检索结果-南通市图书馆

Comparison of open with laparoscopic management of adrenal cysts (report of 24 cases)

在线全文

学校读者我要写书评

暂无评论

Comparison of open with laparoscopic management of adrenal c...

Method for Estimating the State of Health of Lithium-ion Batteries Based on Differential Thermal Voltammetry and Sparrow Search Algorithm-Elman Neural Network

第十五届全国泌尿外科学术会议

作者： SHEN Zhou-jun, TENG ying, zhang Rong-ming, ZHU Yu, SUN Fu-kang, SHAO YuanDepartment of Urology, Ruijin Hospital Affiliated to The Shanghai Jiao Tong University School of Medicine, Shanghai, P.R.China 200025

Objective To clarify the feasibility and ascendency of both the laparoscopic and open management of symptomatic and large adrenal cysts. Materials and Methods From November 1997 to December 2007, 24 patients were evaluated and treated for adrenal cysts at the Department of Urology, Ruijin Hospital Affiliated to The Shanghai Jiao Tong University School of Medicine, Shanghai, ***. 12 patients underwent traditional open operation and 12 patients underwent laparoscopic management. The surgical indications for adrenal cyst management were symptomatic in 17 cases, cyst size 4 cm or greater in 6, one of which was combined with malignancy. Results In the open series, six patients underwent adrenal cystectomy, 1 underwent partial adrenalectomy and 4 underwent total adrenalectomy and one case was performed total nephrectomy and adrenalectomy. In the laparoscopic series, 11 patients underwent adrenal cystectomy and 1 underwent total adrenalectomy. Mean operative time of open series was longer than that of laparoscopic series (123.8±34.2 vs 95.0±38.0 min, P<0.05). There were no intraoperative or postoperative complications. Mean hospital stay of open series was also longer than that of laparoscopic series (9.17 ± 1.85 vs 6.50 ± 1.17 days, P < 0.05). Conclusions Laparoscopic adrenal surgery is a safe and effective treatment. The laparoscopic approach should be considered preferable for patients who require adrenal surgery if no contraindications preclude its use. When the cyst wall thickness is more than 0.5 cm, with calcification and bloody cystofluidus or complicated other urinary touble especially malignant tumor, open management should be considered first.

关键词： laparoscopy adrenal cyst adrenal gland surgery

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Energy Engineering 2025年第1期122卷 203-220页

作者： Yu zhang Daoyu zhang TiezhouWu School of Electrical and Electronic Engineering Hubei University of TechnologyWuhan430068China

Precisely estimating the state of health(SOH)of lithium-ion batteries is essential for battery management systems(BMS),as it plays a key role in ensuring the safe and reliable operation of battery ***,current SOH estimation methods often overlook the valuable temperature information that can effectively characterize battery aging during capacity ***,the Elman neural network,which is commonly employed for SOH estimation,exhibits several drawbacks,including slow training speed,a tendency to become trapped in local minima,and the initialization of weights and thresholds using pseudo-random numbers,leading to unstable model *** address these issues,this study addresses the challenge of precise and effective SOH detection by proposing a method for estimating the SOH of lithium-ion batteries based on differential thermal voltammetry(DTV)and an SSA-Elman neural ***,two health features(HFs)considering temperature factors and battery voltage are extracted fromthe differential thermal voltammetry curves and incremental capacity ***,the Sparrow Search Algorithm(SSA)is employed to optimize the initial weights and thresholds of the Elman neural network,forming the SSA-Elman neural network *** validate the performance,various neural networks,including the proposed SSA-Elman network,are tested using the Oxford battery aging *** experimental results demonstrate that the method developed in this study achieves superior accuracy and robustness,with a mean absolute error(MAE)of less than 0.9%and a rootmean square error(RMSE)below 1.4%.

关键词： Lithium-ion battery state of health differential thermal voltammetry Sparrow Search Algorithm

Structural engineering of high-entropy alloys for advanced electrocatalytic reactions

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Tungsten 2025年第1期 1-31页

作者： Qiao Xie ying-Jie Yu Hai-jun zhang Ya-Ping Deng Wen Lei The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and Technology Department of Chemical Engineering Waterloo Institute for Sustainable Energy Waterloo Institute for Nanotechnology University of Waterloo

High-entropy alloys(HEAs) have emerged as promising candidates to replace traditional precious metal catalysts,owing to their unique chemical and physical *** review commences by revisiting the fundamental concepts of HEAs,including their synthesis methods and structural control strategies in *** underscores the critical role of meticulously manipulating both macroscopic and microscopic structures of the HEAs to optimize their catalytic performance.A deep understanding of the structure-activity relationship in HEAs across various configurations is pivotal in developing more effective *** review methodically encapsulates the research progress of structural control strategies for HEAs in achieving efficient energy conversion,with the aim of gaining a better understanding of the relationship between structure and *** review concludes by summarizing the current achievements and challenges,and suggestions for potential future directions of HEAs in the fields of energy conversion and environmental purification.

关键词：

Safety,tolerability and pharmacokinetic study of recombinant human parathyroid hormone in healthy male Chinese subjects

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Safety,tolerability and pharmacokinetic study of recombinant...

阿替洛尔注射液对血管刺激、溶血和过敏的实验研究

中国药理学会临床药理学专业委员会会议暨第十次全国临床药理学学术会议

作者： LI Wei-yong LI Qian QIAO Jian DENG jun-gang zhang ying Institute of Clinic Pharmacy,Union Hospital Affiliated to Tongji Medical College,Huazhong University of Science & Technology,Wuhan 430022,Hubei,China

AIM:To determine the safety,tolerability and pharmaco- kinetic parameters of a new drug recombinant human para- thyroid hormone [rhPTH(1-84)] in healthy male Chinese subjects. METHODS:Thirty-six healthy male volunteers were ran- domly divided into 3 *** volunteers in these groups received single subcutaneous injection of rhPTH(1- 84)in a dosage of 1,2 and 4 μg/kg *** samples were obtained before and after administration with- in 24 *** rhPTH concentrations in serum were de- termined by enzyme linked immunosorbent assay (ELISA).The pharmacokinetic parameters determined with use of standard noncompartmental analysis were the maximum serum concentration(C),the time to attain that concentration(t),and the area under the serum concentration-time curve up to 24 hours(AUC)and up to infinity(AUC).Dose proportionality of phar- maeokinetic parameters(AUC,Cof every volunteer of each dosage and AUC was computed from log transformed data)and was examined by mean of analysis of variance (ANOVA)using SPSS software *** the study, subjects’ symptoms,objective signs,and vital signs,in- cluding blood pressure,heart rate,respiratory rate and body temperature,were checked and 12-lead electrocar- diography was recorded before and after drug administration within 24 *** laboratory tests,including hema- tology,blood biochemistry,serum electrolyte,and urinal- ysis,were performed before and after drug administration within at 24 hours. RESULTS:The specificity,sensitivity,linear range, precision and accuracy of the method were all satisfied for the determination of rhPTH in *** serum concen- tration-time curve of most volunteers clearly exhibited a double-peak profile,with the first peak appearing approxi- mately 10 to 30 minutes and the second peak appearing ap- proximately 1.5 to 2 hours after subcutaneous injection of the *** concentrations of all subjects 24 hours after dosing in the three groups almost returned to physio- logic p

关键词： recombinant human parathyroid hormone tolerability safety pharmacokinetics single dose

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

中国新药与临床杂志 2004年第3期23卷 133-135页

作者：刘朝阳杜庆成张俊英张伟中国医学科学院中国协和医科大学肿瘤研究所北京100021

目的 :观察阿替洛尔注射液血管刺激性和是否具有溶血、凝聚和过敏作用。方法 :兔耳缘静脉注射阿替洛尔 ,0 .2 5mg·kg- 1,qd× 3d ,停药 2 4h后做病理组织学检查 ,并与氯化钠注射液对照组比较 ;体外不同浓度的阿替洛尔注射液 0 .1～ 0 .... 详细信息

目的 :观察阿替洛尔注射液血管刺激性和是否具有溶血、凝聚和过敏作用。方法 :兔耳缘静脉注射阿替洛尔 ,0 .2 5mg·kg- 1,qd× 3d ,停药 2 4h后做病理组织学检查 ,并与氯化钠注射液对照组比较 ;体外不同浓度的阿替洛尔注射液 0 .1～ 0 .5mL在 5mL兔红细胞氯化钠注射液中放置 0 .5～ 2 4h ,观察对兔红细胞悬液的溶血作用及有无红细胞凝聚作用 ;给豚鼠腹腔注射阿替洛尔 ,每只 0 .5mL ,qod× 3次 ,2wk和 3wk后分别再腹腔注射该药 ,每只2 .5mL- 1,然后观察 30min内是否出现过敏反应。结果 :阿替洛尔注射液对兔血管内皮没有损伤和刺激作用 ,与氯化钠注射液对照血管比较 ,两者无明显差异 ,对兔红细胞没有致溶血作用和凝聚作用 ,豚鼠未出现过敏反应。结论 :阿替洛尔注射液对用药血管没有刺激性反应 ,也无溶血及红细胞凝聚现象 ,对豚鼠无过敏反应。制剂有关安全性检测结果符合新药申报要求。

关键词：阿替洛尔注射刺激化学性溶血超敏反应兔豚鼠

A型流感病毒NS1蛋白羧基端PL结构域影响NS1在细胞核内的定位

在线全文

学校读者我要写书评

暂无评论

生物化学与生物物理进展 2010年第9期37卷 975-982页

作者：张丹桂李卫中王革非张衡曾俊陈幼莹张驰曾祥兴李康生汕头大学医学院微生物学及免疫学教研室广东省高校免疫病理学重点实验室汕头515031

A型流感病毒NS1蛋白羧基端4个氨基酸可以与PDZ结构域(the domain of PSD95,Dig and ZO-1)相结合,称为PL结构域(PDZ ligand domain).对不同亚型或毒株的流感病毒而言,其NS1蛋白PL结构域的组成存在比较大的差异.有研究发现这种差异能够影... 详细信息

A型流感病毒NS1蛋白羧基端4个氨基酸可以与PDZ结构域(the domain of PSD95,Dig and ZO-1)相结合,称为PL结构域(PDZ ligand domain).对不同亚型或毒株的流感病毒而言,其NS1蛋白PL结构域的组成存在比较大的差异.有研究发现这种差异能够影响NS1与宿主细胞蛋白的相互作用进而影响病毒的致病力.为进一步探讨PL结构域对NS1蛋白生物学特性的影响,首先构建出4种不同亚型流感病毒(H1N1、H3N2、H5N1、H9N2)来源的NS1绿色荧光蛋白表达质粒.在此基础上,对野生型H3N2病毒NS1表达质粒进行人工改造,将其PL结构域缺失或者替换为其他亚型流感病毒的PL结构域,制备出4种重组NS1蛋白表达质粒.通过比较上述不同NS1蛋白在HeLa细胞中的定位情况发现,只有野生型H3N2病毒的NS1蛋白可以定位于核仁当中,而野生型H1N1、H5N1、H9N2病毒的NS1蛋白以及PL结构域缺失或替代的H3N2病毒NS1蛋白都不能定位于核仁.而通过比较上述NS1蛋白在流感病毒易感的MDCK细胞中的定位,进一步发现所有这些蛋白均不定位于核仁.上述结果表明:PL结构域的不同可以明显影响NS1蛋白在HeLa细胞核内的定位和分布,这有可能造成其生物学功能的差异.同时,NS1蛋白在细胞核内的定位还与宿主细胞的来源有着密切关系.

关键词： A型流感病毒 NS1蛋白 PL结构域核仁

在线全文

学校读者我要写书评

暂无评论

竞争环境下双目标零售平台销售模式选择

管理工程学报 2025年第1期39卷 227-242页

作者：张冲朱祎宋君南京邮电大学管理学院

电子商务行业发展迅速,具有“超越利润”战略导向以实现更广泛目标的组织正变得越来越普遍,兼顾消费者利益成为企业凸显竞争优势的方式。为此,本文构建由一个制造商和两个零售平台组成的两级供应链。其中,制造商和其中一个零售平台追求... 详细信息

电子商务行业发展迅速,具有“超越利润”战略导向以实现更广泛目标的组织正变得越来越普遍,兼顾消费者利益成为企业凸显竞争优势的方式。为此,本文构建由一个制造商和两个零售平台组成的两级供应链。其中,制造商和其中一个零售平台追求自身利润最大化,另外一个零售平台追求自身利润和消费者剩余的线性组合最大化,即考虑双目标最优。本文具体考虑两个零售平台分别选择转售模式或代理模式共四种情形,进而研究双目标零售平台销售模式选择问题,及其对供应链成员最优决策和供应链整体绩效的影响。结果表明:(1)在一定条件下,双目标零售平台能获得比竞争对手更高的利润;(2)当双目标零售平台选择转售模式时,无论其竞争对手选择哪种销售模式,其双目标策略都能使供应链总体利润得到优化;(3)当双目标零售平台的竞争对手选择代理模式时,其自身根据不同情况选择转售模式或者代理模式可以使两个零售平台的销售模式选择形成均衡。

关键词：双目标企业社会责任零售平台销售模式双渠道

同方期刊数据库

在线全文

学校读者我要写书评

暂无评论

琼东南盆地中央峡谷沉积物源探讨

天然气地球科学 2017年第10期28卷 1574-1581页

作者：张道军张迎朝邵磊刘新宇王亚辉何小胡崔宇驰中海石油(中国)有限公司湛江分公司广东湛江524057 同济大学海洋地质国家重点实验室上海200092

琼东南盆地中央峡谷沉积物来源是南海地区沉积学研究中的热点问题。研究采用稀土元素及碎屑锆石年龄等方法,对琼东南盆地中央峡谷上中新统—上新统以及盆地基底和周边可能源区开展对比分析。研究发现,中央峡谷西侧上中新统—上新统多数... 详细信息

琼东南盆地中央峡谷沉积物来源是南海地区沉积学研究中的热点问题。研究采用稀土元素及碎屑锆石年龄等方法,对琼东南盆地中央峡谷上中新统—上新统以及盆地基底和周边可能源区开展对比分析。研究发现,中央峡谷西侧上中新统—上新统多数样品呈现出Eu元素正异常,峡谷东侧样品则以Eu元素的负异常为主,并且随着时代变新,呈现Eu元素负异常的样品数量增多;同时,样品中碎屑锆石年龄谱系也呈现规律性变化,峡谷西侧沉积物相对包含的古生代及元古代等古老锆石比峡谷东侧多,峡谷东侧的碎屑锆石年龄则以燕山期和印支期2个中生代年龄峰值为主。结果显示,越南中北部印支期的板块拼合带是中央峡谷的重要物源区,控制着中央峡谷的沉积充填,海南岛是中央峡谷另一重要物源区,其在中央峡谷西侧为次要物源,但是到峡谷东侧则为主要物源区。

关键词：南海中新世物源稀土元素锆石定年

在线全文

学校读者我要写书评

暂无评论

烘烤对苦荞抗氧化活性的影响

食品科技 2010年第11期35卷 182-185页

作者：翟金霞秦培军裴颖张民天津科技大学食品工程与生物技术学院天津300457

以苦荞为原料,研究了不同烘烤条件对苦荞提取液抗氧化活性的影响。结果表明,烘烤处理可极显著(P<0.01)降低苦荞提取液的抑制脂质体过氧化活性、清除超氧阴离子能力和清除羟自由基能力。升高温度和延长烘烤时间,都可极显著(P<0.01)降低... 详细信息

以苦荞为原料,研究了不同烘烤条件对苦荞提取液抗氧化活性的影响。结果表明,烘烤处理可极显著(P<0.01)降低苦荞提取液的抑制脂质体过氧化活性、清除超氧阴离子能力和清除羟自由基能力。升高温度和延长烘烤时间,都可极显著(P<0.01)降低苦荞提取液抗氧化活性;增加水分含量,可提高苦荞亲脂性提取液抗氧化活性,并降低苦荞亲水性提取液抗氧化活性。

关键词：苦荞烘烤提取抗氧化活性