检索结果-南通市图书馆

Effect of short neuropeptide F signaling on larval feeding in Mythimna separata

Insect Science 2024年第2期31卷 417-434页

作者： Mei-Mei Li Qi Yang Li-Hui Chen Yan-Ying Li jun-Xiang wu Xiang-Li Xu State Key Laboratory of Crop Stress Biology in Arid Areas College of Plant ProtectionNorthwest A&F UniversityYanglingShaanxi ProvinceChinaand School of Agricultural Sciences Jiangxi Agricultural UniversityNanchangChina

Mythimna separata is a notorious phytophagous pest which poses serious threats to cereal crops owing to the gluttony of the larvae.Because short neuropeptide F(sNPF)and its receptor sNPFR are involved in a diversity of physiological functions,especially in functions related to feeding in insects,it is a molecular target for pest control.Herein,an sNPF and 2 sNPFRs were identified and cloned from M.separata.Bioinformatics analysis revealed that the sNPF and its receptors had a highly conserved RLRFamide C-terminus and 7 transmembrane domains,respectively.The sNPF and its receptor genes were distributed across larval periods and tissues,but 2 receptors had distinct expression patterns.The starvation-induced assay elucidated that sNPF and sNPFR expression levels were downregulated under food deprivation and recovered with subsequent re-feeding.RNA interference knockdown of sNPF,sNPFR1,and sNPFR2 by injection of double-stranded RNA into larvae not only suppressed food consumption and increased body size and weight,but also led to decrease of glycogen and total lipid contents,and increase of trehalose compared with double-stranded green fluorescent protein injection.Furthermore,molecular docking was performed on the interaction mode between sNPFR protein and its ligand sNPF based on the 3-dimensional models constructed by AlphaFold;the results indicated that both receptors were presumably activated by the mature peptide sNPF-2.These results revealed that sNPF signaling played a considerably vital role in the feeding regulation of M.separata and represents a potential control target for this pest.

关键词： feeding regulation Mythimna separata pest control target RNA interference short neuropeptide F sNPF receptors

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Yiwei Xiaoyu granules for treatment of chronic atrophic gastritis with deficiency syndrome of the spleen and stomach

引用

World Journal of Clinical Cases 2024年第13期12卷 2201-2209页

作者： Wan-Qun Chen Qing-Feng Fan Yuan-jun He Fei Li Xin wu Yan-Ping Li Xiao-jun Yang Department of Gastroenterology Chongqing Hospital of Traditional Chinese MedicineChongqing 400000China

BACKGROUND The Correa sequence,initiated by Helicobacter pylori(H.pylori),commonly progresses to gastric cancer through the stage of chronic atrophic gastritis(CAG).Although eradication of H.pylori only reduces the risk of gastric cancer,it does not eliminate the risk for neoplastic progression.Yiwei Xiaoyu granules(YWXY)are a commonly used composite preparation in Chinese clinics.However,the pursuit of excellence in clinical trials and the establishment of standardized animal experiments are still needed to contribute to full understanding and application of traditional Chinese medicine in the treatment of CAG.AIM To demonstrate the effectiveness of YWXY in patients with CAG and spleenstomach deficiency syndrome(DSSS),by alleviating histological scores,improving response rates for pathological lesions,and achieving clinical efficacy in relieving DSSS symptoms.METHODS We designed a double-blind,randomized,controlled trial.The study enrolled seventy-two H.pylori-negative patients(mean age,52.3 years;38 men)who were randomly allocated to either the treatment group or control group in a 1:1 ratio,and treated with 15 g YWXY or 0.36 g Weifuchun(WFC)tablet combined with the respective dummy for 24 wk.The pre-randomization phase resulted in the exclusion of 72 patients:50 participants did not meet the inclusion criteria,12 participants declined to participate,and 10 participants were excluded for various other reasons.Seven visits were conducted during the study,and histopathological examination with target endoscopic biopsy of narrow-band imaging was requested before the first and seventh visits.We also evaluated endoscopic performance scores,total symptom scores,serum pepsinogen and gastrin-17.RESULTS Six patients did not complete the trial procedures.Treatment with YWXY improved the Operative Link on Gastric Intestinal Metaplasia Assessment(OLGIM)stage,compared with WFC(P<0.05).YWXY provided better relief from symptoms of DSSS and better improvement in serum gastric function,compared with WFC(P<0.05).CONCLUSION YWXY

关键词： Chronic atrophic gastritis Yiwei Xiaoyu granules Randomized clinical trial Weifuchun tablet Traditional Chinese medicine Helicobacter pylori

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Facile and One-step Direct Synthesis of Poly(valine)as a Robust Drug Nanocarrier for Enhanced Breast Cancer Therapy

引用

Chinese Journal of Polymer Science 2022年第9期40卷 1016-1027页

作者： Ya-Bin Meng jun wu School of Biomedical Engineering Sun Yat-sen UniversityShenzhen 518107China

Synthetic poly(amino acid)s with good biodegradable and biocompatible properties have attracted increased attention as carriers in biomedical applications in recent years,their synthesis and purification procedures are usually complicated and some by-products would occur yet.Given this,polypeptide with good biodegradable and biocompatible properties is prepared and optimized by one-step and direct synthesis strategy and poly(valine)(PVal)is selected here as a model polypeptide in this study.This newly generated PVal can self-assemble into poly(valine)nanoparticles(PVal-NPs)with a high drug-loading capacity(>20 wt%)of doxorubicin(DOX)and shows strong cytotoxicity against 4T1 cells.Upon cellular internalization,the release of DOX could be accelerated by the endosomal acidic environment which leads to enhanced anticancer effects.The results in vivo show that DOX@PVal-NPs have a long blood circulation time,high cancer accumulation and penetration,and good therapeutic performance in 4T1 tumor-bearing mice without causing obvious adverse effect on main organs.With these combined advantages,these PVal-based nanoplatform would provide an effective drug delivery tool for clinical breast cancer therapy.

关键词： Poly(amino acid) Nanoparticle Drug carrier Doxorubicin Breast cancer

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

High-static-low-dynamic stiffness isolator based on an electromagnetic negative stiffness spring with long linear stroke

引用

Science China(Technological Sciences) 2024年第3期67卷 740-752页

作者： YUAN ShuJin wu Yajun SONG DaiPing PU HuaYan MOU LiSheng HOU Lei ZHAO JingLei LI XuePing LUO jun wu Jie HUANG XiaoXu State Key Laboratory of Mechanical Transmissions Chongqing UniversityChongqing 400044China China Aerodynamics Research and Development Center Mianyang 621000China College of Materials Science and Engineering Chongqing UniversityChongqing 400044China

Negative stiffness mechanisms can improve low-frequency vibration isolation performance and have been widely used in the vibration isolation of precision equipment. However, the negative stiffness mechanism usually introduces a nonlinear stiffness,resulting in a nonlinear response and worsening the vibration isolation performance, especially under large amplitude vibration.In this paper, an electromagnetic spring with linear negative stiffness(ESLNS) is proposed, in which the antagonistic ampere forces of the energized coils are used to generate negative stiffness within a long linear stroke. The magnetic field distribution is improved through the design of the magnetic circuit, thereby increasing the stiffness generation efficiency. The stiffness can be adjusted bidirectionally by current within the range of positive and negative stiffness. An electromagnetic stiffness model was established based on the equivalent magnetic circuit method. Experimental measurements verified the accuracy of the model and proved the linearity of the electromagnetic spring. A vibration isolator with high static and low dynamic stiffness(HSLDS) based on the ESLNS is designed and tested. The experimental results prove that the introduction of the ESLNS can effectively expand the isolation frequency band without changing the equilibrium position. Moreover, the vibration isolator with ESLNS does not produce nonlinear response. The proposed electromagnetic spring with linear negative stiffness extends the application range of HSLDS isolators to a large amplitude vibration environment.

关键词： linear negative stiffness mechanism low-frequency vibration isolation electromagnetic spring vibration control

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Research on a Monte Carlo global variance reduction method based on an automatic importance sampling method

引用

Nuclear Science and Techniques 2024年第5期35卷 200-215页

作者： Yi-Sheng Hao Zhen wu Shen-Shen Gao Rui Qiu Hui Zhang jun-Li Li Department of Engineering Physics Tsinghua UniversityBeijing 100084China Key Laboratory of Particle and Radiation Imaging of Ministry of Education Beijing 100084China Nuctech Company Limited Beijing 100084China

Global variance reduction is a bottleneck in Monte Carlo shielding calculations.The global variance reduction problem requires that the statistical error of the entire space is uniform.This study proposed a grid-AIS method for the global variance reduction problem based on the AIS method,which was implemented in the Monte Carlo program MCShield.The proposed method was validated using the VENUS-Ⅲ international benchmark problem and a self-shielding calculation example.The results from the VENUS-Ⅲ benchmark problem showed that the grid-AIS method achieved a significant reduction in the variance of the statistical errors of the MESH grids,decreasing from 1.08×10^(-2) to 3.84×10^(-3),representing a 64.00% reduction.This demonstrates that the grid-AIS method is effective in addressing global issues.The results of the selfshielding calculation demonstrate that the grid-AIS method produced accurate computational results.Moreover,the grid-AIS method exhibited a computational efficiency approximately one order of magnitude higher than that of the AIS method and approximately two orders of magnitude higher than that of the conventional Monte Carlo method.

关键词： Monte Carlo Global variance reduction Reactor shielding Automatic importance sampling

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Two-dimensional precise figuring of 500 mm-long X-ray mirror using one-dimensional ion beam system

引用

Advances in Manufacturing 2024年第1期12卷 177-184页

作者： Qiu-Shi Huang Han-Dan Huang Qiao-Yu wu jun Yu Zhong Zhang Zhan-Shan Wang MOE Key Laboratory of Advanced Micro-Structured Materials Institute of Precision Optical Engineering(IPOE)School of Physics Science and EngineeringTongji UniversityShanghai200092People’s Republic of China Shanghai Professional Technical Service Platform for Full-Spectrum and High-Performance Optical Thin Film Devices and Applications Tongji UniversityShanghai200092People’s Republic of China Shanghai Frontiers Science Center of Digital Optics Tongji UniversityShanghai200092People’s Republic of China

In this study,a new method was developed to realize two-dimensional(2D)figure correction of grazing-incidence X-ray mirrors using a one-dimensional(1D)ion-beam figuring system.A mask of holes was specifically designed to generate removal functions at different widths and extend the figuring capability over a wide area.Accordingly,a long mirror could be manufactured.Using this method,the surface height root-mean-square(RMS)error of the center area of 484 mm×16 mm was reduced from 11.49 nm to 2.01 nm,and the 1D meridional RMS error reached 1.0 nm.The proposed method exhibits high precision and cost effectiveness for production of long X-ray mirrors.

关键词： Long-size mirrors Ion beam figuring Two-dimensional figure correction Mask

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Endoplasmic reticulum stress improved chicken tenderness,promoted apoptosis and autophagy during postmortem ageing

引用

Food Science and Human Wellness 2024年第4期13卷 2141-2151页

作者： Yuwei Chai Lin Chen Shuya Xiang Linxuan wu Xuebo Liu jun Luo Xianchao Feng College of Food Science and Engineering Northwest A&F UniversityYangling 712100China College of Animal Science and Technology Northwest A&F UniversityYangling 712100China

In this study,endoplasmic reticulum(ER)stress inducer tunicamycin(TM)and inhibitor 4-phenylbutyric acid(4-PBA)were used to treat postmortem chicken breast muscle to investigate changes in tenderness and effects on apoptosis and autophagy during 5 days ageing.TM-induced ER stress reduced shear force,enhanced myofibril fragmentation index(MFI),disrupted myofibril structure,increased desmin degradation,and activatedμ-calpain and caspase-12.In addition,TM-induced ER stress increased the expression of Bax,Bim,and cytochrome c,and decreased the expression of Bcl-x L.Furthermore,TM-induced ER stress improved the conversion of LC3I to LC3II,raised the expression of Beclin-1,and decreased the expression of p62,PI3K,and m TOR.The opposite results were observed after 4-PBA treatment.These results suggested that ER stress could improve chicken tenderness,promote apoptosis and autophagy during chicken postmortem ageing.

关键词： Endoplasmic reticulum stress Tenderness Apoptosis Autophagy Chicken

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Assessing target optical camouflage effects using brain functional networks:A feasibility study

引用

Defence Technology（防务技术） 2024年第4期34卷 69-77页

作者： Zhou Yu Li Xue Weidong Xu jun Liu Qi Jia Jianghua Hu Jidong wu National Key Laboratory of Lightning Protection and Electromagnetic Camouflage Army Engineering University Nanjing 210007JiangsuChina Unit 31608 of PLA Xiamen 361000FujianChina School of Biological Sciences&Medical Engineering Southeast UniversityNanjing 210096JiangsuChina

Brain functional networks model the brain's ability to exchange information across different regions,aiding in the understanding of the cognitive process of human visual attention during target searching,thereby contributing to the advancement of camouflage evaluation.In this study,images with various camouflage effects were presented to observers to generate electroencephalography(EEG)signals,which were then used to construct a brain functional network.The topological parameters of the network were subsequently extracted and input into a machine learning model for training.The results indicate that most of the classifiers achieved accuracy rates exceeding 70%.Specifically,the Logistic algorithm achieved an accuracy of 81.67%.Therefore,it is possible to predict target camouflage effectiveness with high accuracy without the need to calculate discovery probability.The proposed method fully considers the aspects of human visual and cognitive processes,overcomes the subjectivity of human interpretation,and achieves stable and reliable accuracy.

关键词： Camouflage effect evaluation Electroencephalography(EEG) Brain functional networks Machine learning

来源：

维普期刊数据库

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Strategy for Detecting Systemic Treatment Sensitivity of Primary Liver Cancer Based on a Novel Infrared-emissive Organic Nanoparticle

引用

Chemical Research in Chinese Universities 2024年第1期40卷 145-152页

作者： wu jun LI Yongzhi QIN Hanjiao GAO Ying YANG Bing SHENG Jiyao ZHANG Xuewen Department of Hepatobiliary and Pancreatic Surgery the Second Hospital of Jilin UniversityChangchun130022P.R.China Department of Radiation Oncology the Second Hospital of Jilin UniversityChangchun130022P.R.China State Key Laboratory of Supramolecular Structure and Materials Institute of Theoretical ChemistryCollege of ChemistryJilin UniversityChangchun130012P.R.China

In this study,we synthesized an organic material with near-infrared emission capabilities:4-(2-(4-(9-(4-(diphenylamino)phenyl)naphtho[2,3-c][1,2,5]thiadiazol-4-yl)phenyl)-1H-phenol-1-ylidene)malononitrile(TPA).Furthermore,TPA-PEG2000 fluorescent nanoparticles were prepared via coating the shells with PEG2000.TPA-PEG2000 exhibited strong near-infrared emission near 700 nm,with a photoluminescence quantum yield of 15.09%,indicating a high emission efficiency.Molecular biology experiments have confirmed its low toxicity and excellent biocompatibility.Increased cholesterol and phospholipid levels in liver cancer cell membranes with low sensitivity or high drug resistance lead to increased rigidity,reduced membrane fluidity,reduced endocytic efficiency,and reduced uptake.Therefore,the uptake of TPA-PEG2000 nanoparticles into cells and the near-infrared fluorescence intensity can be used to evaluate the sensitivity of systemic liver cancer treatment in a simple and efficient manner.

关键词： Nanoparticle Near-infrared Fluorescence Systemic treatment sensitivity Cell membrane fluidity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Transcriptomic and bioinformatics analysis of the mechanism by which erythropoietin promotes recovery from traumatic brain injury in mice

引用

Neural Regeneration Research 2024年第1期19卷 171-179页

作者： Weilin Tan jun Ma Jiayuanyuan Fu Biying wu Ziyu Zhu Xuekang Huang Mengran Du Chenrui wu Ehab Balawi Qiang Zhou Jie Zhang Zhengbu Liao Department of Neurosurgery The First Affiliated Hospital of Chongqing Medical UniversityChongqingChina

Recent studies have found that erythropoietin promotes the recovery of neurological function after traumatic brain injury.However,the precise mechanism of action remains unclea r.In this study,we induced moderate traumatic brain injury in mice by intrape ritoneal injection of erythro poietin for 3 consecutive days.RNA sequencing detected a total of 4065 differentially expressed RNAs,including 1059 mRNAs,92 microRNAs,799 long non-coding RNAs,and 2115circular RNAs.Kyoto Encyclopedia of Genes and Genomes and Gene Ontology analyses revealed that the coding and non-coding RNAs that were differentially expressed after traumatic brain injury and treatment with erythropoietin play roles in the axon guidance pathway,Wnt pathway,and MAPK pathway.Constructing competing endogenous RNA networks showed that regulatory relationship between the differentially expressed non-coding RNAs and mRNAs.Because the axon guidance pathway was repeatedly enriched,the expression of Wnt5a and Ephb6,key factors in the axonal guidance pathway,was assessed.Ephb6 expression decreased and Wnt5a expression increased after traumatic brain injury,and these effects were reversed by treatment with erythro poietin.These findings suggest that erythro poietin can promote recove ry of nerve function after traumatic brain injury through the axon guidance pathway.

关键词： axon guidance bioinformatics analysis competing endogenous RNA erythropoietin Gene Ontology Kyoto Encyclopedia of Genes and Genomes non-coding RNA RNA sequencing transcriptomics traumatic brain injury

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：