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Chinese Journal of Cancer 2013年第2期32卷 53-58页

作者： Dong-Rong Situ Philippe Dartevelle Thierry Le Chevalier lan-jun zhang State Key Laboratory of Oncology in South China Department of Thoracic Surgery Sun Yat-sen University Cancer Center Department of Thoracic and Vascular Surgery and Heart-Lung Transplantation Marie Lannelongue Hospital Department of Lung Oncology Institute Gustave-Roussy

The Sino-French 2012 Conference in Thoracic Oncology, held November 17-18, 2012, was hosted by the Department of Thoracic Surgery at Sun Yat-sen University Cancer Center and organized in collaboration with two prestigious French hospitals: Institute Gustave Roussy and Marie lannelongue Hospital. The conference was established by leading experts from China and France to serve as an international academic platform for sharing novel findings in basic research and valuable clinical practice experiences. Hot topics including innovation in surgical techniques, diagnosis and staging of early-stage lung cancer, minimally invasive surgery, multidisciplinary treatment of lung cancer, and progress in radiotherapy for lung cancer were explored. Highlights of the conference presentations are summarized in this report.

关键词：交换平台国际性学术肿瘤胸部中山大学外科技术实践经验

Penile rehabilitation with a vacuum erectile device in an animal model is related to an antihypoxic mechanism： blood gas evidence

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Asian Journal of Andrology 2013年第3期15卷 387-390页

作者： Hao-Cheng Lin Wen-Li Yang jun-lan zhang Yu-Tian Dai Run Wang Department of Urology Affiliated Drum Tower Hospital School of Medicine Nanjing University Nanjing 210008 China Division of Urology University of Texas Medical Schoo at Houston TX 77030 USA Division of Gastroenterology Hepatology & Nutrition Department of Internal Medicine University of Texas Medical School at Houston TX 77030 USA Department of Urology University of Texas MD Anderson Cancer Center Houston TX 77030 USA

Our previous study showed that vacuum erectile device （VED） therapy has improved erectile function in rats with bilateral cavernous nerve crush （BCNC） injuries. This study was designed to explore the mechanism of VED in penile rehabilitation by analyzing cavernous oxygen saturation （SO2） and to examine the effect of VED therapy on preventing penile shrinkage after BCNC. Thirty adult Sprague- Dawley rats were randomly assigned into three groups： group 1, sham surgery; group 2, BCNC; and group 3, BCNC＋VED. Penile length and diameter were measured on a weekly basis. After 4 weeks of therapy, the penile blood was extracted by three methods for blood gas analysis （BGA）： method 1, cavernous blood was aspirated at the flaccid state; method 2, cavernous blood was aspirated at the traction state; and method 3, cavernous blood was aspirated immediately after applying VED. SO2 values were tested by the blood gas analyzer. The results showed that VED therapy is effective in preventing penile shrinkage induced by BCNC （Penile shortening： BCNC group 1.9±1.1 mm; VED group 0.3±1.0 mm; P〈0.01. Penile diameter reduction： BCNC group 0.28±0.14 mm; VED group 0.04±0.14 mm; P〈0.01）. The mean SO2±s.d. values were increased by VED application （88.25%±4.94%） compared to the flaccid （76.53%±4.16%） or traction groups （78.93%±2.56%）（P〈0.05）. The calculated blood constructs in the corpus cavernosum right after VED application were 62% arterial and 38% venous blood. These findings suggest that VED therapy can effectively preserve penile size in rats with BCNC injury. The beneficial effect of VED therapy is related to antihypoxia by increasing cavernous blood SO2.

关键词： blood SO2 erectile dysfunction (ED) penile size vacuum therapy

Major complications after radiofrequency ablation for liver tumors:Analysis of 255 patients

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World Journal of Gastroenterology 2009年第21期15卷 2651-2656页

作者： Wen-Tao Kong Wei-Wei zhang Yu-Dong Qiu Tie Zhou jun-lan Qiu Wei zhang Yi-Tao Ding Department of Hepatobiliary Surgery Drum Tower Hospital Medical College of Nanjing University Nanjing 210008 Jiangsu Province China

AIM:To investigate the major complications after radiofrequency ablation(RFA) for the treatment of liver tumors and analyze possible risk factors that precipitate these ***:From March 2001 to April 2008,255 patients with liver tumors(205 male,50 female;age range,18-89 years;mean age,56.0 years) who received RFA were enrolled in this *** these patients,212 had hepatocellular carcinoma,39 had metastatic liver tumors and four had cholangiocellular *** hundred and forty eight patients had a single tumor,and 107 had multiple *** diameter of the tumors ranged 1.3-20 cm(mean,5.1 cm).All patients were treated with a cooled-tip perfusion electrode attached to a radiofrequency generator(Radionics,Burlington,MA,USA).RFA was performed via the percutaneous approach(n = 257),laparoscopy(n = 7),or open surgical treatment(n = 86).The major complications related to RFA were *** resultant data were analyzed to determine risk factors associated these ***:Among the 255 patients,425 liver tumors were treated and 350 RFA sessions were ***-seven(10%) major complications were observed which included 13 cases of liver failure,10 cases of hydrothorax requiring drainage,three casesof tumor seeding,one case of upper gastrointestinal bleeding,one case ofintrahepatic abscess,one case of bile duct injury,one case of cardiac arrest,and five cases of *** patients had more than two *** failure was the most severe complication and was associated with the highest *** patients died due to worsening liver ***-Pugh classification(P = 0.001) and choice of approach(P = 0.045) were related to post-treatment liver failure,whereas patient age,tumor size and number were not significant factors precipitating this ***:RFA can be accepted as a relatively safe procedure for the treatment of liver ***,attention should be paid to possible com

关键词： Complication Hepatocellular carcinoma Metastatic liver tumor Radiofrequency ablation Liverfailure

A Facile Li_(2)TiO_(3) Surface Modification to Improve the Structure Stability and Electrochemical Performance of Full Concentration Gradient Li-Rich Oxides

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Energy & Environmental Materials 2024年第3期7卷 41-48页

作者： Naifang Hu Yuan Yang Lin Li Yuhan zhang Zhiwei Hu lan zhang jun Ma Guanglei Cui Qingdao Industrial Energy Storage Research Institute Qingdao Institute of Bioenergy and Bioprocess TechnologyChinese Academy of SciencesQingdao 266101China Institute of Materials Science and Engineering Ocean University of ChinaQingdao 266100China School of Future Technology University of Chinese Academy of SciencesBeijing 100049China Max Planck Institute for Chemical Physics of Solids Nothnitzer Strasse 40Dresden D-01187Germany CAS Key Laboratory of Green Process and Engineering Beijing Key Laboratory of Ionic Liquids Clean ProcessState Key Laboratory of Multiphase Complex SystemsInstitute of Process EngineeringChinese Academy of SciencesBeijing 100190China Shandong Energy Institute Qingdao 266101China

Full concentration gradient lithium-rich layered oxides are catching lots of interest as the next generation cathode for lithium-ion batteries due to their high discharge voltage,reduced voltage decay and enhanced rate performance,whereas the high lithium residues on its surface impairs the structure stability and long-term cycle ***,a facile multifunctional surface modification method is implemented to eliminate surface lithium residues of full concentration gradient lithium-rich layered oxides by a wet chemistry reaction with tetrabutyl titanate and the post-annealing *** realizes not only a stable Li_(2)TiO_(3)coating layer with 3D diffusion channels for fast Li^(+)ions transfer,but also dopes partial Ti^(4+)ions into the sub-surface region of full concentration gradient lithium-rich layered oxides to further strengthen its crystal ***,the modified full concentration gradient lithium-rich layered oxides exhibit improved structure stability,elevated thermal stability with decomposition temperature from 289.57℃to 321.72℃,and enhanced cycle performance(205.1 mAh g^(-1)after 150 cycles)with slowed voltage drop(1.67 mV per cycle).This work proposes a facile and integrated modification method to enhance the comprehensive performance of full concentration gradient lithium-rich layered oxides,which can facilitate its practical application for developing higher energy density lithium-ion batteries.

关键词： full concentration gradient lithium-rich layered oxides structure stability surface modification

Antisense RNA: the new favorite in genetic research

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2018年第10期19卷 739-749页

作者： Jian-zhong XU jun-lan zhang Wei-guo zhang The Key Laboratory of Industrial Biotechnology Ministry of EducationSchool of BiotechnologyJiangnan UniversityWuxi 214122China Department of ln Vitro Diagnostics(IVD) Baiming Biotechnology Co.Ltd.Yancheng 224000China

Antisense RNA molecule represents a unique type of DNA transcript that comprises 19-23 nucleotides and is complementary to mRNA. Antisense RNAs play the crucial role in regulating gene expression at multiple levels, such as at replication, transcription, and translation. In addition, artificial antisense RNAs can effectively regulate the expression of related genes in host cells. With the development of antisense RNA, investigating the functions of antisense RNAs has emerged as a hot research field. This review summarizes our current understanding of antisense RNAs, particularly of the formation of antisense RNAs and their mechanism of regulating the expression of their target genes. In addition, we detail the effects and applications of antisense RNAs in antivirus and anticancer treatments and in regulating the expression of related genes in plants and microorganisms. This review is intended to highlight the key role of antisense RNA in genetic research and guide new investigators to the study of antisense RNAs.

关键词： Antisense RNA Formation mode Regulatory mechanism Application field Genetic research

Three-field vs two-field lymph node dissection for esophageal cancer:A meta-analysis

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World Journal of Gastroenterology 2014年第47期20卷 18022-18030页

作者： Guo-Wei Ma Dong-Rong Situ Qi-Long Ma Hao Long lan-jun zhang Peng Lin Tie-Hua Rong Department of Thoracic Surgery Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China

AIM: To assess the effects of 3-field lymphadenectomy for esophageal carcinoma.

关键词： Oesophagus Cancer Lymph node dissection Survival Complication

Leveraging the Empirical Wavelet Transform in Combination with Convolutional LSTM Neural Networks to Enhance the Accuracy of Polar Motion Prediction

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Research in Astronomy and Astrophysics 2024年第9期24卷 214-224页

作者： Xu-Qiao Wang lan Du Zhong-Kai zhang Ze-jun Liu Hao Xiang College of Geospatial Information Information Engineering UniversityZhengzhou 450001China Henan Industrial Technology Academy of Spatio-Temporal Big Data Zhengzhou 450046China

High-precision polar motion prediction is of great significance for deep space exploration and satellite *** motion is affected by a variety of excitation factors,and nonlinear prediction methods are more suitable for polar motion *** order to explore the effect of deep learning in polar motion *** paper proposes a combined model based on empirical wavelet transform(EWT),Convolutional Neural Networks(CNN)and Long Short Term Memory(LSTM).By training and forecasting EOP 20C04 data,the effectiveness of the algorithm is verified,and the performance of two forecasting strategies in deep learning for polar motion prediction is *** results indicate that recursive multi-step prediction performs better than direct multi-step prediction for short-term forecasts within 15 days,while direct multi-step prediction is more suitable for medium and long-term *** the 365 days forecast,the mean absolute error of EWT-CNN-LSTM in the X direction and Y direction is 18.25 mas and 15.78 mas,respectively,which is 23.5% and 16.2% higher than the accuracy of Bulletin *** results show that the algorithm has a good effect in medium and long term polar motion prediction.

关键词： data analysis methods:miscellaneous astrometry reference systems Earth

Taphonomy and Paleoecology of Lycoptera: A Case Study from the Lower Jehol Group in Western Liaoning, Northeastern China

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Journal of Earth Science 2024年第3期35卷 737-746页

作者： Zhongwu lan Rong Cao Shujing zhang State Key Laboratory of Lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and PalaeontologyChinese Academy of SciencesNanjing 210008China State Key Laboratory of Geological Processes and Mineral Resources China University of GeosciencesWuhan 430078China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China Department of Geology Trinity CollegeDublin 999015Ireland

Taphonomy and paleoecology(biological behavior)of the Early Cretaceous fish fossils are poorly *** study reports for the first time a detailed taphonomical and paleoecological study on Lycoptera in the Mesozoic strata of western Liaoning Province,NE *** XRD analysis shows that gismondine is the dominant clay minerals that could have contributed to the preservation of Lycoptera fossils and microbial mat fragments in the fossil-bearing *** may have formed under volcanism-related hydrothermal regime that was transformed from crystal and lithic ***μ-XRF imaging analysis shows a dominant chemical composition of Al,Si,P,S,Rh,K,Ca,Ti,C,Cr,Mn,Fe,Ni,among which P,Ca,C and S are enriched in the fish skeleton in comparison to the *** suggests a dominant apatite composition for the fish *** influence did not smear off these organic signals probably because of protection of *** coexistance of C and S with Ni is assumed to represent recovered primary productivity following volcanic explosions and toxic gas *** head of juvenile fish stays close to the body of adult *** further discoveries,such phenomenon is interpreted to suggest that adult fish actively protected juvenile fish in the presence of environmental pressures such as anoxia and deterioration of water quality induced by *** acidification and hypoxia in association with volcanism created a harmful environment causing mass extinction of *** adult Lycoptera protected their juveniles by its body at the moment before *** biological behavior will be increasingly reported given the wide occurrence of Lycoptera in Mesozoic strata.

关键词： Lycoptera taphonomy paleoecology fish Jehol Group NE China.

Surrogate modeling for unsaturated infiltration via the physics and equality-constrained artificial neural networks

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第6期16卷 2282-2295页

作者： Peng lan Jingjing Su Sheng zhang School of Civil Engineering Central South UniversityChangsha410075China Discipline of Civil Surveying and Environmental EngineeringPriority Research Centre for Geotechnical Science and EngineeringThe University of NewcastleCallaghanNSW2308Australia Qinghai University Qinghai810016China

Machine learning(ML)provides a new surrogate method for investigating groundwater flow dynamics in unsaturated *** pure data-driven methods(*** neural network,DNN)can provide rapid predictions,but they do require sufficient on-site data for accurate training,and lack interpretability to the physical processes within the *** this paper,we provide a physics and equalityconstrained artificial neural network(PECANN),to derive unsaturated infiltration solutions with a small amount of initial and boundary *** takes the physics-informed neural network(PINN)as a foundation,encodes the unsaturated infiltration physical laws(*** equation,RE)into the loss function,and uses the augmented Lagrangian method to constrain the learning process of the solutions of RE by adding stronger penalty for the initial and boundary *** unsaturated infiltration cases are designed to test the training performance of PECANN,***-dimensional(1D)steady-state unsaturated infiltration,1D transient-state infiltration,two-dimensional(2D)transient-state infiltration,and 1D coupled unsaturated infiltration and *** predicted results of PECANN are compared with the finite difference solutions or analytical *** results indicate that PECANN can accurately capture the variations of pressure head during the unsaturated infiltration,and present higher precision and robustness than DNN and *** is also revealed that PECANN can achieve the same accuracy as the finite difference method with fewer initial and boundary training ***,we investigate the effect of the hyperparameters of PECANN on solving RE *** provides an effective tool for simulating unsaturated infiltration.

关键词： Richards equation(RE) Unsaturated infiltration Data-driven solutions Numerical modeling Machine learning(ML)

Monothetic and conductive network and mechanical stress releasing layer on micron-silicon anode enabling high-energy solid-state battery

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Rare Metals 2024年第3期43卷 1017-1029页

作者： Xiang Han Min Xu lan-Hui Gu Chao-Fei lan Min-Feng Chen jun-Jie Lu Bi-Fu Sheng Peng Wang Song-Yan Chen Ji-zhang Chen College of Materials Science and Engineering Co-Innovation Center of Efficient Processing and Utilization of Forestry ResourcesNanjing Forestry UniversityNanjing210037China Department of Physics Xiamen UniversityXiamen361005China Western Digital Corporation MilpitasCA95035USA

Silicon has ultrahigh capacity,dendrite-free alloy lithiation mechanism and low cost and has been regarded as a promising anode candidate for solid-state *** to the low infiltration of solid-state electrolyte(SSE),not the unstable solid-electrolyte interphase(SEI),but the huge stress during lithiation-and delithiation-induced particle fracture and conductivity lost tend to be the main *** this study,starting with micron-Si,a novel monothetic carbon conductive framework and a MgO coating layer are designed,which serve as electron pathway across the whole electrode and stress releasing layer,*** addition,the in situ reaction between Si and SSE helps to form a LiF-rich and mechanically stable SEI *** a result,the mechanical stability and charge transfer kinetics of the uniquely designed Si anode are significantly ***,high initial Coulombic efficiency,high capacity and durable cycling stability can be achieved by applying the Si@MgO@C anode in *** example,high specific capacity of 3224.6 mAh·g^(-1)and long cycling durability of 200 cycles are *** work provides a new concept for designing alloy-type anode that combines surface coating on particle and electrode structure design.

关键词： Lithium-ion battery(LIB) Solid-state electrolyte(SSE) Silicon anode Stress relief Coating