The diagnostic and prognostic values of plasma Epstein-Barr virus DNA for residual cervical lymphadenopathy in nasopharyngeal carcinoma patients:a retrospective study
作者机构：State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapySun Yat-sen University Cancer CenterGuangzhou 510060GuangdongP.R.China Department of Nasopharyngeal CarcinomaSun Yat-sen University Cancer CenterGuangzhou 510060Guang-dongP.R.China Department of Radiation OncologySun Yat-sen University Cancer CenterGuangzhou 510060GuangdongP.R.China
出 版 物：《Cancer Communications》 (癌症通讯（英文）)
年 卷 期：2019年第39卷第1期
页 面：135-147页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：This study was supported by grants from the National Key R&D Program of China(2016YFC0902003,2017YFC1309003,2017YFC0908500) the National Natural Science Foundation of China(No.81425018,No.81672868,No.81602371,No.81572848,No.81772877,No.81372814,No.81773103) the Sun Yat-sen University Clinical Research 5010 Program,the Sci-Tech Project Foundation of Guangzhou City(201707020039) the National Key Basic Research Program of China(No.2013CB910304) the Special Support Plan of Guangdong Province(No.2014TX01R145) the Sci-Tech Project Foundation of Guangdong Province(No.2014A020212103,No.2012B031800255,No.2014A020212528) Guangzhou Science and Technology Planning Project China(No.2014J4100181) the Health&Medical Collaborative Innovation Project of Guangzhou City(No.201400000001) the National Science&Technology Pillar Program during the Twelfth Five-year Plan Period(No.2014BAI09B10) the PhD Start-up Fund of Natural Science Foundation of Guangdong Province,China(2016A030310221) the Cultivation Foundation for Junior Teachers of Sun Yat-sen University(16ykpy28) the Fundamental Research Funds for the Central Universities
主 题：Nasopharyngeal carcinoma Residual cervical lymphadenopathy Prognosis Epstein-Barr virus Fine needle aspiration cytology Survival
摘 要：Background:Currently,the diagnosis and treatment of nasopharyngeal carcinoma(NPC)patients with residual cervical lymphadenopathy following radical radiotherapy with or without chemotherapy are *** investigated the prognosis of NPC patients with residual cervical lymphadenopathy and assessed the diagnostic and prognostic values of Epstein-Barr virus(EBV)DNA in these ***:This study included 82 NPC patients who were diagnosed with suspected residual cervical lymphadenopathy following completion of antitumor *** plasma EBV DNA levels were measured using quantitative polymerase chain reaction(qPCR)before the initiation of treatment and before neck *** needle aspiration cytology(FNAC)was performed in 21 *** patients had undergone neck dissection and postoperative pathological examination to identify the nature of residual cervical *** overall survival(OS),progression-free survival(PFS),distant metastasis-free survival(DMFS),and locoregional relapse-free survival(LRRFS)were calculated using the Kaplan-Meier method and compared using the log-rank *** Cox proportional hazards model was used to calculate hazard ratios(HRs)with 95%confidence intervals(CIs).Multivariable analysis was used to estimate the effect of potential prognostic factors on ***:Following a median follow-up of 52.6 months,compared with patients with negative postoperative pathological findings for residual cervical lymphadenopathy,the patients with positive findings had a significantly lower 3-year PFS rate(49.9%vs.83.3%,P=0.008).Among NPC patients with residual cervical lymphadenopathy,the patients with preoperative plasma EBV DNA0 copy/mL had a lower 3-year PFS rate than did those with no detectable EBV DNA(43.7%vs.61.1%,P=0.031).In addition,combining FNAC with preoperative EBV DNA detection improved the diagnostic *** analysis demonstrated that residual cervical lymphadenopathy with positive po
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