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中国睡眠研究会第十届全国学术年会

作者： Yu-Feng Shao Can Wang Chao-Yu Cong Le Xin jun-Fan Xie Hai-Lin Chen jun-quan song Lan-Peng Lu Yi-Ping Hou Departments of Neuroscience AnatomyHistologyand EmbryologyKey Laboratory of Preclinical Study for New Drugs of Gansu ProvinceSchool of Basic Medical SciencesLanzhou University

Alarm pheromones（APs） are important chemical communicating molecules which signal danger,injury,distress,or the presence of predators to *** is unclear as yet whether APs could wake up rodent during sleep period to avoid dangerousness,through a sufficient sleep is required for their *** Moving Olfaction-Sleep Recording System（FMOSRS） was used to analyze sleep-wake states in this ***（collected from mice with electrical stimulation）or their main component（2-sec-butyl-4,5-dihydrothiazole,SBT） were directly delivered to the mouse’s nasal cavity during the period of non-rapid eye movement（NREM） or rapid eye movement（REM） sleep determined by EEG/EMG and digital *** of axons of the Grüeneberg ganglion（GGAxo） or excision of the vomeronasal organ（VNOX） were used to identify the sensory organ of *** addition,microinjection of herpes simplex virus（HSV） was employed to reveal the neural pathways involved in APs-induced *** results shown:（1） Both of APs and SBT deliveries immediately induced an arousal from NREM or REM sleep compared to air in *** SBT-induced awakening efficiency was higher than APs-induced.（2） GG neurons degenerated by GGAxo,and showed an attenuation of the arousal effects of SBT mainly in post-odor stimulate period.（3） VNOX blocked the arousal effects of SBT mainly in odor stimulate period.（4） HSV labeling neurons in the basal forebrain（BF） and locus coeruleus（LC） were found following olfactory bulb（OB） *** percentage of HSV neurons in the LC that also displaystaining for tyrosine hydroxylase（TH） were 75.70% ± 3.20%,whereas,HSV neurons in the BF were not cholinergic ***,nasal delivery of APs or SBT arouses mice from NREM and REM *** and VNO are sensory organs for detecting APs,because the arousal effects of SBT are blocked by GGAxo and ***,HSV injection into the OB markedly labeled LC neurons,most of them also express *** results suggest that APs arouse mice

关键词： alarm pheromones 2-sec-butyl-4,5-dihydrothiazole non-rapid eye movement sleep rapid eye movement sleep arousal Grüeneberg ganglion vomeronasal organ locus coeruleus

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DISlab实验系统在师范生技能训练中的应用

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大学物理实验 2016年第5期29卷 148-150页

作者：杨倩张军廖峻李松权岭南师范学院广东湛江524048

数字化信息系统实验室(Digital Information System Laboratory)(简称DISLab)的引入可以简化物理实验的操作、加快数据采集与处理的速度并提高精度,因此,将DISLab用于课堂演示和微课制作,可以使抽象的理论更加形象化、实验过程动态化,... 详细信息

数字化信息系统实验室(Digital Information System Laboratory)(简称DISLab)的引入可以简化物理实验的操作、加快数据采集与处理的速度并提高精度,因此,将DISLab用于课堂演示和微课制作,可以使抽象的理论更加形象化、实验过程动态化,更易于学生对知识的理解和接受。本文以向心力研究实验为例,说明了通过DISLab实验的微课的设计和录制,可以训练物理师范生从学生视角出发,设计教学内容和教学思想、引导学生跟随实验过程进行思考,提高物理师范生的教学技能。

关键词： DISlab 微课物理师范生技能训练

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冻融循环条件下玄武岩耐久性研究

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中国农村水利水电 2021年第10期 116-121页

作者：李博文荣冠蒙世仟吴琦全军松武汉大学水资源与水利水电工程科学国家重点实验室武汉430072 武汉大学水工岩石力学教育部重点实验室武汉430072 广西壮族自治区水利电力勘测设计研究院南宁530023

通过试验研究了隐晶质玄武岩在不同冻融循环次数下的物理力学特性变化规律与变形破坏特点,并采用Mutlutűk等提出的衰减模型分析了岩石的冻融耐久性。研究发现:冻融作用下玄武岩力学性能显著下降,岩石的损伤劣化主要发生在前20次冻融循... 详细信息

通过试验研究了隐晶质玄武岩在不同冻融循环次数下的物理力学特性变化规律与变形破坏特点,并采用Mutlutűk等提出的衰减模型分析了岩石的冻融耐久性。研究发现:冻融作用下玄武岩力学性能显著下降,岩石的损伤劣化主要发生在前20次冻融循环过程中,随着冻融次数继续增加损伤劣化作用减弱。最终在30次冻融后强度、弹性模量分别降低了44.9%、23.2%;通过试验结果统计分析得到了各物理力学指标随冻融次数的拟合关系式;在冻融作用下玄武岩的强度与特征应力等指标具有较好一致性,其敏感性参数(半衰期)数值也较接近,适用于岩石冻融耐久性分析。

关键词：冻融循环耐久性隐晶质玄武岩负指数模型

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De novo synthesis of atropisomeric benzofurans via Cu/SPDO complex catalyzed asymmetric formal [3 + 2] annulation

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Science China Chemistry 2025年第01期 174-180页

作者： Fan-Xiao Meng Xing-Yu Wang Ka Lu Ju-song Yang Fu-Min Zhang Ai-jun Ma Bao Du Yong-Qiang Tu State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical Engineering Lanzhou University School of Chemistry and Chemical Engineering Shanghai Jiao Tong University School of Biotechnology and Health Sciences Wuyi University

Herein, the de novo synthesis of atropisomeric benzofurans through the Cu/spirocyclic-pyrrolidine-oxazoline(SPDO) complex catalyze asymmetric formal [3 + 2] cycloaddition between quinones and ynamides is explored, producing a range of structurally diverse axially chiral benzofurans in satisfactory yields with good to excellent enantioselectivities. Furthermore, density functional theory calculations were applied to explain the possible reaction mechanism.

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Infiltration by monocytes of the central nervous system and its role in multiple sclerosis: reflections on therapeutic strategies

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Neural Regeneration Research 2025年第3期20卷 779-793页

作者： Guangyong Zhang Qing Yao Chubing Long Pengcheng Yi Jiali song Luojia Wu Wei Wan Xiuqin Rao Yue Lin Gen Wei jun Ying Fuzhou Hua Department of Anesthesiology the Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi ProvinceChina Key Laboratory of Anesthesiology of Jiangxi Province NanchangJiangxi ProvinceChina

Mononuclear macrophage infiltration in the central nervous system is a prominent feature of neuroinflammation. Recent studies on the pathogenesis and progression of multiple sclerosis have highlighted the multiple roles of mononuclear macrophages in the neuroinflammatory process. Monocytes play a significant role in neuroinflammation, and managing neuroinflammation by manipulating peripheral monocytes stands out as an effective strategy for the treatment of multiple sclerosis, leading to improved patient outcomes. This review outlines the steps involved in the entry of myeloid monocytes into the central nervous system that are targets for effective intervention: the activation of bone marrow hematopoiesis, migration of monocytes in the blood, and penetration of the blood–brain barrier by monocytes. Finally, we summarize the different monocyte subpopulations and their effects on the central nervous system based on phenotypic differences. As activated microglia resemble monocyte-derived macrophages, it is important to accurately identify the role of monocyte-derived macrophages in disease. Depending on the roles played by monocyte-derived macrophages at different stages of the disease, several of these processes can be interrupted to limit neuroinflammation and improve patient prognosis. Here, we discuss possible strategies to target monocytes in neurological diseases, focusing on three key aspects of monocyte infiltration into the central nervous system, to provide new ideas for the treatment of neurodegenerative diseases.

关键词： blood–brain barrier macrophages monocytes multiple sclerosis neuroinflammation review therapy

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Enhanced performance based on cross-layer design from physical to transport layers for multihop wireless networks

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The Journal of China Universities of Posts and Telecommunications 2010年第5期17卷 87-92页

作者： CHEN Guang-quan song Mei ZHANG Yong song jun-de School of Computer Science and Technology Beijing University of Posts and Telecommunications Beijing 100876 China School of Electronic Engineering Beijing University of Posts and Telecommunications Beijing 100876 China

This paper puts forward a novel cognitive cross-layer design algorithms for multihop wireless networks optimization across physical,mediam access control （MAC）,network and transport *** is well known,the conventional layered-protocol architecture can not provide optimal performance for wireless networks,and cross-layer design is becoming increasingly important for improving the performance of wireless *** this study,we formulate a specific network utility maximization （NUM） problem that we believe is appropriate for multihop wireless *** using the dual algorithm,the NUM problem has been optimal decomposed and solved with a novel distributed cross-layer design algorithm from physical to transport *** solution enjoys the benefits of cross-layer optimization while maintaining the simplicity and modularity of the traditional layered *** proposed cross-layer design can guarantee the end-to-end goals of data flows while fully utilizing network *** simulations have evaluated an enhanced performance of the proposed algorithm at both average source rate and network ***,the proposed algorithm has low implementation complexity for practical reality.

关键词： multihop wireless networks cross-layer design optimization distributed algorithm

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Preparation of a novel PAN/cellulose acetate-Ag based activated carbon nanofiber and its adsorption performance for low-concentration SO_2

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International Journal of Minerals,Metallurgy and Materials 2015年第4期22卷 437-445页

作者： Yan-bo Wu jun Bi Ting Lou Tie-ben song Hong-quan Yu School of Environmental and Chemical Engineering Dalian Jiaotong University

Polyacrylonitrile （PAN）, PAN/cellulose acetate （CA）, and PAN/CA-Ag based activated carbon nanofiber （ACNF） were prepared using electrostatic spinning and further heat treatment. Thermogravimetrylifferential scanning calorimetry （TG-DSC） analysis indicated that the addition of CA or Ag did not have a significant impact on the thermal decomposition of PAN materials but the yields of fibers could be improved. Scanning electron microscopy （SEM） analysis showed that the micromorphologies of produced fibers were greatly influenced by the viscosity and conductivity of precursor solutions. Fourier transform infrared spectroscopy （FT-IR） analysis proved that a cyclized or trapezoidal structure could form and the carbon scaffold composed of C=C bonds appeared in the PAN-based ACNFs. The characteristic dif- fraction peaks in X-ray diffraction （XRD） spectra were the evidence of a turbostratic structure and silver existed in the PAN/CA-Ag based ACNF. Brurmer-Emmett-Teller （BET） analysis showed that the doping of CA and Ag increased surface area and micropore volume of fi- bers; particularly, PAN/CA-Ag based ACNF exhibited the best porosity feature. Furthermore, SO2 adsorption experiments indicated that all the three fibers had good adsorption effects on lower concentrations of SO2 at room temperature; especially, the PAN/CA-Ag based ACNF showed the best adsorption performance, and it may be one of the most promising adsorbents used in the fields of chemical industry and en- vironment protection.

关键词： activated carbon nanofibers polyacrylonitrile electrospinning adsorption sulfur dioxide

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Mechanism of action of Linggui Zhugan Decoction in treating non-alcoholic fatty liver disease using untargeted metabolomics approach

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Traditional Medicine Research 2025年第2期10卷 65-76页

作者： Huan Pei Ren-Lin Li Xin-Ran song Qian-Qian Wan Yu-Ming Wang Han-Zhou Li Wei-quan Xu Jia-Bao Liao Wei-Bo Wen Jing Miao Huan-Tian Cui School of Basic Medicine Yunnan University of Chinese MedicineKunming 650599China School Clinical Medical College Yunnan University of Chinese MedicineKunming 650599China First School of Clinical Medicine Yunnan University of Chinese MedicineKunming 650599China School of Integrative Chinese and Western Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Pharmacy Tianjin Second People's HospitalTianjin 300192China

Background:Non-alcoholic fatty liver disease(NAFLD)is a liver disorder characterized by the accumulation and degeneration of fat in the liver cells,a condition that may further deteriorate and lead to cirrhosis and liver *** studies showed that metabolic dysfunction can promote NAFLD *** Zhugan Decoction(LGZGD)has therapeutic effects on *** mechanism of LGZGD still remains *** study was to examine the impact of LGZGD on the metabolic processes involved in the development of ***:A mice model of NAFLD was treated with *** therapeutic potential of LGZGD was evaluated by assessing the activity of transaminases,lipids levels of blood,and pathological changes in the liver of the mice model of ***,this study also evaluated the influence of LGZGD on liver inflammation and oxidative ***:The results of untargeted metabolomics analysis showed that LGZGD reduced the disordered lipid metabolism in NAFLD *** improved the oxidative stress and also reduced the levels of pro-inflammatory cytokines in the *** metabolomics analysis of liver samples revealed that LGZGD treatment improved metabolic disorders,including alanine,aspartate,glutamate,glycerophospholipid metabolism,and citrate *** RT-qPCR and Western blot results showed that LGZGD could regulate the expression of key enzymes in the metabolic pathway of the citrate cycle,including ATP-citrate lyase(ACLY),alanine-glyoxylate aminotransferase-2(AGXT2),phosphatidylethanolamine N-methyltransferase(PEMT),and succinate dehydrogenase(SDH).Conclusion:We found that LGZGD can treat NAFLD by reducing inflammatory responses,inhibiting oxidative stress,regulating alanine,aspartate,glutamate,and glycerophospholipid metabolism,and citrate cycle pathways.

关键词： NAFLD LGZGD untargeted metabolomics glycerophospholipid metabolism citrate cycle

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经皮入路与经肌间隙椎弓根钉治疗胸腰椎骨折的临床疗效分析

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中外医药研究 2023年第4期2卷 25-27页

作者：高启龙谭莹全俊松张欣铭陈建琨昆明市中医医院云南昆明650011 云南省药物研究所云南昆明650011

目的:比较经皮入路与经肌间隙椎弓根钉治疗胸腰椎骨折的临床疗效。方法:回顾性分析2016年6月—2020年3月昆明市中医医院收治的采用椎弓根钉治疗的96例患者胸腰椎骨折的临床资料,根据入路方式不同分为经皮组(52例)与经肌间隙组(44例)。... 详细信息

目的:比较经皮入路与经肌间隙椎弓根钉治疗胸腰椎骨折的临床疗效。方法:回顾性分析2016年6月—2020年3月昆明市中医医院收治的采用椎弓根钉治疗的96例患者胸腰椎骨折的临床资料,根据入路方式不同分为经皮组(52例)与经肌间隙组(44例)。经肌间隙组选用经肌间隙椎弓根钉棒系统固定治疗,经皮组选用经皮椎弓根钉棒系统固定治疗。比较两组手术指标、疼痛视觉模拟量表(VAS)评分及治疗优良率。结果:经皮组术中出血量少于经肌间隙组,住院费用高于经肌间隙组,差异有统计学意义(P0.05)。结论:经皮入路及经肌间隙治疗无神经损伤的胸腰椎骨折,疗效相当,不考虑经济的情况下,首选经皮椎弓根钉棒系统固定治疗。

关键词：经皮入路经肌间隙入路椎弓根钉胸腰椎骨折

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东海北部哈氏仿对虾的种群动态及其最高持续渔获量

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水产学报 2000年第4期24卷 364-369页

作者：李明云倪海儿竺俊全宋海棠俞存根宁波大学海洋与水产系!浙江宁波315211 浙江省海洋水产研究所资源研究室!浙江舟山316100

哈氏仿对虾是东海北部主要的拖虾渔业对象。在雌性的体长组成中 ,70～ 90mm的个体占优势 ,占总数的6 3%。应用ELEFANⅠ和ELEFANⅡ技术对哈氏仿对虾每月的体长资料进行分析 ,结果表明 :生长参数K =1.7,极限体长L∞ =12 8mm ,自然死亡系数... 详细信息

哈氏仿对虾是东海北部主要的拖虾渔业对象。在雌性的体长组成中 ,70～ 90mm的个体占优势 ,占总数的6 3%。应用ELEFANⅠ和ELEFANⅡ技术对哈氏仿对虾每月的体长资料进行分析 ,结果表明 :生长参数K =1.7,极限体长L∞ =12 8mm ,自然死亡系数M =2 .742 7,总死亡系数Z =8.32 3 ,利用率E =6 7.0 6 % ,极限年龄为 1.32 34岁 ,选择体长为 5 9.6 7mm ,补充类型为二季补充型。通过单位补充量产量Y/R和单位补充量产值Yv/R分析表明 ,该群体的利用已到了相当充分的水平 ,若保持现有的捕捞水平 ,把开捕体长增大至 70mm时 ,单位补充量产量可增加 1.77% ,产值可增加 10 .78%。但若捕捞死亡水平继续增加 ,产量几乎不再增加 ,而产值却明显下降。

关键词：哈氏仿对虾种群动态最高持续渔获量

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