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Development of Epstein-Barr virus-associated gastric cancer:Infection,inflammation,and oncogenesis

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World Journal of Gastroenterology 2022年第44期28卷 6249-6257页

作者： Hisashi Iizasa Andy Visi Kartika Sintayehu Fekadu Shunpei okada Daichi Onomura Afifah Fatimah Azzahra Ahmad Wadi Mosammat Mahmuda Khatun Thin Myat Moe jun Nishikawa Hironori Yoshiyama Department of Microbiology Shimane University Faculty of MedicineIzumo 693-8501ShimaneJapan Faculty of Medicine Muslim University of IndonesiaMakassar 90231Indonesia Department of Medical Microbiology and Parasitology Hawassa UniversityCollege of Medicine and Health ScienceHawassa 1560Ethiopia Faculty of Laboratory Science Yamaguchi University Graduate School of MedicineUbe 755-8505Japan

Epstein-Barr virus(EBV)-associated gastric cancer(EBVaGC)cells originate from a single-cell clone infected with ***,more than 95%of patients with gastric cancer have a history of Helicobacter pylori(***)infection,and *** is a major causative agent of gastric ***,it has long been argued that *** infection may affect the development of EBVaGC,a subtype of gastric *** gastrointestinal inflammation,a symptom of *** infection,is observed in the gastric mucosa of ***,it remains unclear whether *** infection is a cofactor for gastric carcinogenesis caused by EBV infection or whether *** and EBV infections act independently on gastric cancer *** has been reported that EBV infection assists in the oncogenesis of gastric cancer caused by *** *** contrast,several studies have reported that *** infection accelerates tumorigenesis initiated by EBV *** reviewing both clinical epidemiological and experimental data,we reorganized the role of *** and EBV infections in gastric cancer formation.

关键词： Helicobacter pylori Epstein-Barr virus Epstein-Barr virus-associated gastric cancer Coreceptor Inflammation Oncogenesis

Prediction of flare-ups of ulcerative colitis using quantitative immunochemical fecal occult blood test

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World Journal of Gastroenterology 2010年第9期16卷 1110-1114页

作者： Motoaki Kuriyama jun Kato Koji Takemoto Sakiko Hiraoka Hiroyuki okada Kazuhide Yamamoto Department of Gastroenterology and Hepatology Okayama University Graduate School of MedicineDentistryand Pharmaceutical Sciences

AIM:To examine the feasibility of predicting the flareup of ulcerative colitis (UC) before symptoms emerge using the immunochemical fecal occult blood test (IFOBT).METHODS:We prospectively measured fecal hemoglobin concentrations in 78 UC patients using the I-FOBT every 1 or 2 ***:During a 20 mo-period,823 fecal samples from 78 patients were *** median concentration of fecal hemoglobin was 41 ng/mL (range:0-392 500 ng/mL).There were three types of patients with regard to the correlation between I-FOBT and patient symptoms;the synchronous transition type with symptoms (44 patients),the unrelated type withsymptoms (19 patients),and the flare-up predictive type (15 patients).In patients with the flare-up predictive type,the values of I-FOBT were generally low during the study period with stable *** to four weeks before the flare-up of symptoms,the I-FOBT values were ***,in these patients,I-FOBT could predict the flare-up before symptoms ***:Flare-up could be predicted by I-FOBT in approximately 20% of UC *** results warrant periodical I-FOBT in UC patients.

关键词： Flare-ups Immunochemical fecal occult blood test Inflammatory bowel disease Prediction Ulcerative colitis

MK615 decreases RAGE expression and inhibits TAGE-induced proliferation in hepatocellular carcinoma cells

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World Journal of Gastroenterology 2010年第42期16卷 5334-5341页

作者： Yuhki Sakuraoka Tokihiko Sawada Toshie okada Takayuki Shiraki Yoshikazu Miura Katsuya Hiraishi Tatsushi Ohsawa Masakazu Adachi jun-ichi Takino Masayoshi Takeuchi Keiichi Kubota Second Department of Surgery Dokkyo Medical UniversitySchool of MedicineKitakobayashi 880MibuShimotsugaTochigi 321-0293Japan Public Health Dokkyo Medical UniversitySchool of MedicineKitakobayashi 880MibuShimotsugaTochigi 321-0293Japan AdaBio Co.Ltd.21-1 Kenzaki-machiTakasakiGunma 370-0883Japan Department of Life Pharmacy Faculty of Pharmaceutical SciencesHokuriku UniversityHo-3Kanagawa-machiKanazawaIshikawa 920-1181Japan

AIM:To investigate the proliferative effect of advanced glycation end-products(AGEs) and the role of their cellular receptor(RAGE) on hepatocellular carcinoma(HCC) cells,and the inhibitory effects of MK615,an extract from Japanese apricot,against AGEs were also ***:Two HCC cell lines,HuH7 and HepG2,were *** of RAGE was investigated by poly-merase chain reaction,Western blotting,and flow cytemetry(FACS).The effect of MK615 on RAGE expression was also evaluated by *** proliferative effects of a control(unglycated bovine serum albumin),glucosederived AGEs(Glc-AGE),and glyceraldehyde-derived AGEs(Glycer-AGE),and the anti-proliferative effect of MK615 against AGEs,were evaluated using MTT ***:Expression of RAGE was confirmed at both the mRNA and protein levels in both HuH7 and *** revealed that the level of RAGE expression was higher in HuH7 than in *** with 0.1 μg/mL MK615 decreased the expression level of RAGE from 24.3% to 3.7% in HuH7 and from 6.2% to 4.8% in *** growth indices for the control,Glc-AGE,and Glycer-AGE were 1.06 ± 0.08,0.99 ± 0.04,and 1.38 ± 0.05,respectively,in HuH7(P = 0.037),and were 1.03 ± 0.04,1.04 ± 0.03,and 1.07 ± 0.05,respectively,in HepG2(P > 0.05).When the cells were cultured simultaneously with Glycer-AGE and MK615,MK615 abrogated the proliferative effect of Glycer-AGE in ***:Only Glycer-AGE has a proliferative effect on HuH7,which expresses a higher level of ***615 suppresses the proliferative effect of GlycerAGE on HuH7 by decreasing the expression of RAGE.

关键词： Hepatocellular carcinoma Receptor of advanced glycation end-product Advanced glycation endproducts MK615 Toxic advanced glycation end-products

Does an “Overactive to Underactive Bladder Transition” Phenomenon Exist in a Rat Lumbar Spinal Canal Stenosis Model?

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Open Journal of Urology 2015年第5期5卷 57-64页

作者： Noritoshi Sekido jun Kida Daisuke Wakamatsu Hiroki okada Hidekazu Matsuya Department of Urology School of Medicine Faculty of Medicine Toho University Medical Center Ohashi Hospital Tokyo Japan Group2 Discovery Research Laboratories Ono Pharmaceutical Co. Ltd. Osaka Japan

Purpose: To investigate the association between the maximum cystometric capacity (MCC) and other cystometric parameters in lumbar canal stenosis (LCS) rats. Material and Methods: One small hole was drilled at the fifth lumbar vertebral arch (Sham), and a rectangular piece of silicone rubber was then placed in the epidural space (LCS) of Wister rats. Two weeks after surgery, awake cystometry was performed. LCS rats were divided into three groups: Group A (n = 5, MCC 1.81 mL). Cystometric parameters were investigated in sham and LCS groups. Results: MCC did not significantly correlate to the frequency of non-voiding contractions (NVCs), voided volume (VV), or maximum intravesical pressure during voiding (Pmax), but significantly positively correlated to postvoid residual urine volume (PVR) and residual urine rate (RUR) (Spearman’s correlation coefficients (ρ) = 0.8973 (p < 0.0001) and 0.4915 (p = 0.0068), respectively). Compared with the sham rats, LCS rats in each group revealed significantly smaller VV, larger RUR, and lower Pmax. On the other hand, among LCS rats, VV, RUR, and Pmax were not significantly different. The frequency of NVCs in each LCS group was not significantly different from that in sham-operated rats (Tukey-Kramer’s HSD test). However, a Jonckheere-Terpstra trend test revealed a significant trend toward higher NVCs in the order of sham, Groups C, B, and A (p = 0.036). Conclusions: LCS rats showed the same degree of detrusor underactivity regardless of MCC. NVCs did not significantly increase in LCS rats with decreased MCC, but the trend toward higher NVCs with smaller MCC was significant.

关键词： Underactive Bladder Detrusor Underactivity Lumbar Canal Stenosis Animal Model Overactive Bladder

Solar power sail mission of OKEANOS

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Astrodynamics 2020年第3期4卷 233-248页

作者： Osamu Mori jun Matsumoto Toshihiro Chujo Masanori Matsushita Hideki Kato Takanao Saiki Yuichi Tsuda jun'ichiro Kawaguchi Fuyuto Terui Yuya Mimasu Go Ono Naoko Ogawa Yuki Takao Yuki Kubo Kaoru Ohashi Ahmed Kiyoshi Sugihara Tatsuaki okada Takahiro Iwata Hajime Yano Japan Aerospace Exploration Agency Sagarmihara 252-5210Japan Tokyo Institute of Technology Tokyo 152-8550Japan The University of Tokyo Tokyo 113-8654Japan Patchedconics LLCSagarmihara 252-5210Japan

The solar power sail is an original Japanese concept in which electric power is generated by thin-film solar cells attached on the solar sail *** Aerospace Exploration Agency(JAXA)successfully demonstrated the world’s first solar power sail technology through IKAROS(Interplanetary Kite-craft Accelerated by Radiation of the Sun)mission in *** demonstrated photon propulsion and power generation using thin-film solar cells during its interplanetary *** up,solar power sails can generate enough power to drive high specific impulse ion thrusters in the outer planetary *** this concept,we propose a landing or sample return mission to directly explore a Jupiter Trojan asteroid using solar power sail-craft OKEANOS(Oversize Kite-craft for Exploration and AstroNautics in the Outer Solar System).After rendezvousing with a Trojan asteroid,a lander separates from OKEANOS to collect samples,and perform in-situ analyses in three proposed mission sequences,including sending samples back to *** paper proposes a system design for OKEANOS and includes analyses of the latest mission.

关键词： solar power sail Trojan asteroid landing in-situ analysis outer solar system OKEANOS

Late-onset non-islet cell tumor hypoglycemia: A case report

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World Journal of Clinical Cases 2021年第1期9卷 163-169页

作者： Shunichi Matsumoto Eijiro Yamada Yasuyo Nakajima Naoki Yamaguchi Takashi Okamura Toshiki Yajima Satoshi Yoshino Kazuhiko Horiguchi Emi Ishida Masashi Yoshikawa jun Nagaoka Sho Sekiguchi Mai Sue Shuichi okada Izumi Fukuda Ken Shirabe Masanobu Yamada Department of Medicine and Molecular Science Gunma University Graduate School of MedicineMaebashi 371-8511GunmaJapan Division of General Thoracic Surgery Integrative Center of General SurgeryGunma University HospitalMaebashi 371-8511GunmaJapan Department of Endocrinology Diabetes and MetabolismGraduate School of Medicine Nippon Medical SchoolTokyo 1138602Japan

BACKGROUND Hypoglycemia due to non-insulin-producing tumors is referred to as non-islet cell tumor hypoglycemia(NICTH).As NICTH is a rare lesion,the natural course of NICTH is not well *** report a case of NICTH that was observed 30 years before the onset of *** SUMMARY A 50-year-old man was diagnosed with an abnormal right chest shadow during a routine X-ray examination,but no further examination was undertaken because the lesion appeared *** years after the tumor discovery,the patient was admitted to the hospital with symptoms of severe hypoglycemia,which was diagnosed as NICTH based on a complete *** tumor was resected and found to be a solitary fibrous mass(15.6 cm×13.7 cm×10.4 cm);thereafter,the patient’s blood glucose levels normalized and he completely *** NICTH can have an acute onset,even if the tumor has been present and asymptomatic over a long time period.

关键词： Hypoglycemia Non-islet cell tumor hypoglycemia Blood glucose Solitary tumor Late onset Case report Insulin-like growth factor II

Effectiveness of rehabilitation based on recreational activities:A systematic review

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World Journal of Meta-Analysis 2013年第1期1卷 27-46页

作者： Hiroharu Kamioka Kiichiro Tsutani Minoru Yamada Hyuntae Park Hiroyasu Okuizumi Takuya Honda Shinpei okada Sang-jun Park jun Kitayuguchi Shuichi Handa Yoshiteru Mutoh Faculty of Regional Environment Science Tokyo University of Agriculture Tokyo 156-8502 Japan Department of Drug Policy and Management Graduate School of Pharmaceutical Sciences University of TokyoTokyo 113-0033 Japan Human Health Sciences Kyoto University Graduate School of Medicine Kyoto 606-8507 Japan Department of Functioning Activation National Center for Geriatrics and Gerontology Aichi 474-8511 Japan Mimaki Onsen(Spa) Clinic Nagano 389-0402 Japan Japan Society for Promotion of Science Kyoto 619-0288 Japan Physical Education and Medicine Research Foundation Nagano 389-0402 Japan Physical Education and Medicine Research Center Unnan Shimane 690-2404 Japan Research Institute of Nippon Sport Science University Tokyo 158-0081 Japan

AIM: To summarize the evidence from randomized controlled trials(RCTs) on the rehabilitation effects of recreational ***: Studies were eligible if they were RCTs. Studies included one treatment group in which recreational activity was applied. We searched the following databases from 1990 to May 31, 2012: MEDLINE via Pub Med, CINAHL, Web of Science, and Ichushi-Web. We also searched all Cochrane Databases and Campbell Systematic Reviews up to May 31, 2012. RESULTS: Eleven RCTs were identified, which included many kinds of target diseases and/or symptoms such as stroke, dementia, Parkinson's disease, acquired brain injury,chronic non-malignant pain, adolescent obesity, high-risk pregnancy, and the frail elderly. Various intervention methods included gaming technology, music, dance, easy rider wheelchair biking, leisure education programs, and leisure tasks. The RCTs conducted have been of relatively low quality. A meta-analysis(pooled sample; n = 44, two RCTs) for balance ability using tests such as "Berg Balance Scale" and "Timed Up and Go Test" based on game intervention revealed no significant difference between interventions and controls. In all other interventions, there were one or more effects on psychological status, balance or motor function, and adherence as primary or secondary ***: There is a potential for recreational activities to improve rehabilitation-related outcomes, particularly in psychological status, balance or motor function, and adherence.

关键词： Recreation activities Randomized controlled trial Rehabilitation effect

Distinctive magnetic resonance imaging findings of hepatocellular carcinoma after hepatitis C virus eradication with direct-acting antivirals

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Hepatoma Research 2020年第3期6卷 41-49页

作者： Takao Shimizu Kaoru Tsuchiya Masayuki Kurosaki Yutaka Yasui Sakura Kirino Keiya Watakabe Leona Osawa Mao okada Wan Wang Mayu Higuchi Kenta Takaura Shun Kaneko Nobuharu Tamaki Hiroyuki Nakanishi jun ltakura Yuka Takahashi Tadakazu Hisamatsu Namiki lzumi Department of Gastroenterology and Hepatology Musashino Red Cross HospitalTokyo 180-8610Japan Department of Gastroenterology and Hepatology Kyorin University HospitalTokyo 180-8610Japan

Aim:The aim of the present study was to evaluate the characteristics of the magnetic resonance imaging features of hepatocellular carcinoma(HCC)that developed early after the eradication of hepatitis C virus(HCV)by direct-acting antiviral(DAA)***:This study included 26 patients who achieved sustained viral response with DAA and developed HCC thereafter within one year(DAA-SVR HCC).The radiologic characteristics of these patients were evaluated by contrast-enhanced magnetic resonance imaging,including diffusion-weighted imaging(DWI)and T2-weighted imaging(T2WI).For comparison,80 HCC patients with positive HCV RNA(HCV-positive HCC)were *** 42 patients where tumor biopsy was available,histological grade and radiologic findings were ***:The rates of high intensity on DWI and T2WI were significantly higher in DAA-SVR HCC compared to HCV-positive HCC(DWI:100%vs.67.5%,P<0.001T2WI:92.6%vs.67.5%,P=0.01).HCC with high intensity on DWI or T2WI was more likely to have moderately or poorly differentiated HCC compared to well-differentiated HCC(DWI:69.7%vs.30.3%,P=0.02;T2WI:66.7%vs.27.3%,P=0.03).Conclusion:High intensity on DWI and hyperintensity on T2WI were distinctive features of HCC that developed within one year after the end of DAA treatment.

关键词： Hepatocellular carcinoma direct-acting antivirals sustained viral response contrast enhanced magnetic resonance imaging

Disparity in clinical care for patients with inflammatory bowel disease between specialists and non-specialists

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Open Journal of Gastroenterology 2013年第1期3卷 64-71页

作者： Tomoko Hirakawa jun Kato Sakuma Takahashi Hideyuki Suzuki Mitsuhiro Akita Izumi Inoue Hisanobu Deguchi Sakiko Hiraoka Hiroyuki okada Kazuhide Yamamoto Department of Endoscopy Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences Okayama Japan Department of Gastroenterology and Hepatology Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences Okayama Japan Second Department of Internal Medicine Wakayama Medical University Wakayama Japan

Background: Although inflammatory bowel disease (IBD) patients have been increasing and new thera-peutic options for IBD have been developed, there are relatively few clinicians who specialize in IBD. Patients treated by a non-specialist of IBD may not receive appropriate treatment. This study aimed to compare disease and medication status between IBD patients treated by a specialist and those treated by a non-specialist. Methods: Medical charts of ambulating IBD patients in two hospitals were examined. All patients in one hospital were treated by one of the IBD specialists, while in the other hospital, patients were treated by one of the gastroenterologists who was a non-specialist of IBD. Results: The numbers of IBD patients were 255 (hospital with specialists) and 74 (hospital without specialists), respectively. Disease activity of the patients was not well-controlled in the hospital without specialists compared to in the hospi- tal with specialists (ulcerative colitis (UC): p = 0.0006 and Crohn’s disease: p = 0.012, respectively). The proportion of UC patients who received an insufficient dose of mesalazine (Pentasa < 3 g/day or Asacol < 3.6 g/day) was higher in the hospital without specialists (47% vs. 15%, p < 0.0001). In the hospital without specialists, more patients received long-term corticosteroids (UC: 23% vs. 5%, p < 0.0001), while fewer patients received immunomodulators (UC: 8% vs. 46%, p < 0.0001). Conclusions: IBD patients of the hospital without specialists were not well-controlled and were not prescribed appropriately with thera-peutic drugs. Fostering and placement of the specialist of IBD is an urgent problem.

关键词： Inflammatory Bowel Disease Clinical Care Specialist