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International Journal of Minerals,Metallurgy and Materials 2018年第12期25卷 1447-1456页

作者： Seung-Woo lee Yong-Jae Kim jun-Hwan Bang Soochun Chae Center for carbon mineralization Korea Institute of Geosciences and Mineral Resources Frontier in extreme physics Korea Research Institute of Standards and Science

A rapidly air-cooled ladle furnace slag(RA-LFS), which is a type of steelmaking slag discharged from a steel mill, was used to synthesize CaCO_3 film. The CaCO_3 film with 35 cm^2 of surface area was synthesized under atmospheric conditions, and the surface morphology of the CaCO_3 films was changed by using additives(CaCl_2 and ethylene glycol). Especially, the addition of CaCl_2 changed the surface morphology of CaCO_3 film with pore and induced new material properties, such as water adsorption. The(012) face of CaCO_3 film(calcite) was rapidly decreased by the addition of CaCl_2. The major components of RA-LFS were calcium(type of CaO, 53.9 wt%) and aluminum(type of Al_2 O_3, 37.9 wt%), and the major crystal phases of RA-LFS were C_3 S, C_(12) A_7, and C_3 A. The calcium extraction efficiency of RA-LFS was significantly increased after the CaCO_3 film synthesis. The material properties(hardness and elastic modulus) and the thermal characteristics of the CaCO_3 films were analyzed by nano-indentation and thermogravimetry–differential thermal analysis. The synthesized CaCO_3 films from RA-LFS and Ca(OH)_2(reagent) showed similarities in terms of their material properties and the decomposition temperature.

关键词： carbon dioxide ladle furnace slag carbonation calcium carbonate film calcium efficiency

Impression of prognosis regarding pathologic stage after preoperative chemoradiotherapy in rectal cancer

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World Journal of Gastroenterology 2015年第2期21卷 563-570页

作者： Kyungyeon Hwang In Ja Park Chang sik Yu Seok-Byung Lim Jong Lyul lee Yong sik Yoon Chan Wook Kim Jin Cheon Kim Department of Colon and Rectal Surgery University of Ulsan College of Medicine and Asan Medical CenterSeoul 138-736South Korea

AIM: To ascertain pathologic stage as a prognostic indicator for rectal cancer patients receiving preoperative chemoradiotherapy(PCRT).METHODS: Patients with mid- and low rectal carcinoma(magnetic resonance imaging- based clinical stage Ⅱ or Ⅲ) between 2000 and 2009 and treated with curative radical resection were identified. Patients were divided into two groups: PCRT and No-PCRT. Recurrence-free survival(RFS) was examined according to pathologic stage and addition of adjuvant ***: Overall, 894 patients were identified. Of these, 500 patients received PCRT. Adjuvant chemotherapy was delivered to 81.5% of the No-PCRT and 94.8% of the PCRT patients. Adjuvant radiotherapy was given to 29.4% of the patients in the No PCRT group. The 5-year RFS for the No-PCRT group was 92.6% for StageⅠ, 83.3% for Stage Ⅱ, and 72.9% for Stage Ⅲ. The 5-year RFS for the PCRT group was 95.2% for yp Stage 0, 91.7% for yp StageⅠ, 73.9% for yp Stage Ⅱ, and 50.7% for yp Stage Ⅲ.CONCLUSION: Pathologic stage can predict prognosis in PCRT patients. Five-year RFS is significantly lower among PCRT patients than No-PCRT patients in pathologic stage Ⅱ and Ⅲ. These results should be taken into account when considering adjuvant treatment for patients treated with PCRT.

关键词： Preoperative Chemoradiotherapy Rectal cancer Patho

Optical Gain Analysis of Graded InGaN/GaN Quantum-Well Lasers

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Chinese Physics Letters 2011年第7期28卷 319-322页

作者： Seoung-Hwan Park Yong-Tae Moon Jeong sik lee Ho Ki Kwon Joong Seo Park Doyeol Ahn Department of Electronics Engineering Catholic University of DaeguHayangKyeongsanKyeongbuk 712-702Republic of Korea SLED R&D Center LG Innotek16 Woomyeon-dongSeocho-guSeoul 137-140Republic of Korea Department of Electrical and Computer Engineering University of SeoulSeoul 130-743Republic of Korea

Optical properties of graded InGaN/GaN quantum well(QW)lasers are analyzed as improved gain media for laser diodes emitting near 500 *** results are compared with those of conventional InGaN/GaN QW *** heavy-hole effective mass around the topmost valence band is found to nearly not be affected by the inclusion of the graded *** graded InGaN/GaN QW structure shows a much larger matrix element than the conventional InGaN/GaN QW *** radiative current density dependences of the optical gain are similar to each ***,the graded QW structure is expected to have lower threshold current density than the conventional QW structure because the former has a lower threshold carrier density than the latter.

关键词： InGaN/GaN graded Lasers

Fingerprint inspired advanced end-effector and its applications

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Friction 2022年第10期10卷 1739-1750页

作者： Sung Ho lee Hyo Sung KIM Han jun PARK Moon Kyu KWAK Department of Electrical Engineering and Computer Science University of MichiganAnn Arbor 48109USA Department of Mechanical Engineering Kyungpook National UniversityDaegu 41566Republic of Korea

The human fingertip consists of a fingerprint with many micro-grating *** main roles of the fingerprint could be divided into two purposes,namely,the enhancement of the frictional force and the effective transmittance of the *** this study,we present the fingerprint-inspired end-effector that has not only admirable frictional force but also electric *** end-effector is composed of fluorocarbon rubber,one of the famous materials to achieve high frictional force and *** various experiments,the novel performance of micro structured fluorocarbon rubber end-effector(MSFE)is characterized by comparing with a macroscale patterned sample(MPS),which has been already used in real industrial *** results are analyzed ***,as feasible applications,we suggest two applications based on the role of the *** is the conductive astronaut glove with high frictional force,and the other one is a non-slip pad for the next-generation glass transfer *** these experiments,we successfully observe the enhanced system performance and confirm the possibility of using the MSFE as feasible *** believe that the MSFE could be a useful and powerful alternative as an end-effector,not only in the aerospace industry but also in display manufacturing processes.

关键词： fingerprint end-effector fluorocarbon rubber(FKM) glass transfer system spacesuit

Formation of intermetallic compound at interface between rare earth elements and ferritic-martensitic steel by fuel cladding chemical interaction

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Journal of Rare Earths 2012年第6期30卷 599-603页

作者： jun Hwan Kim Byoung Oon lee Chan Bock lee Seung Hyun Jee Young Soo Yoon Advanced Fuel Development Division Korea Atomic Energy Research InstituteP.O.Box 105YuseongDaejeon305-600Republic of Korea Department of Mate-rials Science and Engineering Yonsei University134 Sinchon DongSeoul120-749Republic of Korea

The intermetallic compounds formation at interface between rare earth elements and clad material were investigated to demonstrate the effects of rare earth elements on fuel-cladding chemical interaction （FCCI） behavior. Mischmetal （70Ce-30La） and Nd were prepared as rare earth elements. Diffusion couple testing was performed on the rare earth elements and cladding （9Cr2W steel） near the operation temperature of （sodium-cooled fast reactor） SFR fuel. The performance of a diffusion barrier consisting of Zr and V metallic foil against the rare earth elements was also evaluated. Our results showed that Ce and Nd in the rare earth elements and Fe in the clad material interdiffused and reacted to form intermetallic species according to the parabolic rate law, describing the migration of the rare earth element. The diffusion of Fe limited the reaction progress such that the entire process was governed by the cubic rate law. Rare earth materials could be used as a surrogate for high burnup metallic fuels, and the performance of the barrier material was demonstrated to be effective.

关键词： intermetallic compound sodium-cooled fast reactor (SFR) metallic fuel fuel-cladding chemical interaction (FCCI) rare earths Barrier

Effects of Melandrium firmum methanolic extract on testosterone-induced benign prostatic hyperplasia in Wistar rats

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Asian Journal of Andrology 2012年第2期14卷 320-324页

作者： Mee-Young lee In-sik Shin Chang-Seob Seo Nam-Hun lee Hye-Kyung Ha Jong-Keun Son Hyeun-Kyoo Shin Herbal Medicine EBM Research Center Korea institute of Oriental MedicineExporo 483Yusung-guDaejeon 305-811Koreaand Coilege of Pharmacy Yeungnam UniversityGyonsan 712-749Korea

Benign prostatic hyperplasia （BPH） is an age-related disease of unknown aetiology characterized by prostatic enlargement coincident with distinct alterations in tissue histomorphology. Instead of therapeutic agents that can cause severe side effects, plant extracts are frequently used to treat BPH. In this study, we investigated whether the Melandrium firmum methanolic extract （MFME） improves BPH, using the testosterone propionate （TP）-induced BPH rat model. Castration was performed via the scrotal route under sodium pentobarbital anaesthesia. BPH in castrated rats was generated via daily subcutaneous injections of TP （3 mg kg-1） dissolved in corn oil, for 4 weeks. MFME was administered daily by oral garage at a dose of 200 mg kg-1 for 4 weeks, along with the TP injections. The control group received injections of corn oil subcutaneously. At the scheduled termination of the experiment, all rats were killed and their prostates weighed; the relative prostate weight （prostate/body weight ratio） was calculated, and histomorphological changes in the prostate were examined. Additionally, we measured the levels of testosterone and dihydrotestosterone （DHT） in the serum and the prostate. Experimentally induced BPH led to marked decreases in the relative prostate weight and the DHT levels in the serum and the prostate. Histologically, BPH was evident in the ventral lobe of the prostate, and MFME treatment suppressed the severity of the lesions. These results indicate that MFME effectively inhibits the development of BPH induced by testosterone in a rat model. Further studies will be needed to identify the compound（s） responsibility for inducing the protective effect against BPH and determine its mechanism of action,

关键词： benign prostatic hyperplasia dihydrotestosterone Melandrium firmum (S. et Z.)RoHRB prostate testosterone

Cr/nanodiamond composite plating with cobalt cation additive

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中国有色金属学会会刊：英文版 2009年第4期19卷 975-978页

作者： Viet-Hue NGUYEN Thi-Nam HOANG Ngoc-Phong NGUYEN sik-Chol KWON Man KIM Joo-Yul lee Institute of Materials Science Korea Institute of Materials Science

The effect of cationic additive on Cr/nanodiamond plating was *** plating was performed in Sargent *** of deposit was observed by scanning electron microscope(SEM);microhardness by hardness tester;wear rate by tribometer;amount of diamond in deposit by combustion method and passivity by potentiodynamic *** results show that in the presence of cobalt cation,the amount of nanodiamond particle in the deposit is *** increasing diamond particle amount,the metallurgical,mechanical and electrochemical properties of Cr/nanodiamond deposit are ***,this improvement seems to be *** the presence of 10 g/L of nanodiamond powder and 2.5 g/L of cobalt cation in the bath,the amount of diamond particle in deposit is increased by 4 times;and wear rate of Cr-Co/nanodiamond deposit is decreased by 2-3 times as compared with pure Cr/*** passive current of Cr-Co/nanodiamond composite deposit is decreased from 18 to 8 μ*** morphology of Cr/nanodiamond is smooth remarkably in the presence of cobalt cation.

关键词：纳米金刚石粉复合镀层钴离子镀铬添加剂金刚石颗粒扫描电子显微镜形态观察

Fabrication of two-layer flexible copper clad laminate by electroless-Cu plating on surface modified polyimide

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中国有色金属学会会刊：英文版 2009年第4期19卷 970-974页

作者： Soo-Min HWANG jun-Hyung LIM Chang-Min lee Eui-Cheol PARK jun-Hyuk CHOI Jinho JOO Hoo-Jeong lee Seung-Boo junG School of Advanced Materials Science and Engineering Sungkyunkwan University

A flexible copper clad laminate(FCCL) was fabricated using electroless-and electro-Cu plating processes and the effects of pre-treatment time on the adhesion strength of the FCCL were evaluated based on interfacial *** neutralization and catalyst time were varied in the range of 0-20 min and 0.1-10 min,respectively,and the interfacial condition of the FCCL was characterized by atomic force microscopy(AFM) and X-ray photoelectron spectroscopy(XPS).It is observed that the peel strength increases significantly as the neutralization and catalyst time *** strength as high as 7.2-7.3 N/cm is obtained as the neutralization and catalyst time increase up to 20 min and 10 min,respectively,which is comparable to the strength achieved by the conventional laminating and sputtering *** improvements are probably due to an increase in the surface roughness of polyimide(PI),the activated surface condition,and the adsorption of palladium ions/atoms(Pd) on the PI surface which act as nucleation sites for Cu.

关键词：聚酰亚胺表面改性化学制备层压板铜电镀铜箔软性 X射线光电子能谱

Adaptive immunity of materials: Implications for tissue healing and regeneration

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Bioactive Materials 2024年第11期41卷 499-522页

作者： jung-Hwan lee Seong-Jin Shin jun Hee lee Jonathan CKnowles Hae-Hyoung lee Hae-Won Kim Institute of Tissue Regeneration Engineering(ITREN) Dankook UniversityCheonan 31116Republic of Korea Department of Biomaterials Science College of DentistryDankook UniversityCheonan 31116Republic of Korea Department of Nanobiomedical Science and BK21 NBM Global Research Center for Regenerative Medicine Dankook UniversityCheonan 31116Republic of Korea Cell&Matter Institute Dankook UniversityCheonan 31116Republic of Korea Mechanobiology Dental Medicine Research Center Dankook UniversityCheonan 31116Republic of Korea UCL Eastman-Korea Dental Medicine Innovation Centre Dankook UniversityCheonan 31116Republic of Korea UCL Eastman Dental Institute University College LondonLondon NW32PXUnited Kingdom

Recent cumulative findings signify the adaptive immunity of materials as a key agenda in tissue healing that can improve regenerative events and outcomes. Modulating immune responses, mainly the recruitment and functions of T and B cells and their further interplay with innate immune cells (e.g., dendritic cells, macrophages) can be orchestrated by materials. For instance, decellularized matrices have been shown to promote muscle healing by inducing T helper 2 (Th2) cell immunity, while synthetic biopolymers exhibit differential effects on B cell responses and fibrosis compared decellularized matrices. We discuss the recent findings on how implantable materials instruct the adaptive immune events and the subsequent tissue healing process. In particular, we dissect the materials’ physicochemical properties (shape, size, topology, degradation, rigidity, and matrix dynamic mechanics) to demonstrate the relations of these parameters with the adaptive immune responses in vitro and the underlying biological mechanisms. Furthermore, we present evidence of recent in vivo phenomena, including tissue healing, cancer progression, and fibrosis, wherein biomaterials potentially shape adaptive immune cell functions and in vivo outcomes. Our discussion will help understand the materials-regulated immunology events more deeply, and offer the design rationale of materials with tunable matrix properties for accelerated tissue repair and regeneration.

关键词： Adaptive immunity Materials interactions Tissue healing Physicochemical properties Immune cell interplay

Primary malignant melanoma of uterine cervix: a suggestion of new scheme of treatment combination

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Chinese Journal of Cancer Research 2014年第3期26卷 351-354页

作者： Kyung-Jin Min Yeun-Sun Kim Jin-Hwa Hong Jae-Kwan lee Dae-sik Yang Department of Obstetrics and Gynaecology Korea University Medical Centre Department of Radiation Oncology Korea University Medical Centre

Historically, the lack of melanocytes in the vaginal and cervical mucus membranes has deterred the findings of primary melanomas. Mainly due to its rarity, difficulty to diagnose, and poor prognosis, there has been no absolute agreement on comprehensive treatment so far. In this case report, we present a case of a 46-year-old woman with primary malignant melanoma of uterine cervix. She underwent neo-adjuvant chemotherapy initially followed by a radical hysterectomy. After adjuvant concurrent chemo-radiation, the patient has been followed up for 24 months. So far, she has not shown any symptoms or signs of recurrence. Further studies with more cases based on variable combinations of treatment regimen have been on the way.

关键词： Malignant melanoma uterine cervix neo-adjuvant chemotherapy chemo-radiation