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The protean manifestations of central nervous system IgG4-related hypertrophic pachymeningitis:a report of two cases

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Chinese Neurosurgical Journal 2021年第4期7卷 306-312页

作者： Peter Y.m.Woo Ben C.F.Ng june h.m.wong Oliver K.S.Ng Timothy S.K.Chan Ngai-Fung Kwok Kwong-Yau Chan Department of Neurosurgery Kwong Wah HospitalHong KongHong KongChina Department of Internal medicine Caritas Medical CenterHong KongHong KongChina Department of Pathology Kwong Wah Hospital25 Waterloo RoadYaumateiHong KongHong KongChina Department of Neurosurgery Queen Elizabeth HospitalHong KongHong KongChina

Background:IgG4-related hypertrophic pachymeningitis is a relative newly recognized and rare manifestation of IgG4-related disease,an immune-mediated fibroinflammatory tumefactive *** than 80 patients have been reported in the literature,and it can mimic common neurosurgical *** describe the clinical presentation of two patients that were initially considered to have a subdural collection,tuberculous meningitis,and a cervical spinal meningioma,but were eventually diagnosed with this *** presentation:Two ethnic Chinese men,86 and 62 years old,experienced a 4-week history of *** patients had a history of autoimmune disease,namely glomerulonephritis and Grave’s disease,*** resonance brain imaging revealed diffuse dural thickening with the latter patient exhibiting homogeneous and intense gadolinium-contrast *** the 86-year-old patient also had progressive bilateral visual loss,giant cell arteritis was suspected and a 2-week course of glucocorticoid therapy was prescribed,but his symptoms failed to *** 62-year-old patient also had accompanying low-grade fever and was treated empirically as having tuberculous meningitis although there were no confirmatory microbiological *** patient further developed right hemiparesis,and additional imaging revealed a C4/5 intradural-extramedullary contrast-enhancing lesion resembling a meningioma causing cord *** patients underwent neurosurgical intervention with the former undergoing a dural biopsy and the latter having the cervical lesion *** final diagnosis was IgG4-related hypertrophic pachymeningitis with the hallmark histological features of lymphoplasmacytic infiltration of IgG4+plasma cells,storiform fibrosis,and obliterative *** addition,their serum IgG4 levels were elevated(i.e.,>135 mg/dL).Both patients received at least 6 months of glucocorticoid therapy while the latter also had *** symptom

关键词： hypertrophic pachymeningitis IgG4-related disease IgG4-related sclerosing disease Central nervous system

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A pipeline to characterize p53 effectors by integrative cistrome and transcriptome analysis in a genetically-defined organoid model

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Genes & Diseases 2024年第2期11卷 512-515页

作者： june-ha Shin hwa-Ryeon Kim Jae-Seok Roe Department of Biochemistry College of Life Science and BiotechnologyYonsei UniversitySeoul 120-749Republic of Korea

Tumor-protein 53(p53)is a transcription factor(TF)encoded by TP53(Trp53 in mice)and is a master regulator of tumor-suppressive programs'.Importantly,TP53 is the most frequently mutated gene in human cancer,and its loss of function contributes to tumor development,exemplified by variable p53 mutations detected in 50%-75%of pancreatic cancers.2 From these perceptions,a number of targets transcribed by p53 that confer tumor suppression have been ***,our understanding of how p53 prevents normal cells from initiating tumorigenesis is still *** complement this limitation,herein,we established a new approach to identify underlying effectors transcribed by p53 in normal physiology.

关键词： incomplete initiating herein

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Superior antibody and membrane protein‑specific T‑cell responses to CoronaVac by intradermal versus intramuscular routes in adolescents

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World Journal of Pediatrics 2024年第4期20卷 353-370页

作者： Jaime S.Rosa Duque Samuel m.S.Cheng Carolyn A.Cohen Daniel Leung Xiwei Wang Xiaofeng mu Yuet Chung Tsun ming Lau manni Wang Wenyue Zhang Yanmei Zhang howard h.W.wong Leo C.h.Tsang Sara Chaothai Tsz Chun Kwan John K.C.Li Karl C.K.Chan Leo L.h.Luk Jenson C.h.ho Wing Yan Li Amos m.T.Lee Jennifer h.Y.Lam Sau man Chan Wilfred h.S.wong Issan Y.S.Tam masashi mori Sophie A.Valkenburg malik Peiris Wenwei Tu Yu Lung Lau Department of Paediatrics and Adolescent medicine The University of Hong KongHong KongChina School of Public health The University of Hong KongHong KongChina hKU‑Pasteur Research Pole School of Public HealthThe University of Hong KongHong KongChina Research Institute for Bioresources and Biotechnology Ishikawa Prefectural UniversityNonoichiJapan Department of microbiology and Immunology Peter Doherty Institute for Infectionand ImmunityUniversity of MelbourneMelbourneVICAustralia Center for Immunology and Infection C2i Hong KongChina

Background Optimising the immunogenicity of COVID-19 vaccines to improve their protection against disease is *** dosing by intradermal(ID)administration has been shown to be equally immunogenic as intramuscular(Im)administration for several vaccines,but the immunogenicity of ID inactivated whole severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)at the full dose is *** study(NCT04800133)investigated the superiority of antibody and T-cell responses of full-dose CoronaVac by ID over Im administration in *** Participants aged 11–17 years received two doses of Im or ID vaccine,followed by the 3rd dose 13–42 days *** and cellular immunogenicity outcomes were measured post-dose 2(Im-CC versus ID-CC)and post-dose 3(ImCCC versus ID-CCC).Doses 2 and 3 were administered to 173 and 104 adolescents,*** Spike protein(S)immunoglobulin G(IgG),S-receptor-binding domain(RBD)IgG,S IgG Fcγreceptor IIIa(FcγRIIIa)-binding,SNm[sum of individual(S),nucleocapsid protein(N),and membrane protein(m)peptide pool]-specific interleukin-2(IL-2)+CD4^(+),SNm-specific IL-2^(+)CD8^(+),S-specific IL-2^(+)CD8^(+),N-specific IL-2^(+)CD4^(+),N-specific IL-2^(+)CD8^(+)and m-specific IL-2^(+)CD4^(+)responses fulfilled the superior and non-inferior criteria for ID-CC compared to Im-CC,whereas IgG avidity was *** ID-CCC,S-RBD IgG,surrogate virus neutralisation test,90%plaque reduction neutralisation titre(PRNT90),PRNT50,S IgG avidity,S IgG FcγRIIIa-binding,m-specific IL-2^(+)CD4^(+),interferon-γ+CD8^(+)and IL-2^(+)CD8^(+)responses were superior and non-inferior to *** estimated vaccine efficacies were 49%,52%,66%and 79%for Im-CC,ID-CC,Im-CCC and ID-CCC,*** ID groups reported more local,mild adverse *** This is the first study to demonstrate superior antibody and m-specific T-cell responses by ID inactivated SARSCoV-2 vaccination and serves as the basis for future research to improve the

关键词： CoronaVac Coronavirus disease 2019 Immunity Intradermal Vaccine

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Insights on advanced substrates for controllable fabrication of photoanodes toward efficient and stable photoelectrochemical water splitting

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Carbon Energy 2024年第4期6卷 164-221页

作者： huilin hou Gang Shao Yang Wang Wai‐Yeung wong Weiyou Yang Institute of micro/Nano materials and Devices Ningbo University of TechnologyNingboChina School of materials Science and Engineering Zhengzhou UniversityZhengzhouChina Department of Applied Biology and Chemical Technology and Research Institute for Smart Energy The Hong Kong Polytechnic UniversityHong KongChina

Conversion of solar energy into h_(2) by photoelectrochemical(PEC)water splitting is recognized as an ideal way to address the growing energy crisis and environmental *** a typical PEC cell,the construction of photoanodes is crucial to guarantee the high efficiency and stability of PEC reactions,which fundamentally rely on rationally designed semiconductors(as the active materials)and substrates(as the current collectors).In this review work,we start with a brief introduction of the roles of substrates in the PEC ***,we provide a systematic overview of representative strategies for the controlled fabrication of photoanodes on rationally designed substrates,including conductive glass,metal,sapphire,silicon,silicon carbide,and flexible ***,some prospects concerning the challenges and research directions in this area are proposed.

关键词： hydrogen photoanode photoelectrochemical substrates water splitting

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Surface-modified Ag@Ru-P25 for photocatalytic CO_(2) conversion with high selectivity over Ch_(4) formation at the solid–gas interface

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Carbon Energy 2024年第1期6卷 182-196页

作者： Chaitanya B.hiragond Sohag Biswas Niket SPowar Junho Lee Eunhee Gong hwapyong Kim hong Soo Kim Jin-Woo Jung Chang-hee Cho Bryan m.wong Su-Il In Department of Energy Science&Engineering Daegu Gyeongbuk Institute of Science and Technology(DGIST)DaeguRepublic of Korea Department of Chemical&Environmental Engineering Materials Science&Engineering ProgramDepartment of ChemistryDepartment of Physics&AstronomyUniversity of California-RiversideRiversideCaliforniaUSA Department of Physics and Chemistry Daegu Gyeongbuk Institute of Science and Technology(DGIST)DaeguRepublic of Korea NiceScience Corporation DaeguRepublic of Korea

Systematic optimization of the photocatalyst and investigation of the role of each component is important to maximizing catalytic activity and comprehending the photocatalytic conversion of CO_(2) reduction to solar fuels.A surface-modified Ag@Ru-P25 photocatalyst with h_(2)O_(2) treatment was designed in this study to convert CO_(2) and h_(2)O vapor into highly selective *** doping followed by Ag nanoparticles(NPs)cocatalyst deposition on P25(TiO_(2))enhances visible light absorption and charge separation,whereas h_(2)O_(2) treatment modifies the surface of the photocatalyst with hydroxyl(–Oh)groups and promotes CO_(2) ***-resonance transmission electron microscopy,X-ray photoelectron spectroscopy,X-ray absorption near-edge structure,and extended X-ray absorption fine structure techniques were used to analyze the surface and chemical composition of the photocatalyst,while thermogravimetric analysis,CO_(2) adsorption isotherm,and temperature programmed desorption study were performed to examine the significance of h_(2)O_(2) treatment in increasing CO_(2) reduction *** optimized Ag1.0@Ru1.0-P25 photocatalyst performed excellent CO_(2) reduction activity into CO,Ch4,and C2h6 with a~95%selectivity of Ch4,where the activity was~135 times higher than that of pristine TiO_(2)(P25).For the first time,this work explored the effect of h_(2)O_(2) treatment on the photocatalyst that dramatically increases CO_(2) reduction activity.

关键词： gas-phase CO_(2) reduction h_(2)O_(2) treatment plasmonic nanoparticles solar fuel photocatalyst surface modification

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Tilted global solar irradiance in Bahrain: an experimental study

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CLEAN ENERGY 2024年第2期8卷 27-34页

作者： Vasilikos, N. Georgantopoulou, C. Alajaimi, h. Almajed, S. h. Ahmed, m. mathioulakis, D. Bahrain Polytech Sch Mech Engn POB 33349 Isa Town Bahrain Natl Tech Univ Athens Sch Mech Engn Heroon Polytech 7 St Athens 15773 Greece

In the present work, tilted global solar irradiance data are presented and analysed, measured for a period of 1 year on the campus of Bahrain Polytechnic, Kingdom of Bahrain, from both a fixed photovoltaic panel and a moving one via a two-axis solar tracker. The fixed panel faces south with an angle of 26 degrees with respect to the horizontal, coinciding with the local geographical latitude. The second panel is moved by two motors, controlled by a global positioning system and suitable software so that the Sun's rays are perpendicular to the panel surface. A pyranometer is installed on each panel, recording the tilted global solar irradiance, stored by using a data logger. The analysis of the data obtained shows a 33% solar energy gain on an annual basis for the moving panel (2780 versus 2088 kWh/m2 on the fixed panel). more importantly, in june, when the energy demand in Bahrain is elevated due to the increased residential cooling loads, the solar energy received by the moving panel is 54.7% higher compared with that of the fixed panel. On a percentage basis, the increase in solar energy from the moving panel is profound in the early morning and late evening hours. moreover, the reduction in the solar energy received by the fixed panel from may to june does not appear in the moving panel because of the adjustable orientation of the latter. Throughout the year, the mean daily solar power varies between 0.37 and 0.56 kW/m2 for the fixed panel, and 0.45 and 0.70 kW/m2 for the moving panel. In winter, solar energy fluctuations are elevated due to erratic weather conditions that present a peak standard deviation of 28% of the corresponding mean. The data presented are useful for potential solar investments in Gulf countries. Tilted global solar irradiance data are measured and analysed for a period of 1 year on the campus of Bahrain Polytechnic, Kingdom of Bahrain, from both a fixed photovoltaic panel and a moving one via a two-axis solar tracker. Graphical Abstract

关键词： tilted solar irradiance renewable energy solar tracking photovoltaic Gulf Cooperation Council Countries SUN TRACKING ENERGY SYSTEmS PANELS WORLD

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Empirical model for fusion cross sections of Ca-induced reactions

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Chinese Physics C 2024年第3期48卷 126-132页

作者： Reddi Rani.L N.Sowmya K.N Sridhar h C.manjunatha m.m.Armstrong Arasu Department of Physics St.Joseph's College(Autonomous)Affiliated to Bharathidasan UniversityTiruchirappalli620002TNIndia Department of Physics Govt.First.Grade CollegeChikkaballapur-562101KarnatakaIndia Department of Physics Govt.First.Grade CollegeMalur-563160KarnatakaIndia Department of Physics Govt.First.Grade CollegeDevanahalli-562110KarnatakaIndia

A new empirical formula for the astrophysical S-factor has been suggested as a function of the Coulomb interaction parameter,center of mass energy,and barrier *** 22 fusion reactions with ^(40,48)Ca as projectiles were considered for different targets,leading to compound nuclei with atomic and mass numbers varying between 40≤Z≤≤Z≤112 and 88≤A≤27888≤A≤278,*** fusion cross-sections have been estimated using the geometric factor,the Gamow-Sommerfield factor,and the empirical formula for the *** study's findings showed better agreement with those of available experiments when compared to wong's *** present work leads to a smaller standard deviation value than wong's formula when used to correlate the experimental data of calcium-induced fusion ***'s formula provides a good approximation of fusion cross-sections when the center of mass energy is below the fusion barrier when compared to above the fusion barrier.

关键词： fusion cross-sections wong formula Gamow-Sommerfield-factor Geometric-factor S-factor

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Chemical biology investigation of a triple-action,smart-decomposition antimicrobial booster based-combination therapy against“ESKAPE”pathogens

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Science China Chemistry 2024年第9期67卷 3071-3082页

作者： min Wang huangsheng Pu Yangfan Xu Chenxuan Wu Yuanxin Gu Qingyun Cai Guoxing Yin Peng Yin Chunhui Zhang Wing-Leung wong muyang Wan Yugang Bai Xinxin Feng State Key Laboratory of Chem-/Bio-Sensing and Chemometrics Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biologyand School of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China College of Biology Hunan UniversityChangsha 410082China College of Advanced Interdisciplinary Studies&hunan Provincial Key Laboratory of Novel Nano Optoelectronic Information materials and Devices National University of Defense TechnologyChangsha 410073China Nanhu Laser Laboratory National University of Defense TechnologyChangsha 410073China Key Laboratory of Chemical Biology and Traditional Chinese medicine Research(ministry of Education) College of Chemistry and Chemical EngineeringHunan Normal UniversityChangsha 410081China State Key Laboratory of Chemical Biology and Drug Discovery Department of Applied Biology and Chemical TechnologyThe Hong Kong Polytechnic UniversityHong Kong SAR 999077China hunan Provincial Key Laboratory of Anti-Resistance microbial Drugs The Third Hospital of Changsha(The Affiliated Changsha Hospital of Hunan University)Changsha 410015China

The global antibiotic resistance crisis necessitates urgent *** innovative approach involves potentiating antibiotics and non-antibiotic drugs with adjuvants or boosters.A major drawback of these membrane-active boosters is their limited biocompatibility,as they struggle to differentiate between prokaryotic and eukaryotic *** study reports the chemical biology investigation of a dual-action oligoamidine(OA1)booster with a glutathione-triggered decomposition ***1,when combined with other antimicrobial molecules,exhibits a triple-targeting mechanism including cell membrane disruption,DNA targeting,and intracellular enzyme *** multi-targeting mechanism not only enhances the in vitro and in vivo eradication of antibiotic-resistant“ESKAPE”pathogens,but also suppresses the development of bacterial ***,OA1 maintains its activity in bacterial cells by creating an oxidative environment,while it quickly decomposes in mammalian cells due to high glutathione *** mechanistic insights and design principles may provide a feasible approach to develop novel antimicrobial agents and effective anti-resistance combination therapies.

关键词： antimicrobial booster oligoamidine membrane disruption DNA targeting triggered degradation anti-resistance

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Slide-free histological imaging by microscopy with ultraviolet surface excitation using speckle illumination

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Photonics Research 2022年第1期10卷 120-125页

作者： IVY h.m.wong YAN ZhANG ZhENGhUI ChEN LEI KANG TERENCE T.W.wong Translational and Advanced Bioimaging Laboratory Department of Chemical and Biological EngineeringHong Kong University of Science and TechnologyHong KongChina

microscopy with ultraviolet surface excitation(mUSE)is a promising slide-free imaging technique to improve the time-consuming histopathology ***,since the penetration depth of the excitation light is tissue dependent,the image contrast could be significantly degraded when the depth of field of the imaging system is shallower than the penetration ***-resolution cellular imaging normally comes with a shallow depth of field,which also restricts the tolerance of surface roughness in biological *** we propose the incorporation of mUSE with speckle illumination(termed mUSES),which can achieve sharp imaging on thick and rough *** experimental results demonstrate the potential of mUSES in providing histological images with~1μm spatial resolution and improved contrast,within 10 minutes for a field of view of 1.7 mm×1.2 *** the extended depth of field feature,mUSES also relieves the constraint of tissue ***,with a color transformation assisted by deep learning,a virtually stained histological image can be generated without manual tuning,improving the applicability of mUSES in clinical settings.

关键词： excitation illumination speckle

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The Effects of Organic Ligands on the Survival of Daphnia in Zn Solution

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Biomedical and Environmental Sciences 1991年第4期4卷 433-440页

作者： m.h.wong Department of Biology Hong Kong Baptist College 224 Waterloo Road Kowloon Hong Kong

Bioassays involving zinc alone and in combinations with two organic ligands, namely histidine and EDTA were conducted on Daphnia longispina over a period of 96 h. The percentage of mortality was recorded and the median Lethal Concentration (LC50) at 96 h estmated. The 96 h LC50 of D. longispina in zinc solution was 91 μg/1 whereas no values of LC50 were revealed when D. longispina were exposed to histidine or EDTA alone although the organic ligands seemed to exert harmful effects (e.g. The mortality at 96 h was 18% at a concentration of 10×10^(-5) m histidine and 16% at a concentration of 6×10~6 m EDTA). however, addition of histidine and EDTA effectively reduced the toxicity of zinc to the test animals. The detoxification effect was the most obvious at the concentration of 100×g/1 Zn added with 5×10^(-5) m histidine and 3×10^(-6) m EDTA where 7-fold and 5-fold reduction in terms of mortality were noted.

关键词： Zn

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