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Research progress of slippage characteristic and gas film stability enhancement methods on biomimetic hydrophobic surfaces

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Journal of Hydrodynamics 2024年第1期36卷 87-101页

作者： Meng-zhuo Zhang Hai-bao Hu Liu-zhen Ren Lu-yao Bao jun Wen Luo xie School of Marine Science and Technology Northwestern Polytechnical UniversityXi’an710072China Research and Development Institute of Northwestern Polytechnical University in Shenzhen Shenzhen518063China

The biomimetic hydrophobic surface is a potentially efficient underwater drag reduction method and the drag reduction mechanism of this kind of surface comes from the interfacial *** now,it is a hotspot to grasp the slippage characteristic and explore slippage enhancement *** paper not only summarizes our numerical simulation and experimental results of slippage characteristic at the solid-liquid interface(SLI)of hydrophobic surfaces(HS)and the gas-liquid interface(GLI)of superhydrophobic surfaces(SHS)in recent years,but also introduces some innovative methods that can effectively improve the gas film stability and drag reduction effect of ***,we used the molecular dynamics(MD)simulation method to figure out the effect of the solid-liquid interaction strength,the system temperature and the shear rate on the slippage of SLI,and expound their action mechanism from molecular ***,by MD and multibody dissipative particle dynamics(MDPD)method,the slippage behavior at the GLI was studied under the influence of the microstructure size and the flow driving *** proposed a new kind of hybrid slip boundary condition model to describe the slippage characteristic on *** addition,we found through experiment that a three-dimensional backflow will appear on the GLI under the interfacial adsorption of surfactants,and the backflow direction will reverse with the change of GLI ***,we put forward the wettability step structure and gas injection method to enhance the stability and drag reduction effect of the gas film on SHS.

关键词： Hydrophobic surface superhydrophobic surface interfacial slip underwater drag reduction

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Elemene Antitumor Drugs Development Based on "Molecular Compatibility Theory" and Clinical Application: A Retrospective and Prospective Outlook

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Chinese Journal of Integrative Medicine 2024年第1期30卷 62-74页

作者： JIANG xiao-ying SHI Li-ping ZHU jun-long BAI Ren-ren xie Tian School of Pharmacy Hangzhou Normal UniversityHangzhou(311121)China Key Laboratory of Elemene Class Anti-cancer Chinese Medicines Engineering Laboratory of Development and Application of Traditional Chinese MedicinesCollaborative Innovation Center of Traditional Chinese Medicines of Zhejiang ProvinceHangzhou Normal UniversityHangzhou(311121)China Good Clinical Practice Center Affliliated Hospital of Nanjing University of Chinese MedicineNanjing(210000)China

Elemene, derived from Curcuma wenyujin, one of the "8 famous genuine medicinal materials of Zhejiang province," exhibits remarkable antitumor activity. It has gained wide recognition in clinical practice for effectiveness on tumors. Dr. xie Tian introduced the innovative concept of "molecular compatibility theory" by combining Chinese medicine principles, specifically the "monarch, minister, assistant, and envoy" theory, with modern biomedical technology. This groundbreaking approach, along with a systematic analysis of Chinese medicine and modern biomedical knowledge, led to the development of elemene nanoliposome formulations. These novel formulations offer numerous advantages, including low toxicity, well-defined composition, synergistic effects on multiple targets, and excellent biocompatibility. Following the principles of the "molecular compatibility theory", further exploration of cancer treatment strategies and methods based on elemene was undertaken. This comprehensive review consolidates the current understanding of elemene's potential antitumor mechanisms, recent clinical investigations, advancements in drug delivery systems, and structural modifications. The ultimate goal of this review is to establish a solid theoretical foundation for researchers, empowering them to develop more effective antitumor drugs based on the principles of "molecular compatibility theory".

关键词： molecular compatibility theory Chinese integrative medicine elemene antitumor activity drug delivery structural modification

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e^(+)e^(-)→Λ_(c)+Λ_(c)^(- ) Cross Sections and the Λ_(c)^(+) Electromagnetic Form Factors within the Extended Vector Meson Dominance Model

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Chinese Physics Letters 2024年第2期41卷 36-41页

作者：陈诚闫冰谢聚军 Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China School of Nuclear Sciences and Technology University of Chinese Academy of SciencesBeijing 101408China College of Mathematics and Physics Chengdu University of TechnologyChengdu 610059China Southern Center for Nuclear-Science Theory(SCNT) Institute of Modern PhysicsChinese Academy of SciencesHuizhou 516000China

Within the extended vector meson dominance model,we investigate the𝑒e^(+)e^(-)→Λ_(c)+Λ_(c)^(- ) reaction and the electromagnetic form factors of the charmed baryon𝛬 Λ_(c)^(+)𝑐.The model parameters are determined by fitting them to the cross sections of the process𝑒e^(+)e^(-)→Λ_(c)+Λ_(c)^(- ) and the magnetic form factor|G_(M)|of Λ_(c)^(+) .By considering four charmonium-like states,called𝜓(4500),𝜓(4660),𝜓(4790),and𝜓(4900),we can well describe the current data on the𝑒e^(+)e^(-)→Λ_(c)+Λ_(c)^(- ) reaction from the reaction threshold up to 4.96 *** addition to the total cross sections and|𝐺M|,the ratio|G_(E)/G_(M)|and the effective form factor|Geff|for Λ_(c)^(+) 𝑐are also calculated,and found that these calculations are consistent with the experimental *** the fitted model parameters,we have also estimated the charge radius of the charmed Λ_(c)^(+) baryon.

关键词： fitted radius meson

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Overexpression of ferroportinl and/or hephaestin attenuated iron induced oxidative stress in MES23.5 cells

Overexpression of ferroportinl and/or hephaestin attenuated ...

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中国神经科学学会第四次会员代表大会暨第七届全国学术会议

作者： Ning SONG,jun WANG,Hong JIANG,jun-xia xie~* Department of Physiology,Medical College of Qingdao University,Qingdao,266071

＜正＞Ferroportin1（FP1） and hephaestin（HP） are newly-found iron transporters cooperating in the iron efflux process in the *** their roles in brain iron homeostasis are not fully *** previous study demonstrated that decreased FP1 and HP expression were involved in the iron accumulation and dopaminergic neurons degeneration in Parkinson’s disease（PD） animal *** investigate whether overexpressed FP1 and/or HP could attenuate iron induced oxidative stress,in the present study we generated the stable MES23.5 dopaminergic cell lines with over expression of FP1 and/or HP,and the dopamine（DA） content and cellular oxidative stress under iron overloaded circumstances in control and transfected cells were *** results showed that iron reduced DA content in the control,however, a significantly less reduction of DA content was observed in transfected cells with high expression of FP1 and/or HP. Further investigations demonstrated that high expression of FP1 and/or HP could surpressed reactive oxygen species production and restored mitochondrial menbrane potential under iron overloaded conditions,due to more iron efflux from the *** findings suggest that overexpression of FP1 and/or HP can protect cells from iron induced oxidative stress by enhancing iron efflux process.

关键词： ferroportin1 hephaestin iron dopamine

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Thermoelectric transport properties of p-type Bi_(2)Se_(3)-Sb_(2)Se_(3)-In_(2)Se_(3) high entropy compounds

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Rare Metals 2024年第7期43卷 3415-3421页

作者： Feng Jiang Cheng-Liang xia Yong-Bin Zhu jun Li Yue Chen Wei-Shu Liu Department of Materials Science and Engineering Southern University of Science and TechnologyShenzhen 518055China Department of Mechanical Engineering The University of Hong KongHong Kong 999077China Guangdong Provincial Key Laboratory of Functional Oxide Materials and Devices Southern University of Science and TechnologyShenzhen 518055China

The introduction of entropy concept into thermoelectric materials recently has attracted broad ***,we showed the phase diagram of the ternary systems of Bi_(2)Se_(3)-Sb_(2)Se_(3)-In_(2)Se_(3).Among the high entropy compounds (HECs),we have identified an intrinsic p-type region near our previously reported Bi_(0.8)Sb_(0.8)In_(0.4)Se_(3) in the phase diagram.

关键词： entropy (3) compounds

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Octopus-like DNA nanostructure coupled with graphene oxide enhanced fluorescence anisotropy for hepatitis B virus DNA detection

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Chinese Chemical Letters 2024年第6期35卷 531-535页

作者： Jia-Li xie Tian-Jin xie Yu-Jie Luo Kai Mao Cheng-Zhi Huang Yuan-Fang Li Shu-jun Zhen Key Laboratory of Luminescence Analysis and Molecular Sensing(Southwest University) Ministry of EducationCollege of Chemistry and Chemical EngineeringSouthwest UniversityChongqing 400715China Key Laboratory of Luminescent and Real-Time Analytical Chemistry(Southwest University) Chongqing Science and Technology BureauCollege of Pharmaceutical SciencesSouthwest UniversityChongqing 400715China

Fluorescence Anisotropy(FA)is an effective biochemical detection method based on molecular *** oxide(GO)has been extensively used as an FA ***,the enhancement of FA by GO alone is limited and the strong scattering of GO will easily make the measurement of FA *** order to address these problems,an octopus-like DNA nanostructure(ODN)was designed and coupled with GO to enhance the FA together in this *** mimicking the multi-clawed structure of the octopus,the ODN can be adsorbed on GO tightly,which not only could improve the sensitivity because of the double FA enhancement abilities of GO and ODN,but also could improve the specificity due to the decrease of the nonspecific interaction in complex ***,ODN could maintain a certain distance between the fluorophore and GO to reduce the fluorescence quenching efficiency of GO,which could improve the *** method has been applied for the detection of hepatitis B virus DNA(HBV-DNA)in a range of 1-50 nmol/L and the limit of detection(LOD)was 330 pmol/*** addition,the proposed method has been successfully utilized to detect HBV-DNA in human serum,indicating that this method has a great practical application prospect.

关键词： Fluorescence anisotropy Graphene oxide(GO) Octopus-like DNA nanostructure HBV-DNA

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Ghrelin protects dopaminergic neurons in the substantia nigra from MPTP- induced neurodegeneration in vivo

Ghrelin protects dopaminergic neurons in the substantia nigr...

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中国神经科学学会第四次会员代表大会暨第七届全国学术会议

作者： Lin-Jing LI,Hong JIANG,jun WANG,jun-xia xie~* Medical college of Qingdao university,Qingdao 266071,China

＜正＞The aim of the study was to investigate the anti-apoptotic effect of an endogenous neuropeptide,ghrelin on the mouse MPTP model of ***,a stomach-derived hormone inducing growth hormone（GH） release and promotes positive energy balance,has been reported to stimulate proliferation and inhibit apoptosis in several cell *** immuno-fluorescence staining,we showed that growth hormone secretagogue receptor（GHS-R） la expressed on dopamine neurons in the SNpc in *** studies by HPLC and immunohistochemistry showed that ghrelin could protect against MPTP-induced dopamine depletion in the striatum as well as the dopaminergic neuronal loss in the Substatia *** RT-PCR studies demonstrated that pre-treatment with ghrelin inhibited MPTP-induced down-regulation of caspase-3,Bcl-2 mRNA expression,and up-regulation of Bax mRNA expression in the *** effects were fully abolished by the antagonist for GHS-R 1a,*** study is the first to demonstrate that the neuroprotective effect of ghrelin on dopaminergic neurons in MPTP-treated PD mouse model was through the anti-apoptotic pathway.

关键词： Ghrelin 1-methy-4-phenyl-1,2,3,6-tetrahydropyridine apoptosis dopaminergic neuron Parkinson’s disease

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Non-linear relationship between age and subfoveal choroidal thickness in Chinese patients with proliferative diabetic retinopathy

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World Journal of Diabetes 2024年第9期15卷 1903-1915页

作者： Chun-Yan Lei Jiang-Ying xie Qi-Bo Ran Mei-xia Zhang Department of Ophthalmology and Research Laboratory of Macular Disease West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Sichuan University Operating Room Department of AnesthesiologyWest China HospitalSichuan University/West China School of NursingSichuan UniversityChengdu 610041Sichuan ProvinceChina

BACKGROUND No study has investigated the change regularity between age and subfoveal choroidal thickness(SFCT)in proliferative diabetic retinopathy(PDR).AIM To investigate the relationship between the SFCT and age in Chinese patients with *** This was a cross-sectional retrospective *** participants were hospitalized individuals with type 2 diabetes who underwent vitrectomy for *** eyes that met the criteria were included in the *** necessary laboratory tests were performed at the time of *** macular thickness(CMT)and SFCT were two quantitative assessments made using enhanced depth imaging optical coherence *** was measured automatically and SFCT was measured manually with digital calipers provided by the Heidelberg Eye Explorer *** The final analysis included a total of 234 individuals with *** average age was 55.60 years old±10.03 years old,and 57.69%of the population was *** analysis revealed a significant negative connection between age and SFCT in patients with PDR[β=-2.44,95%confidence interval(95%CI):-3.46 to-1.42;P<0.0001].In the fully adjusted model,the correlation between SFCT and age remained steady(β=-1.68,95%CI:-2.97 to-0.39;P=0.0117).Spline smoothing showed that the relationship between SFCT and age in patients with PDR was non-linear,with an inflection point at 54 years of *** Our findings suggest that age is a key determinant of choroidal *** non-linear link between SFCT and age in PDR patients should be taken into account.

关键词： Age Subfoveal choroidal thickness Proliferative diabetic retinopathy Optical coherence tomography Central macular thickness

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Neurotoxic effect of zinc on MES23.5 dopaminergic cells

Neurotoxic effect of zinc on MES23.5 dopaminergic cells

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中国神经科学学会第四次会员代表大会暨第七届全国学术会议

作者： Limin SHI,jun WANG,Hong JIANG,jun-xia xie~* Department of physiology,Medical college of Qingdao University,Qingdao,266071

Evidence demonstrated that the Zn level in the substantia nigra(SN) of patients with Parkinson’s disease(PD) is high, suggesting that Zn may participate in the pathology of *** the present study,neurotoxic effect of ... 详细信息

关键词： Zn2+ Mes23.5 cells Parkinson’s disease Dopaminergic neurons Apoptosis

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Backward scattering of laser plasma interactions from hundreds-of-joules broadband laser on thick target

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Matter and Radiation at Extremes 2024年第1期9卷 5-14页

作者： Peipei Wang Honghai An Zhiheng Fang jun Xiong Zhiyong xie Chen Wang Zhiyu He Guo Jia Ruirong Wang Shu Zheng Lan xia Wei Feng Haitao Shi Wei Wang Jinren Sun Yanqi Gao Sizu Fu Shanghai Institute of Laser Plasma CAEPShanghai 201899People’s Republic of China

The use of broadband laser technology is a novel approach for inhibiting processes related to laser plasma interactions(LPIs).In this study,several preliminary experiments into broadband-laser-driven LPIs are carried out using a newly established hundreds-of-joules broadband second-harmonic-generation laser *** direct comparison with LPI results for a traditional narrowband laser,the actual LPI-suppression effect of the broadband laser is *** broadband laser had a clear suppressive effect on both back-stimulated Raman scattering and back-stimulated Brillouin scattering at laser intensities below 1×10^(15) W cm^(−2).An abnormal hot-electron phenomenon is also investigated,using targets of different thicknesses.

关键词： scattering laser hundreds

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