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Physical understanding of axonal growth patterns on grooved substrates:groove ridge crossing versus longitudinal alignment

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Bio-Design and Manufacturing 2020年第4期3卷 348-360页

作者： Deming zhang Hairui Suo Jin qian jun Yin Jianzhong Fu Yong Huang The State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhou 310028China Key Laboratory of 3D Printing Process and Equipment of Zhejiang Province School of Mechanical EngineeringZhejiang UniversityHangzhou 310028China School of Automation Hangzhou Dianzi UniversityHangzhou 310018China Key Laboratory of Soft Machines and Smart Devices of Zhejiang Province Department of Engineering MechanicsZhejiang UniversityHangzhou 310027China Department of Mechanical and Aerospace Engineering University of FloridaGainesvilleFL 32611USA

Surface topographies such as micrometric edges and grooves have been widely used to improve neuron ***,finding the mechanism of neuron–surface interactions on grooved substrates remains a *** this work,PC12 cells and chick forebrain neurons(CFNs)were cultured on grooved and smooth polyacrylonitrile *** was found that CFNs showed a tendency of growing across groove ridges;while PC12 cells were only observed to grow in the longitudinal direction of *** further investigate these observations,a 3D physical model of axonal outgrowth was *** this model,axon shafts are simulated as elastic 3D beams,accounting for the axon outgrowth as well as the focal contacts between axons and ***,the bending direction of axon tips during groove ridge crossing is governed by the energy minimization *** physical model predicts that axonal groove ridge crossing is contributed by the bending compliance of axons,caused by lower Young’s modulus and smaller *** work will aid the understanding of the mechanisms involved in axonal alignment and elongation of neurons guided by grooved substrates,and the obtained insights can be used to enhance the design of instructive scaffolds for nerve tissue engineering and regeneration applications.

关键词： Grooved substrates Neuron outgrowth Axonal outgrowth model Axonal crossing

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Supermassive Primordial Black Holes for Nano-Hertz Gravitational Waves and High-redshift JWST Galaxies

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Research in Astronomy and Astrophysics 2024年第9期24卷 1-6页

作者： Hai-Long Huang Yong Cai jun-qian Jiang jun zhang Yun-Song Piao School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China Institute for Astrophysics School of PhysicsZhengzhou UniversityZhengzhou 450001China International Centre for Theoretical Physics Asia-Pacific University of Chinese Academy of SciencesBeijing 100190China Taiji Laboratory for Gravitational Wave Universe(Beijing/Hangzhou) University of Chinese Academy of SciencesBeijing 100049China School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUCASHangzhou 310024China Institute of Theoretical Physics Chinese Academy of SciencesBeijing 100190China

Recently,observational hints for supermassive black holes have been accumulating,prompting the question:Can primordial black holes(PBHs)be supermassive,particularly with masses M■10^(9)M_(⊙)?A supercritical bubble,containing an inflating baby universe,that nucleated during inflation can evolve into a PBH in our observable *** find that when the inflaton slowly transitions past a neighboring vacuum,the nucleation rate of supercritical bubbles inevitably peaks,leading to a mass distribution of multiverse PBHs with a peak mass up to M■10^(11)M_(⊙).Thus,our mechanism naturally provides a primordial origin for supermassive black holes.

关键词： (cosmology:)early universe (cosmology:)inflation (galaxies:)quasars:supermassive black holes

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Prevalence of osteoarthritis and association between smoking patterns and osteoarthritis in China:a cross-sectional study

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Frontiers of Nursing 2018年第2期5卷 111-118页

作者： qian-qian He jun-Feng zhang School of Management Shanxi Medical UniversityTaiyuanShanxi 030001China The Publishing house Chinese Journal of RheumatologyTaiyuanShanxi 030001China

Objective： The aims of this study were to estimate the prevalence of radiographic osteoarthritis （OA） and to assess the association between smoking patterns and OA prevalence in adults aged 50 years or older belonging to the Shanxi province of ***： A cross-sectional study in the rural regions of the Shanxi province was conducted among 2638 Chinese adults （aged ≥50 years）. Demographic characteristics and behavioral information were collected through epidemiological surveys. All participants with joint pain underwent plain radiographic examination and were diagnosed by a professional orthopedist. Associations between smoking patterns and the prevalence of OA were assessed using binary logistic regression ***： Among 2638 individuals （men, 50.3% and women, 49.7%; mean age, 61.5 years） included in the analysis, 49.8% had radiographic OA and 27.5% had knee OA. The prevalence of radiographic OA was higher in women than in men （P〈0.001）. After adjusting for potential confounding factors, there was a nonsignificant correlation between smoking and OA prevalence in the muttivariate model. Odds ratios （ORs） for all types of OA and knee OA were higher in active and passive smokers than in nonsmoking individuals after adjustments （OR 1.374; 95% confidence interval [CI] 1.049-1.802; OR 1.440; 95% CI 1.059-1.958, respectively）.Conclusions： This study showed th at smoking may not be an independent risk factor for OA; however, there was a positive correlation between active and passive smoking and OA.

关键词： osteoarthritis prevalence smoking patterns correlation radiographic

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Comparison of microstructure and heat treatment distortion of gear steels with and without Nb addition

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Journal of Iron and Steel Research International 2021年第4期28卷 488-495页

作者： Guo-qiang zhang Xiao-fei He qian-zhen zhang Wen-jun Wang Mao-qiu Wang Institute of Special Steel Central Iron and Steel Research InstituteBeijing 100081China NGC Group Nanjing 211102JiangsuChina Technical Center CITIC Metal GroupBeijing 100027China

In order to research the effect of microalloying Nb,the microstructure and heat treatment distortion of case carburizing steels with and without Nb addition are *** show that a uniform and fine prior austenite grain size was obtained for the steel with the addition of 0.03 wt.%Nb even after being carburized at 980℃for 37 h,resulting in a very deep hardened layer of about 4 *** is an effective microalloying element to hinder austenite grain growth of gears during high-temperature *** calculation and experimental observation of NbC precipitates indicate that fine NbC precipitates have not evidently dissolved at 980℃,and thus they can act as grain refiners due to pinning *** treatment distortion of Nb-added steel is much lower than that of the steel without Nb *** may be contributed to its fine and uniform grain size,which presumably influences stress during martensitic transformation.

关键词： Case hardening steel High-temperature carburizing Grain size Heat treatment distortion Microstructure

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广东省建筑工程废弃物产生量及减排措施调研与分析

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广州建筑 2016年第5期44卷 18-23页

作者：吕卫国王龙赖俊钱红岗张国强广州大学土木工程学院广州510006 广州建筑股份有限公司广州510030

以广东省主要城市的建筑工程为调研对象,调查了100个新建工程项目,包括住宅建筑、商业建筑、公共建筑、工业建筑4种类别建筑工程的建筑工程废弃物产生量以及建筑工程废弃物产生的原因、主要处理途径,并建议了其减量化及回收利用的相关... 详细信息

以广东省主要城市的建筑工程为调研对象,调查了100个新建工程项目,包括住宅建筑、商业建筑、公共建筑、工业建筑4种类别建筑工程的建筑工程废弃物产生量以及建筑工程废弃物产生的原因、主要处理途径,并建议了其减量化及回收利用的相关措施。本次调研的建筑工程废弃物分为混凝土、砌块、石材、砂浆、金属、竹木、玻璃7种类别。通过调研分析,引入建筑材料损耗率,得出了广东省建筑工程废弃物产生量计算公式;利用matlab对调研数据进行拟合,提出了建筑工程废弃物产生量的估算公式;结合施工现场的实际情况,提出了建筑工程废弃物的减排技术方案。

关键词：新建工程项目建筑工程废弃物产生量减排措施

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Recent progress of electronic materials based on 2,1,3-benzothiadiazole and its derivatives:synthesis and their application in organic light-emitting diodes

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Science China Chemistry 2021年第3期64卷 341-357页

作者： Youming zhang jun Song junie Qu Peng-Cheng qian Wai-Yeung Wong Department of Applied Biology and Chemical Technology and Research Institute for Smart Energy1 The Hong Kong Polytechnic University(PolyU)Hung HomHong KongChina PolyU Shenzhen Research Institute Shenzhen 518057China College of Materials Science and Engineering Shenzhen UniversityShenzhen 518060China Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Physics and Optoelectronic Engineering.Shenzhen UniversityShenzhen 518060China Key Laboratoty of Environmental Functional Materials Technology and Application of Wenzhou City Institute of New Materials&IndustiyCollege of Chemistry&Materials Engineering.Wenzhou UniversityWenzhou 325035China

2,1,3-Benzothiadiazole(BT)and its derivatives are very important acceptor units used in the development of photoluminescent compounds and are applicable for the molecular construction of organic light-emitting diodes,organic solar cells and organic field-effect *** to their strong electron-withdrawing ability,construction of molecules with the unit core of BT and its derivatives can usually improve the electronic properties of the resulting organic *** this contribution,we review the synthesis of various polymers,small molecules and metal complexes with BT and its derivatives and their applications in organic light-emitting ***,the molecular design rules based on these cores are discussed.

关键词： 2,1,3-benzothiadiazole organic light-emitting diodes synthesis electronic properties photoluminescence

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Is it possible to foot reflexology for infants with sensorineural hearing loss?

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World Journal of Clinical Cases 2025年第2期13卷 1-4页

作者： Min Ai Hang-Hang zhang jun-Bang Feng Chuan-Ming Li Wen-Jing Wang Meng-Die Hu Department of Anesthesiology Nanan District People's Hospital of ChongqingChongqing 400060China Department of Breast and Thyroid Surgery Chongqing Bishan District Maternal and Child Health Care HospitalChongqing 402760China Department of Medical Imaging Chongqing University Central HospitalChongqing 400014China

Foot reflexology is a non-invasive and safe complementary therapy that works by massaging the reflex zones of the feet and exerts systemic or whole-body regulation through meridian nerve *** therapy is commonly used in the treatment of various conditions such as autism and Parkinson's ***,there is limited reporting on the use of foot reflexology therapy for infants with sensorineural hearing loss(SNHL).Currently,there is no definitive conclusion on how foot reflexology therapy can influence *** editorial holds some guiding significance regarding this clinical *** aim is to present physiological evidence of how foot reflexology therapy can impact infants with SNHL,thereby enhancing clinician’s awareness of foot reflexology in treating infants with SNHL.

关键词： Foot reflexology Sensorineural Hearing Loss Future perspectives Limitations Neural conduction

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自主D1规格与API CK-4规格对比分析及自主复合剂技术开发

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石油炼制与化工 2025年第1期56卷 160-166页

作者：孙文斌张倩黄作鑫张峰中石化石油化工科学研究院有限公司北京100083

综合对比了柴油机油我国自主D1规格和API CK-4规格在理化性能指标、发动机台架试验性能指标等方面的差异;进而,结合中国石化自主开发的符合API CK-4规格的柴油机油复合剂技术(RIPP C0010)在两种规格发动机台架试验中的评价结果,系统分... 详细信息

综合对比了柴油机油我国自主D1规格和API CK-4规格在理化性能指标、发动机台架试验性能指标等方面的差异;进而,结合中国石化自主开发的符合API CK-4规格的柴油机油复合剂技术(RIPP C0010)在两种规格发动机台架试验中的评价结果,系统分析D1规格与API CK-4规格的相关性,以及RIPP C0010柴油机油技术对国产发动机的适用性。结果表明:除柴油喷嘴剪切后高温高剪切黏度存在差异外,D1规格与API CK-4规格的其他理化性能指标,包括高低温运动黏度、蒸发损失率、高温抗腐蚀性、抗泡性能、元素含量等均基本相同;D1规格的4种台架试验均可以评价多项油品性能,如抗氧化性能、清净性能、分散性能、抗磨性能等,实现了API CK-4规格10种台架试验的评价效果,但仍需进一步完善其基础油互换规则和黏度级别延伸规则;行车试验结果表明,自主研发RIPP C0010柴油机油可满足重载柴油发动机60000 km换油周期使用要求。

关键词：柴油机油 D1规格 API CK-4规格发动机台架试验

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Hydrodynamic Study on Energy Capturing Performance of Horizontal Axis Blades Under Sub-Low Speed Tidal Current

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China Ocean Engineering 2020年第3期34卷 374-386页

作者： GAO Ru-jun CHEN jun-hua zhang jun-jie ZHOU Si-yu XU Hua-fei WU jun-de qian Xiao-hua State Key Laboratory of Fluid Power&Mechatronic Systems Zhejiang UniversityHangzhou 310027China School of Mechanical Engineering Zhejiang UniversityHangzhou 310027China Ningbo Institute of Technology Zhejiang UniversityNingbo 315100China

The research on the hydrodynamics of blades is mainly focused on sea areas with high-speed ***,the average velocity in most territorial waters of China is smaller than 1 m/s,and the lift type of airfoil blades has limited application in most of these ***,it is of great significance to study the tidal current energy capture of blades in sub-low speed sea *** effect of flow impact resistance on the blade at sub-low current speed is considered and a new type of thin-walled blade based on the lift type of blade is proposed,and then the lift-impact combined hydrodynamic model of horizontal axis blade is *** on this model,and considering the characteristics of tidal current and velocity in the sea area of Yushan Islands,simulation and optimization of blade design are carried ***,the horizontal axis thin-walled blade and the NACA airfoil contrast blade under the same conditions are *** using a synthetical experimental test system,the power,torque,rotational speed and load characteristics of these two blades are *** performance of the thin-walled blade and the design theory are *** shows that this type of blade has much better energy capture efficiency in the sub-low speed sea *** research will promote the study and development of turbines that can be used in low-speed current sea areas in the future.

关键词： sub-low speed horizontal axis thin-walled blade hydrodynamic model energy capture performance

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Synthesis and Crystal Structure of (2S,5S)-1-Aza-2- (2-pyridyl)-3-oxa-4,4-diphenylbicyclo [3.3.0] Octane

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Chinese Journal of Structural Chemistry 2004年第6期23卷 527-530页

作者： LU jun JI Shun-jun qian Rong JIANG Zhao-Qin zhang Yong LANG Jian-Ping School of Chemistry and Chemical Engineering Suzhou UniversityJiangsu 215006China Key Lab of Organic Synthesis of Jiangsu Province Suzhou University 215006China

The title compound (C23H22N2O) 3 has been synthesized by the reaction of (S)- (-)-1,1-diphenyl-2-pyrrolidinemethanol 1 with 2-pyridinecarboxaldehyde 2 in refluxing benzene catalyzed by TsOH, and its structure was determined by single-crystal X-ray diffraction. The crystal belongs to orthorhombic, space group P212121 with a = 8.4747(8), b = 10.8829(10), c = 19.777(2) , Mr = 342.43, V =1824.0(3) 3, Dc = 1.247 g/cm3, Z = 4, m = 0.077 mm-1 and F(000) = 728. The structure was solved by direct methods and refined by full-matrix least-squares techniques to the final R = 0.0497 and wR = 0.0927.

关键词： synthesis crystal structure (2S,5S)-1-aza-2-(2-pyridyl)-3-oxa-4,4- diphenylbicyclo [3.3.0] octane

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