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Hapln1 promotes dedifferentiation and proliferation of iPSC-derived cardiomyocytes by promoting versican-based GDF11 trapping

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Journal of Pharmaceutical Analysis 2024年第3期14卷 335-347页

作者： Ding-jun Hao Yue Qin Shi-Jie zhou Bu-Huai Dong jun-Song Yang Peng Zou li-Ping Wang Yuan-Ting Zhao Department of Spine Surgery Honghui HospitalXi'an Jiaotong UniversityXi'an710054China Department of Anesthesiology Honghui HospitalXi'an Jiaotong UniversityXi'an710054China Department of Cardiovascular Medicine Honghui HospitalXi'an Jiaotong UniversityXi'an710054China State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy West China HospitalSichuan UniversityChengdu610041China

Hyaluronan and proteoglycan link protein 1(Hapln1)supports active cardiomyogenesis in zebrafish hearts,but its regulation in mammal cardiomyocytes is *** study aimed to explore the potential regulation of Hapln1 in the dedifferentiation and proliferation of cardiomyocytes and its therapeutic value in myocardial infarction with human induced pluripotent stem cell(hiPSC)-derived cardiomyocytes(CMs)and an adult mouse model of myocardial ***-CMs and adult mice with myocardial infarction were used as in vitro and in vivo models,*** single-cell RNA sequencing data were retrieved for bioinformatic *** results showed that recombinant human Hapln1(rhHapln1)promotes the proliferation of hiPSC-CMs in a dose-dependent *** a physical binding protein of Hapln1,versican interacted with Nodal growth differentiation factor(NODAL)and growth differentiation factor 11(GDF11).GDF11,but not NODAL,was expressed by ***11 expression was unaffected by rhHapln1 ***,this molecule was required for rhHapln1-mediated activation of the transforming growth factor(TGF)-β/Drosophila mothers against decapentaplegic protein(SMAD)2/3 signaling in hiPSC-CMs,which stimulates cell dedifferentiation and *** mouse Hapln1(rmHapln1)could induce cardiac regeneration in the adult mouse model of myocardial *** addition,rmHapln1 induced hiPSC-CM *** conclusion,Hapln1 can stimulate the dedifferentiation and proliferation of iPSC-derived cardiomyocytes by promoting versican-based GDF11 trapping and subsequent activation of the TGF-β/SMAD2/3 signaling ***1 might be an effective hiPSC-CM dedifferentiation and proliferation agent and a potential reagent for repairing damaged hearts.

关键词： Hapln1 Versican GDF11 iPSC-CMs Cardiomyocyte proliferation

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Formula Revision of Natural Ventilation Driven by Hot Pressure in Single Large Window Opening

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湖南大学学报（自然科学版） 2009年第S1期36卷 26-29页

作者： liN Wen,ZHANG Quan,HOU Xi-kuai,li Ping,zhou jun-li,ZHANG Guo-qiang(Key Laboratory of Building Safety and Energy Efficiency(MOE),College of Civil Engineering,Hunan University,Changsha,Hunan 410082,China) Key Laboratory of Building Safety and Energy Efficiency College of Civil Engineering Hunan University Changsha 410082 China

This paper investigated the natural ventilation driven by hot pressure on a typical office building with single window *** actual result indicates that the ventilation rate of natural ventilation driven by hot pressure in the actual single window opening construction is very different from that obtained by the theoretical formula,since the ventilation conditions between actual environment and ventilation driven by hot pressure in the single window opening are ***,the theoretical formula is amended,and it becomes more consistent with the actual ventilation rate of natural ventilation driven by hot pressure under conditions that the construction is in the form of single window opening.

关键词： single opening natural ventilation theoretical formula

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Enhanced Electrical Properties of Styrene-grafted Polypropylene Insulation for Bulk Power Transmission HVDC Cables

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CSEE Journal of Power and Energy Systems 2024年第1期10卷 361-370页

作者： Hao Yuan Shixun Hu Yao zhou Chao Yuan Wenbo Song Qing Shao Hongwei Shi Juan li jun Hu Qi li Jinliang He SINOPEC Beijing Research Institute of Chemical Industry Beijing 100013China State Key Laboratory of Power Systems Department of Electrical EngineeringTsinghua UniversityBeijing 100084China

Polypropylene(PP)is considered to be a rather promising material for HVDC cable *** modification has proved to be an effective method on the electrical property improvements of *** paper reports on the highlyenhanced electrical properties of styrene-grafted polypropylene(PP-g-St)and their related *** influence of grafting styrene on crystallization structures,thermal properties and electrical properties of PP-g-St are characterized and *** results show that PP-g-St exhibits remarkably enhanced DC volume resistivity,suppressed space charge accumulation and improved DC breakdown strengths as compared to *** observation shows PP-g-St has small,imperfect spherulites with indistinct boundaries,which is strongly correlated to enhanced electrical *** study provides an effective grafting strategy to design high-performance HVDC cable insulation materials for bulk power transmission systems.

关键词： Electrical properties grafting modification polypropylene styrene

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The Crystallization Behavior of L-Poly(lactic acid)/Polypropylene Blends:The Acceleration for Both L-Poly(lactic acid)and Polypropylene

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Chinese Journal of Polymer Science 2024年第6期42卷 775-786页

作者： Shuang-Cheng li Wei-Jia zhou Wen-Jie Wu jun Shao Shui-liang Chen Hao-Qing Hou Sheng Xiang College of Chemistry&Chemical Engineering and Nanofiber Engineering Center of Jiangxi Province Jiangxi Normal UniversityNanchang330022China National Engineering Research Center for Carbohydrate Synthesis/Key Lab of Fluorine and Silicon for Energy Materials and Chemistry of Ministry of Education Jiangxi Normal UniversityNanchang330022China Wenzhou Institute University of Chinese Academy of SciencesWenzhou325001China

For a polymer/polymer dismissible blend with two crystallizable components,the crystallization behavior of different components and the reciprocal influences between different crystals are interesting and important,but did not investigate in *** this study,the L-poly(lactic acid)/polypropylene(PLLA/PP)blends with different weight ratios were prepared by melt mixing and the crystallization behavior of the blends were *** showed that the crystalline structures of PLLA and PP were not altered by the *** the crystallization of PLLA,both the diffusion of chain segments and crystallization rate were enhanced under the existence of PP *** the crystallization of PP,its crystallization rate was depressed under the existence of amorphous PLLA molecular *** the PP crystallized from the existence of PLLA crystals,although the diffusion rate of PP was reduced by PLLA crystals,the nucleation positions were obviously enhanced,which accelerated the formation of PP *** investigation would supply more basic data for the application of PLLA/PP blend.

关键词： L-poly(lactic acid) Polypropylene Blends Crystalization behavior Crystallization acceleration

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Highly dispersive tetrahedral vanadium species on pure silica ZSM-12 zeolite boosting the selective oxidation of cyclohexane into cyclohexanone

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Science China Chemistry 2024年第7期67卷 2206-2214页

作者： Menglin Xie Ting li Chao Wu Xiaoling liu Jinling Ni Siqin Yao Yu zhou Shibo Xi jun Wang State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical EngineeringNanjing Tech UniversityNanjing 211816China Institute of Sustainability for Chemicals Energy and Environment(ISCE2)Agency for ScienceTechnology and Research(A*STAR)Singapore 627833Republic of Singapore College of Materials Science and Engineering Sichuan UniversityChengdu 610065China

The selective oxidation of cyclohexane is a promising green route for the production of KA oil(cyclohexanol and cyclohexanone),but remains a huge challenge to design high-performing heterogeneous catalysts under mild ***,a pure silica ZSM-12(MTW topology)zeolite was applied as the support to immobilize highly dispersive tetrahedrally coordinated vanadium(V)species and the constructed catalyst 1%V/SZ-12 exhibited high efficiency in the fast and selective oxidation of cyclohexane into cyclohexanone with H_(2)O_(2).The reaction completed within 30 s,affording the selectivity of 99%towards cyclohexanone and the extremely high turnover frequency(TOF)of 5,891 h^(-1).1%V/SZ-12 was facilely reused with stable activity and feasibly extended to the oxidation of various cyclohexane *** one-dimensional 12-membered ring microchannels contributed to the formation and accessibility of tetrahedrally coordinated high valent V5+species as the robust active centers,which activated H_(2)O_(2) to generate V–O–O·,the active oxygen species for the electrophilic attack on cyclohexane to produce cyclohexanone as the sole product.

关键词： zeolite metal doping cyclohexane oxidation heterogeneous catalysis

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The Necessary and Sufficient Conditions of Exponential Stability for Heat and Wave Equations with Memory

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Journal of Systems Science & Complexity 2024年第3期37卷 1037-1051页

作者： li lingfei ZHANG Xiaoyi zhou Xiuxiang School of Science Northeast Electric Power UniversityJilin 132012China School of Mathematics and Statistics Lingnan Normal UniversityZhanjiang 524048China

This paper is addressed to a study of the stability of heat and wave equations with *** necessary and sufficient conditions of the exponential stability are investigated by the theory of Laplace transform. The results show that the stability depends on the decay rate and the coefficient of the kernel functions of the memory. Besides, the feedback stabilization of the heat equation is obtained by constructing finite dimensional controller according to unstable eigenvalues. This stabilizing procedure is easy to operate and can be applicable for other parabolic equations with memory.

关键词： Memory stability stabilization

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The manipulation of rectifying contact of Co and nitrogen-doped carbon hierarchical superstructures toward high-performance oxygen reduction reaction

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Carbon Energy 2024年第9期6卷 338-349页

作者： Jing li Tingyu Lu Yu Fang Guangyao zhou Mingyi Zhang Huan Pang jun Yang Yawen Tang lin Xu Jiangsu Key Laboratory of New Power Batteries School of Chemistry and Materials ScienceJiangsu Collaborative Innovation Center of Biomedical Functional MaterialsNanjing Normal UniversityNanjingJiangsuChina College of Science Jinling Institute of TechnologyNanjingJiangsuChina Key Laboratory for Photonic and Electronic Bandgap Materials Ministry of EducationSchool of Physics and Electronic EngineeringHarbin Normal UniversityHarbinHeilongjiangChina School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhouJiangsuChina State Key Laboratory of Multiphase Complex Systems Center of MesoscienceInstitute of Process EngineeringChinese Academy of SciencesBeijingChina

Rational design and construction of oxygen reduction reaction(ORR)electrocatalysts with high activity,good stability,and low price are essential for the practical applications of renewable energy conversion devices,such as metal-air *** modification through constructing metal/semiconductor Schottky heterointerface represents a powerful strategy to enhance the electrochemical ***,we demonstrate a concept of Schottky electrocatalyst composed of uniform Co nanoparticles in situ anchored on the carbon nanotubes aligned on the carbon nanosheets(denoted as Co@N-CNTs/NSs hereafter)toward *** experimental findings and theoretical simulation testify that the rectifying contact could impel the voluntary electron flow from Co to N-CNTs/NSs and create an internal electric field,thereby boosting the electron transfer rate and improving the intrinsic *** a consequence,the Co@N-CNTs/NSs deliver outstanding ORR activity,impressive long-term durability,excellent methanol tolerance,and good performance as the air-cathode in the Zn-air *** design concept of Schottky contact may provide the innovational inspirations for the synthesis of advanced catalysts in sustainable energy conversion fields.

关键词： Co-based electrocatalysts oxygen reduction reaction rectifying contact Zn-air batteries

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Numerical study on local failures of reinforced concrete slabs against underwater close-in explosions

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2024年第8期25卷 650-669页

作者： Fei zhou Hedong li Hao WU College of Civil Engineering Tongji UniversityShanghai 200092China School of Civil Engineering and Architecture Zhejiang Sci-Tech UniversityHangzhou 310018China

Reinforced concrete(RC)slabs are the primary load-carrying member of underwater *** can suffer severe local failures such as cratering,spalling,or breaching as a result of underwater close-in(UWCI)*** this study,we established a fully validated high-fidelity finite element analysis approach to precisely reproduce the local failures of RC slabs after a UWCI explosion.A recently proposed dynamic constitutive model is used to describe wet *** effects of free water content on the material properties,including the tensile/compressive strength,elastic modulus,strain rate effect,failure strength surface,and equation of state,are comprehensively calibrated based on existing test *** calibrated material parameters are then verified by a single-element test.A high-fidelity finite element analysis(FEA)approach of an RC slab subjected to a UWCI explosion is established using an arbitrary Lagrangian-Eulerian(ALE)*** previous UWCI explosion tests on RC orifice targets and underwater contact explosion tests on saturated concrete slabs showed that the established FEA approach could accurately reproduce the pressure-time history in water and damage patterns,including the cracking,cratering,and spalling,of the RC orifice target and saturated concrete ***,parametric studies conducted by simulating an RC slab subjected to a UWCI explosion showed that:(i)the local failure of an RC slab enlarges with increased charge weight,reduced standoff distance,and reduced structural thickness;(ii)compared to a water-backed RC slab,an air-backed RC slab exhibits much more obvious local and structural ***,to aid the anti-explosion design of relevant underwater facilities,based on over 90 simulation cases empirical formulae are summarized to predict local failure modes,i.e.,no spall,spall,and breach,of water-and air-backed RC slabs subjected to a UWCI explosion.

关键词： Reinforced concrete slab(RC) Underwater close-in(UWCI)explosion Saturated concrete Failure modes Numerical simulation

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A Novel Rolling and Fractional-ordered Grey System Model and Its Application for Predicting Industrial Electricity Consumption

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Journal of Systems Science and Systems Engineering 2024年第2期33卷 207-231页

作者： Wenhao zhou Hailin li Zhiwei Zhang College of Business Administration Huaqiao UniversityQuanzhou 362021China College of Business Administration Capital University of Economics and BusinessBeijing 100070China

Accurate and reasonable prediction of industrial electricity consumption is of great significance for promoting regional green transformation and optimizing the energy ***,the regional power system is complicated and uncertain,affected by multiple factors including climate,population and *** paper incorporates structure expansion,parameter optimization and rolling mechanism into a system forecasting framework,and designs a novel rolling and fractional-ordered grey system model to forecast the industrial electricity consumption,improving the accuracy of the traditional grey *** optimal fractional order is obtained by using the particle swarm optimization algorithm,which enhances the model ***,the proposed model is employed to forecast and analyze the changing trend of industrial electricity consumption in Fujian *** results show that industrial electricity consumption in Fujian will maintain an upward growth and it is expected to 186.312 billion kWh in *** with other seven benchmark prediction models,the proposed grey system model performs best in terms of both simulation and prediction performance metrics,providing scientific reference for regional energy planning and electricity market operation.

关键词： Electricity consumption grey system theory prediction model fractional order

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Generating ^(1)O_(2) and Co^(IV)=O through efficient peroxymonosulfate activation by ZnCo_(2)O_(4)nanosheets for pollutant control

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Nano Research 2024年第9期17卷 8025-8035页

作者： Xiaoke Zhang Yangyang Zhang Jiaqi Tian Yadan Guo Zhongkui zhou Zhongyi liu Zaiwang Zhao Bin liu jun li College of Chemistry Henan Institute of Advanced TechnologyZhengzhou UniversityZhengzhou 450052China State Key Laboratory of Coking Coal Resources Green Exploitation Zhengzhou UniversityZhengzhou 450001China School of Water Resources and Environmental Engineering East China University of TechnologyNanchang 330013China Department of Materials Science and Engineering City University of Hong KongHong Kong 999077China College of Energy Materials and Chemistry College of Chemistry and Chemical EngineeringInnerMongolia UniversityHohhot 010070China

Heterogeneous advanced oxidation processes(AOPs)based on non-radical reactive species are considered as a powerful technology for wastewater purification due to their long half-lives and high adaptation in a wide pH ***,we fabricate surface Co defect-rich spinel ZnCo_(2)O_(4)porous nanosheets,which can generate≡CoIV=O and ^(1)O_(2) over a wide pH range of 3.81-10.96 by the formation of amphoteric≡Zn(OH)2 in peroxymonosulfate(PMS)activation *** functional theory(DFT)calculations show Co defect-rich ZnCo_(2)O_(4)possesses much stronger adsorption ability and more electron transfer to ***,the adsorption mode changes from terminal oxygen Co-O-Co to Co-O,accelerating the polarization of adjacent oxygen,which is beneficial to the generation of≡CoIV=O and Generating ^(1)O_(2) .Co defect-rich ZnCo_(2)O_(4)porous nanosheets exhibit highly active PMS activation activity and stability in p-nitrophenol(PNP)degradation,whose toxicity of degradation intermediates is significant *** Co defect-rich ZnCo_(2)O_(4)nanosheet catalyst sponge/PMS system achieved stable and efficient removal of PNP with a removal efficiency higher than 93%over 10 *** work highlights the development of functional catalyst and provides an atomic-level understanding into non-radical PMS activation process in wastewater treatment.

关键词： advanced oxidation processes ZnCo_(2)O_(4)nanosheets peroxymonosulfate activation CoIV=O,wastewater treatment

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