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Interaction between Schwann cells and other cells during repair of peripheral nerve injury

Neural Regeneration Research 2021年第1期16卷 93-98页

作者： Wen-Rui Qu Zhe Zhu jun Liu De-Biao Song Heng Tian Bing-Peng Chen Rui Li ling-Xiao Deng Department of Hand Surgery the Second Hospital of Jilin UniversityChangchunJilin ProvinceChina Department of Emergency and Critical Medicine the Second Hospital of Jilin UniversityChangchunJilin ProvinceChina Orthopedic Medical Center the Second Hospital of Jilin UniversityChangchunJilin ProvinceChina Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteDepartment of Neurological SurgeryIndiana University School of MedicineIndianapolisINUSA

Peripheral nerve injury(PNI)is common and,unlike damage to the central nervous system injured nerves can effectively regenerate depending on the location and severity of *** myelinating glia,Schwann cells(SCs),interact with various cells in and around the injury site and are important for debris elimination,repair,and nerve *** PNI,Wallerian degeneration of the distal stump is rapidly initiated by degeneration of damaged axons followed by morphologic changes in SCs and the recruitment of circulating *** with fibroblasts from the injured nerve microenvironment also plays a role in nerve *** replication and migration of injury-induced dedifferentiated SCs are also important in repairing the *** particular,SC migration stimulates axonal regeneration and subsequent myelination of regenerated nerve *** mobility increases SC interactions with other cells in the nerve and the exogenous environment,which influence SC behavior *** PNI,SCs directly and indirectly interact with other SCs,fibroblasts,and *** addition,the inter-and intracellular mechanisms that underlie morphological and functional changes in SCs following PNI still require further research to explain known phenomena and less understood cell-specific roles in the repair of the injured peripheral *** review provides a basic assessment of SC function post-PNI,as well as a more comprehensive evaluation of the literature concerning the SC interactions with macrophages and fibroblasts that can influence SC behavior and,ultimately,repair of the injured nerve.

关键词： axon regeneration cell-cell interactions nerve injury nerve repair peripheral nerve recovery regeneration repair Schwann cell migration

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Exhaustive Exercise Does Not Affect Humoral Immunity and Protection after Rabies Vaccination in a Mouse Model

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Virologica Sinica 2018年第3期33卷 241-248页

作者： Lun Xia Minrui Li Yajing Zhang juncheng Ruan jie Pei Jiale Shi Zhen F.Fu ling Zhao Ming Zhou Dayong Tian Department of Physical Education Huazhong Agricultural University School of Foreign Languages Huazhong Agricultural University State Key Laboratory of Agricultural Microbiology Huazhong Agricultural University College of Veterinary Medicine Huazhong Agricultural University

Rabies is one of the most dangerous and widespread zoonosis and is characterized by severe neurological signs and a high case-mortality rate of nearly 100%. Vaccination is the most effective way to prevent rabies in humans and animals. In this study, the relationship between exhaustive exercise and the humoral immune response after immunization with inactivated rabies vaccine was investigated in a mouse model with one-time exhaustive exercise. It was found that compared with the mice with no exercise after vaccination, no significant differences were found in those with exhaustive exercise after vaccination on body-weight changes, virus-neutralizing antibody(VNA) titers, antibody subtypes and survivor ratio after lethal rabies virus(RABV) challenge. This study indicated that exhaustive exercise does not reduce the effects of the rabies inactivated vaccine.

关键词： Rabies Vaccination - Exhaustive exercise Virus neutralizing antibody Protection

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基于奇异值分解算法的电气设备绝缘介损传感信号检测方法

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环境技术 2024年第4期42卷 116-122页

作者：翁良杰景瑶杨彬彬朱俊王雄奇国网安徽省电力有限公司超高压分公司合肥230000 安徽继远软件有限公司合肥230000

针对信号起伏特性冗余,忽略了双重信号噪声的影响,导致检测结果的绝缘介损因数偏差较大的问题,提出基于奇异值分解算法的电气设备绝缘介损传感信号检测方法。构建时序特征窗口平滑处理原始传感信号,分析处理后传感信号的脉冲与高斯双重... 详细信息

针对信号起伏特性冗余,忽略了双重信号噪声的影响,导致检测结果的绝缘介损因数偏差较大的问题,提出基于奇异值分解算法的电气设备绝缘介损传感信号检测方法。构建时序特征窗口平滑处理原始传感信号,分析处理后传感信号的脉冲与高斯双重噪声,分离重构去除相应噪声值,引入奇异值分解算法将绝缘介质电流传感信号分解出来,解析分解信号的形态波计算得到绝缘介损传感信号检测结果。实验结果表明:所提方法应用后得出的检测结果,表现出的绝缘介损因数偏差较小,检测准确度较高,满足了电气设备绝缘性能运维的实际需求。

关键词：电气设备设备绝缘介损传感信号奇异值分解算法

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水产胶原蛋白热稳定性与环境温度相关性研究进展

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食品安全质量检测学报 2024年第2期15卷 251-257页

作者：王柯郭志文段蕊周天宇张俊杰江苏海洋大学海洋食品与生物工程学院连云港222005 江苏海洋大学海洋科学与水产学院连云港222005

水产胶原蛋白是一种优良的生物材料,被广泛应用于医药、化妆品、食品加工等领域。但水产胶原蛋白热稳定性较差,且目前对其热稳定性与环境温度相关性的研究较少。本文详细论述水产胶原蛋白的三螺旋结构,对其热稳定性的来源作出详细分析,... 详细信息

水产胶原蛋白是一种优良的生物材料,被广泛应用于医药、化妆品、食品加工等领域。但水产胶原蛋白热稳定性较差,且目前对其热稳定性与环境温度相关性的研究较少。本文详细论述水产胶原蛋白的三螺旋结构,对其热稳定性的来源作出详细分析,并以环境温度为主导因素,综述生存环境温度差异带来的水产胶原蛋白氨基酸组成变化、结构变化(亚基组成,翻译后修饰)与热稳定性差异。生存在较高温度下的生物,其胶原的变性温度(denaturation temperature, Td)也相对较高,且含有较高比例的α1亚基与较少的α2、α3亚基,反之亦然。这种亚基比例改变的实质可能涉及Ⅰ型胶原α1(Ⅰ)α2(Ⅰ)α3(Ⅰ)与α1(Ⅰ)2α2(Ⅰ)分子构型的互相转变。除上述变化,变温动物可以调节胶原翻译后修饰数量,辅助亚基比例的变化,增强或降低胶原的热稳定性,这是变温动物特有的一种能力。水产胶原蛋白的热稳定性随环境温度的变化而改变,是生物对环境适应能力的一部分。本文对现阶段关于胶原蛋白结构、热稳定性与环境温度相关性的研究进行总结,以期为胶原蛋白材料的研究与应用提供参考。

关键词：胶原蛋白热稳定性三螺旋结构亚基环境温度

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Facile synthesis of hollow Ti2Nb10O29 microspheres for high-rate anode of Li-ion batteries

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Science China Chemistry 2018年第6期61卷 670-676页

作者： Yong-Gang Sun Tian-Qi Sun Xi-jie Lin Xian-Sen Tao Dong Zhang Chen Zeng An-Min Cao Li-jun Wan Key Laboratory of Molecular Nanostructure and Nanotechnology and Beijing National Laboratory for Molecular Sciences Institute of Chemistry Chinese Academy of Sciences Beijing 100190 China University of Chinese Academy of Sciences Beijing 100049 China State Key Laboratory of Fine Chemicals Dalian University of Technology Dalian 116024 China College of Food Science & Technology Huazhong Agricultural University Wuhan 430070 China

Titanium niobium oxides emerge as promising anode materials with potential for applications in lithium ion batteries with high safety and high energy ***,the innate low electronic conductivity of such a composite oxide seriously limits its practical capacity,which becomes a serious concern especially when a high rate charge/discharge capability is ***,using a modified template-assisted synthesis protocol,which features an in-situ entrapment of both titanium and niobium species during the formation of polymeric microsphere followed by a pyrolysis process,we succeed in preparing hollow microspheres of titanium niobium oxide with high efficiency in structural *** used as an anode material,the structurally-controlled hollow sample delivers high reversible capacity(103.7 m A h g^(-1)at 50 C)and extraordinary cycling capability especially at high charge/discharge currents(164.7 m A h g^(-1)after 500 cycles at 10 C).

关键词： hollow microspheres Ti2Nb10O29 anode materials high rate capability Li-ion batteries

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Catalytic transfer hydrogenation of biomass-derived furfural to furfuryl alcohol with formic acid as hydrogen donor over CuCs-MCM catalyst

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Chinese Chemical Letters 2021年第3期32卷 1186-1190页

作者： Tao Wang Juan Du Yong Sun Xing Tang Zuo-jun Wei Xianhai Zeng Shi-jie Liu Lu Lin Xiamen Key Laboratory of Clean and High-valued Utilization for Biomass College of EnergyXiamen UniversityXiamen 361102China Fujian Engineering and Research Center of Clean and High-valued Technologies for Biomass Xiamen 361102China School of Chemical and Biological Engineering Zhejiang UniversityHangzhou 310058China Department of Paper and Bioprocess Engineering State University of New York College of Environmental Science and ForestrySyracuseNew York 13210United States State Key Laboratory of Applied Microbiology Southern China Guangdong Provincial Key Laboratory of Microbial Culture Collection and ApplicationGuangdong Open Laboratory of Applied MicrobiologyGuangdong Microbial Culture Collection Center(GDMCC)Guangdong Institute of MicrobiologyGuangdong Academy of SciencesGuangzhou 510070China

Catalytic transfer hydroge nation(CTH)of furfural(FF)to furfu ryl alcohol(FFA)has received great intere st in recent *** rein,Cu-Cs bimetallic supported catalyst,CuCs(2)-MCM,was developed for the CTH of FF to FFA using formic as hydrogen ***(2)-MCM achieved a 99.6%FFA yield at an optimized reaction conditions of 170℃,1 *** species in CuCs(2)-MCM had dual functions in catalytically decomposing formic acid to generate hydrogen and hydrogenating FF to *** doping of Cs made the size of Cu particles smaller and improved the dispersion of the Cu active *** rtantly,the Cs species played a favorable role in enhancing the hydrogenation activity as a promoter by adjusting the surface acidity of Cu species to an appropriate *** analysis showed that surface acidity is the primary factor to affect the catalytic activity of CuCs(2)-MCM.

关键词： Furfural Furfuryl alcohol CuCs(x)-MCM catalysts Catalytic transfer hydrogenation Formic acid

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绵羊源荚膜血清D型多杀性巴氏杆菌的生物学特性及2种候选疫苗的免疫效果评价

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畜牧与兽医 2024年第4期56卷 108-116页

作者：汪阳张凌金映红汪萍薛晶梁芊芊李晓卓郑启铭刘文锴韩翔舒夏俊新疆农业大学动物医学学院新疆乌鲁木齐830000 农业农村部草食动物疫病防控重点实验室(部省共建) 新疆乌鲁木齐830000 新疆畜牧科学院兽医研究所/动物临床医学研究中心新疆乌鲁木齐830000 石河子大学动物科技学院新疆石河子832061

旨在研究新疆绵羊源荚膜血清D型多杀性巴氏杆菌(PmD)的生物学特性,探索其灭活疫苗与OmpH重组疫苗对小鼠的免疫保护效果,为防控新疆地区绵羊巴氏杆菌病提供参考。采用细菌分离鉴定、PCR鉴定、药敏试验、耐药与毒力基因检测、致病性试验... 详细信息

旨在研究新疆绵羊源荚膜血清D型多杀性巴氏杆菌(PmD)的生物学特性,探索其灭活疫苗与OmpH重组疫苗对小鼠的免疫保护效果,为防控新疆地区绵羊巴氏杆菌病提供参考。采用细菌分离鉴定、PCR鉴定、药敏试验、耐药与毒力基因检测、致病性试验等方法初步明确PmD的生物学特性;并通过最佳灭活条件和佐剂筛选、安全性试验、原核表达等方法制备PmD灭活疫苗与PmD-OmpH重组疫苗,采取小鼠攻毒保护试验评价2种疫苗的免疫效力。结果:从绵羊肺脏中分离出1株PmD,药敏试验显示,该菌为7重耐药菌,未检测到耐药基因;毒力基因检测显示,该菌具有12种毒力基因(exbB、exbD、hgbA、tonB、fimA、Oma87、OmpH、Psl、sodA、sodC、tbpA、toxA);致病性较强,对小鼠的最小致死菌量为2.2×105 CFU;灭活疫苗和重组疫苗对相同血清型菌株攻毒的保护率分别为80%和10%;灭活疫苗对血清型A、F和未知菌株攻毒保护率分别为0、20%和0,而重组疫苗的保护率则全为0。本研究发现1株强耐药、强毒力的绵羊源PmD,灭活疫苗对同种血清型菌株的保护性远高于重组疫苗,发病地区羊场可采用同种血清型灭活疫苗进行预防和控制绵羊巴氏杆菌病,对多价疫苗和新型疫苗的研制还有待进一步发掘。

关键词：绵羊荚膜血清D型多杀性巴氏杆菌生物学特性灭活疫苗 OmpH蛋白重组疫苗

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Aqueous angiopoietin-like levels correlate with optical coherence tomography angiography metrics in diabetic macular edema

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International Journal of Ophthalmology(English edition) 2021年第12期14卷 1888-1894页

作者： jie Yan Wu-jun Li Ya-Zhou Qin Xuan-Yu Qiu Li Qin Jing-Ming Li Department of Ophthalmology the First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina Department of Ophthalmology Yulin Hospital of Traditional Chinese MedicineYulin 719000Shaanxi ProvinceChina

AIM:To quantitatively detect aqueous levels of angiopoietin-like(ANGPTL)3,ANGPTL4,and ANGPTL6 and investigate their correlation with optical coherence tomography angiography(OCTA)findings in patients with diabetic macular edema(DME).METHODS:This cross-sectional study included 23 patients(27 eyes)with type 2 diabetes and 16 control subjects(20 eyes).All patients underwent OCTA imaging and ultra-wide field fundus *** patients were categorized into two groups according to the presence or absence of diabetic retinopathy(DME group,14 patients,16 eyes);and non-diabetic retinopathy(NDR)group,9 patients,11 eyes,*** levels of ANGPTL3,ANGPTL4,and ANGPTL6 were assessed using suspension array technology,and foveal-centered 3×3 mm2 OCTA scans were automatically graded to determine the central,inner,and full vessel density(CVD,IVD,FVD);central,inner,and full perfusion density(CPD,IPD,FPD),foveal avascular zone(FAZ)area,FAZ perimeter,and FAZ circularity index(FAZ-CI)on superficial capillary ***,central subfield thickness(CST),cube volume(CV),and cube average thickness(CAT)were measured in a model of macular cube 512×***:Aqueous ANGPTL3 levels were not significantly different among the three groups(P>0.05).ANGPTL4 levels were significantly higher in the DME group than the control and NDR groups(P<0.0001 and P<0.001),while ANGPTL6 levels were significantly higher in the DME group than the control group(P<0.05).In the whole cohort,the aqueous ANGPTL3 levels correlated negatively with the IVD,FVD,IPD,and FPD,and positively with the CV and *** aqueous ANGPTL4 levels correlated negatively with the CVD,IVD,FVD,CPD,IPD,and FPD,and positively with the FAZ perimeter,CST,CV,and *** aqueous ANGPTL6 levels correlated negatively with the IVD,FVD,IPD,FPD,FAZCI and positively with CST,CV,***:ANGPTL4 and ANGPTL6 may be associated with vascular leakage in DME and may represent good targets for DME *** addition,OCT

关键词： diabetic retinopathy diabetic macular edema optical coherence tomography angiography angiopoietin-like vascular leakage

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D-serine reduces memory impairment and neuronal damage induced by chronic lead exposure

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Neural Regeneration Research 2021年第5期16卷 836-841页

作者： Jian-Zhu Bo ling Xue Shuang Li Jing-Wen Yin Zheng-Yao Li Xi Wang jun-Feng Wang Yan-Shu Zhang College of Public Health North China University of Science and TechnologyTangshanHebei ProvinceChina Laboratory Animal Center North China University of Science and TechnologyTangshanHebei ProvinceChina

Although exogenous D-serine has been applied as a neural regulatory intervention in many studies,the role played by D-serine in hippocampal injuries caused by lead exposure remains poorly *** models of chronic lead exposure were established through the administration of 0.05%lead acetate for 8 ***,rats were administered 30 or 60 mg/kg D-serine,intraperitoneally,twice a *** results showed that D-serine treatment shortened the escape latency from the Morris water maze,increased the number of times that mice crossed the original platform location,and alleviated the pathological damage experienced by hippocampal neurons in response to lead *** D-serine administration did not increase the expression levels of the N-methyl-D-aspartate receptor subtype 2B(NR2B)in the hippocampi of lead-exposed rats,60 mg/kg D-serine treatment restored the expression levels of NR2A,which are reduced by lead *** findings suggested that D-serine can alleviate learning and memory impairments induced by lead exposure and that the underlying mechanism is associated with the increased expression of NR2A in the *** study was approved by the Animal Ethics Committee of North China University of Science and Technology,China(approval ***2018155)on December 21,2018.

关键词： D-serine hippocampus lead neurological function N-methyl-D-aspartate poisoning protection repair

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Identification of QTL Affecting Protein and Amino Acid Contents in Rice

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Rice science 2011年第3期18卷 187-195页

作者： Ming ZHONG ling-qiang WANG De-jun YUAN Li-jun LUO Cai-guo XU Yu-qing HE National Key Laboratory of Crop Genetic Improvement National Center of Plant Gene Research (Wuhan) and National Center of Crop Molecular Breeding Huazhong Agricultural University Wuhan 430070 China Shanghai Agrobiological Gene Center Shanghai 201106 China

The phenotypes of protein and amino acid contents were measured in an F9 recombinant inbred line population derived from a cross between Zhenshan 97B and Delong 208. A total of 48 and 64 QTLs were identified in 2004 and 2005, respectively. The contribution of each QTL to the phenotypic variation ranged from 4.0% to 43.7%. Most QTLs co-localized, forming 29 QTL clusters on the chromosomes with three major ones detected in both years, which were mapped on chromosomes 1, 7 and 9, respectively. The two QTL clusters for amino acid content, qAa1 and qAa7, influenced almost all the traits with the allele from Zhenshan 97B, and the third QTL cluster for amino acid content, qAa9, increased the lysine content with the allele from Delong 208. A wide coincidence was found between the QTL detected under this study and the loci involved in amino acid metabolism pathways in nitrogen assimilation and transport, or protein biosynthesis. The results would facilitate the identification of candidate genes and could be used in marker-assisted selection for the favorable allele in rice quality improvement.

关键词： amino acid content protein content quantitative trait locus grain quality Oryza sativa

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