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Integrated transcriptome analysis for the hepatic and jejunal mucosa tissues of broiler chickens raised under heat stress conditions

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Journal of Animal Science and Biotechnology 2022年第6期13卷 1768-1784页

作者： Deok Yun kim Byeonghwi Lim jun-mo kim Dong Yong Kil Department of Animal Science and Technology Chung-Ang UniversityAnseong-siGyeonggi-do 17546Republic of Korea

Background:Heat stress(HS)is one of the most important threats for the current poultry ***,many efforts have been made to ameliorate the adverse effect of HS on poultry production;however,physiological and molecular mechanisms pertaining to HS are still limited in ***,the objective of the current study was to investigate functional alterations based on individual and integrated transcriptomes in the liver and jejunal mucosa tissues of broiler chickens exposed to HS ***:Broiler chickens exposed to HS showed decreased growth performance and increased corticosterone concentrations in the *** the transcriptome analysis,the number of differentially expressed genes(DEGs)were identified in the liver and jejunal mucosa by HS *** the liver,genes related to amino acid oxidation,tryptophan metabolism,lipid metabolism,oxidative phosphorylation,and immune responses were altered by HS,which support the reason why heat-stressed poultry had decreased productive *** the jejunal mucosa,genes related to defense systems,glutathione metabolism,detoxification of xenobiotics,and immune responses were differently expressed by HS *** integrated transcriptome analysis with DEGs found in the liver and jejunal mucosa showed a considerable connectivity between the core nodes in the constructed networks,which includes glutathione metabolism,xenobiotic metabolism,carbon metabolism,and several amino acid ***:The core network analysis may indicate that increased requirement of energy and amino acids in the jejunal mucosa of broiler chickens exposed to HS conditions is likely compromised by increased oxidation and synthesis of amino acids in the ***,our results may provide comprehensive insights for molecular and metabolic alterations of broiler chickens raised under HS conditions,which can aid in the development of the novel strategies to ameliorate the negative effect of HS on poultry

关键词： Broiler chicken Heat stress Jejunal mucosa Liver Transcriptome

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Ear keloid and epidermal cyst following auricular cartilage harvest for rhinoplasty:A case report

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World Journal of Clinical Cases 2024年第20期12卷 4434-4439页

作者： jun mo kim Ji Seon Cheon Woo Young Choi Department of Plastic Reconstructive Surgery Chosun University College of MedicineGwangju 61453South Korea Department of Plastic and Reconstructive Surgery Chosun University College of MedicineGwangju 61453South Korea

BACKGROUND This case report highlights a rare instance of concurrent keloid and epidermal cyst development at an ear cartilage harvest site following rhinoplasty in a 25-year-old *** conditions,which typically stem from skin trauma,seldom occur together,demonstrating the exceptional characteristics of this *** SUMMARY The patient underwent successful surgical removal of both the keloid and the epidermal *** treatment included the use of silicone sheets,gel,and oral tranilast to reduce *** recurrence was observed over a 6-mo follow-up period,indicating effective management of the *** The effective management of complex skin trauma cases underscores the need for individualized treatment strategies in plastic surgery.

关键词： Ear keloids Epidermal cysts Auricular cartilage harvesting Rhinoplasty complications Case report

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Diagnostic and management challenges in primary cutaneous anaplastic large cell lymphoma with necrosis,inflammation,and surgical intervention:A case report

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World Journal of Clinical Cases 2024年第31期12卷 6486-6492页

作者： jun mo kim Woo Young Choi Ji Seon Cheon Department of Plastic Reconstructive Surgery Chosun University College of MedicineGwangju 61453South Korea

BACKGROUND Primary cutaneous anaplastic large cell lymphoma(PC-ALCL)poses significant diagnostic difficulties due to its similarity in the appearance of skin lesions with chronic inflammatory disorders and other dermatological *** study aims to investigate these challenges by conducting a comprehensive analysis of a case presenting with PC-ALCL,emphasizing the necessity of accurate differentiation for appropriate *** SUMMARY An 89-year-old female patient with diabetes and hypertension presented with arm and abdominal ulcerated mass *** procedures included skin biopsies,histopathological assessments,and immunohistochemistry,complemented by advanced imaging techniques to confirm the *** patient’s lesions were determined as PC-ALCL,characterized by necrosis,chronic inflammation,and a distinct immunophenotypic profile,including CD30,CD3,CD4,and EBER,CD56,MUM-1,Ki 67-positive in>80%of tumor cells,CD10,but negative for anaplastic lymphoma kinase,CD5,CD20,PAX-5,Bcl-2,Bcl-6,CD8,and *** was not reported at the 6-month *** Accurate PC-ALCL differentiation from similar conditions is crucial for effective management and requires a multidisciplinary approach.

关键词： Primary cutaneous anaplastic large cell lymphoma Chronic inflammation Necrosis Diagnostic challenges Dermatological oncology Case report

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High mobility group box 1 in the central nervous system:regeneration hidden beneath inflammation

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Neural Regeneration Research 2025年第1期20卷 107-115页

作者： Hanki kim Bum jun kim Seungyon Koh Hyo Jin Cho Xuelian Jin Byung Gon kim jun Young Choi Department of Brain Science Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Ajou University Graduate School of MedicineSuwonSouth Korea Department of Neurology Ajou University School of MedicineSuwonSouth Korea Department of Geriatrics The Affiliated Suqian First People’s Hospital of Nanjing Medical UniversitySuqianJiangsu ProvinceChina

High-mobility group box 1 was first discovered in the calf thymus as a DNA-binding nuclear protein and has been widely studied in diverse fields,including neurology and ***-mobility group box 1 in the extracellular space functions as a pro-inflammatory damage-associated molecular pattern,which has been proven to play an important role in a wide variety of central nervous system disorders such as ischemic stroke,Alzheimer’s disease,frontotemporal dementia,Parkinson’s disease,multiple sclerosis,epilepsy,and traumatic brain *** drugs that inhibit high-mobility group box 1 as a damage-associated molecular pattern,such as glycyrrhizin,ethyl pyruvate,and neutralizing anti-high-mobility group box 1 antibodies,are commonly used to target high-mobility group box 1 activity in central nervous system *** it is commonly known for its detrimental inflammatory effect,high-mobility group box 1 has also been shown to have beneficial pro-regenerative roles in central nervous system *** this narrative review,we provide a brief summary of the history of high-mobility group box 1 research and its characterization as a damage-associated molecular pattern,its downstream receptors,and intracellular signaling pathways,how high-mobility group box 1 exerts the repair-favoring roles in general and in the central nervous system,and clues on how to differentiate the pro-regenerative from the pro-inflammatory *** targeting high-mobility group box 1 in the central nervous system may benefit from differentiating between the two functions rather than overall suppression of high-mobility group box 1.

关键词： central nervous system damage-associated molecular pattern ethyl pyruvate glycyrhizzin high mobility group box 1 inflammation neural stem cells neurodevelopment oligodendrocyte progenitor cells redox status regeneration

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Refractory lipoatrophy treated with autologous whole blood injection:A case report

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World Journal of Clinical Cases 2025年第2期13卷 33-38页

作者： Wonnam kim jun Su Park En Hyung kim Department of Pharmacology School of Korean MedicinePusan National UniversityYangsan 50612GyeongnamSouth Korea Department of Dermatology College of MedicineChungbuk National UniversityCheongju 28644ChungbukSouth Korea Department of Dermatology Chungbuk National University HospitalCheongju 28644ChungbukSouth Korea

BACKGROUND Intramuscular corticosteroid injection may cause adverse effects such as dermal and/or subcutaneous atrophy,alopecia,hypopigmentation,and *** cutaneous atrophy can spontaneously resolve,several treatment options have been suggested for this *** SUMMARY In this paper,we report a case of corticosteroid injection induced lipoatrophy treated with autologous whole blood(AWB)injection,as the condition had been unresponsive to fractional laser therapy.A 29-year-old female patient visited the dermatology clinic complaining of skin depression on her right buttock area,which had appeared six months *** had been only subtle improvement at the margins after fractional CO_(2) laser treatment;therefore,after obtaining informed consent from the patient,AWB treatment was *** month after the first AWB injection,the size and depth of the lesion had noticeably improved,and a slight improvement was also observed in *** Close observation is the initial treatment of choice for steroid induced skin atrophy;however,for patients in need of immediate cosmetic improvement,AWB injection may be a safe and cost-effective alternative.

关键词： Atrophy Corticosteroid Subcutaneous fat Autologous whole blood injection Laser therapy Case report

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Sampled Value Attack Detection for Busbar Differential Protection Based on a Negative Selection Immune System

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Journal of modern Power Systems and Clean Energy 2023年第2期11卷 421-433页

作者： jun mo Hui Yang Guangxi Key Laboratory of Power System Optimization and Energy Technology Guangxi UniversityNanning 530004China

Considering a variety of sampled value(SV)attacks on busbar differential protection(BDP)which poses challenges to conventional learning algorithms,an algorithm to detect SV attacks based on the immune system of negative selection is developed in this *** healthy SV data of BDP are defined as self-data composed of spheres of the same size,whereas the SV attack data,i.e.,the nonself data,are preserved in the nonself space covered by spherical detectors of different *** avoid the confusion between busbar faults and SV attacks,a self-shape optimization algorithm is introduced,and the improved self-data are verified through a power-frequency fault-component-based differential protection criterion to avoid false *** on the difficulty of boundary coverage in traditional negative selection algorithms,a self-data-driven detector generation algorithm is proposed to enhance the detector coverage.A testbed of differential protection for a 110 kV double busbar system is then *** SV attacks of BDP such as amplitude and current phase tampering,fault replays,and the disconnection of the secondary circuits of current transformers are considered,and the delays of differential relay operation caused by detection algorithms are investigated.

关键词： Cyberattack busbar differential protection(BDP) negative selection self-data-driven detector sampled value attacks internal faults

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Mechanical behavior of segment rebar of shield tunnel in construction stage

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第7期9卷 888-899页

作者： jun-sheng CHEN Hai-hong mo Department of Civil Engineering South China University of Technology Guang＇zhou 510640 China State Key Laboratory of Subtropical Building Science South China University of Technology Guang＇zhou 510640 China

In this paper, a 3D finite element （FE） program ADINA was applied to analyzing a tunnel with 9 segment tings. The loads acting on these segment tings included the squeezing action of tail brush of shield machine under attitude deflection, the jacking forces, the grouting pressure and the soil pressure. The analyses focused on the rebar stress in two statuses：（1） normal construction status without shield machine squeezing; （2） squeezing action induced by shield machine under attitude deflection. The analyses indicated that the rebar stress was evidently affected by the construction loads. In different construction status, the rebar stress ranges from -80 MPa to 50 MPa, and the rebar is in elastic status. Even some cracks appear on segments, the stress of segment rebar is still at a low level. It is helpful to incorporate a certain quantity of steel fiber to improve the anti-crack and shock resistance performance.

关键词： Shield tunnel Construction Segment Rebar Finite element (FE) analysis

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Achieving tunable long persistent luminescence in metal organic halides based on pyridine solvent

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Chinese Chemical Letters 2024年第9期35卷 227-231页

作者： jun-Ting mo Zheng Wang College of Chemistry and Chemical Engineering Key Laboratory of Chemical Additives for China National Light IndustryShaanxi University of Science and TechnologyXi’an 710021China moE Laboratory of Bioinorganic and Synthetic Chemistry Lehn Institute of Functional MaterialsSchool of ChemistrySun Yat-sen UniversityGuangzhou 510275China

The research of long persistent luminescence(LPL)materials has yield brilliant results in many ***,the efforts are still needed for the regulation of the LPL *** this work,a series of LPL metal organic halides with rich halogen-bond interactions,Py-CdX_(2)(X=Cl,Br,I)were synthesized through self-assembly by Cd X_(2)and pyridine *** steady-state emission redshifted and phosphorescence lifetime declined as the halogen atoms are *** halides exhibit adjustable emission from blue to green and multiple phosphorescence from green to yellow at room temperature by changing the excitation ***,Py-CdX_(2)can emit the visible color-tunable LPL from green to yellow after removing different excitation sources at ambient *** the results of theoretical calculation and experimental analysis,it is found that heavy atom effect and the rich intermolecular halogen bond help realize LPL and multiple triplet states originated from the pyridine ring and the halogens.

关键词： Metal organic halide Heavy atom effect Halogen bond Tunable long persistent luminescence Anti-counterfeiting

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Effect of sulfamethazine on the horizontal transfer of plasmid-mediated antibiotic resistance genes and its mechanism of action

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Journal of Environmental Sciences 2023年第5期127卷 399-409页

作者： Xiaojing Yan Wenwen Liu Shengfang Wen Lanjun Wang Lusheng Zhu jun Wang Young mo kim Jinhua Wang National Engineering Laboratory for Efficient Utilization of Soil and Fertilizer Resources Key Laboratory of Agricultural Environment in Universities of ShandongCollege of Resources and EnvironmentShandong Agricultural UniversityTai’an 271018China Department of Civil and Environmental Engineering Hanyang UniversitySeongdong-guSeoul 04763Korea

As a new type of environmental pollutant,antibiotic resistance genes(ARGs)pose a huge challenge to global *** gene transfer(HGT)represents an important route for the spread of *** widespread use of sulfamethazine(SM2)as a broad-spectrum bacteriostatic agent leads to high residual levels in the environment,thereby increasing the spread of ***,we chose to study the effect of SM2 on the HGT of ARGs mediated by plasmid RP4 from Escherichia coli(***)HB101 to *** NK5449 as well as its mechanism of *** results showed that compared with the control group,SM2 at concentrations of 10 mg/L and 200 mg/L promoted the HGT of ARGs,but transfer frequency decreased at concentrations of 100 mg/L and 500 mg/*** transfer frequency at 200 mg/L was 3.04×10^(−5),which was 1.34-fold of the control *** mechanism of SM2 improving conjugation transfer is via enhancement of the mRNA expression of conjugation genes(trbBP,trfAP)and oxidative stress genes,inhibition of the mRNA expression of vertical transfer genes,up regulation of the outer membrane protein genes(ompC,ompA),promotion of the formation of cell pores,and improvement of the permeability of cell membrane to promote the conjugation transfer of plasmid *** results of this study provide theoretical support for studying the spread of ARGs in the environment.

关键词： Sulfamethazine Plasmid Antibiotic resistance gene Conjugation transfer

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HOS1 Facilitates the Phytochrome B-Mediated Inhibition of PIF4 Function during Hypocotyl Growth in Arabidopsis

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molecular Plant 2017年第2期10卷 274-284页

作者： Ju-Heon kim Hyo-jun Lee Jae-Hoon jung Sangmin Lee Chung-mo Park Department of Chemistry Seoul National University Seoul 08826 Korea Sainsbury Laboratory University of Cambridge Cambridge CB2 1LR UK Plant Genomics and Breeding Institute Seoul National University Seoul 08826 Korea These authors contributed equally to this article Present address: SK Innovation Daejeon 34124 Korea

Upon exposure to light, developing seedlings undergo photomorphogenesis, as illustrated by inhibition of hypocotyl elongation, cotyledon opening, and leaf greening. During hypocotyl photomorphogenesis, light signals are sensed by multiple photoreceptors, among which the red/far-red light-sensing phytochromes have been extensively studied. However, it is not fully understood how the phytochromes modulate hypo- cotyl growth. Here, we demonstrated that HIGH EXPRESSION OF OSmoTICALLY RESPONSIVE GENES 1 （HOS1）, which is known to either act as E3 ubiquitin ligase or affect chromatin organization, inhibits the transcriptional activation activity of PHYTOCHROME INTERACTING FACTOR 4 （PIF4）, a key transcrip- tion factor that promotes hypocotyl growth. Consistent with the negative regulatory role of HOSl in hypo- cotyl growth, HOSl-defective mutants exhibited elongated hypocotyls in the light. Notably, phyB induces HOS1 activity in inhibiting PIF4 function. Taken together, these observations provide a molecular basis for the phyB-mediated suppression of hypocotyl growth in Arabidopsis.

关键词： photomorphogenesis hypocotyl growth phytochrome signaling HOS1 PIF4

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