检索结果-南通市图书馆

Preliminary study on detection and cleaning of parasitic bunches

在线全文

学校读者我要写书评

暂无评论

Nuclear Science and Techniques 2021年第10期32卷 1-11页

作者： jun He Yan-Feng Sui Yan-Hua Lu Di Yin Zhe Duan Sai-Ke Tian De-Chong Zhu Ying Zhao jun-hui yue Jian-She Cao Key Laboratory of Particle Acceleration Physics and Technology Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China

To establish a nuclear resonant scattering beamline at the High Energy Photon Source(HEPS),it is essential to develop tools for detection and cleaning of parasitic bunches,for meeting the stringent demands on bunch *** this end,a novel time-correlated single-photon counting system was implemented at the electron storage ring of the Beijing Electron–Positron Collider II(BEPCII).The purity deterioration process over a week-long operation was recorded by the *** this study,the mechanism of impurity growth was analyzed by numerical methods and validated on *** agreement between the experimental results and the cal-culation was fairly *** main sources of parasitic bunches,pre-accelerators and the Touschek scattering were confirmed.A bunch-cleaning technique,based on a sinu-soidal signal mixed with a pseudo-square wave,was also developed and implemented,and its capability to improve the bunch purity to the level of 10–7 was experimentally *** present the experimental setup,princi-ple,and measurement results of a system for detection and cleaning of parasitic bunches.

关键词： Parasitic bunches Impurity growth High energy photon source(HEPS)

A high sensitivity tune measurement system for BEPCII

在线全文

学校读者我要写书评

暂无评论

Radiation Detection Technology and Methods 2022年第1期6卷 88-96页

作者： jun He Yan-feng Sui Yan-hua Lu Yao-yao Du Lin Wang hui-zhou Ma Yong Li Ying Zhao Ling-da Yu Tao-guang Xu jun-hui yue Jian-she Cao Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China

Background The tune is one of the most important parameters of the storage ring which play a crucial role in the brightness *** synchrotron radiation will suppress the oscillation and make the detection unusual difficulty without any kicker *** A new high sensitivity tune measurement system is developed to show the real-time tune during the *** Peak diode detectors are used to convert short beam pulses from a button BPM into slowly varying *** DC components,constituting a large background related to beam offsets,are suppressed by series capacitors,while the small signals related to beam oscillations are passed to the subsequent stages for amplification and *** A direct diode detection technique based on the diode peak hold circuit could increase the sensitivity by hundreds time which gets a clearly tune peak even with synchrotron radiation and bunch-by-bunch feedback damping.

关键词： Collider High sensitivity Direct diode detection Real-time tune Red Pitaya

Performance of beam size monitor based on Kirkpatrick–Baez mirror at SSRF

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nuclear Science and Techniques 2018年第10期29卷 236-244页

作者： De-Chong Zhu jun-hui yue Yan-Feng Sui Da-Heng Ji Jian-She Cao Kai-Rong Ye Shun-Qiang Tian Jie Chen Yong-Bin Leng Key Laboratory of Particle Acceleration Physics and Technology Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China

High-energy photon source(HEPS) is a 6 GeV ultralow emittance storage ring light source to be built in Beijing, China. Both the horizontal and vertical beam sizes of the HEPS storage ring are below 10 lm. It is a challenge to measure such a small beam size in both directions. To this end, measurement by a Kirkpatrick–Baez(KB) mirror imaging system was evaluated. A test KB system for the Shanghai Synchrotron Radiation Facility storage ring was designed and tested. Two crossed cylindrical mirrors were used to image the dipole source point. Both mirrors can be moved in and out so that the monitor is interchangeable with the original X-ray pinhole monitor. The aberration and point spread function, which would cause image blur, were evaluated. A beam-based calibration scheme was used by varying the beam size with different quadrupole settings and fitting them with the corresponding theoretical *** updated the original X-ray camera with a new camera having a 5-lm-thick LuAG/Ce scintillator, and the imaging result shows greatly decreased image blur.

关键词： KB mirror Beam size measurement Beam diagnostic Emittance Synchrotron radiation

A scintillator detector for beam tuning of low-energy single electron accelerator

在线全文

学校读者我要写书评

暂无评论

Radiation Detection Technology and Methods 2017年第1期1卷 29-39页

作者： Yu-lan Li Yun-ting Gu Yu-guang Xie jun-hui yue jun-guang Lv Shun-li Niu Shi-lun Pei Feng Shi Ling-da Yu Hang Zhao Wen-qi Yan Pin Lv Zhi-yuan Peng Geng-lan Li Guangxi University Nanning 530004GuangxiChina Institute of High Energy Physics Beijing 100049China State Key Laboratory of Particle Detection and Electronics Beijing 100049China University of Chinese Academy of Sciences Beijing 100049China

Purpose Nine scintillator detectors were developed for beam tuning of low-energy single electron accelerator instead of the picoammeter and Faraday cup,both of which will be insensitive to the weak-current beam lower than *** The detectors are based on plastic scintillator and photomultiplier tube(PMT)and the beam is 100 Hz pulsed electrons in the energy range of 0.1 to *** beam flux was tuned from about 107 to quasi-single electron for each bunch according to the measurement results of these detectors installed along the beam pipe and after *** order to determine the number of electrons in a bunch,the gains of each PMT were finely calibrated,and the energy response of each detector was calibrated with 207Bi radioactive ***,the deposited energy in the plastic scintillator,the electron detection efficiency and light collection efficiency,as a function of electron incident energy,were also simulated in detail by *** Nine detectors worked well at a gain of 0.6×10^(6) after installation in the beam pipe,and the number of electrons in a bunch could be measured at each detector *** single electron peak was seen when the beam reached the final *** The commissioning result shows that the beam was tuned to quasi-single electron level successfully and the scintillator detector is an effective method to measure the weak-current beam lower than picoampere.

关键词： Beam tuning Single electron beam PMT Plastic scintillator Slit

从新型智库功能看地方科技情报机构主要问题及转型途径

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

情报科学 2017年第8期35卷 141-145页

作者：王君王慧万玥张薇南京大学信息管理学院江苏南京210023 江苏省科技情报研究所江苏南京210042 南京交通职业技术学院江苏南京211188

【目的/意义】面向国家加强中国特色新型智库建设,探讨江苏省科学技术情报研究所的研究现状及服务转型。【方法/过程】对CNKI数据库中2001-2015年江苏省科学技术情报研究所发表的期刊文献进行关键词的分析,借用布拉德福定律对关键词表... 详细信息

【目的/意义】面向国家加强中国特色新型智库建设,探讨江苏省科学技术情报研究所的研究现状及服务转型。【方法/过程】对CNKI数据库中2001-2015年江苏省科学技术情报研究所发表的期刊文献进行关键词的分析,借用布拉德福定律对关键词表二次分区,并对核心区关键词进行了对比分析。【结果/结论】情报机构在新型智库时代背景下应当充分认识到自身的使命担当,积极向新型智库所要求的功能进行服务转型与创新,充分发挥情报机构的前端作用,助推中国新型智库建设。

关键词：新型智库科技情报机构情报布拉德福定律

氢化可的松角质类脂脂质体的理化性质及其体外经皮渗透研究

在线全文

学校读者我要写书评

暂无评论

中国新药杂志 2017年第15期26卷 1822-1826页

作者：郑雪花于黎鹏杨君杨跃辉中国医科大学附属盛京医院药学部沈阳110004 武汉市妇女儿童医疗保健中心药学部武汉430014

目的:制备氢化可的松角质类脂脂质体,并考察其理化性质和体外透皮性能。方法:采用乙醇注入法制备氢化可的松角质类脂脂质体并通过透射电镜观察外观形态;通过葡聚糖凝胶微柱测定包封率;用激光散色法测定粒径和Zeta电位;以大鼠皮肤为渗透... 详细信息

目的:制备氢化可的松角质类脂脂质体,并考察其理化性质和体外透皮性能。方法:采用乙醇注入法制备氢化可的松角质类脂脂质体并通过透射电镜观察外观形态;通过葡聚糖凝胶微柱测定包封率;用激光散色法测定粒径和Zeta电位;以大鼠皮肤为渗透屏障,采用透皮扩散仪测定氢化可的松角质类脂脂质体的体外透皮累积渗透量和皮肤滞留量。结果:氢化可的松角质类脂脂质体粒径均匀且圆整,粒径为(433.90±30.71)nm,Zeta电位为(-33.09±1.86)m V,包封率为(40.32±1.56)%,p H值为(5.77±0.03);角质类脂脂质体的体外经皮渗透率为(10.87±0.76)μg·cm-2·h-1,为普通脂质体的1.91倍;12 h后皮肤中药物滞留量为(3.31±0.15)μg·cm-2,显著高于普通脂质体。结论:氢化可的松角质类脂脂质体制备工艺简单,可有效促进氢化可的松的经皮渗透,为氢化可的松经皮给药新制剂的研究提供了参考。

关键词：氢化可的松角质类脂脂质体理化性质经皮渗透

Hypidone hydrochloride(YL-0919)ameliorates functional deficits after traumatic brain injury in mice by activating the sigma-1 receptor for antioxidation

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第8期20卷 2325-2336页

作者： Yafan Bai hui Ma yue Zhang Jinfeng Li Xiaojuan Hou Yixin Yang Guyan Wang Yunfeng Li Department of Anesthesiology Beijing Tongren HospitalCapital Medical UniversityBeijingChina Beijing Institute of Basic Medical Sciences BeijingChina Hebei North University ZhangjiakouHebei ProvinceChina Beijing Institute of Pharmacology and Toxicology State Key Laboratory of Toxicology and Medical CountermeasuresBeijing Key Laboratory of NeuropsychopharmacologyBeijingChina

Traumatic brain injury involves complex pathophysiological mechanisms,among which oxidative stress significantly contributes to the occurrence of secondary *** this study,we evaluated hypidone hydrochloride(YL-0919),a self-developed antidepressant with selective sigma-1 receptor agonist properties,and its associated mechanisms and targets in traumatic brain *** experiments to assess functional deficits were followed by assessment of neuronal damage through histological analyses and examination of blood-brain barrier permeability and brain ***,we investigated the antioxidative effects of YL-0919 by assessing the levels of traditional markers of oxidative stress in vivo in mice and in vitro in HT22 ***,the targeted action of YL-0919 was verified by employing a sigma-1 receptor antagonist(BD-1047).Our findings demonstrated that YL-0919 markedly improved deficits in motor function and spatial cognition on day 3 post traumatic brain injury,while also decreasing neuronal mortality and reversing blood-brain barrier disruption and brain ***,YL-0919 effectively combated oxidative stress both in vivo and in *** protective effects of YL-0919 were partially inhibited by *** results indicated that YL-0919 relieved impairments in motor and spatial cognition by restraining oxidative stress,a neuroprotective effect that was partially reversed by the sigma-1 receptor antagonist ***-0919 may have potential as a new treatment for traumatic brain injury.

关键词： antidepressant drug blood-brain barrier cognitive function hypidone hydrochloride(YL-0919) neurological function nuclear factor-erythroid 2 related factor 2 oxidative stress sigma-1 receptor superoxide dismutase traumatic brain injury

Microglia lactylation in relation to central nervous system diseases

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第1期20卷 29-40页

作者： hui Yang Nan Mo Le Tong Jianhong Dong Ziwei Fan Mengxian Jia Juanqing yue Ying Wang School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Clinical Laboratory The Fourth Clinical Medical College of Zhejiang University of Traditional Chinese Medicine(Hangzhou First People’s Hospital)HangzhouZhejiang ProvinceChina College of Medical Veterinary and Life SciencesUniversity of GlasgowGlasgowUK Department of Orthopedics(Spine Surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Pathology Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhouZhejiang ProvinceChina Department of Clinical Research Center Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhouZhejiang ProvinceChina

The development of neurodegenerative diseases is closely related to the disruption of central nervous system ***,as innate immune cells,play important roles in the maintenance of central nervous system homeostasis,injury response,and neurodegenerative *** has been considered a metabolic waste product,but recent studies are revealing ever more of the physiological functions of *** is an important pathway in lactate function and is involved in glycolysis-related functions,macrophage polarization,neuromodulation,and angiogenesis and has also been implicated in the development of various *** review provides an overview of the lactate metabolic and homeostatic regulatory processes involved in microglia lactylation,histone versus non-histone lactylation,and therapeutic approaches targeting ***,we summarize the current research on microglia lactylation in central nervous system diseases.A deeper understanding of the metabolic regulatory mechanisms of microglia lactylation will provide more options for the treatment of central nervous system diseases.

关键词： brain central nervous system glycolysis immune response inflammation lactate metabolism lactate lactylation microglia neurodegenerative diseases

Targets capture by distributed active swarms via bio-inspired reinforcement learning

在线全文

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 210-221页

作者： Kun Xu yue Li jun Sun Shuyuan Du Xinpeng Di Yuguang Yang Bo Li Institute of Biomechanics and Medical Engineering Applied Mechanics Laboratory Department of Engineering MechanicsTsinghua University Institute of Nuclear and New Energy Technology Tsinghua University Shanghai Aerospace Control Technology Institute Shanghai Key Laboratory of Aerospace Intelligent Control Technology College of Automation Engineering Nanjing University of Aeronautics and Astronautics

Natural swarms arranged from cells to herds are usually decentralized but display intriguing collective intelligence in coordinating individuals across large scales to efficiently achieve their common goals. Learning from nature may provide new strategies for controlling collective dynamics of synthetic swarms to accomplish specific functions. Here, we present a bioinspired computational framework that steers distributed active swarms to collectively capture and merge targets via reinforcement learning. We exploit collective milling structures of natural herds to cage the targets, and adopt a switching control policy inspired by sperms' chiral dynamics to optimize the trajectories of individuals, through which the active swarms can selforganize to enclose single or multiple distant targets in a dynamical, adaptive and scalable manner. There exists a critical swarm size, beyond which the excessive competition between agents would generate large mechanical forces, leading to capture instability but enabling the transition from short-distance to long-distance merging capture of multiple targets. This work provides physical insights into distributed active swarms and could offer a multilevel, decentralized strategy toward controlling swarm robotics in wide applications such as bio-medical devices, machine immunity, and target clearance.

关键词： swarm intelligence robotics multi-tasks artificial intelligence bionics