Interaction between Schwann cells and other cells during repair of peripheral nerve injury

作     者：Wen-Rui Qu Zhe Zhu Jun Liu De-Biao Song Heng Tian Bing-Peng Chen Rui Li Ling-Xiao Deng Wen-Rui Qu;Zhe Zhu;Jun Liu;De-Biao Song;Heng Tian;Bing-Peng Chen;Rui Li;Ling-Xiao Deng

作者机构：Department of Hand Surgerythe Second Hospital of Jilin UniversityChangchunJilin ProvinceChina Department of Emergency and Critical Medicinethe Second Hospital of Jilin UniversityChangchunJilin ProvinceChina Orthopedic Medical Centerthe Second Hospital of Jilin UniversityChangchunJilin ProvinceChina Spinal Cord and Brain Injury Research GroupStark Neurosciences Research InstituteDepartment of Neurological SurgeryIndiana University School of MedicineIndianapolisINUSA 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2021年第16卷第1期

页      面：93-98页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：This work was also supported by the National Natural Science Foundation of China,No.81901365(to WRQ) Jilin Science and Technology Agency Funds in China,Nos.20180101118JC(to RL),20180520115JH(to BPC)and 20190103076JH(to WRQ) 

主　　题：axon regeneration cell-cell interactions nerve injury nerve repair peripheral nerve recovery regeneration repair Schwann cell migration 

摘      要：Peripheral nerve injury(PNI)is common and,unlike damage to the central nervous system injured nerves can effectively regenerate depending on the location and severity of *** myelinating glia,Schwann cells(SCs),interact with various cells in and around the injury site and are important for debris elimination,repair,and nerve *** PNI,Wallerian degeneration of the distal stump is rapidly initiated by degeneration of damaged axons followed by morphologic changes in SCs and the recruitment of circulating *** with fibroblasts from the injured nerve microenvironment also plays a role in nerve *** replication and migration of injury-induced dedifferentiated SCs are also important in repairing the *** particular,SC migration stimulates axonal regeneration and subsequent myelination of regenerated nerve *** mobility increases SC interactions with other cells in the nerve and the exogenous environment,which influence SC behavior *** PNI,SCs directly and indirectly interact with other SCs,fibroblasts,and *** addition,the inter-and intracellular mechanisms that underlie morphological and functional changes in SCs following PNI still require further research to explain known phenomena and less understood cell-specific roles in the repair of the injured peripheral *** review provides a basic assessment of SC function post-PNI,as well as a more comprehensive evaluation of the literature concerning the SC interactions with macrophages and fibroblasts that can influence SC behavior and,ultimately,repair of the injured nerve.