripotency and paracrine ***,their stemness and immunomod-ulatory capabilities are sub-optimal in conventional two-dimensional(2D)*** To enhance the efficiency and therapeutic efficacy of MSCs,an in vivo-like 3D culture condition was *** MSCs were cultured on polystyrene(2D)or in a gellan gum-based 3D *** vitro,prostaglandin-endoperoxide synthase 2,indoleamine-2,3-dioxygenase,heme oxygenase 1,and prostaglandin E synthase gene expression was quantified by quantitative real-time polymerase chain *** were incubated with lipopolysaccharide(LPS)-treated mouse splenocytes,and prostaglandin E2 and tumor necrosis factor-alpha levels were measured by enzyme linked immuno-sorbent *** vivo,LPS was injected into the lateral ventricle of mouse brain,and MSCs were administered intravenously the next *** were sacrificed and analyzed on days 2 and *** Gellan gum polymer-based 3D culture significantly increased expression of octamer-binding transcription factor 4 and Nanog homeobox stemness markers in human MSCs compared to 2D *** 3D environment also heightened expression of cyclooxygenase-2 and heme-oxygenase 1,enzymes known for immunomodulatory functions,including production of prostaglandins and heme degradation,*** in 3D culture secreted more prostaglandin E2 and effectively suppressed tumor necrosis factor-alpha release from LPS-stimulated splenocytes and surpassed the efficiency of MSCs cultured in *** a murine neuroinflammation model,intravenous injection of 3D-cultured MSCs significantly reduced ionized calcium-binding adaptor molecule 1 and glial fibrillary acidic protein expression,mitigating chronic inflammation more effectively than 2D-cultured *** The microenvironment established in 3D culture serves as an in vivo mimetic,enhancing the immunomodulatory function of *** sugge

关键词： Mesenchymal stromal cells Three-dimensional culture Immunomodulatory function Neuroinflammation Cell therapy

Half-Covered'Glitter-Cake'AM@SE Composite:A Novel Electrode Design for High Energy Density All-Solid-State Batteries

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Nano-Micro Letters 2025年第5期17卷 463-478页

作者： Min Ji Kim Jin-Sung Park Jin Woong Lee Sung Eun Wang Dowoong Yoon jong Deok Lee jung hyun Kim Taeseup Song Ju Li Yun Chan Kang Dae Soo jung Energy and Environmental Division Korea Institute of Ceramic Engineering and TechnologyJinjuGyeongnam 52851Republic of Korea Department of Materials Science and Engineering Korea UniversityAnam-DongSeongbuk-GuSeoul 136-713Republic of Korea Department of Nuclear Science and Engineering Massachusetts Institute of TechnologyCambridgeMA 20139USA Department of Materials Science and Engineering Ajou UniversitySuwon 16499Republic of Korea Department of Energy Systems Research Ajou UniversitySuwon 16499Republic of Korea Department of Energy Engineering Hanyang UniversitySeoul 04763Republic of Korea Department of Materials Science and Engineering Massachusetts Institute of TechnologyCambridgeMA 02139USA

All-solid-state batteries(ASSBs)are pursued due to their potential for better safety and high energy ***,the energy density of the cathode for ASSBs does not seem to be satisfactory due to the low utilization of active materials(AMs)at high *** small amount of solid electrolyte(SE)powder in the cathode,poor electrochemical performance is often observed due to contact loss and non-homogeneous distribution of AMs and SEs,leading to high tortuosity and limitation of lithium and electron transport ***,we propose a novel cathode design that can achieve high volumetric energy density of 1258 Wh L^(-1)at high AM content of 85 wt%by synergizing the merits of AM@SE core–shell composite particles with conformally coated thin SE shell prepared from mechanofusion process and small SE *** core–shell structure with an intimate and thin SE shell guarantees high ionic conduction pathway while unharming the electronic *** addition,small SE particles play the role of a filler that reduces the packing porosity in the cathode composite electrode as well as between the cathode and the SE separator *** systematic demonstration of the optimization process may provide understanding and guidance on the design of electrodes for ASSBs with high electrode density,capacity,and ultimately energy density.

关键词： All-solid-state batteries Cathodes Sulfide-based solid electrolytes Interfaces Mechanofusion

Novel transparent high-entropy sesquioxide ceramics with high physicochemical plasma etching resistance

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joURNAL OF ADVANCED CERAMICS 2025年第1期14卷 163-176页

作者： Shin, Yu-Bin Ham, Su Been Kim, Ha-Neul Kim, Mi-Ju Ko, Jae-Woong Lee, Jae-Wook Park, Young-jo Kim, jung-hyung Lee, Hyo-Chang jung, Young Hwa Lee, jung Woo Ma, Ho Jin Korea Inst Mat Sci Nano Mat Res Div Chang Won 51508 Gyeongsangnam South Korea Pusan Natl Univ Dept Mat Sci & Engn Pusan 46241 South Korea Korea Res Inst Stand & Sci Semicond Integrated Metrol Team Daejeon 34113 South Korea Korea Aerosp Univ Dept Semicond Sci Engn & Technol Goyang 10540 South Korea Korea Aerosp Univ Sch Elect & Informat Engn Goyang 10540 South Korea Pohang Accelerator Lab PLS II Beamline Div Pohang 37673 South Korea

High-entropy ceramics exhibit novel intrinsic properties. Hence, they have been explored for a wide range of applications ranging from thermal insulation and energy storage to advanced optical components. Recently, the semiconductor industry has faced a demand for higher-performance chips, necessitating higher aspect ratios in wafer fabrication and further miniaturization of linewidths. Therefore, novel materials with high plasma etching resistance and minimal contaminant generation are needed. The plasma-etching resistance displayed by high-entropy ceramics can be an innovative solution to this emerging challenge. In this study, we successfully fabricated single-phase high-entropy sesquioxide ceramics with high optical transparency, dense microstructure, and minimal residual pores. A structural analysis of the fabricated samples revealed a single-phase structure with excellent phase homogeneity. An evaluation of the plasma-etching resistance of high-entropy ceramics revealed for the first time a low etching rate of 8 nm/h compared with that of conventional plasma-resistant materials. These comprehensive characterizations of high-entropy ceramics indicate that they are promising candidates for significantly improving the production yield of semiconductors and for a wide range of potential applications, such as next-generation active optical ceramics.

关键词： high-entropy ceramics plasma etching resistance transparent ceramics sintering semiconductor manufacturing

LED照射光催化剂用于苯、甲苯、乙苯和二甲苯分解(英文)

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催化学报 2012年第10期33卷 1672-1680页

作者： jo Wan-Kuen KANG hyun-jung Department of Environmental Engineering Kyungpook National University

Studies on the use of gas phase applications of light emitting diodes(LEDs) in photocatalysis are scarce although their photocatalytic decomposition kinetics of environmental pollutants are likely different from those in aqueous *** present study evaluated the use of chips of visible light LEDs to irradiate nitrogen doped titania(N-TiO2) prepared by hydrolysis to decompose gaseous benzene,toluene,ethyl benzene,m-xylene,p-xylene,and *** calcined at different temperatures were characterized by various analytical *** degradation efficiency of benzene was close to zero for all *** the other compounds,a conventional 8 W daylight lamp/N-TiO2 unit gave a higher photocatalytic degradation efficiency as compared with that of visible-LED/N-TiO2 ***,the ratios of degradation efficiency to electric power consumption were higher for the photocatalytic units that used two types of visible-LED lamps(blue and white LEDs).The highest degradation efficiency was observed with the use of a calcination temperature of 350 *** average degradation efficiencies for toluene,ethyl benzene,m-xylene,p-xylene,and o-xylene were 35%,68%,94%,and 93%,*** use of blue-and white-LEDs,high light intensity,and low initial concentrations gave high photocatalytic activities for the photocatalytic units using *** morphological and optical properties of the photocatalysts were correlated to explain the dependence of photocatalytic activity on calcination *** results suggest that visible-LEDs are energy efficient light source for photocatalytic gas phase applications,but the activity depends on the operational conditions.

关键词： light emitting diode energy efficiency gas phase degradation photocatalyst characterization calcination temperature