Pretreatment serum albumin-to-alkaline phosphatase ratio is an independent prognosticator of survival in patients with metastatic gastric cancer
作者机构：Cancer CenterUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022Hubei ProvinceChina Department of Ultrasound MedicineJingmen Second People’s HospitalJingchu University of Technology Affiliated Central HospitalJingmen 448000Hubei ProvinceChina Department of OncologyHubei Cancer HospitalThe Seventh Clinical School Affiliated of Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430000Hubei ProvinceChina
出 版 物：《World Journal of Gastrointestinal Oncology》 (世界胃肠肿瘤学杂志（英文版）（电子版）)
年 卷 期：2022年第14卷第5期
页 面：1002-1013页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Albumin-to-alkaline phosphatase ratio Gastric cancer overall survival Progression-free survival
摘 要：BACKGROUND Previous studies have suggested that a low albumin-to-alkaline phosphatase ratio(AAPR)is associated with a lower survival rate in patients with various ***,the relationship between pretreatment AAPR and the prognosis of patients with gastric cancer(GC)remains *** To investigate the prognostic value of AAPR in distant metastatic *** A total of 191 patients with distant metastatic cancer from a single institute were enrolled in this *** clinical data,including serum albumin and alkaline phosphatase levels,were collected.A chi-square test or Fisher’s exact test was applied to evaluate the correlations between AAPR and various clinical parameters in GC *** Kaplan-Meier method and Cox proportional hazards regression model were used to evaluate the prognostic efficacy of AAPR in metastatic GC patients.A two-sided P value lower than 0.05 was considered statistically *** A receiver operating characteristic curve indicated that 0.48 was the optimal threshold value for ***≤0.48 was significantly associated with bone(P0.05)and liver metastasis(P0.05).Patients with high levels of AAPR had better survival in terms of overall survival(OS)and progression-free survival(PFS),regardless of the presence of liver/bone *** AAPR was found to be a favorable predictor of OS and PFS based on a multivariate cox regression ***-M system,constructed based on AAPR and number of metastatic sites,showed superior predictive ability relative to the number of metastatic sites for predicting *** Pretreatment AAPR may serve as an independent prognostic factor for predicting PFS and OS in patients with metastatic ***,AAPR may assist clinicians with individualizing treatment.
维普期刊数据库