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Granulomatous prostatitis after bacille Calmette-Guérin instillation resembles prostate carcinoma:A case report and review of the literature

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World Journal of Clinical Cases 2023年第9期11卷 2051-2059页

作者： Yu Yao jun-jie ji Hai-Yun Wang Li-jiang Sun Gui-Ming Zhang Department of Urology The Affiliated Hospital of Qingdao UniversityQingdao 266003Shandong ProvinceChina

BACKGROUND Bacille Calmette-Guérin(BCG)instillation is recommended in patients with nonmuscle-invasive bladder cancer who have intermediate-risk and high-risk ***,granulomatous prostatitis is a rare complication induced by BCG instillation,which can easily be misdiagnosed as prostate ***,we report a case of granulomatous prostatitis that resembled prostate *** SUMMARY A 64-year-old Chinese man with bladder cancer received BCG *** days later,he stopped BCG instillation and received anti-infective therapy due to the urinary tract *** months after BCG restart,he had rising total prostate-specific antigen(PSA)(9.14 ng/mL)and decreasing free PSA/total PSA(0.09).T2-weighted images of magnetic resonance imaging(MRI)showed a 28 mm×20 mm diffuse low signal abnormality in the right peripheral zone,which was markedly hyperintense on high b-value diffusion-weighted MRI and hypointense on apparent diffusion coefficient map *** Prostate Imaging Reporting and Data System score of 5 and possibility of prostate cancer,a prostate biopsy was *** showed typical features of granulomatous *** nucleic acid test for tuberculosis was *** was finally diagnosed with BCG-induced granulomatous ***,he stopped BCG instillation and received anti-tuberculosis *** 10 mo follow-up,he had no evidence of tumor recurrence or symptoms of *** Temporarily elevated PSA and high followed by low signal abnormality on diffusion-weighted MRI are important indicators of BCG-induced granulomatous prostatitis.

关键词： Granulomatous prostatitis Prostate cancer Bacille Calmette-Guérin Magnetic resonance imaging Prostate-specific antigen Case report

Structural engineering of high-entropy alloys for advanced electrocatalytic reactions

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Tungsten 2025年第1期7卷 1-31页

作者： Qiao Xie Ying-jie Yu Hai-jun Zhang Ya-Ping Deng Wen Lei The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and Technology Department of Chemical Engineering Waterloo Institute for Sustainable Energy Waterloo Institute for Nanotechnology University of Waterloo

High-entropy alloys(HEAs) have emerged as promising candidates to replace traditional precious metal catalysts,owing to their unique chemical and physical *** review commences by revisiting the fundamental concepts of HEAs,including their synthesis methods and structural control strategies in *** underscores the critical role of meticulously manipulating both macroscopic and microscopic structures of the HEAs to optimize their catalytic performance.A deep understanding of the structure-activity relationship in HEAs across various configurations is pivotal in developing more effective *** review methodically encapsulates the research progress of structural control strategies for HEAs in achieving efficient energy conversion,with the aim of gaining a better understanding of the relationship between structure and *** review concludes by summarizing the current achievements and challenges,and suggestions for potential future directions of HEAs in the fields of energy conversion and environmental purification.

关键词： Electrocatalytic Energy conversion High-entropy alloys Structural modulation

High‑Entropy Electrode Materials:Synthesis,Properties and Outlook

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Nano-Micro Letters 2025年第1期17卷 472-506页

作者： Dongxiao Li Chang Liu Shusheng Tao jieming Cai Biao Zhong jie Li Wentao Deng Hongshuai Hou Guoqiang Zou Xiaobo ji College of Chemistry and Chemical Engineering Central South UniversityChangsha 410083People’s Republic of China School of Chemistry and Chemical Engineering Hunan Institute of EngineeringXiangtan 411104People’s Republic of China

High-entropy materials represent a new category of high-performance materials,first proposed in 2004 and extensively investigated by researchers over the past two *** definition of high-entropy materials has continuously *** the last ten years,the discovery of an increasing number of high-entropy materials has led to significant advancements in their utilization in energy storage,electrocatalysis,and related domains,accompanied by a rise in techniques for fabricating high-entropy electrode ***,the research emphasis has shifted from solely improving the performance of high-entropy materials toward exploring their reaction mechanisms and adopting cleaner preparation ***,the current definition of high-entropy materials remains relatively vague,and the preparation method of high-entropy materials is based on the preparation method of single metal/low-or medium-entropy *** should be noted that not all methods applicable to single metal/low-or medium-entropy materials can be directly applied to high-entropy *** this review,the definition and development of high-entropy materials are briefly ***,the classification of high-entropy electrode materials is presented,followed by a discussion of their applications in energy storage and catalysis from the perspective of synthesis ***,an evaluation of the advantages and disadvantages of various synthesis methods in the production process of different high-entropy materials is provided,along with a proposal for potential future development directions for high-entropy materials.

关键词： High-entropy Energy storage Electrode materials

Evapotranspiration and its components partitioning based on an improved hydrological model: historical attributions and future projections

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Journal of Earth Science 2025年

作者： Hong Du Sidong Zeng Yongyue ji jun Xia College of Resources and Environmental Science， South-Central Minzu University Chongqing Institute of Green and Intelligent Technology， Chinese Academy of Sciences Chongqing School， University of Chinese Academy of Sciences State Key Laboratory of Water Resources and Hydropower Engineering Science， Wuhan University

Estimation and attribution of evapotranspiration （ET） and its components under changing environment is still a challenge but is essential for understanding the mechanisms of water and energy transfer subsequently regional water resources management. In this study， an improved hydrological model is developed to estimate evapotranspiration and its components i.e.， evaporation （E） and transpiration （T） by integrated the advantages of hydrological modeling constrained by water balance and the water-carbon close relationships. Results show that the improved hydrological model could captures ET and its components well in the study region. During the past years， annual ET and E increase obviously about 2.40mm/a and 1.42mm/a， particularly in spring and summer accounting for 90%. T shows less increasement and mainly increases in spring while it decreases in summer. Precipitation is the dominant factor and contributes 74.1% and 90.0% increases of annual ET and E， while the attribution of T changes is more complex by coupling of the positive effects of precipitation， rising temperature and interactive influences， the negative effects of solar diming and elevated CO2. In the future， ET and its components tend to increase under most of the Shared Socioeconomic Pathways （SSP） scenarios except for T decreases under the very high emissions scenario （SSP5-8.5） based on the projections. From seasonal perspective， the changes of ET and the components are mainly in spring and summer accounting for 75%， while more slightly changes are found in autumn and winter. This study highlights the effectiveness of estimating ET and its components by improving hydrological model within water-carbon coupling relationships， and more complex mechanisms of transpiration changes than evapotranspiration and evaporation changes under the interactive effects of climate variability and vegetation dynamics. Besides， decision makers should pay attention to the more increases in the undesirable E than desirab

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Nanomaterials-mediated lysosomal regulation:a robust protein-clearance approach for the treatment of Alzheimer’s disease

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Neural Regeneration Research 2025年第2期20卷 424-439页

作者： Mengqi Hao jianjian Chu Tinglin Zhang Tong Yin Yuankai Gu Wendanqi Liang Wenbo ji jianhua Zhuang Yan Liu jie Gao You Yin Department of Neurology Second Affiliated Hospital of Naval Medical University(Shanghai Changzheng Hospital)ShanghaiChina School of Health Science and Engineering University of Shanghai for Science and TechnologyShanghaiChina Changhai Clinical Research Unit Shanghai Changhai HospitalNaval Medical UniversityShanghaiChina Department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Neurology Shanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina

Alzheimer’s disease is a debilitating,progressive neurodegenerative disorder characterized by the progressive accumulation of abnormal proteins,including amyloid plaques and intracellular tau tangles,primarily within the ***,crucial intracellular organelles responsible for protein degradation,play a key role in maintaining cellular *** studies have suggested a link between the dysregulation of the lysosomal system and pathogenesis of neurodegenerative diseases,including Alzheimer’s *** the normal physiological function of lysosomes hold the potential to reduce the pathological burden and improve the symptoms of Alzheimer’s ***,the efficacy of drugs in treating Alzheimer’s disease is limited,with major challenges in drug delivery efficiency and ***,nanomaterials have gained widespread use in Alzheimer’s disease drug research owing to their favorable physical and chemical *** review aims to provide a comprehensive overview of recent advances in using nanomaterials(polymeric nanomaterials,nanoemulsions,and carbon-based nanomaterials)to enhance lysosomal function in treating Alzheimer’s *** review also explores new concepts and potential therapeutic strategies for Alzheimer’s disease through the integration of nanomaterials and modulation of lysosomal *** conclusion,this review emphasizes the potential of nanomaterials in modulating lysosomal function to improve the pathological features of Alzheimer’s *** application of nanotechnology to the development of Alzheimer’s disease drugs brings new ideas and approaches for future treatment of this disease.

关键词： Alzheimer’s disease autophagy dysfunction lysosomal acidification lysosomal system nanomaterials neurodegenerative diseases

四对结核分枝杆菌毒素-抗毒素系统基因功能的初步研究

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中国人兽共患病学报 2017年第5期33卷 413-417页

作者：刘静仪贾俊楠李卫民张俊杰高基民温州医科大学检验医学院生命科学学院浙江省模式生物技术与应用重点实验室温州325035 首都医科大学附属北京胸科医院国家结核病临床实验室北京101149 北京师范大学生命科学学院教育部细胞增殖及调控生物学重点实验室北京100875

目的探讨结核分枝杆菌毒素-抗毒素(toxin-antitoxin,TA)系统中的4对基因的功能,为研究结核分枝杆菌的传播机制提供基础科学数据。方法选取结核分枝杆菌TA系统VapBC家族中4对基因,包括VapC 4个毒素基因(Rv1720c、Rv2103c、Rv2494和Rv3408... 详细信息

目的探讨结核分枝杆菌毒素-抗毒素(toxin-antitoxin,TA)系统中的4对基因的功能,为研究结核分枝杆菌的传播机制提供基础科学数据。方法选取结核分枝杆菌TA系统VapBC家族中4对基因,包括VapC 4个毒素基因(Rv1720c、Rv2103c、Rv2494和Rv3408)和VapB4个抗毒素基因(Rv1721c、Rv2104c、Rv2493、Rv3407),在大肠杆菌和耻垢分枝杆菌中分别构建严谨型阿拉伯糖诱导质粒体系及乙酰胺诱导穿梭质粒体系观察VapC对细菌生长的抑制作用,及其对应的VapB解除抑制作用。结果在大肠杆菌和耻垢分枝杆菌的实验结果一致,Rv2103c具有一定抑制作用和Rv2104c具有消除抑制作用,其余3对毒素-抗毒素基因未见到明显的对细菌生长的抑制和消除抑制的作用。结论成功构建了VapBC家族在大肠杆菌及耻垢分枝杆菌中的表达体系,并发现了一对TA系统基因对细菌生长的抑制和消除抑制的作用。

关键词：结核分枝杆菌毒素-抗毒素系统 VapBC家族

中国西北生态脆弱区天然气管线建设的生态环境影响

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水土保持学报 2004年第6期18卷 196-199页

作者：赵丹王伯铎马俊杰林积泉西北大学环境科学系西安710069

基于在中国西北生态脆弱区天然气管线建设的工程实例,利用夏季陆地卫星(TM)图像为基本信息源,应用遥感解译分析、野外样方调查等方法,以植被类型、土地利用、土壤侵蚀为基本评价因子,对天然气管线建设前、后项目区的生态环境变化进行了... 详细信息

基于在中国西北生态脆弱区天然气管线建设的工程实例,利用夏季陆地卫星(TM)图像为基本信息源,应用遥感解译分析、野外样方调查等方法,以植被类型、土地利用、土壤侵蚀为基本评价因子,对天然气管线建设前、后项目区的生态环境变化进行了分析研究。研究结果表明,在中国西北生态脆弱区建设天然气输送管道,必须采取积极、适宜的生态环境保护措施,并及时进行生态恢复,可使工程对环境影响降至最小,进而达到生态恢复。

关键词：中国西北地区生态脆弱区天然气管线建设生态环境

Identification of a dual functional betulinic acid analog for the treatment of osteoarthritis by phenotypic screening

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Science China Life Sciences 2025年第1期68卷 300-302页

作者： Ze-Min Lin Mai Xiang Wen-Hui Wei Shu-Hui Fan Li Chen jie Wang Xiao-Qian Yang Chun-Hao Yang Shi-jun He jian-Ping Zuo Laboratory of Immunopharmacology State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of Sciences School of Pharmacy University of Chinese Academy of Sciences School of Pharmacy Nanjing University of Chinese Medicine State Key Laboratory of Drug Research Department of Medicinal ChemistryShanghai Institute of Materia MedicaChinese Academy of Sciences Innovation Research Institute of Traditional Chinese Medicine Shanghai University of Traditional Chinese Medicine Experiment Center for Science and Technology Shanghai University of Traditional Chinese Medicine

Dear Editor, Phenotypic drug discovery, which observes compound effects on physiology,has given way to targeting specific molecules, but has revived by using modern methods to find drugs based on therapeutic outcomes in disease models(Vincent et al., 2022). Osteoarthritis(OA) is a prevalent chronic joint disorder, primarily affecting knee joints, with osteoclast activation due to low-grade inflammation resulting in increased bone resorption and structural changes in the joint(Katz et al.,2021).

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认知空间映射及其神经机制

心理科学进展 2025年第1期33卷 62-76页

作者：吴际李会杰南宁师范大学教育科学学院南宁530001 中国科学院行为科学重点实验室(中国科学院心理研究所) 北京100101 中国科学院大学心理学系北京100049

认知地图不仅可以映射物理空间,还可以支持认知空间映射,形成包括感知空间、情景记忆空间、概念空间和社会空间等在内的跨不同信息领域的地图式表征。认知空间映射的神经机制包括海马体对潜在结构的抽象和概括、支持分布式位置地图的生... 详细信息

认知地图不仅可以映射物理空间,还可以支持认知空间映射,形成包括感知空间、情景记忆空间、概念空间和社会空间等在内的跨不同信息领域的地图式表征。认知空间映射的神经机制包括海马体对潜在结构的抽象和概括、支持分布式位置地图的生成、将信息与背景结构捆绑,以及海马体与其它脑区的协同。未来研究应关注预测性的认知空间地图、海马体对不同精度和层级信息的表征、认知空间映射微观和介观层面的研究空缺以及物理空间和认知空间映射的共同机制和特异性机制等问题。

关键词：认知地图网格细胞位置细胞海马体

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