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NνDEx-100 conceptual design report

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Nuclear Science and Techniques 2024年第1期35卷 18-33页

作者： Xi-Guang Cao Yan-Long Chang Kai Chen Emilio Ciuffoli li-Min Duan Dong-liang Fang Chao-Song Gao Surja K.Ghorui Peng-Chong Hu Qiang Hu Si-Yuan Huang Ze-Yu Huang Lei lang Yu-lan li Zhi-Jie li Tian-Yu liang jun liu Chen-Gui Lu Fa-Tai Mai Yuan Mei Hao Qiu Xiang-Ming Sun xiao-Xing Tang Hu-lin Wang Qian-Ming Wang Le xiao mu-Yun xiao Jian-Yu Xin Nu Xu Peng Yang Yi-Chen Yang Zhen Yang Zong-Yang Yu Dong-liang Zhang jun-Wei Zhang Cheng-Xin Zhao Dou Zhu NνDEx-100 collaboration Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201210China lanzhou University Lanzhou 730000China Central China Normal University Wuhan 430079China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China Lawrence Berkeley National Laboratory BerkeleyCA 94720USA North China University of Water Resources and Electric Power Zhengzhou 450045China 不详

Observing nuclear neutrinoless double beta (0vββ) decay would be a revolutionary result in particle *** such a decay would prove that the neutrinos are their own antiparticles,help to study the absolute mass of neutrinos,explore the origin of their mass,and may explain the matter-antimatter asymmetry in our universe by lepton number *** propose developing a time projection chamber (TPC) using high-pressure ^(82)SeF_(6) gas and Topmetal silicon sensors for readout in the China Jinping Underground Laboratory (CJPL) to search for neutrinoless double beta decay of82Se,called the NvDEx *** being located at CJPL with the world’s thickest rock shielding,NvDEx combines the advantages of the high Qββ(2.996 MeV) of82Se and the TPC’s ability to distinguish signal and background events using their different topological *** makes NvDEx unique,with great potential for low-background and high-sensitivity 0 vββ***-100,a NvDEx experiment phase with 100 kg of SeF_(6)gas,is being built,with plans to complete installation at CJPL by *** report introduces 0 vββ physics,the NvDEx concept and its advantages,and the schematic design of NvDEx-100,its subsystems,and background and sensitivity estimation.

关键词： Neutrinoless double beta decay Time projection chamber ^(82)SeF_(6) China Jinping Underground Laboratory

CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci xiao-jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui xiaohao Cui Zhaoyuan Cui Brunella D'Anzi ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of Mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(Amu/IPhU&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

The diagnostic and prognostic values of plasma Epstein-Barr virus DNA for residual cervical lymphadenopathy in nasopharyngeal carcinoma patients:a retrospective study

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Cancer Communications 2019年第1期39卷 135-147页

作者： Sai-lan liu Xue-Song Sun xiao-Yun li lin-quan Tang Qiu-Yan Chen Huan-Xin lin Yu-Jing liang Jin-Jie Yan Chao lin Shan-Shan Guo li-Ting liu Yang li Hao-jun Xie Qing-Nan Tang Hu liang ling Guo Hai-Qiang Mai State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineGuangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapySun Yat-sen University Cancer CenterGuangzhou 510060GuangdongP.R.China Department of Nasopharyngeal Carcinoma Sun Yat-sen University Cancer CenterGuangzhou 510060Guang-dongP.R.China Department of Radiation Oncology Sun Yat-sen University Cancer CenterGuangzhou 510060GuangdongP.R.China

Background:Currently,the diagnosis and treatment of nasopharyngeal carcinoma(NPC)patients with residual cervical lymphadenopathy following radical radiotherapy with or without chemotherapy are *** investigated the prognosis of NPC patients with residual cervical lymphadenopathy and assessed the diagnostic and prognostic values of Epstein-Barr virus(EBV)DNA in these ***:This study included 82 NPC patients who were diagnosed with suspected residual cervical lymphadenopathy following completion of antitumor *** plasma EBV DNA levels were measured using quantitative polymerase chain reaction(qPCR)before the initiation of treatment and before neck *** needle aspiration cytology(FNAC)was performed in 21 *** patients had undergone neck dissection and postoperative pathological examination to identify the nature of residual cervical *** overall survival(OS),progression-free survival(PFS),distant metastasis-free survival(DMFS),and locoregional relapse-free survival(LRRFS)were calculated using the Kaplan-Meier method and compared using the log-rank *** Cox proportional hazards model was used to calculate hazard ratios(HRs)with 95%confidence intervals(CIs).multivariable analysis was used to estimate the effect of potential prognostic factors on ***:Following a median follow-up of 52.6 months,compared with patients with negative postoperative pathological findings for residual cervical lymphadenopathy,the patients with positive findings had a significantly lower 3-year PFS rate(49.9%vs.83.3%,P=0.008).Among NPC patients with residual cervical lymphadenopathy,the patients with preoperative plasma EBV DNA>0 copy/mL had a lower 3-year PFS rate than did those with no detectable EBV DNA(43.7%vs.61.1%,P=0.031).In addition,combining FNAC with preoperative EBV DNA detection improved the diagnostic *** analysis demonstrated that residual cervical lymphadenopathy with positive po

关键词： Nasopharyngeal carcinoma Residual cervical lymphadenopathy Prognosis Epstein-Barr virus Fine needle aspiration cytology Survival

Vimentin significantly promoted gallbladder carcinoma metastasis

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Chinese Medical Journal 2011年第24期124卷 4236-4244页

作者： DONG Ping HE xiao-wei GU jun WU Wen-guang li Mao-lan YANG Jia-hua ZHANG ling DING Qi-chen LU Jian-hua mu Jia-sheng CHEN Lei li Song-gan DING liang-fu WANG Jian-wei liu Ying-bin Department of General Surgery Xinhua Hospital affiliated toSchool of Medicine Shanghai Jiao Tong University Shanghai200092 China Department of General Surgery First Hospital Affiliated to JiaxingMedical School Jiaxing Zhejiang 314000 China Department of General Surgery Baozhen Hospital ChongmingShanghai 200092 China Department of Surgery Second Affiliated Hospital School ofMedicine Zhejiang University Hangzhou Zhejiang 310009China

Background The precise molecular mechanisms underlying the gallbladder carcinoma （GBC） metastasis has not been fully elucidated. Methods In the present study, metastasis-associated proteins were identified by comparative proteomic analysis. The functional study of the candidate protein vimentin was further investigated. First, a pair of higher and lower metastatic sublines （termed GBC-SD/M3 and GBC-SD, respectively）, originated from the same parental cell line, was screened by spontaneous tumorigenicity and metastasis in vivo in animal study and further characterized by metastatic phenotypes analysis in vitro. Subsequently, a proteomic approach comprised two-dimensional gel electrophoresis analysis and mass spectroscopy was used to identify and compare the protein expression patterns between higher metastatic GBC-SD/M3 and lower metastatic GBC-SD cell lines. Then twenty-six proteins were identified. Results Among the 26 proteins identified, fourteen proteins were up-regulated and 12 proteins were down-regulated in GBC-SD/M3. Vimentin was identified and found to be overexpressed in GBC-SD/M3 as compared with GBC-SD. This result was further confirmed by quantitative PCR and Western blotting analysis. Furthermore, the cell migration and invasion potency of GBC-SD/M3 in vitro was remarkably suppressed after small interference RNA-mediated knockdown of vimentin. Moreover, immunoblot and immunohistochemical analysis on 12 human GBC specimens showed consistently increased vimentin expression in metastases compared with primary tumors. Conclusion Tumor vimentin level may reflect the pathological progression in some GBC and may be a useful marker for predicting tumor metastasis and a therapeutic target for the treatment of GBC patients with metastases.

关键词： gallbladder neoplasm hepatic metastasis vimentin proteomics

血浆Epstein-Barr病毒DNA对鼻咽癌患者颈部淋巴结残留的诊断和预后价值：一项回顾性研究

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癌症 2019年第9期38卷 390-403页

作者： Sai‑lan liu Xue‑Song Sun xiao‑Yun li lin‑quan Tang Qiu‑Yan Chen Huan‑Xin lin Yu‑Jing liang Jin‑Jie Yan Chao lin Shan‑Shan Guo li‑Ting liu Yang li Hao‑jun Xie Qing‑Nan Tang Hu liang ling Guo Hai‑Qiang Mai 华南肿瘤学国家重点实验室肿瘤医学协同创新中心中山大学肿瘤防治中心广东省鼻咽癌诊断与治疗重点实验室广东广州510060 鼻咽癌科中山大学肿瘤防治中心广东广州510060 放射肿瘤科中山大学肿瘤防治中心广东广州510060

背景与目的目前,诊断鼻咽癌(nasopharyngeal carcinoma,NPC)患者进行联合化疗的根治性放疗后是否出现颈部淋巴结残留及治疗是具有挑战性的。我们分析了颈部淋巴结残留NPC患者的预后,并评估了Epstein-Barr病毒(Epstein-Barr virus,EBV)DN... 详细信息

背景与目的目前,诊断鼻咽癌(nasopharyngeal carcinoma,NPC)患者进行联合化疗的根治性放疗后是否出现颈部淋巴结残留及治疗是具有挑战性的。我们分析了颈部淋巴结残留NPC患者的预后,并评估了Epstein-Barr病毒(Epstein-Barr virus,EBV)DNA对这些患者的诊断和预后的价值。方法本研究纳入了82例NPC患者,他们在完成抗肿瘤治疗后被诊断出疑似发生颈部淋巴结残留。在开始进行治疗和颈部清扫之前,使用定量聚合酶链反应(quantitative polymerase chain reaction,qPCR)检测患者血浆EBV DNA水平。21例患者接受了细针抽吸细胞学检查(fine needle aspiration cytology,FNAC)。所有患者均接受了颈部清扫术和术后病理检查,以明确颈淋巴结的性质。采用Kaplan-Meier法计算总生存期(overall survival,OS)、无进展生存期(progression-free survival,PFS)、无远处转移生存期(distant metastasis-free survival,DMFS)和局部区域无复发生存期(locoregional relapse-free survival,LRRFS),并使用log-rank检验进行比较。采用Cox比例风险模型计算置信区间(confidenceinterval,CI)为95%时的风险比(hazardratio,HR)。采用多变量分析估计潜在预后因素对生存的影响。结果中位随访52.6个月后,与术后病理结果阴性的患者相比,结果阳性的颈淋巴结残留患者的3年PFS率显著降低(49.9%vs.83.3%,P=0.008)。在颈淋巴结残留的鼻咽癌患者中,术前血浆EBV DNA>0拷贝/mL的患者的3年PFS率低于未检测到EBV DNA的患者(43.7%vs.61.1%,P=0.031)。此外,将FNAC与术前EBVDNA检测相结合可提高诊断灵敏度。多变量分析显示,术后颈部淋巴结残留病理结果阳性是PFS的独立预后因素,术前可检测到血浆EBV DNA是OS的独立预后因素。结论采用FNAC联合术前EBV DNA检测可提高对颈部淋巴结残留的NPC的诊断敏感性。与未检出EBV DNA的患者相比,术前检出血浆EBV DNA的患者预后较差,并且可能需要更积极的治疗方案。

关键词：鼻咽癌颈部淋巴结残留预后 Epstein-Barr病毒细针穿刺细胞学检查生存期

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通络方剂减轻糖尿病大鼠肾小球足细胞损伤

第二军医大学学报 2012年第2期33卷 165-169页

作者：孙亮亮李文桐冯晓云张兰予邹俊杰石勇铨刘志民第二军医大学长征医院内分泌科上海200003 上海警备区第一干休所上海200040

目的观察通络方剂(TLR)和抗氧化剂α-硫辛酸减轻糖尿病大鼠肾小球足细胞损伤的作用,探讨糖尿病肾病足细胞损伤的可能机制。方法通过高脂饮食和腹腔注射链脲佐菌素(35 mg/kg)制作糖尿病大鼠模型,将成模大鼠随机分为糖尿病组(DM组,8只)、... 详细信息

目的观察通络方剂(TLR)和抗氧化剂α-硫辛酸减轻糖尿病大鼠肾小球足细胞损伤的作用,探讨糖尿病肾病足细胞损伤的可能机制。方法通过高脂饮食和腹腔注射链脲佐菌素(35 mg/kg)制作糖尿病大鼠模型,将成模大鼠随机分为糖尿病组(DM组,8只)、糖尿病α-硫辛酸干预组(DM+ALA组,8只)、糖尿病TLR干预组(DM+TLR组,8只),另设正常对照组(CON组,8只)。DM+ALA组大鼠予以α-硫辛酸(0.1 ***-1.d-1)灌胃,DM+TLR组大鼠予以TLR(0.4 ***-1.d-1)灌胃,DM组和CON组每日均在同一时间予同体积蒸馏水一次性灌胃。干预12周后测定各组大鼠肾质量/体质量比值及24 h尿蛋白定量、BUN、Cr、Alb/Cr等肾功能指标;采用体视学方法计数足细胞和计算足细胞相对密度;采用蛋白质印迹分析法检测足细胞nephrin蛋白的表达;测定血浆和肾皮质中超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)活性和脂质过氧化产物丙二醛(MDA)含量。结果 12周时,与CON组相比,DM组大鼠肾质量/体质量增大,24 h尿蛋白、尿白蛋白/肌酐升高(P均<0.01);足细胞计数减少、足细胞密度降低且nephrin表达减少(P均<0.01);DM+ALA组和DM+TLR组大鼠肾质量/体质量、24 h尿蛋白、尿白蛋白/肌酐均低于DM组(P<0.01),足细胞计数、足细胞相对密度和nephrin表达量均高于DM组(P<0.01,P<0.05)。与CON组相比,DM组、DM+ALA组和DM+TLR组大鼠在观察终点血浆和肾皮质SOD、GSH-Px活性均降低(P<0.01,P<0.05),MDA含量则升高(P<0.01,P<0.05);与DM组相比,DM+ALA组和DM+TLR组血浆和肾皮质SOD、GSH-Px活性增加(P均<0.01),MDA含量降低(P<0.01,P<0.05)。DM+ALA组与DM+TLR组之间差异无统计学意义。结论 TLR可改善糖尿病大鼠肾小球足细胞损伤,可能与其抗氧化应激作用有关。

关键词：通络方剂糖尿病肾病足细胞氧化性应激

Transarterial chemoembolization with PD-(L)1 inhibitors plus molecular targeted therapies for hepatocellular carcinoma(CHANCE001)

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Signal Transduction and Targeted Therapy 2023年第3期8卷 1198-1207页

作者： Hai-Dong Zhu Hai-liang li Ming-Sheng Huang Wei-Zhu Yang Guo-Wen Yin Bin-Yan Zhong jun-Hui Sun Zhi-Cheng Jin Jian-Jian Chen Nai-Jian Ge Wen-Bin Ding Wen-Hui li Jin-Hua Huang Wei mu Shan-Zhi Gu Jia-Ping li Hui Zhao Shu-Wei Wen Yan-Ming Lei Yu-Sheng Song Chun-Wang Yuan Wei-Dong Wang Ming Huang Wei Zhao Jian-Bing Wu Song Wang Xu Zhu Jian-jun Han Wei-Xin Ren Zai-Ming Lu Wen-Ge Xing Yong Fan Hai-lan lin Zi-Shu Zhang Guo-Hui Xu Wen-Hao Hu Qiang Tu Hong-Ying Su Chuan-Sheng Zheng Yong Chen Xu-Ya Zhao Zhu-Ting Fang Qi Wang Jin-Wei Zhao Ai-Bing Xu Jian Xu Qing-Hua Wu Huan-Zhang Niu Jian Wang Feng Dai Dui-Ping Feng Qing-Dong li Rong-Shu Shi Jia-Rui li Guang Yang Hai-Bin Shi Jian-Song Ji Yu-E liu Zheng Cai Po Yang Yang Zhao xiao-li Zhu li-Gong Lu Gao-jun Teng Center of Interventional Radiology&Vascular Surgery Department of RadiologyZhongda HospitalMedical SchoolSoutheast UniversityNanjing 210009China Department of Minimally invasive Intervention The Affiliated Cancer Hospital of Zhengzhou UniversityZhengzhou 450008China Department of Interventional Radiology the Third Affiliated HospitalSun Yat-Sen UniversityGuangzhou 510630China Department of Interventional Radiology Union Hospital of Fujian Medical UniversityFuzhou 350001China Department of Interventional Radiology Jiangsu Cancer Hospital&Jiangsu Institute of Cancer Research&The Affiliated Cancer Hospital of Nanjing Medical UniversityNanjing 210009China Department of Interventional Radiology The First Affiliated Hospital of Soochow UniversitySoochow UniversitySuzhou 215006China Hepatobiliary and Pancreatic Interventional Treatment Center Division of Hepatobiliary and Pancreatic SurgeryThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Interventional Radiology Eastern Hospital of Hepatobiliary SurgeryNavy Medical University(Second Military Medical University)Shanghai 200438China Department of Interventional Radiology Nantong First People’s HospitalNantong 226001China Department of Interventional Radiology Yancheng Third People’s HospitalYancheng 224008China Department of Minimally Invasive Interventional Therapy Sun YatSen University Cancer CenterGuangzhou 510060China Department of Vascular Surgery Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China. Department of Interventional Radiology Hunan Cancer HospitalChangsha 410031China Department of Interventional Oncology The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510080China Department of Interventional Radiology The Hospital of Nantong UniversityNantong 226001China Department of Interventional Therapy Shanxi Tumor HospitalTaiyuan 030001China Department of Interventional Radiology Tibet Autonomous Region People’s

There is considerable potential for integrating transarterial chemoembolization(TACE),programmed death-(ligand)1(PD-[L]1)inhibitors,and molecular targeted treatments(MTT)in hepatocellular carcinoma(HCC).It is necessary to investigate the therapeutic efficacy and safety of TACE combined with PD-(L)1 inhibitors and MTT in real-world *** this nationwide,retrospective,cohort study,826 HCC patients receiving either TACE plus PD-(L)1 blockades and MTT(combination group,n=376)or TACE monotherapy(monotherapy group,n=450)were included from January 2018 to May *** primary endpoint was progression-free survival(PFS)according to modified *** secondary outcomes included overall survival(OS),objective response rate(ORR),and *** performed propensity score matching approaches to reduce bias between two *** matching,228 pairs were included with a predominantly advanced disease *** PFS in combination group was 9.5 months(95%confidence interval[CI],8.4-11.0)versus 8.0 months(95%CI,6.6-9.5)(adjusted hazard ratio[HR],0.70,P=0.002).OS and ORR were also significantly higher in combination group(median OS,19.2[16.1-27.3]vs.15.7 months[13.0-20.2];adjusted HR,0.63,P=0.001;ORR,60.1%vs.32.0%;P<0.001).Grade 3/4 adverse events were observed at a rate of 15.8%and 7.5%in combination and monotherapy groups,*** results suggest that TACE plus PD-(L)1 blockades and MTT could significantly improve PFS,OS,and ORR versus TACE monotherapy for Chinese patients with predominantly advanced HCC in real-world practice,with an acceptable safety profile.

关键词： hepatocellular targeted matching

Efficacy and safety of sirolimus early conversion protocol in liver transplant patients with hepatocellular carcinoma:A single-arm, multicenter, prospective study

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Hepatobiliary & Pancreatic Diseases International 2022年第2期21卷 106-112页

作者： Ren-Yi Su Sun-Bin ling Qiao-Nan Shan Xu-Yong Wei Rui Wang Chang-Ku Jia li Zhuang Tian Shen li-Min Ding Zhi-Dan Xu Lai-Bang Luo li-Bo Sun Guang-Ming li Tai-Shi Fang Nan Jiang Kun Zhang Zhao-Jie Su Zhi-Hai Peng Ren lang Tao Jiang Qiang He lin-Sen Ye Yang Yang Yu-Ting He Wen-Zhi Guo liu-Gen lan Xu-Yong Sun Dong Chen Zhi-Shui Chen Da-Wei Zhou Shao-jun Ye Qi-Fa Ye Min Tian Jian-Hua Shi Bo Wang Jiang liu Qian Lu Wei Rao Jin-Zhen Cai Tao Lv Jia-Yin Yang Pu-Sen Wang lin Zhong Jing-Sheng Ma Qi-Gen li Sheng-Dong Wu Chang-Jiang Lu Cai-De Lu Dong-Hua Zhang Xuan Wang Zi-Qiang li mu-Jian Teng jun-Jie li Wen-Tao Jiang Jian-Hua li quan-Bao Zhang Ning-Qi Zhu Zheng-Xin Wang Kang He Qiang Xia Shao-Hua Song Zhi-Ren Fu Wei Qiu Guo-Yue Lv Rui-Peng Song Ji-Zhou Wang Zheng Wang Jian Zhou Gang Chen Ying-Peng Zhao li li Ze-Min Hu Qi-Jie Luo Zhong-Zhou Si Bin Xie xiao-Shun He Zhi-Yong Guo Shu-Sen Zheng xiao Xu Department of Hepatobiliary and Pancreatic Surgery The Center for Integrated Oncology and Precision MedicineAffiliated Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhou 310006China NHC Key Laboratory of Combined multi-organ Transplantation Hangzhou 310003China Department of Hepatobiliary and Pancreatic Surgery Shulan(Hangzhou)HospitalZhejiang Shuren University School of MedicineHangzhou 310022China Department of Hepatobiliary and Pancreatic Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Transplantation Jiangxi Provincial People’s Hospital Affiliated to Nanchang UniversityNanchang 330006China liver Transplantation Center Beijing You’an HospitalCapital Medical UniversityBeijing 100069China Department of Hepatic Surgery National Clinical Research Center for Infectious DiseaseShenzhen Third People’s HospitalThe Second Affiliated Hospital of Southern University of Science and TechnologyShenzhen 518112China Department of General Surgery Xiang’an Hospital of Xiamen UniversityXiamen 361000China Deartment of Hepatobiliary and Pancreaticosplenic Surgery Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China Department of Hepatic Surgery and liver Transplantation Center The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China Department of Hepatobiliary and Pancreatic Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Department of liver Transplantation The Second Affiliated Hospital of Guangxi Medical UniversityNanning 530000China Institute of Organ Transplantation Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Institute of Hepatobiliary Diseases of Wuhan University Transplant Center of Wuhan UniversityHubei Key Laboratory of Medical Technology on TransplantationZhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Hepatobiliary Surgery The First Affiliated Hos

Mammalian target of rapamycin(m TOR) inhibitor as an attractive drug target with promising antitumor effects has been widely investigated. High quality clinical trial has been conducted in liver transplant(LT) recipients in Western countries. However, the pertinent studies in Eastern world are paucity. Therefore, we designed a clinical trial to test whether sirolimus can improve recurrence-free survival(RFS) in hepatocellular carcinoma(HCC) patients beyond the Milan criteria after LT. This is an open-labeled, single-arm, prospective, multicenter, and real-world study aiming to evaluate the clinical outcomes of early switch to sirolimus-based regimens in HCC patients after LT. Patients with a histologically proven HCC and beyond the Milan criteria will be enrolled. The initial immunosuppressant regimens are center-specifc for the frst 4-6 weeks. The following regimens integrated sirolimus into the regimens as a combination therapy with reduced calcineurin inhibitors based on the condition of patients and centers. The study is planned for 4 years in total with a 2-year enrollment period and a 2-year follow-up. We predict that sirolimus conversion regimen will provide survival benefts for patients particular in the key indicator RFS as well as better quality of life. If the trial is conducted successfully, we will have a continued monitoring over a longer follow-up time to estimate indicator of overall survival. We hope that the outcome will provide better evidence for clinical decision-making and revising treatment guidelines based on Chinese population data.

关键词： Sirolimus Immunosuppressive agents Hepatocellular carcinoma liver transplantation Conversion

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EARS在北京市流感大流行预警中的应用

北京大学学报（医学版） 2012年第3期44卷 412-415页

作者：张代涛杨鹏张奕张莉彭晓旻石伟先卢桂兰梁慧洁刘医萌刘民王全意北京市疾病预防控制中心传染病地方病控制所北京100013 北京大学公共卫生学院流行病与卫生统计学系北京100191

目的:阐明累积和法用于北京市流感暴发预警的有效性。方法:应用基于累积和算法的早期异常报告系统(early aberration reporting system,EARS)对北京市流感样病例监测数据进行预警分析,以流感病原学监测结果作为判断流感高峰来临的金标... 详细信息

目的:阐明累积和法用于北京市流感暴发预警的有效性。方法:应用基于累积和算法的早期异常报告系统(early aberration reporting system,EARS)对北京市流感样病例监测数据进行预警分析,以流感病原学监测结果作为判断流感高峰来临的金标准。结果:2009年至2010年北京市共有421家医院开展了流感样病例监测,7家网络实验室开展了流感病原学监测。2009年6月至2010年4月,421家医院的平均流感样病例百分比为2.56%,共在11家医院采集流感样病例咽拭子19 262份,分离流感病毒5 045株,以新甲型H1N1流感病毒为主。使用累积和法对北京市二级以上医院流感样病例监测数据进行分析较好地预警了流感高峰的来临。结论:应用累积和法对北京市流感监测数据进行分析,可以高效准确地对流感高峰进行预警。

关键词：流感疾病暴发流行人群监测疾病报告数据说明,统计