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首届东方药理论坛暨2018年全国心脑血管药理学术会议、上海市药理学会第十九届学术年会

作者： Wen ZHANG jun-ke song Guan-hua DU Beijing key Laboratory of Drug Target Identification and Drug Screening Institute of Materia MedicaChinese Academy of Medical Sciences & Peking Union Medical College

The middle cerebral artery occlusion/reperfusion injury model in rats and oxygen-glucose deprivation/reoxygenation injury model in PC12 cells were established to study the therapeutic effect and mechanism of salvianolic acids for injection(SAFI).The results showed that SAFI could significantly reduce the cerebral infarct volume in rats with cerebral ischemia reperfusion and reduce the symptoms of neurological ***,SAFI could activate the PI3 K/Akt and JAK2/STAT3 signaling pathways in neurons,significantly increase the phosphorylation levels of PI3 K,Akt,JAK2,STAT3,inhibit neuronal apoptosis,and improve the tissue morphology and neuron *** significantly inhibited the expression of pro-apoptotic protein Bax,promoted the expression of anti-apoptotic protein Bcl-2,reduced the release of Cytochrome C,and inhibit the activation of Caspase 3 to exert cytoprotection *** vitro PC 12 cells injury model,SAFI significantly increased the survival rate of PC12 cells,inhibited cell apoptosis,decreased the expression of pro-apoptotic protein Bax,and increased the expression of anti-apoptotic protein *** also significantly promoted the phosphorylation of Akt and STAT3 in PC12 ***,the PI3 K specific inhibitor LY294002 or JAK2 specific AG490 treatment partially inhibited the protective effect of SAFI on PC 12 cells individually,but when both LY294002 and AG490 inhibitors were added for co-incubation,the protective effect of SAFI was completely *** above results indicated that SAFI exerted anti-cerebral ischemia reperfusion injury effect through the activation of PI3 K/Akt and JAK2/STAT3 pathways.

关键词： salvianolic acids for injection network pharmacology cerebral ischemia-reperfusion PI3K/Akt JAK2/STAT3

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Molecular Characterization of Cryptosporidium *** Pre-Weaned Calves in Shaanxi Province,Northwestern China

Molecular Characterization of Cryptosporidium *** Pre-Weaned...

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中国畜牧兽医学会兽医寄生虫学分会第十三次学术研讨会

作者： Xue-ting Wang San-ke Yu Qin Lin jun-ke song Long-xian Zhang Rong-jun Wang Guang-hui Zhao College of Veterinary Medicine Northwest A&F University College of Animal Science and Veterinary Medicine Henan Agricultural University

Cryptosporidium,a worldwide protozoan parasite,is one of the most common causes of diarrhea for humans and *** aim of the present study was to determine Cryptosporidium species/genotypes in pre-weaned calves in Shaanxi Province using PCR and sequencing based on small subunit ribosomal RNA(SSU rRNA) gene.A total of 258 fecal samples were collected from pre-weaned calves in 19 different farms of six areas in Shaanxi Province,Northwestern *** infection was detected in 14 of 19farms(73.7%),with the total prevalence of 20.2%(52/258).Both dairy and Qinchuan(beef) cattle were found with Cryptosporidium *** Cryptosporidium species,namely ***(n=26),***(n=14)and ***(n=12),were detected in pre-weaned calves in Shaanxi province,with ***(in 12 of farms)as the most common species in cattle *** additional previously unknown *** genotypes CRType Ⅲ and Ⅳ were observed in the present ***,the zoonotic species,***,was not detected in this study,which suggested a low zoonotic potential in Cryptosporidium infected pre-weaned calves in this province.

关键词： Cryptosporidium spp. Cattle Shaanxi province Subtype

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Expression dynamics of anaphylatoxin C3a and C5a in Cryptosporidium parvum infecting Mice

Expression dynamics of anaphylatoxin C3a and C5a in Cryptosp...

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中国畜牧兽医学会兽医寄生虫学分会第十三次学术研讨会

作者： Qing Lin Ya-Xu Guo Yan-Qin Fang Fei Wu Xue-Ting Wang San-ke Yu jun-ke song Guang-Hui Zhao Department of Parasitology College of Veterinary MedicineNorthwest A&F University

Cryptosporidium parvum is the most important common enteropathogen inhabiting in many *** of *** in immunocompetent livestock are commonly asymptomatic or self-limited,but it can be life-threaten in immunocomprised or immunodeficent ***,there have been no efficient treatment and prevention measures to control cryptosporidiosis currently and better understanding of the immune response to this parasite is *** anaphylatoxins were throught to be potent proinflammatory mediators among complement activation *** a pivotal part of innate immunity,complement can be triggered via three pathways and product anaphylatoxin which can cause a variety of biological *** order to evaluate the role of anaphylatoxins during Cryptosporidium parvum infection,a curtain number of BABL/c mice were inoculated orally with 1×10 *** oocysts and real-time quantitative PCR(qPCR) were used to exam the expression levels of the C3 a,C5a and their receptors(C3aR and C5aR) in ***-infected *** of C3 a in small intestine showed mRNA level of C3 a was elevated at 48 h pi,peaking at 7d pi,while C3 aR expression increased as early as 6h pi compared with control mice,with a peak at 24 h pi and continuously enhanced at 48 h *** of them were even up-regulated after clearance of parasites(21d pi).In spleen,C3 a and C3 aR were synchronous intensified at 6h pi,12 h pi,7d pi and 21 d *** in small intestine,C5 a were up-regulated at 6h pi,and sustaining elevated at 24 h pi,peaking at 48 h *** the mine time,accelerated expression of C5 aR was also observed at 6h pi,with a peak at 24 h *** spleen,C5 a lifting expression at 6h pi,and with a peak at 72 h *** C5 aR were enhanced at12 h pi,peaking at 14 d *** line of these datas,there is hypothesis that anaphylatoxins may play a contribution role to against *** obtained results could serve as guidelines for future studies on the immunologic mechanism to *** in

关键词： Cryptosporidium parvum anaphylatoxin spleen small intestine quantitative real-time PCR

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Genetic variability among Dicrocoelium dendriticum isolates from different regions in Shaanxi Province,China revealed by sequences of three mitochondrial genes

Genetic variability among Dicrocoelium dendriticum isolates ...

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中国畜牧兽医学会兽医寄生虫学分会第十三次学术研讨会

作者： Ya-xu Guo Qing-qing Bian Yan-qin Fang Fei Wu Xue-ting Wang San-ke Yu jun-ke song Qing Lin Guang-Hui Zhao Department of Parasitology College of Veterinary MedicineNorthwest A&F University

The genetic variations in three mitochondrial DNA(mtDNA) regions,namely portion of cytochrome c oxidase subunit 1(pcox1),NADH dehydrogenase subunit 1(pnad1) and cytochrome b(pcytb),were examined for Dicrocoelium dendriticum samples isolated from different origins in Shaanxi province,northwestern *** intra-specific sequence differences within *** samples were 0-0.52%for pcox1,0-0.73%for pnad1,and 0-0.58%for *** analyses based on combined sequences of three mtDNA showed that all *** samples were clustered together in same clade of Paragonimus *** the phylogenetic trees could not revealed geographically genetic relationships of *** isolates in this *** findings will provide basic information for further study of molecular epidemiology and control of *** infection in this province as well as in China.

关键词： Dicrocoelium dendriticum genetic variation mitochondrial DNA phylogenetic analysis

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Serum metabolomics in chickens infected with Cryptosporidium baileyi

Serum metabolomics in chickens infected with Cryptosporidium...

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2021中国畜牧兽医学会兽医寄生虫学分会第二届青年科学家学术论坛

作者： Xue-Mei Wu Xin Yang Xian-Cheng Fan Xi Chen Yu-Xin Wang Long-Xian Zhang jun-ke song Guang-Hui Zhao

Cryptosporidium baileyi is an important zoonotic pathogen causing serious respiratory symptoms in chickens,but no effective measures are available to control *** ***,increasing evidence indicates the novelty and usefulness of metabolomics to understand interaction between pathogens and hosts,and to search new diagnostic or pharmacological biomarkers of complex *** present study aimed to reveal the impact of *** infection on the serum metabolism of chickens,and to search several metabolites as potential diagnostic biomarkers for *** *** the present study,the ultra performance liquid chromatography-mass spectrometry(UPLC-MS) and subsequent multivariate statistical analysis were applied to investigate the metabolomics profiles in the serum samples of chickens infected with ***,and to identify potential metabolites that can be used to distinguish chickens infected with *** from non-infected *** statistics identified 138 differential serum metabolites between mock and infected chickens at 5 days post infection(dpi),including 115 up-regulated and 23 down-regulated *** metabolites were significantly enriched into 6 pathways,and 2 pathways associated with energy and lipid metabolism were the most enriched,namely glycerophospholipid metabolism and sphingolipid ***,some important immune-related pathways were also significantly enriched,including intestinal immune network for IgA production,autophagy,and cellular ***,9 potential *** responsive metabolites were identified,including choline,sirolimus,all-trans-Retinoic acid,PC(14:0/22:1(13 Z)),PC(15:0/22:6(4 Z,7 Z,10 Z,13 Z,16 Z,19 Z)),PE(16:1(9 Z)/24:1(15 Z)),phosphocholine,SM(d18:0/16:1(9 Z)(OH)) and *** is the first report on serum metabolic profilings of chickens during *** early infection,and the findings in the present study provide novel insights for revealing pathop

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Circular RNA CiRS-7 promotes propagation of Cryptosporidium parvum in HCT-8 cells via sponging miR-1270 to active NF-κB signaling pathway

Circular RNA CiRS-7 promotes propagation of Cryptosporidium ...

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2021中国畜牧兽医学会兽医寄生虫学分会第16次学术研讨会

作者： Yan-Ling Yin Ting-Li Liu Qian Yao Yu-Xin Wang Xue-Mei Wu Xue-Ting Wang Xin Yang jun-ke song Guang-Hui Zhao

Cryptosporidium parvum is an important zoonotic pathogen responsible for severe enteric diseases in humans and ***,the underly molecular mechanisms of Cryptosporidium infection are not *** studies confirmed that *** can alternate the expression of ncRNAs(e.g.,long non-coding RNAs and micro RNAs) of hosts during infection,and some of these ncRNAs played a vital role in regulating cellular responses to Cryptosporidium *** this study,we found that *** infection caused great alterations of the expression profiles of circRNAs in HCT-8 *** them,the significantly up-regulated ciRS-7 was chosen for further *** starBase v2.0 database and luciferase reporter assays,we predicted and verified that ciRS-7 sponged miR-1270 and miR-1270 targeted ***-PCR and western blot assays revealed that *** infection decreased miR-1270 expression,while induced RelA ***,we confirmed that ciRS-7 may act as a ceRNA to relieve miR-1270-mediated suppression on RelA in HCT-8 cells following *** ***,the upregulation of ciRS-7 was involved in enhancing the expression of NF-κB signal downstream molecules of NOS2 and CXCL2,while miR-1270 mimics attenuated the ***,overexpression of ciRS-7 promoted the parasite burden,while induction of miR-1270 could reverse the effect of ciRS-7 on parasite *** conclusion,our results unveiled that ciRS-7 was beneficial to *** proliferation via regulating miR-1270/RelA axis and activating the NF-κB signal pathway.

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Synthesis of Thio α-Aminoxy Acid Peptides

Synthesis of Thio α-Aminoxy Acid Peptides

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中国化学会第四届有机化学学术会议

作者： YANG,Dan LIU, Guo-jun song, ke-Sheng LUO, Zheng ZHANG, Dan-Wei (Department of Chemistry, Fudan University, Shanghai 200433) (Department of Chemistry, The University of Hong Kong, Hong Kong)

＜正＞The right-handed turns with eight-membered-ring intramolecular hydrogen bonds between adjacent residues （called the N-O turns, like γ-turns） were preferred for D-α-aminoxy acid residues, and they were independent of the side chains. Seebach et al. introduced thioamide into the β-peptides and got a novel secondary structure. It was reported that thioamide was not a good hydrogen bond acceptor, but a better donor than regular amide.3 We

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Photothermal probiotics delivery of photodynamic agents for enhanced immunogenic cell death within hypoxia center of solid tumors

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Nano Research 2025年第1期18卷 642-652页

作者： Wen Luo Shiyu Du Yateng Jiang Bangshun He jun Tang Jingjing Yang Yujun song Jiangsu key Laboratory of Artificial Functional Materials State Key Laboratory of Analytical Chemistry for Life ScienceNational Laboratory of Solid State MicrostructuresCollege of Engineering and Applied SciencesNanjing UniversityNanjing 210023China Department of Laboratory Medicine Nanjing First HospitalNanjing Medical UniversityNanjing 210006China Department of Anesthesiology Jinling HospitalMedical School of Nanjing UniversityNanjing 210000China Department of Biochemistry and Molecular Biology School of Medicine&Holistic Integrative MedicineJiangsu Collaborative Innovation Center of Chinese Medicinal Resources IndustrializationNanjing University of Chinese MedicineNanjing 210023China

Resulting from harsh hypoxic environmental conditions,central cells in the core of solid tumors are usually more aggressive and malignant with a less stable ***,therapeutic agents with improved penetration for the activation of immunity in tumor centers exhibit promising potential in ***,polydopamine-coated Escherichia coli Nissle 1917(EcN)bearing chlorin e6(Ce6)-loaded and polyethyleneimine(PEI)-coated hollow manganese dioxide(shorted as EP-ChP)are applied for enhanced immunotherapy in deep *** accumulation in tumor center through hypoxia targeting,manganese dioxide is degradated under the tumor microenvironment with released Ce6 and thus generates reactive oxygen species(ROS)upon 660 nm laser irradiation,which can further lower thermalresistance of cancer cells via HSP90α*** to that,heating induced by polydopamine upon 808 nm laser irradiation can achieve effective tumor *** upon dual laser induces enhanced immunogenic cell death,while bacterial infections in tumor tissues also trigger innate *** bacteria-based approach provides enhanced antitumor immune responses in deep tumors with great potential in the reshaping of immunosuppression tumor microenvironment.

关键词： bacteria phototherapies immunotherapy hypoxia targeting tumor penetration

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Extramedullary plasmacytoma with the uvula as first affected site:A case report

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World Journal of Clinical Oncology 2025年第1期16卷 53-58页

作者： Jing Yang Hui Peng Sheng-ke Tu Min Li Kui song Department of Hematology The First Affiliated Hospital of Jishou UniversityJishou 416000Hunan ProvinceChina Department of Pharmacy The First Affiliated Hospital of Jishou UniversityJishou 416000Hunan ProvinceChina

BACKGROUND Extramedullary plasmacytoma(EMP)represents one of the rarer forms of plasma cell malignancies,capable of impacting a variety of tissues and organs throughout the *** majority of EMP cases are predominantly found in the head and neck region,especially within the laryngopharynx,as well as in the gastrointestinal *** there have been documented instances of oropharyngeal involvement in EMP cases in the academic literature,it is important to note that EMP specifically affecting the uvula is exceedingly ***,it is noteworthy that over 60% of epithelial carcinomas in the upper respiratory tract and oropharynx tend to metastasize to the cervical lymph nodes,indicating a propensity for regional spread in these types of *** this context,we present a rare case of extramedullary plasmacytoma where the uvula served as the initially affected *** case emphasizes the need for heightened awareness among clinicians regarding such unusual comorbidities,as early recognition and diagnosis can significantly influence patient management and treatment *** addition,a review of the relevant literature is included to further educate and inform healthcare professionals about this rare presentation,ultimately aiming to enhance clinical understanding and improve patient care in similar *** SUMMARY A 51-year-old man was admitted to our hospital because of a slowly enlarging neck mass.A physical examination revealed a palpable left lymph node,and magnetic resonance imaging(MRI)of the oropharynx and the neck showed a soft tissue mass in the oropharynx and enlargement of multiple lymph nodes in the *** soft tissue mass was diagnosed as plasmacytoma by immunohistochemical *** immunoglobulins and bone marrow biopsy showed normal ***,we diagnosed that as EMP of the *** four cycles of adjuvant chemotherapy dominated by bortezomib,MRI reexamination showed a significant reduction of the mass

关键词： Extramedullary plasmacytoma Plasmacytoma Uvula Multiple myeloma Case report

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Hypoxia-preconditioned bone marrow-derived mesenchymal stem cells protect neurons from cardiac arrest-induced pyroptosis

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Neural Regeneration Research 2025年第4期20卷 1103-1123页

作者： Xiahong Tang Nan Zheng Qingming Lin Yan You Zheng Gong Yangping Zhuang Jiali Wu Yu Wang Hanlin Huang jun ke Feng Chen Shengli Clinical Medical College of Fujian Medical University Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Emergency Fujian Provincial HospitalFuzhouFujian ProvinceChina Fujian Provincial key Laboratory of Emergency Medicine FuzhouFujian ProvinceChina The Second Department of Intensive Care Unit Fujian Provincial Hospital South BranchFuzhouFujian ProvinceChina

Cardiac arrest can lead to severe neurological impairment as a result of inflammation,mitochondrial dysfunction,and post-cardiopulmonary resuscitation neurological *** preconditioning has been shown to improve migration and survival of bone marrow–derived mesenchymal stem cells and reduce pyroptosis after cardiac arrest,but the specific mechanisms by which hypoxia-preconditioned bone marrow–derived mesenchymal stem cells protect against brain injury after cardiac arrest are *** this end,we established an in vitro co-culture model of bone marrow–derived mesenchymal stem cells and oxygen–glucose deprived primary neurons and found that hypoxic preconditioning enhanced the protective effect of bone marrow stromal stem cells against neuronal pyroptosis,possibly through inhibition of the MAPK and nuclear factor κB ***,we transplanted hypoxia-preconditioned bone marrow–derived mesenchymal stem cells into the lateral ventricle after the return of spontaneous circulation in an 8-minute cardiac arrest rat model induced by *** results showed that hypoxia-preconditioned bone marrow–derived mesenchymal stem cells significantly reduced cardiac arrest–induced neuronal pyroptosis,oxidative stress,and mitochondrial damage,whereas knockdown of the liver isoform of phosphofructokinase in bone marrow–derived mesenchymal stem cells inhibited these *** conclude,hypoxia-preconditioned bone marrow–derived mesenchymal stem cells offer a promising therapeutic approach for neuronal injury following cardiac arrest,and their beneficial effects are potentially associated with increased expression of the liver isoform of phosphofructokinase following hypoxic preconditioning.

关键词： bone marrow–derived mesenchymal stem cells cardiac arrest cardiac resuscitation hypoxic preconditioning liver isoform of phosphofructokinase mitochondria neuroinflammation oxidative stress pyroptosis reactive oxygen species

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