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Agricultural Sciences in China 2011年第7期10卷 1106-1116页

作者： TONG Hui-li GAO Xue-jun li Qing-zhang liu Jie li Nan WAN Zhong-ying Key Laboratory of Dairy Science Ministry of Education/Life College Northeast Agricultural University Harbin 150030 P.R.China

In previous experiment, we isolated a compound dibutyl phthalate （DBP） from Vaccaria segetalis which had galactopoietic function on mammary gland epithelial cells of dairy cow （DCMECs）. In this experiment, we ascertained the metabolic regulation function of DBP on DCMECs. Many genes related to lactation including Stat5, AMPK, b-casein, Glut1, SREBP-1, PEPCK, and ACC were detected by real-time PCR. Furthermore, Stat5 and AMPK were detected by Western blot and immunofluorescence co-localization, respectively. The results showed that DBP stimulates the expression of Stat5 and p-Stat5, thus activates Stat5 cell signal transduction pathway and stimulates b-casein synthesis. DBP also raises the activities of Glut1 and AMPK to stimulate glucose uptake and glycometabolism and activates the expression of AMPK downstream target genes PEPCK and ACC and expression of SREBP-1 to stimulate milk fat synthesis. In addition, the activities of HK, G-6-PDH, ICDH, ATPase, and energy charges were stimulated by DBP to increase the energy metabolism level of DCMECs. The results showed DBP stimulates energy metabolism related to galactopoietic function in DCMECs.

关键词： Vaccaria segetalis DBP dairy cow mammary gland epithelial cell metabolic regulation

Ionized cocatalyst to promote CO_(2) photoreduction activity over core-triple-shell ZnO hollow spheres

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Rare Metals 2022年第4期41卷 1077-1079页

作者： Swelm Wageh Omar A.Al-Hartomy Maged F.Alotaibi li-jun liu Department of Physics Faculty of ScienceKing Abdulaziz UniversityJeddah21589Saudi Arabia College of Chemistry and Chemical Engineering Wuhan Textile UniversityWuhan430200China

Solar-driven CO_(2) conversion into value-added chemicals is a sustainable solution to achieve carbon ***’s group have recently reported Mn,C-codoped ZnO coretriple-shell hollow spheres(CTSHSs)for efficient CO_(2) **... 详细信息

关键词： reduction spheres catalyst

Tongmai Yangxin Pill combined with metoprolol or metoprolol alone for the treatment of symptomatic premature ventricular complex:a multicenter,randomized,parallel-controlled clinical study

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Journal of Geriatric Cardiology 2022年第4期19卷 284-291页

作者： li-jun liu Guo-Hua ZHU Hong-Yu LUO Xi-Peng SUN Jing li Qi HUA Department of Cardiology Xuanwu Hospital Capital Medical UniversityBeijingChina Department of Geriatrics Xuanwu Hospital Capital Medical UniversityBeijingChina

OBJECTIVE To investigate the effects of Tongmai Yangxin Pill(TMYXP)combined with metoprolol tartrate or metoprolol alone for the treatment of premature ventricular complex(PVC)in patients with symptomatic frequent *** A total of 584 patients with symptomatic frequent PVC were randomly assigned(in a 1:1 ratio)into two groups:study group[n=292,TMYXP(40 pills twice/day,orally)combined with metoprolol tartrate(25 mg twice/day,orally)]and control group[n=292,metoprolol tartrate(25 mg twice/day,orally)plus placebo pill(40 pills twice/day,orally)].The total treatment period was eight *** After eight weeks of treatment,the total effective rate of reduction of PVC in the study group and the control group were 76.4%and 51.4%,respectively(P<0.001).TMYXP combined with metoprolol tartrate demonstrated a significantly greater reduction of the frequency of PVCs compared with the metoprolol tartrate alone(−4537 times/24 h vs.−3013 times/24 h,P<0.001).The study group also showed a better result compared with the control group with respect to PVC related *** terms of New York Heart Association classification improvement,the total effective rates were 21.9%in the study group and 12.4%in the control group(P<0.05).Both the study group and the control group exhibited improvements in echocardiographic *** ventricular ejection fraction was significantly improved in the study group compared with the control group(P<0.05).There was no significant difference in the incidence of adverse events between the two *** Compared with metoprolol tartrate alone,TMYXP combined with metoprolol tartrate could more effectively reduce the frequency of PVC and alleviated PVC related symptoms,and improve cardiac function in patients with symptomatic PVC.

关键词： treatment alone complex

Optimal indicator for changing the filter during the continuous renal replacement therapy in intensive care unit patients with acute kidney injury:A crossover randomized trial

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World Journal of Emergency Medicine 2022年第3期13卷 196-201页

作者： Cheng Hang li-jun liu Zhao-yun Huang Jian-liang Zhu Bao-chun Zhou Xiao-zhen li Intensive Care Unit Kunshan Hospital of TCMSuzhou 215300China Intensive Care Unit the Second Affiliated Hospital of Soochow UniversitySuzhou 215004China

BACKGROUND:The study aims to investigate an optimal indicator for changing the filter during the continuous renal replacement therapy(CRRT)in intensive care unit(ICU)patients with acute kidney injury(AKI).METHODS:Patients with AKI requiring CRRT in an ICU were randomly divided into two groups for crossover trial,i.e.,groups A and *** in the group A were firstly treated with continuous veno-venous hemofiltration(CVVH),followed by continuous veno-venous hemodiafiltration(CVVHDF).Patients in the group B were firstly treated with CVVHDF followed by *** doses of solutes with different molecular weights at the indicated time points between groups were compared.A correlation analysis between the delivered dose and pre-filter pressure(P_(PRE))and transmembrane pressure(P_(TM))was *** operating characteristic(ROC)curves were constructed to evaluate the accuracy of P_(TM) as an indicator for filter ***:A total of 50 cases were analyzed,27 in the group A and 23 in the group *** doses of different molecular-weight solutes significantly decreased before changing the filter in both modalities,compared with those at the initiation of treatment(all Plivered dose of medium-molecular-weight solute in both *** threshold for predicting the rebound of serum concentration of medium-molecularweight solute by P_(TM) was 146.5 mm Hg(1 mm Hg=0.133 k Pa).CONCLUSIONS:The filter can be used as long as possible within the manufacturer’s safe use time limits to remove small-molecular-weight solutes.P_(TM) of 146.5 mm Hg may be an optimal indicator for changing the filter in CRRT therapies to remove medium-molecular-weight solutes.

关键词： Acute kidney injury Continuous renal replacement therapy Solute removal efficiency Delivered dose

Designed synthesis of cobalt-oxide-based nanomaterials for superior electrochemical energy storage devices

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Nano Research 2015年第2期8卷 321-339页

作者： Hua-jun Qiu li liu Yan-Ping Mu Hui-Juan Zhang Yu Wang School of Chemistry and Chemical Engineering Changqing University Chongqing 400044 China

Cobalt oxides, such as C0304 and CoO, have received increasing attention as potential anode materials for rechargeable lithium-ion batteries （liBs） owing to their high theoretical capacity. Nanostructure engineering has been demonstrated as an effective approach to improve the electrochemical performance of electrode materials for liBs. In this review, we summarize recent developments in the rational design and fabrication of various cobalt oxide-based nanomaterials and their lithium storage performance, including 1D nanowires/belts, 2D nanosheets, 3D hollow/hierarchical structures, hybrid nanostructures with carbon （amorphous carbon, carbon nanotubes and graphene） and mixed metal oxides. By focusing on the effects of their structure on their electrochemical performance, effective strategies for the fabrication of cobalt oxide/carbon hybrid nanostructures are highlighted. This review shows that by rational design, such cobalt-oxide-based nanornaterials are very promising as next generation liB anodes.

关键词： lithium ion battery hybrid peapod structure graphene

Comparison of the autofluorescence bronchoscope and the white light bronchoscope in airway examination

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Chinese Journal of Cancer 2010年第12期29卷 1018-1022页

作者： Yun li Xiao li Xi-Zhao Sui liang Bu Zu-li Zhou Fan Yang Yan-Guo liu Hui Zhao Jian-Feng li jun liu Guan-Chao Jiang jun Wang Department of Thoracic Surgery People's Hospital Peking University Beijing 100044 P. R. China

Background and Objective: The sensitivity and accuracy of white light bronchoscopy (WLB) in airway examination are low. Autofluorescence bronchoscope (AFB) can determine early lesions in bronchial mucosa more sensitively, but it has seldom performed in China. To assess the clinical value of the AFB in airway examination, we compared the sensitivity and specificity of the AFB and WLB in detecting cancer of the airway mucosa. Methods: Between September 2009 and May 2010, bronchoscope examinations using both the AFB and WLB were performed on 136 patients, 95 men and 41 women with a median age of 61.5 years (ranged from 25 to 84 years). There were 46 lesions located in the central airway, 84 in the peripheral lung parenchyma, and 6 in the mediastinal region. All patients received local and general anesthesia and were subsequently examined with the WLB and AFB in tandem. All procedures were completed safely. Abnormal visual findings were recorded, and biopsies of the affected regions were collected for pathologic examination. Results: Of 241 regions sampled for biopsy, 76 sites contained malignant lesions, whereas 165 sites contained benign lesions. The AFB detected 72 of the 76 malignant lesions, but the WLB detected only 50. The sensitivities of the AFB and WLB were 94.7% and 65.8%, respectively, and the specificities were 57.0% and 83.6%, respectively. The negative predictive values of the AFB and WLB were 95.9% and 84.1%, respectively. Conclusions: The AFB is more sensitive than the WLB in detecting cancerous lesions in the mucosa, and is an effective airway examination.

关键词：病理检查支气管气道萤光自体检测灵敏度空军基地色光

Blood compatibility of zinc-calcium phosphate conversion coating on Mg-1.33li-O.6Ca alloy

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Frontiers of Materials Science 2016年第3期10卷 281-289页

作者： Yu-Hong ZOU Rong-Chang ZENG Qing-Zhao WANG li-jun liu Qian-Qian XU Chuang WANG Zhi-Wei liu College of Chemical and Environmental Engineering Shandong University of Science and Technology Qingdao 266590 China College of Materials Science and Engineering Shandong University of Science and Technology Qingdao 266590 China Hospital of Shandong University of Science and Technology Qingdao 266590 China State Key Laboratory of Mining Disaster Prevention and Control Co-founded by Shandong Province and the Ministry of Science and Technology Shandong University of Science and Technology Qingdao 266590 China

Magnesium alloys as a new class of biomaterials possess biodegradability and biocompatibility in comparison with currently used metal implants. However, their rapid corrosion rates are necessary to be manipulated by appropriate coatings. In this paper, a new attempt was used to develop a zinc-calcium phosphate （Zn-Ca-P） conversion coating on Mg-1.33li-0.6Ca alloys to increase the biocompatibility and improve the corrosion resistance. In vitro blood biocompatibility of the alloy with and without the Zn-Ca-P coating was investigated to determine its suitability as a degradable medical biomaterial. Blood biocompatibility was assessed from the hemolysis test, the dynamic cruor time test, blood cell count and SEM observation of the platelet adhesion to membrane surface. The results showed that the Zn-Ca-P coating on Mg-1.33li-0.6Ca alloys had good blood compatibility, which is in accordance with the requirements for medical biomaterials.

关键词： magnesium alloy lithium biomaterial biocompatibility zinc-calciumphosphate coating

Corrosion Resistance of Silane-Modified Hydroxide Zinc Carbonate Film on AZ31 Magnesium Alloy

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Acta Metallurgica Sinica(English Letters) 2015年第3期28卷 373-380页

作者： Rong-Chang Zeng li-jun liu Ting-Ting Pang Fen Zhang Wei-Wei Zhang Shuo-Qi li Hong-Zhi Cui En-Hou Han College of Materials Science and Engineering Shandong University of Science and Technology State Key Laboratory of Mining Disaster Prevention and Control Co-founded by Shandong Province and the Ministry of Science and Technology Shandong University of Science and Technology Institute of Metals Research Chinese Academy of Sciences

The corrosion resistance of magnesium alloys can be improved using functional surface modification such as hydrophobic *** this study,a hierarchical hydroxide zinc carbonate（HZC） film was fabricated on AZ31 magnesium alloy via a simple chemical-bath deposition process using urea aqueous *** morphologies,compositions and corrosion resistance of the hydrophobic film were analyzed using scanning electron microscopy,X-ray diffraction and Fourier transform infrared spectrometer,and electrochemical measurements as *** results revealed that the HZC film displayed flower-like protrusions and had a thickness of approximately 100 *** fluoroalkylsilane（FAS）-modified HZC film exhibited a hydrophobic property with a water contact angle of 131.3°.The FAS/HZC film significantly improved the corrosion resistance of the AZ31 alloy due to hierarchical structures and hydrophobic modification.

关键词： Magnesium alloy Hydrophobicity Silane Surface modification Corrosion

Pretreatment serum albumin-to-alkaline phosphatase ratio is an independent prognosticator of survival in patients with metastatic gastric cancer

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World Journal of Gastrointestinal Oncology 2022年第5期14卷 1002-1013页

作者： Yu-Ting li Xiao-Shu Zhou Xiao-Ming Han Jing Tian You Qin Tao Zhang jun-li liu Cancer Center Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022Hubei ProvinceChina Department of Ultrasound Medicine Jingmen Second People’s HospitalJingchu University of Technology Affiliated Central HospitalJingmen 448000Hubei ProvinceChina Department of Oncology Hubei Cancer HospitalThe Seventh Clinical School Affiliated of Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430000Hubei ProvinceChina

BACKGROUND Previous studies have suggested that a low albumin-to-alkaline phosphatase ratio(AAPR)is associated with a lower survival rate in patients with various ***,the relationship between pretreatment AAPR and the prognosis of patients with gastric cancer(GC)remains *** To investigate the prognostic value of AAPR in distant metastatic *** A total of 191 patients with distant metastatic cancer from a single institute were enrolled in this *** clinical data,including serum albumin and alkaline phosphatase levels,were collected.A chi-square test or Fisher’s exact test was applied to evaluate the correlations between AAPR and various clinical parameters in GC *** Kaplan-Meier method and Cox proportional hazards regression model were used to evaluate the prognostic efficacy of AAPR in metastatic GC patients.A two-sided P value lower than 0.05 was considered statistically *** A receiver operating characteristic curve indicated that 0.48 was the optimal threshold value for ***≤0.48 was significantly associated with bone(Pliver metastasis(Pliver/bone *** AAPR was found to be a favorable predictor of OS and PFS based on a multivariate cox regression ***-M system,constructed based on AAPR and number of metastatic sites,showed superior predictive ability relative to the number of metastatic sites for predicting *** Pretreatment AAPR may serve as an independent prognostic factor for predicting PFS and OS in patients with metastatic ***,AAPR may assist clinicians with individualizing treatment.

关键词： Albumin-to-alkaline phosphatase ratio Gastric cancer overall survival Progression-free survival

Risk assessment,fitness cost,cross-resistance,and mechanism of tetraniliprole resistance in the rice stem borer,Chilo suppressalis

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Insect Science 2024年第3期31卷 835-846页

作者： Hao Sun Shuai Wang Chong liu Wen-Kai Hu Jin-Wei liu ling-jun Zheng Meng-Yue Gao Fang-Rui Guo Song-Tao Qiao jun-li liu Bo Sun Cong-Fen Gao Shun-Fan Wu College of Plant Protection Nanjing Agricultural UniversityState&Local Joint Engineering Research Center of Green Pesticide Invention and ApplicationNanjingChina Bayer Cropscience(China)Co. Ltd.HangzhouChina

The rice stem borer(RSB),Chilo suppressalis,a notorious rice pest in China,has evolved a high resistance level to commonly used ***,a new anthranilic diamide insecticide,effectively controls multiple pests,including ***,the potential resistance risk of RSB to tetraniliprole is still *** this study,the tetraniliprole-selection(Tet-R)strain was obtained through 10 continuous generations of selection with tetraniliprole 30%lethal concentration(LC_(30)).The realized heritability(h^(2))of the Tet-R strain was 0.387,indicating that resistance of RSB to tetraniliprole developed rapidly under the continuous selection of *** Tet-R strain had a high fitness cost(relative fitness=0.53).We established the susceptibility baseline of RSB to tetraniliprole(lethal concentration at LC_(50)=0.727 mg/L)and investigated the resistance level of 6 field populations to *** tested strains that had resistance to chlorantraniliprole exhibited moderate-to high-level resistance to tetraniliprole(resistance ratio=27.7-806.8).Detection of ryanodine receptor(RyR)mutations showed that the Y4667C,Y4667D,I4758M,and Y4891F mutations were present in tested RSB field *** mutations were responsible for the cross-resistance between tetraniliprole and ***,the clustered regularly interspaced palindromic repeats(CRISPR)/CRISPR-associated protein 9-mediated genome-modified flies were used to study the contribution of RyR mutations to tetraniliprole *** order of contribution of a single RyR mutation to tetraniliprole resistance was Y4667D>G4915E>Y4667C~~I4758M>*** addition,the I4758M and Y4667C double mutations conferred higher tetraniliprole resistance than single Y4667C *** results can guide resistance management practices for diamides in RSB and other arthropods.

关键词： Chilo suppressalis diamide resistance fitness cost cross-resistance RyR target-site mutations