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Chemoprophylaxis, diagnosis, treatments, and discharge management of COVID-19: An evidence-based clinical practice guideline(updated version)

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Military Medical research 2020年第3期7卷 249-282页

作者： Ying-Hui Jin Qing-Yuan Zhan Zhi-Yong peng Xue-Qun ren Xun-Tao Yin lin Cai Yu-Feng Yuan Ji-rong Yue xiao-Chun Zhang Qi-Wen Yang Jianguang Ji Jian xia Yi-rong li Fu-xiang Zhou Ya-Dong Gao Zhui Yu Feng Xu Ming-li Tu li-Ming Tan Min Yang fang Chen xiao-Ju Zhang Mei Zeng Yu Zhu Xin-Can liu Jian Yang Dong-Chi Zhao Yu-Feng Ding Ning Hou Fu-Bing Wang Hao Chen Yong-Gang Zhang Wei li Wen Chen Yue-xian Shi Xiu-Zhi Yang Xue-jun Wang Yan-jun Zhong Ming-Juan Zhao Bing-Hui li lin-Lu Ma Hao Zi Na Wang Yun-Yun Wang shao-Fu Yu Lu-Yao li Qiao Huang Hong Weng xiang-Ying ren li-Sha Luo Man-ru fan Di Huang Hong-Yang Xue lin-Xin Yu Jin-ping Gao Tong Deng xian-Tao Zeng Hong-jun li Zhen-Shun Cheng xiao-Mei Yao Xing-Huan Wang Center for Evidence-Based and Translational Medicine Zhongnan Hospital of Wuhan UniversityWuhan 430071China National Clinical research Center for respiratory Diseases China-Japan Friendship HospitalBeijing 100029China department of pulmonary and Critical Care Medicine China-Japan Friendship HospitalBeijing 10029China Leishenshan hospital in Wuhan Wuhan 430200China department of Critical Care Medicine Zhongnan Hospital of Wuhan UniversityWuhan 430071China Institutes of Evidence-based Medicine and Knowledge Translation Henan UniversityKaifeng 475000HenanChina department of Medical Imaging Guizhou Provincial People’s HospitalGuiyang 550002China departments of Orthopedics Zhongnan Hospital of Wuhan UniversityWuhan 430071China department of Hepatobiliary surgery Zhongnan Hospital of Wuhan UniversityWuhan 430071China National Clinical research Center for Geriatrics West China Hospital of Sichuan UniversityChengdu 610041China department of Geriatrics West China Hospital of Sichuan UniversityChengdu 610041China department of radiology Zhongnan Hospital of Wuhan UniversityWuhan 430071China department of Clinical Laboratory Peking Union Medical College Hospital(PUMCH)Peking Union Medical CollegeChinese Academy of Medical Sciences(CAMS)Beijing 100730China Center for primary Health Care research Lund University and Region Skåne25002 MalmöSweden Emergency Center Zhongnan Hospital of Wuhan UniversityWuhan 403371China department of Allergology Zhongnan Hospital of Wuhan UniversityWuhan 430071China department of radiation and Medical Oncology Zhongnan Hospital of Wuhan UniversityWuhan 43071China department of Critical Care Medicine Renmin Hospital of Wuhan UniversityWuhan 430060China department of Emergency Medicine and Chest pain Center Qilu Hospital of Shandong UniversityJinan 250002China department of respiratory and Critical Care Medicine Suizhou Central HospitalHubei University of MedicineSuizhou 441300HubeiChina department of Clinic pharmacy Second People’s Hospital of Huaihua Ci

The novel severe acute respiratory syndrome coronavirus 2(SArS-CoV-2)is the cause of a rapidly spreading illness,coronavirus disease 2019(COVID-19),affecting more than seventeen million people around the *** and treatment guidelines for clinicians caring for patients are *** the early stage,we have issued"A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus(2019-nCoV)infected pneumonia(standard version)";now there are many direct evidences emerged and may change some of previous recommendations and it is ripe for develop an evidence-based *** formed a working group of clinical experts and *** steering group members proposed 29 questions that are relevant to the management of COVID-19 covering the following areas:chemoprophylaxis,diagnosis,treatments,and discharge *** searched the literature for direct evidence on the management of COVID-19,and assessed its certainty generated recommendations using the Grading of recommendations,Assessment,Development and Evaluation(GrADE)*** were either strong or weak,or in the form of ungraded consensus-based ***,we issued 34 *** them,6 were strong recommendations for,14 were weak recommendations for,3 were weak recommendations against and 11 were ungraded consensus-based *** covered topics of chemoprophylaxis(including agents and Traditional Chinese Medicine(TCM)agents),diagnosis(including clinical manifestations,reverse transcription-polymerase chain reaction(rT-pCr),respiratory tract specimens,IgM and IgG antibody tests,chest computed tomography,chest X-ray,and CT features of asymptomatic infections),treatments(including lopinavirritonavir,umifenovir,favipiravir,interferon,remdesivir,combination of antiviral drugs,hydroxychloroquine/chloroquine,interleukin-6 inhibitors,interleukin-1 inhibitors,glucocorticoid,qingfei paidu decoction,lianhua qingwen granules/capsules,convalescent plasma,lung

关键词： COVID-19 SArS-CoV-2 recommendation Chemoprophylaxis Diagnosis Treatment Discharge management Traditional Chinese medicine guideline

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Onco-mir-24 regulates cell growth and apoptosis by targeting BCL2L11 in gastric cancer

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protein & Cell 2016年第2期7卷 141-151页

作者： Haiyang Zhang Jingjing Duan Yanjun Qu Ting Deng rui liu Le Zhang Ming Bai Jialu li Tao Ning shaohua Ge xia Wang ZhenzhenWang~ Qian fan Hongli li Guoguang Ying Dingzhi Huang Yi Ba Tianjin Medical University Cancer Institute and hospital Key Laboratory of Cancer Prevention and Therapy National ClinicalResearch Center for Cancer Tianjin 300060 China department of Gastroenterology Tianjin First Center Hospital Tianjin 300192 China Changchun GeneScience pharmaceuticals Co. Ltd Changchun 130012 China

Gastric cancer is one of the most common malignancies worldwide; however, the molecular mechanism in tumorigenesis still needs exploration. BCL2L11 belongs to the BCL-2 family, and acts as a central regulator of the intrinsic apoptotic cascade and mediates cell apoptosis. Although mirNAs have been reported to be involved in each stage of cancer development, the role of mir-24 in GC has not been reported yet. In the present study, mir- 24 was found to be up-regulated while the expression of BCL2L11 was inhibited in tumor tissues of GC. Studies from both in vitro and in vivo shown that mir-24 regulates BCL2L11 expression by directly binding with 3＇UTr of mrNA, thus promoting cell growth, migration while inhibiting cell apoptosis. Therefore, mir-24 is a novel onco-mirNA that can be potential drug targets for future clinical use.

关键词： gastric cancer BCL2L11 mir-24,tumorigenesis cell apoptosis proliferation migration

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repurposing of a clinically used anti-HpV agent to prevent and treat SArS-CoV-2 infection as an intranasal formulation

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Signal Transduction and Targeted Therapy 2021年第9期6卷 2631-2633页

作者： Chen Hua Qinhai Ma Yun Zhu Shuai xia Zezhong liu lin li Lu Lu Nanshan Zhong Shuwen liu Zifeng Yang Shibo Jiang Key Laboratory of Medical Molecular Virology(MOE/NHC/CAMS) School of Basic Medical SciencesShanghai Institute of Infectious Disease and BiosecurityFudan UniversityShanghaiChina State Key Laboratory of respiratory Disease National Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory Healththe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouChina National Laboratory of Biomacromolecules Institute of BiophysicsChinese Academy of SciencesBeijingChina State Key Laboratory of Organ Failure research Guangdong Provincial Key Laboratory of New Drug ScreeningSchool of Pharmaceutical SciencesSouthern Medical UniversityGuangzhouChina Guangzhou Laboratory Bio-IslandGuangzhouChina

Dear Editor,fan et *** shown that whey protein,such as that found in human,bovine,and goat milk,could effectively inhibit SArS-CoV-2 infection,but they did not identify the components in whey protein having this activity.1 Since p-lactoglobulin(p-LG)is the main component of whey protein,we herein tested the anti-SArS-CoV-2 activity of p-LG and 3-hydroxyphthalic anhydride(3Hp)-modified p-LG(3Hp-p-LG),an active component in anti-human papillomavirus(HpV)biological dressing(JB01-BD)that has been used in clinics since 2013 to block cervical infection of HpV.

关键词： infection nasal

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Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A retrospective Cohort Study from Nine provinces in china

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Biomedical and Environmental Sciences 2020年第12期33卷 893-905页

作者： MA Yan ZHU Dong Shan CHEN ren Bo SHI Nan Nan liU Si Hong fan Yi pin WU Gui Hui YANG pu Ye BAI Jiang Feng CHEN Hong CHEN li Ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU xiao Mei HU Yun Hong HUANG Jin HUANG Qiu Hua HUANG shao Zhen JI liang JIN Hai Hao LEI xiao li Chun Yan li Min Qing li Qun Tang li xian Yong liU Hong De liU Jin ping liU Zhang MA Yu Ting MAO Ya MO liu Fen NA Hui WANG Jing Wei SONG fang li SUN Sheng WANG Dong Ting WANG Ming Xuan WANG xiao Yan WANG Yin Zhen WANG Yu Dong WU Wei WU Lan ping xiaO Yan Hua XIE Hai jun XU Hong Ming XU Shou fang XUE rui xia YANG Chun YANG Kai jun YUAN Sheng li ZhanG Gong Qi ZhanG Jin Bo ZhanG lin Song ZHAO Shu Sen ZHAO Wan Ying ZHENG Kai ZHOU Ying Chun ZHU jun Teng ZHU Tian Qing ZhanG Hua Min WANG Yan ping WANG Yong Yan 无 Institute of Basic research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing 100700China Centre for Health Management and policy research School of Public HealthCheeloo College of MedicineShandong UniversityJinan 250012ShandongChina Institute of Information on Traditional Chinese Medicine China Academy of Chinese Medical SciencesBeijing 100700China department of Tuberculosis The Public Health Clinical Center of ChengduChengdu 610066SichuanChina department of Infectious Disease Shaanxi Infectious Disease HospitalXi'an 610113ShaanxiChina department of Infectious Disease Yulin Chinese Medicine HospitalYulin 719000ShaanxiChina president's Office The First Hospital of QiqiharQiqihar 161005HeilongjiangChina department of Traditional Chinese Medicine Shangluo Central HospitalShangluo 726000ShaanxiChina department of Traditional Chinese Medicine The People's Hospital of QitaiheQitaihe 154603HeilongjiangChina department of Scientific research Xianyang Central HospitalXianyang 712000ShaanxiChina department of traditional Chinese medicine The First Affiliated Hospital of Anhui University of Traditional Chinese MedicineHefei 230012AnhuiChina department of Infectious Disease Heping Hospital Affiliated to Changzhi Medical CollegeChangzhi 046000ShanxiChina department of Traditional Chinese Medicine Langfang Hospital of Chinese MedicineLangfang 065000HeibeiChina department of Traditional Chinese Medicine Xingtai Hospital of Chinese MedicineXingtai 054001HeibeiChina department of Traditional Chinese Medicine The People's Hospital of Guangxi Zhuang Autonomous RegionNanning 168600GuangxiChina department of Traditional Chinese Medicine The First People'sHospital of FangchenggangFangchenggang 538001GuangxiChina department of Traditional Chinese Medicine Mianyang Hospital of Traditional Chinese MedicineMianyang 621000SichuanChina department of Traditional Chinese Medicine Liuzhou People's HospitalLiuzhou 545006GansuChina department of Traditional Chinese Medici

Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains *** A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in china. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(Or) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of *** Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two *** Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes.

关键词： Comorbidities COVID-19 Severity Gender Age Treatment outcome

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基于OpLS模型分析生态因子对当归质量的影响

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中成药 2021年第5期43卷 1226-1230页

作者：樊秦张延英陈辉萍蔺兴遥夏鹏飞孙宇靖赵磊雒军杨飞霞李少泓甘肃中医药大学甘肃兰州730000 甘肃省高校中(藏)药化学与质量研究省级重点实验甘肃兰州730000 甘肃省金昌市药品检验检测中心甘肃金昌737100 无锡市第二人民医院江苏无锡214002

目的基于OpLS模型分析生态因子对当归质量的影响。方法采用HpLC法测定10个产地当归药材中9种主要活性成分的含量,利用主成分分析法对其进行综合质量评价。运用OpLS法建立当归药材质量和生态因子回归模型,分析两者之间相关性和变量投影... 详细信息

目的基于OpLS模型分析生态因子对当归质量的影响。方法采用HpLC法测定10个产地当归药材中9种主要活性成分的含量,利用主成分分析法对其进行综合质量评价。运用OpLS法建立当归药材质量和生态因子回归模型,分析两者之间相关性和变量投影重要性。结果不同地区生态因子对当归活性成分积累影响很大,在10种生态因子中平均气温、平均最低气温、平均日降水量和日照时数对当归质量影响最显著。结论明确当归活性成分与生态因子之间的关系,可为当归药材规范化种植,提高当归的产量和质量以及指导临床合理用药提供参考。

关键词：当归质量有效成分正交投影偏最小二乘法生态因子

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腰方肌阻滞疗法中国专家共识(2024版)

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中华疼痛学杂志 2024年第2期20卷 179-190页

作者：腰方肌阻滞疗法中国专家共识编写组王小平段彬姚军陈宇蔡宇晶冯霞范坤宫庆娟郭海军黄雪花姜莹莹李水清李雅兰廖琴雷洪伊马彬马武华马璐璐马柯舒海华孙涛徐世元王锷王亚平王海棠王勇肖礼祖余日丽邹海盯郑拥军不详暨南大学附属第一医院疼痛科广州市510630 中南大学湘雅医院麻醉科长沙市410008 上海交通大学医学院附属第六人民医院麻醉科上海市200233 中山大学附属第一医院麻醉科广州市510080 广东省人民医院麻醉科广州市510080 广州医科大学附属第二医院疼痛科广州市510260 乔治全球健康研究院(澳大利亚)北京代表处营养和生活方式部北京市100060 上海交通大学医学院附属新华医院疼痛科上海市200092 中国疾病预防控制中心慢性非传染性疾病预防控制中心综合防控与评价室北京市100050 北京大学第三医院疼痛科北京市100191 暨南大学附属第一医院麻醉科广州市510630 中南大学湘雅三医院麻醉科长沙市410013 南方医科大学珠江医院麻醉科广州市510282 兰州大学基础医学院循证医学中心兰州市730000 广州中医药大学第一附属医院麻醉科广州市510140 北京协和医院麻醉科北京市100730 山东第一医科大学附属省立医院疼痛科济南市250021 中南大学湘雅二医院疼痛科长沙市410011 南方医科大学南方医院麻醉科广州市510515 华中科技大学协和深圳医院疼痛科深圳市518052 中南大学湘雅二医院麻醉科长沙市410011 复旦大学附属华东医院疼痛科上海市200040

腰方肌阻滞是将局麻药物注入到腰方肌邻近的筋膜间隙内,阻滞在其内行走的相关胸腰神经产生镇痛的神经阻滞方法。可为腹部、髋部、下肢等手术提供镇痛,在急慢性疼痛管理中亦有良好效果,还可缓解腹部内脏疼痛。本专家共识系统介绍了腰方... 详细信息

腰方肌阻滞是将局麻药物注入到腰方肌邻近的筋膜间隙内,阻滞在其内行走的相关胸腰神经产生镇痛的神经阻滞方法。可为腹部、髋部、下肢等手术提供镇痛,在急慢性疼痛管理中亦有良好效果,还可缓解腹部内脏疼痛。本专家共识系统介绍了腰方肌阻滞的相关解剖特点、不同入路阻滞方法及阻滞范围、常用麻醉药物、并发症以及临床应用等,为其在临床的有效安全应用提供参考。

关键词：神经传导阻滞腰方肌阻滞专家共识

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Characteristics of Viral Shedding in respiratory Samples and Specific Antibodies production in 564 COVID-19 patients

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Current Medical Science 2021年第1期41卷 46-50页

作者： Jing GONG Hui DONG Ding-kun WANG Fu-er LU Zhao-yi HUANG Ke fanG Wen-ya HUANG Fen YUAN Xing CHEN Qing-song xia Le-yi MA fan WU Hao SU Min-min GONG Yue-heng TANG Ke-xin NIE Zhi WANG Sheng-hao TU Ming-min ZhanG Jing-bin li department of Integrated Traditional Chinese and Western Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Institute of Integrated Traditional Chinese and Western Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China department of Clinical Laboratory Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

positive nucleic acid(NA)results have been found in recovered and discharged COVID-19 patients,but the proportion is *** study was designed to analyze the recurrent positive rate of NA results after consecutively negative results,and the relationship between the specific antibody production and positive NA *** to Strengthening the reporting of Observational Studies in Epidemiology guidelines,data of inpatients in Sino-French New city Branch of Tongji hospital between Jan.28 and Mar.6,2020 were collected.A total of 564 COVID-19 patients over 14 years old who received the examinations of NA and antibodies against SArS-CoV-2 were *** of viral shedding and specific antibodies were recorded and *** NA tests in respiratory samples(throat swabs,nasopharyngeal swabs,sputum and flushing fluid in alveoli),the patients with all-negative NA results accounted for 17.20%,those with single-positive results for 46.63%,and those with multiple-positive results for 36.17%***,the recurrent positive NA results after consecutively negative results appeared in 66 patients(11.70%).For multiple-positive patients,median viral shedding duration was 20 days(range:1 to 57 days).Of the 205 patients who received 2 or more antibody tests,141(68.78%)had decreased IgG and IgM *** decreased to normal range in 24 patients,with a median of 44 days from symptom *** shedding duration was not significantly correlated with gender,age,disease severity,changes in pulmonary imaging,and antibody *** is concluded that antibody level and antibody change had no significant correlation with the positive rate of NA tests and the conversion rate after continuous negative NA *** order to reduce the recurrent positive proportion after discharge,3 or more consecutive negative NA test results with test interval more than 24 h every time are suggested for the discharge or release from quarantine.

关键词： COVID-19 viral shedding specific antibodies

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抑郁在妊娠晚期孕妇身体不满与母胎依恋间的中介效应

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护理学报 2023年第6期30卷 68-71页

作者：李梦帆张侠李晓媛郑州大学第二附属医院护理部河南郑州450000

目的探讨妊娠晚期孕妇抑郁在身体不满及母胎依恋间的中介效应。方法便利选取2022年7—8月在郑州市某三级甲等医院产科门诊做产前常规检查的246例妊娠晚期的孕妇为研究对象。使用母胎依恋关系量表、孕期身体感受测评量表及爱丁堡产后抑... 详细信息

目的探讨妊娠晚期孕妇抑郁在身体不满及母胎依恋间的中介效应。方法便利选取2022年7—8月在郑州市某三级甲等医院产科门诊做产前常规检查的246例妊娠晚期的孕妇为研究对象。使用母胎依恋关系量表、孕期身体感受测评量表及爱丁堡产后抑郁量表对其进行调查。结果妊娠晚期孕妇母胎依恋得分为(73.89±7.31)分、身体不满得分为(47.91±7.47)分、抑郁得分为(8.09±3.25)分。身体不满与抑郁呈正相关(p1),与母胎依恋呈负相关(p1);母胎依恋与抑郁呈负相关(p1)。抑郁在身体不满与母胎依恋起部分中介作用,中介效应占总效应的60.25%。结论妊娠晚期孕妇抑郁、身体不满和母胎依恋关系密切,身体不满可通过抑郁间接影响母胎依恋。医护人员可通过降低孕妇的身体不满程度,改善抑郁状况,增强母胎依恋水平。

关键词：孕妇抑郁身体不满母胎依恋中介效应

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高效体积排阻色谱法测定头孢噻肟钠及其注射剂中的聚合物杂质

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中国药学杂志 2018年第8期53卷 639-645页

作者：赵丽丽侯玉荣王昉袁耀佐张玫杭太俊樊夏雷赵述强中国药科大学南京210009 江苏省食品药品监督检验研究院南京210019 圣裘德儿童研究医院孟菲斯38105 中国医药城江苏泰州225300

目的建立高效体积排阻色谱法分离分析头孢噻肟钠和其注射剂中的聚合物杂质,采用LC-MS对聚合物杂质进行结构推定。方法采用Sepax SrT SEC^(-1)50(7.8 mm×300 mm,5μm)色谱柱,以0.1 mol·L^(-1)磷酸缓冲液为流动相,流速0.8 m L·min^(-1)... 详细信息

目的建立高效体积排阻色谱法分离分析头孢噻肟钠和其注射剂中的聚合物杂质,采用LC-MS对聚合物杂质进行结构推定。方法采用Sepax SrT SEC^(-1)50(7.8 mm×300 mm,5μm)色谱柱,以0.1 mol·L^(-1)磷酸缓冲液为流动相,流速0.8 m L·min^(-1),检测波长为235 nm,进样量:10μL,柱温:35℃,外标法定量;LC-MS/MSn系统:以20 mmol·L^(-1)乙酸铵为流动相,流速0.8 m L·min^(-1),质谱检测器采用电喷雾离子源(ESI),正离子扫描;扫描范围:m/z 200~1 600;柱后分流1∶4。结果主成分前后共分离得到8个杂质峰,分离度均大于1.5;头孢噻肟检测质量浓度线性范围为1~100μg·m L^(-1)(r=1.000 0),重复性试验rSD=1.2%(n=6),检测限为0.2μg,定量限为0.4μg;采用LC-MS推定了3个聚合物杂质的结构。结论该方法能够准确地对单个聚合物杂质进行定量和定性研究,适用于头孢噻肟钠中聚合物杂质的控制。

关键词：头孢噻肟钠高效体积排阻色谱法聚合物杂质液质联用

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血清代谢物在饮酒所致食管鳞状细胞癌中的中介效应

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中华肿瘤防治杂志 2022年第12期29卷 909-914页

作者：魏梦珂吕嘉丽李霞范冰冰薛付忠王家林张涛山东大学齐鲁医学院公共卫生学院山东济南250012 山东大学健康医疗大数据研究院山东济南250002 山东省肿瘤防治研究院(山东省肿瘤医院)科教科山东第一医科大学(山东省医学科学院)山东济南250117

目的基于一项横断面研究探讨饮酒所致食管鳞状细胞癌(ESCC)发生通路中的潜在中介血清代谢物。方法基于“国家食管癌早诊早治示范基地(山东省肥城市)”食管癌筛查平台,收集2013-07-23-2014-04-30(山东省肥城市)40~69岁参加筛查的农村... 详细信息

目的基于一项横断面研究探讨饮酒所致食管鳞状细胞癌(ESCC)发生通路中的潜在中介血清代谢物。方法基于“国家食管癌早诊早治示范基地(山东省肥城市)”食管癌筛查平台,收集2013-07-23-2014-04-30(山东省肥城市)40~69岁参加筛查的农村居民为研究对象,并获得血清代谢谱、病理诊断和基线信息。多元logistic回归计算饮酒暴露对ESCC风险的Or值和95%CI。并采用高维中介分析和单因素中介分析筛选饮酒暴露导致ESCC的潜在中介代谢物。结果共纳入463名研究对象,其中健康对照组250名,病例组213例(癌前病变192例,原位癌21例)。饮酒与ESCC风险增加1.973倍相关,Or=1.973,95%CI:1.049~3.769,p1。通过高维中介分析筛选出4个代谢物作为中介变量,分别为pC(p-16:0/14:1)、组氨酸、门冬酰胺-苯丙氨酸和谷氨酰胺。单变量中介分析进一步证明了pC(p-16:0/14:1)、组氨酸和谷氨酰胺存在中介作用,中介比例分别为49.14%、58.14%和26.39%。结论饮酒与ESCC事件有关,这一过程可能是由pC(p-16:0/14:1)、谷氨酰胺和组氨酸介导。

关键词：食管鳞状细胞癌饮酒暴露代谢组学中介分析高维数据

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