检索结果-南通市图书馆

Establishment of simultaneous pancreas and kidney transplantation (SPK) model with cuff technique and portal venous drainage in rats

在线全文

学校读者我要写书评

暂无评论

Journal of Nanjing Medical University 2007年第1期21卷 8-10页

作者： shuguang han zekuan xu xuan Zhang yi miao Department of General Surgery the First Affiliated Hospital of Nanjing Medical University Nanjing 210029 China

To establish a simultaneous pancreas and kidney transplantation （SPK） model in the rat. Methods： SD rats served as donors and recipients. The donor portal vein and the recipient superior mesenteric vein were anastomosed and the donor renal veins and recipient renal veins were anastomosed by cuff method. Arterial reconstruction was carried out by end to side anastomosis of the donor abdominal aorta to the recipient abdominal aorta. Enteric drainage was performed by side to side anastomosis between donors＇ duodenum and recipients＇ jejunum. The donor ureter -bladder valve was anastomosed to the bladder of recipients. Results： Out of 30 cases of SPK transplantation, 24 had normal serum glucose and serum creatinine after operation. The successful rate was 80 %. Conclusion： This model of SPK in rats is stable and reliable, which could be applied for further scientific research.

关键词： simultaneous pancreas and kidney transplantation rat model

Pathological Change of Chronic Hepatitis B Patients with Different Tongue Coatings by Circular Multi-omics Integrated Analysis

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Integrative Medicine 2022年第1期28卷 28-35页

作者： TANG yi-shuang GUO Jian-chun xu Lin ZhanG Xiao-na SHEN Xiao-ping HAI Ya-mei MAO yu-feng HU yi-yang ZHAO yu Key Laboratory of Liver and Kidney Diseases Institute of Liver DiseasesShuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai(201203)China Department of Integrated Chinese and Western Medicine Hangzhou Xixi HospitalHangzhou(310023)China National Engineering Center for Biochip at Shanghai Shanghai(201203)China Institute of Clinical Pharmacology Shuguang Hospital affiliated to Shanghai University of Traditional Chinese MedicineShanghai(201203)China Shanghai Key Laboratory of Traditional Chinese Clinical Medicine Shanghai(201203)China

Objective:To compare the circular pathological changes of chronic hepatitis B(CHB)patients according to the tongue ***:Totally 41 CHB patients with typical white tongue coating(WTC)or yellow tongue coating(YTC)were enrolled and 14 healthy volunteers with normal tongue manifestation served as *** mRNA expression of peripheral leukocytes was detected by GeneChips,and 9 genes were randomly selected for expression *** metabolites were detected by gas chromatographymass *** information was analyzed based on ingenuity pathways analysis or metabolomics database and the integrated networks were constructed by ***:A total of 945 and 716 differentially expressed genes were found in patients with WTC and YTC relative to healthy volunteers *** biological information analysis indicated that CHB patients had obviously increased functions in cell death,apoptosis and necrosis(Z-score 2,Phan patients with *** results facilitate the modern pathological annotation of Chinese medicine tongue diagnosis theory and provide a reference for the interpretation of pharmacological mechanisms of Chinese medicine treatment.

关键词： Chinese medicine chronic hepatitis B tongue diagnosis metabolomics transcriptomic

Terahertz time-domain spectroscopy and micro-cavity components for probing samples: a review

在线全文

学校读者我要写书评

暂无评论

Frontiers of Information Technology & Electronic Engineering 2019年第5期20卷 591-607页

作者： Lin CHEN Deng-gao LIAO xu-guang GUO Jia-yu ZHAO yi-ming ZHU Song-lin ZHUANG Shanghai Key Lab of Modern Optical System University of Shanghai for Science and Technology Shanghai 200093 China Shanghai Cooperation Innovation Centre of Terahertz Spectroscopy and Imaging Technology Shanghai 200093 China Cooperative Innovation Center of Terahertz Science University of Electronic Science and Technology Chengdu 611731 China

We give a brief review of the developments in terahertz time-domain spectroscopy(THz-TDS) systems and microcavity components for probing samples in the University of Shanghai for Science and Technology. The broadband terahertz(THz) radiation sources based on GaAs m-i-n diodes have been investigated by applying high electric fields. Then, the free space THz-TDS and fiber-coupled THz-TDS systems produced in our lab and their applications in drug/cancer detection are introduced in detail. To further improve the signal-to-noise ratio(SNR) and enhance sensitivity, we introduce three general micro-cavity approaches to achieve tiny-volume sample detection, summarizing our previous results about their characteristics, performance, and potential applications.

关键词： Terahertz (THz) time-domain spectroscopy Micro-cavity Metal holes array Waveguide cavities Spoof localized surface plasmons (LSPs)

Key Symptoms Selection for Two Major SyndromesDiagnosis of Chinese Medicine in Chronic Hepatitis B

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Integrative Medicine 2017年第4期23卷 253-260页

作者： ZHAO yu KANG Hong PENG Jing-hua xu Lin CAO Zhi-wei HU yi-yang Institute of Liver Disease Shuguang Hospital Shanghai University of Traditional Chinese Medicine Shanghai 201203 China School of Life Sciences and Technology Tongji University Shanghai 200092 China E-institute of Shanghai Municipal Education Commission Shanghai 201203 China

To identify key symptoms of two major syndromes in chronic hepatitis B (CHB), which can be the clinical evidence for Chinese medicine (CM) doctors to make decisions. Standardization scales on diagnosis for CHB in CM were designed including physical symptoms, tongue and pulse appearance. The total of 695 CHB cases with dampness-heat (DH) syndrome or Pi (Spleen) deficiency (SD) syndrome were collected for feature selection and modeling, another 275 CHB patients were collected in different locations for validation. Key symptoms were selected based on modified information gain (IG), and 5 classifiers were applied to assist with models training and validation. Classification accuracy and area under receiver operating characteristic curves (AUC) were evaluated. (1) Thirteen DH syndrome key symptoms and 13 SD syndrome key symptoms were selected from original 125 symptoms; (2) The key symptoms could achieve similar or better diagnostic accuracy than the original total symptoms; (3) In the validation phase, the key symptoms could identify syndromes effectively, especially in DH syndrome, which average prediction accuracy on 5 classifiers could achieve 0.864 with the average AUC 0.772. The selected key symptoms could be simple DH and SD syndromes diagnostic elements applied in clinical directly. (Registration N0.: ChiCTR-DCC-10000759).

关键词： Chinese medicine syndrome chronic hepatitis B information gain

基于Wnt1/β-catenin信号通路观察白藜芦醇对小鼠炎症相关结直肠癌的作用机制

在线全文

学校读者我要写书评

暂无评论

现代消化及介入诊疗 2021年第11期26卷 1384-1389页

作者：马佳懿许宇文韩刚上海中医药大学附属曙光医院药学部 201203

目的基于无翅型小鼠乳房肿瘤病毒整合位点1(Wnt1)/β-连环蛋白(β-catenin)信号通路观察白藜芦醇对炎症相关性结肠癌(CAC)小鼠的抑制机制。方法采用氧化偶氮甲烷(AOM)/葡聚糖硫酸钠(DSS)诱导构建CAC小鼠,实验分为正常组、模型组、实验... 详细信息

目的基于无翅型小鼠乳房肿瘤病毒整合位点1(Wnt1)/β-连环蛋白(β-catenin)信号通路观察白藜芦醇对炎症相关性结肠癌(CAC)小鼠的抑制机制。方法采用氧化偶氮甲烷(AOM)/葡聚糖硫酸钠(DSS)诱导构建CAC小鼠,实验分为正常组、模型组、实验组、对照组,自造模开始,实验组每日定点腹腔注射100 mg/kg白藜芦醇,每日一次;对照组小鼠每日定点腹腔注射100 mg/kg的β-catenin通路抑制剂(iCRT14),每日一次;正常组、模型组小鼠腹腔注射等剂量的0.9%生理盐水。酶联免疫(ELISA)检测血清中肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)的含量。免疫组化检测结肠组织中髓过氧化物酶(MPO)的表达。免疫印迹技术(Western-blot)检测小鼠结肠组织中骨髓细胞瘤原癌基因(c-Myc)、Wnt1、β-catenin的表达。结果与正常组相比,模型组小鼠血清中IL-6、TNF-α的含量,以及结肠组织中MPO、c-myc、Wnt1、β-catenin的表达明显升高(P均<0.05);与模型组相比,实验组和对照组小鼠血清中IL-6、TNF-α的含量,以及结肠组织中MPO、c-myc、Wnt1、β-catenin的表达明显降低(P均<0.05)。结论白藜芦醇能够在炎症相关结直肠癌小鼠中发挥抗肿瘤、抗炎性的作用,可能是通过抑制Wnt1/β-catenin信号的激活实现的。

关键词：白藜芦醇炎症相关性结肠癌无翅型小鼠乳房肿瘤病毒整合位点1/β-连环蛋白通路抑制机制

Differential regulation of JAK1 expression by ETS1 associated with predisposition to primary biliary cholangitis

在线全文

学校读者我要写书评

暂无评论

Journal of Genetics and Genomics 2023年第10期50卷 807-812页

作者： Peng Jiang Chan Wang Mingming Zhang Ye Tian Weifeng Zhao Junyi Xin Yexi Huang Zhibin Zhao Wenjuan Sun Jie Long Ruqi Tang Fang Qiu Xingjuan Shi yi Zhao Li Zhu Na Dai Lei Liu xudong Wu Jinshan Nie Bo Jiang Youlin Shao yueqiu Gao Jianjiang yu Zhigang Hu Zhidong Zang yuhua Gong Yaping Dai Lan Wang Ningling Ding Ping xu Sufang Chen Lu Wang Jing xu Luyao Zhang Junyan Hong Ruonan Qian Hu Li xuan Jiang Congwei Chen Wenyan Tian Jian Wu yuzhang Jiang Chongxu han Kui Zhang Hong Qiu Li Li Hong Fan Liming Chen Jianqiong Zhang Zhongsheng Sun Xiao han Zhenhua Dai Erguang Li M.Eric Gershwin Zhexiong Lian Xiong Ma Michael F.Seldin Weichang Chen Meilin Wang Xiangdong Liu Key Laboratory of Developmental Genes and Human Diseases School of Life Science and TechnologySoutheast UniversityNanjingJiangsu 210096China Institute of Translational Medicine Yangzhou University Medical CollegeYangzhouJiangsu 225009China Department of Radiology&Oncology The Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu 215004China The First Affiliated Hospital of Soochow University SuzhouJiangsu 215006China Department of Bioinformatics School of Biomedical Engineering and InformaticsNanjing Medical UniversityNanjingJiangsu 210029China Author links open overlay panelYexi Huang Guangdong Provincial People's Hospital Guangdong Academy of Medical SciencesGuangzhouGuangdong 510080China Department of Gastroenterology and Hepatology Shanghai Institute of Digestive DiseasesShanghai Jiao Tong University School of Medicine Affiliated Renji HospitalShanghai 200001China Department of Laboratory Medicine The Fourth Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210031China Department of Gastrointestinal Endoscopy Eastern Hepatobiliary Surgery HospitalShanghai 201800China The Fifth People's Hospital Soochow UniversitySuzhouJiangsu 215007China Department of Gastroenterology Jiangsu University Affiliated Kunshan HospitalKunshanJiangsu 215300China Department of Gastroenterology Yixing People's HospitalYixinJiangsu 214200China Department of Gastroenterology Yancheng First People's HospitalYanchengJiangsu 224005China Department of Gastroenterology Taicang First People's HospitalSoochow UniversityTaicangJiangsu 215400China Department of Hepatology Jingjiang Second People's HospitalJingjiangJiangsu 214500China Department of Hepatology The Third People's Hospital of ChangzhouChangzhouJiangsu 213001China Department of Liver Diseases Shuguang HospitalShanghai University of Traditional Chinese MedicineShanghai 201203China Department of Laboratory Medicine Jiangyin People's HospitalSoutheast UniversityJiangyinJiangsu 214400China Department of Labora

Primary biliary cholangitis(PBC)is an autoimmune liver disease characterized by the destruction of intrahepatic small bile ducts and progressive cholestasis,eventually leading to liver cirrhosis and hepatic failure wi... 详细信息

关键词： cholangitis biliary

Long-Term Androgen-Induced Nonalcoholic Fatty Liver Disease in a Polycystic Ovary Syndrome Mouse Model is Related to Mitochondrial Dysfunction

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Reproductive and Developmental Medicine 2021年第2期5卷 71-80页

作者： Peng Cui Jie-Mei Shi Tong Ma Lin Rao Xiao-yu Tong Wei Hu Xiao-Qing xu Fei-Fei Zhang Xin Li Hakan Billig Linus R.Shao yi Feng Department of Integrative Medicine and Neurobiology State Key Lab of Medical NeurobiologyInstitute of Acupuncture Research(WHO Collaborating Center for Traditional Medicine)Institute of Integrative MedicineInstitute of Brain ScienceSchool of Basic Medical SciencesFudan UniversityShanghai 200032China Department of Obstetrics and Gynecology Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 201203China Nursing Department the International Peace Maternal and Child Health HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200030China Department of Gynecology Obstetrics and Gynecology Hospital of Fudan UniversityShanghai 200011China Department of Physiology/Endocrinology Institute of Neuroscience and Physiologythe Sahlgrenska AcademyUniversity of GothenburgGothenburg 40530Sweden

Objective:Metabolic disorders are markedly common in women with polycystic ovary syndrome(PCOS),and nonalcoholic fatty liver disease(NAFLD)is observed in 30%-55%of all PCOS *** studies have reported that autophagy and apoptosis,which are closely related to mitochondrial function,play important roles in the development of ***,in this study,we aimed to explore the role of mitochondrial dysfunction caused by liver apoptosis and autophagy imbalance in the development of NAFLD in a PCOS mouse ***:We used a dihydrotestosterone(DHT)-induced PCOS model to mimic the pathological process of *** and eosin and Oil Red O staining assays were used to observe the pathological changes in the *** blotting and quantitative real-time polymerase chain reaction were used to perform mitochondrion-related ***:Hepatic steatosis and different degrees of inflammation were observed in the DHT-treated *** expression of molecules involved in the respiratory chain and aerobic respiration process was *** levels of the key molecules associated with apoptosis and autophagy were ***:Androgens may play a role in the process of hepatic steatosis development by affecting mitochondrial function and subsequently inducing apoptosis and *** phenomena might be involved in the pathogenesis of NAFLD in women with PCOS.

关键词： Apoptosis Autophagy Mitochondrial Function Nonalcoholic Fatty Liver Disease Polycystic Ovary Syndrome

基于碳储量视角的城镇土地利用模式与生态效益分异特征

在线全文

学校读者我要写书评

暂无评论

中国土地科学 2017年第4期31卷 61-70页

作者：郭旭东常青刘筱包慧敏孙艺吕春艳张衍毓中国土地勘测规划院国土资源部土地利用重点实验室北京100035 中国农业大学观赏园艺与园林系北京100193

研究目的:探析不同土地利用模式下碳储量的空间差异特征,为优化城镇土地利用及其生态效益提供参考。研究方法:InVEST碳储量修正模型、归一化不透水地表指数(NDISI)和层次聚类分析。研究结果:(1)2014年北京市三山五园地区碳储量为23.31×... 详细信息

研究目的:探析不同土地利用模式下碳储量的空间差异特征,为优化城镇土地利用及其生态效益提供参考。研究方法:InVEST碳储量修正模型、归一化不透水地表指数(NDISI)和层次聚类分析。研究结果:(1)2014年北京市三山五园地区碳储量为23.31×10~4 t,单位土地面积平均碳储量32.28 t/hm^2;各街道碳储量差异明显。(2)以NDISI变化率表征土地利用开发强度,1992-2014年间上地街道开发强度最高,青龙桥街道(颐和园)开发强度最低。(3)该区各街道碳储量与其区位、用地结构及开发建设模式密切相关,开发建设活动并非一定会降低城镇土地碳汇能力。研究结论:土地利用模式影响城镇土地碳储能力,加强城镇土地利用模式与生态效益研究,有助于合理制定城镇土地利用政策。

关键词：土地利用碳储量生态效益土地开发模式三山五园

加味参芪地黄汤对去势后激素敏感性前列腺癌骨转移患者的疗效研究

在线全文

学校读者我要写书评

暂无评论

中华男科学杂志 2021年第2期27卷 161-166页

作者：顾坚毅谈鸣岳葛旻垚翟新宇郭冬冬徐东亮上海中医药大学附属曙光医院泌尿中心上海201203

目的:观察中药加味参芪地黄汤对去势后激素敏感性前列腺癌骨转移患者的临床疗效。方法:将76例去势后激素敏感且伴有骨转移的前列腺癌患者随机分为对照组与加味参芪地黄汤组。对照组予最大限度雄激素阻断治疗,加味参芪地黄汤组在对照组... 详细信息

目的:观察中药加味参芪地黄汤对去势后激素敏感性前列腺癌骨转移患者的临床疗效。方法:将76例去势后激素敏感且伴有骨转移的前列腺癌患者随机分为对照组与加味参芪地黄汤组。对照组予最大限度雄激素阻断治疗,加味参芪地黄汤组在对照组治疗的基础上加服加味参芪地黄汤治疗,比较去势抵抗发生率、观察患者的中医症候评分、骨转移情况、生存质量及不良事件的发生率。结果:最终统计纳入患者64例。加味参芪地黄汤组去势抵抗发生率为28.12%,新发骨及内脏转移病灶为18.75%,治疗后血清碱性磷酸酶(AKP)水平为(318.5±165.8)U/L,均显著低于对照组71.87%、40.63%、(328.5±170.6)U/L(P均<0.05)。加味参芪地黄汤组中医症候评分:尿频尿不畅(1.64±0.66)分、食欲不振(1.41±0.39)分、神疲乏力(1.39±0.58)分、腰酸背痛(1.26±0.38)分、体重减轻(1.26±0.80)分、自我评价(1.54±0.63)分,均明显优于对照组(2.05±0.51)分、(1.95±0.48)分、(2.59±0.68)分、(1.76±0.41)分、(1.88±0.75)分、(1.89±0.58)分,(P均<0.05)。治疗后加味参芪地黄汤组体力状况评分(卡氏评分,KPS)为(79.87±11.23)分,显著高于对照组(70.45±12.16)分(P<0.05)。加味参芪地黄汤组和对照组患者治疗后疼痛数字评分(NRS)及不良事件发生率无明显差异。结论:加味参芪地黄汤对去势后激素敏感性前列腺癌骨转移患者治疗后可有效提高患者的生活质量和中医症候评分,增加现代药物治疗激素敏感性前列腺癌的疗效,降低新发转移病灶发生率,改善患者血清指标并减轻骨转移相关的疼痛,提高患者的生存质量。

关键词：激素敏感性前列腺癌骨转移加味参芪地黄汤中医药