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Advancements of Macrophages Involvement in Pathological Progression of Colitis-Associated Colorectal Cancer and Associated Pharmacological Interventions

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Chinese Journal of Integrative Medicine 2024年第6期30卷 565-576页

作者： KE jun-yu SONG Jin-bin LI Long HE Zhen-fan HUANG Zhuo-jian LIU Zheng-lin CHEN Gui-rong WANG Hai-yan WEN Su-ru ZHOU Heng-li MA Hui-lin DU Qun WU Yong-qiang LI Yan-wu CHEN Xin-lin School of Basic Medical Sciences Guangzhou University of Chinese MedicineGuangzhou510006China Department of Surgery II Gaozhou Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Chinese MedicineGaozhou525200China Science and Technology Innovation Center Guangzhou University of Chinese MedicineGuangzhou510405China The First Clinical Medical College of Guangzhou University of Traditional Chinese Medicine Guangzhou510405China

Intestinal macrophages play crucial roles in both intestinal inflammation and immune homeostasis. They can adopt two distinct phenotypes, primarily determined by environmental cues. These phenotypes encompass the classically activated pro-inflammatory M1 phenotype, as well as the alternatively activated anti-inflammatory M2 phenotype. In regular conditions, intestinal macrophages serve to shield the gut from inflammatory harm. However, when a combination of genetic and environmental elements influences the polarization of these macrophages, it can result in an M1/M2 macrophage activation imbalance, subsequently leading to a loss of control over intestinal inflammation. This shift transforms normal inflammatory responses into pathological damage within the intestines. In patients with ulcerative colitis-associated colorectal cancer (UC-CRC), disorders related to intestinal inflammation are closely correlated with an imbalance in the polarization of intestinal M1/M2 macrophages. Therefore, reinstating the equilibrium in M1/M2 macrophage polarization could potentially serve as an effective approach to the prevention and treatment of UC-CRC. This paper aims to scrutinize the clinical evidence regarding Chinese medicine (CM) in the treatment of UC-CRC, the pivotal role of macrophage polarization in UC-CRC pathogenesis, and the potential mechanisms through which CM regulates macrophage polarization to address UC-CRC. Our objective is to offer fresh perspectives for clinical application, fundamental research, and pharmaceutical advancement in UC-CRC.

关键词： macrophage ulcerative colitis colon cancer Chinese medicine

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行政行为程序轻微违法的识别

行政法学研究 2024年第2期 109-120页

作者：梁君瑜武汉大学法学院湖北武汉430072

识别“程序轻微违法”的唯一要件是被诉行政行为“对重要程序性权利不产生实质损害”。“重要程序性权利”包括对不利处分的申辩权、要求行政机关中立地作出决定的权利等;“产生实质损害”指向违反正当程序原则的情形。考察裁判文书所... 详细信息

识别“程序轻微违法”的唯一要件是被诉行政行为“对重要程序性权利不产生实质损害”。“重要程序性权利”包括对不利处分的申辩权、要求行政机关中立地作出决定的权利等;“产生实质损害”指向违反正当程序原则的情形。考察裁判文书所勾勒的“程序轻微违法”情形并借此实现与一种更轻微的狭义程序瑕疵之界分,乃是我国学界研究“程序轻微违法”的现有范式。但通过梳理最高人民法院审理的案件会发现,其归纳的“程序轻微违法”情形因与狭义程序瑕疵、“违反法定程序”情形屡屡重合而存疑。试图提炼程序违法之“轻微”与“更轻微”的各自表现,并以此实现界分的横向界分思路并不成功,亟待向纵向界分思路转换。当满足被诉行政行为“对重要程序性权利不产生实质损害”时,可对程序违法之“轻微”与“更轻微”暂作模糊化处理。在此基础上,若行政主体自行实施了有意义的补正,则构成狭义程序瑕疵;反之,构成“程序轻微违法”。

关键词：程序轻微违法狭义程序瑕疵横向界分纵向界分有意义的补正

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以建设成效为导向的海绵城市评价体系研究

中国给水排水 2024年第4期40卷 13-18页

作者：陈俊宇厦门市城市规划设计研究院有限公司福建厦门361012

落实海绵城市理念的优质建设项目能够产生示范效应,有助于推动海绵设施质量不断提升。基于管控制度、设施功能、设施外观、示范效应四项因素,以建设成效为导向,采用层次分析法,构建了基于建设项目尺度的海绵城市评价体系。评价结果表明... 详细信息

落实海绵城市理念的优质建设项目能够产生示范效应,有助于推动海绵设施质量不断提升。基于管控制度、设施功能、设施外观、示范效应四项因素,以建设成效为导向,采用层次分析法,构建了基于建设项目尺度的海绵城市评价体系。评价结果表明,现阶段建设项目尺度上的海绵城市建设,在设计变更管控、运维制度建立方面存在欠缺,普遍存在竖向控制不够精细以及设计、施工中各专业衔接配合不足、景观营造与海绵设施功能不够融合等问题,除公园类项目外,其他各类项目在理念宣传、共同缔造方面有待提升。

关键词：海绵城市建设成效评价体系层次分析法

Tunable spectral continuous shift of high-order harmonic generation in atoms by a plasmon-assisted shaping pulse

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Chinese Physics B 2024年第3期33卷 433-440页

作者：王源李玉龙乔月高娜郭福明陈洲赫兰海杨玉军赵曦王俊 Institute of Atomic and Molecular Physics Jilin UniversityChangchun 130012China Jilin Provincial Key Laboratory of Applied Atomic and Molecular Spectroscopy Jilin UniversityChangchun 130012China Beijing Institute of Space Launch Technology Beijing 100076China School of Physics and Information Technology Shaanxi Normal UniversityXi'an 710062China

We delve into the phenomenon of high-order harmonic generation within a helium atom under the influence of a plasmon-assisted shaping pulse.Our findings reveal an intriguing manipulation of the frequency peak position in the harmonic emission by adjusting the absolute phase parameter within the frequency domain of the shaping pulse.This phenomenon holds potential significance for experimental setups necessitating precisely tuned single harmonics.Notably,we observe a modulated shift in the created harmonic photon energy,spanning an impressive range of 1.2 eV.This frequency peak shift is rooted in the asymmetry exhibited by the rising and falling edges of the laser pulse,directly influencing the position of the peak frequency emission.Our study quantifies the dependence of this tuning range and the asymmetry of the laser pulse,offering valuable insights into the underlying mechanisms driving this phenomenon.Furthermore,our investigation uncovers the emergence of semi-integer order harmonics as the phase parameter is altered.We attribute this discovery to the intricate interference between harmonics generated by the primary and secondary return cores.This observation introduces an innovative approach for generating semi-integer order harmonics,thus expanding our understanding of high-order harmonic generation.Ultimately,our work contributes to the broader comprehension of complex phenomena in laser-matter interactions and provides a foundation for harnessing these effects in various applications,particularly those involving precise spectral control and the generation of unique harmonic patterns.

关键词： high-order harmonic semi-integer-order spectra shift inhomogeneous field

On the ultimate finishing line of the Human Genome Project

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The Innovation 2021年第3期2卷 13-14页

作者： jun yu Songnian Hu University of Chinese Academy of Sciences Beijing 100190China The Institute of Microbiology Chinese Academy of SciencesBeijing 100101China

The Human Genome Project(HGP)has paved the way for the Digital Personal Genomes(DPG),whereby a person’s complete genome sequence serves as the primary entry for the Digital Healthcare Systems(DHS).If the goal is to deliver PDG on demand,affordability,mainly the cost,becomes one of the primary issues.However,as a once-in-a-lifetime event,a total cost of US$100 is close to$1 per year contribution.Therefore,what remains is still largely an engineering challenge,since a multi-fold reduction of the current per-genome sequencing cost may be achievable by increasing the scale of operation and the degree of automation over 5–10 years.The second issue is to differentiate scientific achievements from what is applicable to the healthcare systems and human well-being in general.The original thought of HGP is to understand the genetics of cancers—an idea or a proposal was made and debated in the early 1980s,and it is still clear that we need both high-quality genome sequences and time to fully understand their encoded biological information;the success of HGP lies on the separation of these two goals.

关键词： Human finishing lifetime

Genome-wide mapping of conserved microRNAs and their host transcripts in Tribolium castaneum

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Journal of Genetics and Genomics 2008年第6期35卷 349-355页

作者： Qibin Luo Qing Zhoub Xiaomin yu Hongbin Lin Songnian Hu jun yu James D. Watson Institute of Genome Sciences Zhejiang University Hangzhou 310008 China Key Laboratory of Genome Information and Sciences Beijing Institute ofGenomics ChineseAcademy of Sciences Beijing 100029 China Graduated School of the Chinese Academy of Sciences Beijing 100049 China

MicroRNAs （miRNAs） are endogenous 22-nt RNAs, which play important regulatory roles by post-transcriptional gene silencing. A computational strategy has been developed for the identification of conserved miRNAs based on features of known metazoan miRNAs in red flour beetle （Tribolium castaneum）, which is regarded as one of the major laboratory models of arthropods. Among 118 putative miRNAs, 47% and 53% of the predicted miRNAs from the red flour beetle are harbored by known protein-coding genes （intronic） and genes located outside （intergenic miRNA）, respectively. There are 31 intronic miRNAs in the same transcriptional orientation as the host genes, which may share RNA polymerase II and spliceosomal machinery with their host genes for their biogenesis. A hypothetical feed-back model has been proposed based on the analysis of the relationship between intronic miRNAs and their host genes in the development of red flour beetle.

关键词： miRNA host transcript intronic miRNA Tribolium castaneum

数字化转型如何影响企业可持续绩效——来自fsQCA的发现

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软科学 2024年第5期38卷 13-21页

作者：於军隋艮上海海事大学经济管理学院上海201306

基于双元理论,对302家企业进行模糊集定性比较分析(fsOCA),探索数字化转型的工具性因素(数字平台、客户体验、员工体验、运营和商业模式)和道德性因素(企业数字责任)对企业可持续绩效的组态效应。结果表明:(1)工具性和道德性因素的组合... 详细信息

基于双元理论,对302家企业进行模糊集定性比较分析(fsOCA),探索数字化转型的工具性因素(数字平台、客户体验、员工体验、运营和商业模式)和道德性因素(企业数字责任)对企业可持续绩效的组态效应。结果表明:(1)工具性和道德性因素的组合可以改善数字化转型企业的可持续绩效,其中企业数字责任起到了关键作用;(2)存在不同的组态可以实现不同维度的企业可持续绩效,且不同因素可以相互替代;(3)数字平台、客户体验、运营、商业模式和企业数字责任的组合能够同时实现数字化转型企业的经济、环境和社会绩效。

关键词：双元理论企业数字责任企业可持续绩效数字化转型 fsQCA

司法裁判中的宪法援引:制度框架、实践逻辑与机制完善

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浙江学刊 2024年第1期 101-111页

作者：余军曹竞雄浙江大学立法研究院杭州310008 浙江大学光华法学院杭州310008

探寻中国法院司法裁判中援引宪法活动的实践逻辑,需要厘清最高人民法院相关司法政策的制度框架,并对法院援引宪法的裁判文书进行实证考察。以宪法作为“说理依据”和“裁判依据”分类考察1944份司法裁判文书,可以得出中国法院援引宪法... 详细信息

探寻中国法院司法裁判中援引宪法活动的实践逻辑,需要厘清最高人民法院相关司法政策的制度框架,并对法院援引宪法的裁判文书进行实证考察。以宪法作为“说理依据”和“裁判依据”分类考察1944份司法裁判文书,可以得出中国法院援引宪法规范的基本逻辑,并发现实践逻辑与现行司法政策存在显著张力。这一司法活动的机制完善,需要与正处于生成、发展过程中的中国宪法审查制度衔接、联系起来,使宪法审查实践中取得的最新成果及时地反映到司法裁判过程中来,并通过最高人民法院进一步完善司法政策,促进各级法院宪法理念的更新与裁判说理过程中司法技术的正确运用。

关键词：宪法援引司法政策说理依据裁判依据政治化实施

The Pendulum Model for Genome Compositional Dynamics:from the Four Nucleotides to the Twenty Amino Acids

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Genomics, Proteomics & Bioinformatics 2012年第4期10卷 175-180页

作者： Zhang Zhang jun yu CAS Key Laboratory of Genome Sciences and Information Beijing Institute of GenomicsChinese Academy of SciencesBeijing 100029China

The genetic code serves as one of the natural links for life＇s two conceptual frameworks--the informational and operational tracks-- bridging the nucleotide sequence of DNA and RNA to the amino acid sequence of protein and thus its structure and function. On the informational track, DNA and its four building blocks have four basic variables： order, length, GC and purine contents; the latter two exhibit unique characteristics in prokaryotic genomes where protein-coding sequences dominate. Bridging the two tracks, tRNAs and their aminoacyl tRNA synthases that interpret each codon--nucleotide triplet, together with ribosomes, form a complex machinery that translates genetic information encoded on the messenger RNAs into proteins. On the operational track, proteins are selected in a context of cellular and organismal functions constantly. The principle of such a functional selection is to minimize the damage caused by sequence alteration in a seemingly random fashion at the nucleotide level and its function-altering consequence at the protein level; the principle also suggests that there must be complex yet sophisticated mechanisms to protect molecular interactions and cellular processes for cells and organisms from the damage in addition to both immediate or short-term eliminations and long-term selections. The two- century study of selection at species and population levels has been leading a way to understand rules of inheritance and evolution at molecular levels along the informational track, while ribogenomics, epigenomics and other operationally-defined omits （such as the metabolite-centric metabolomics） have been ushering biologists into the new millennium along the operational track.

关键词： Eubacteria Genome sequence Compositional dynamics Genetic code