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Natural lotus root-based scaffolds for bone regeneration

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Chinese Chemical Letters 2022年第4期33卷 1941-1945页

作者： Keqing huang Jun HUANG Jinmin Zhao Zhipeng Gu jun Wu School of Biomedical Engineering Sun Yat-sen UniversityShenzhen 518107China Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Guangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration the First Affiliated Hospital of Guangxi Medical UniversityNanning 530021China Research Institute of Sun Yat-sen University in Shenzhen Shenzhen 518057China College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065China Guangdong Academy of Sciences Institute of Biological and Medical EngineeringGuangzhou 510316China

A high incidence of bone defects and the limitation of autologous bone grafting require 3 D scaffolds for bone repair. Compared with synthetic materials, natural edible materials possess outstanding advantages in terms of biocompatibility, bioactivities and low manufacturing cost for bone tissue engineering. In this work, attracted by the natural porous/fabric structure, good biocompatibility and bioactivities of the lotus root, the lotus root-based scaffolds were fabricated and investigated their potential to serve as natural porous bone tissue engineering scaffolds. The results indicated that the lotus root-based scaffolds possess suitable natural microstructure, excellent biocompatibility and promising functions, such as antioxidant capacity and angiogenesis promotion. Remarkably, lotus root scaffolds showed encouraging possibility of bone tissue engineering while the mineralized lotus root could further improve the bone regeneration in vivo. All the results demonstrated the bone regeneration potential of lotus root-based scaffolds equipped with suitable natural architecture, excellent biocompatibility, specific bioactivities and low manufacturing cost.

关键词： Bone regeneration Lotus root Porous structure Mineralization

MRN complex is an essential effector of DNA damage repair

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2021年第1期22卷 31-37页

作者： Shan QIU Jun HUANG The MOE Key Laboratory of Biosystems Homeostasis&Protection Zhejiang Provincial Key Laboratory for Cancer Molecular Cell Biology and Innovation Center for Cell Signaling NetworkLife Sciences InstituteZhejiang UniversityHangzhou 310058China Zhejiang University-University of Edinburgh Institute School of MedicineZhejiang UniversityHaining 314400China

Genome stability can be threatened by both endogenous and exogenous agents.Organisms have evolved numerous mechanisms to repair DNA damage,including homologous recombination(HR)and non-homologous end joining(NHEJ).Among the factors associated with DNA repair,the MRE11-RAD50-NBS1(MRN)complex(MRE11-RAD50-XRS2 in Saccharomyces cerevisiae)plays important roles not only in DNA damage recognition and signaling but also in subsequent HR or NHEJ repair.Upon detecting DNA damage,the MRN complex activates signaling molecules,such as the protein kinase ataxia-telangiectasia mutated(ATM),to trigger a broad DNA damage response,including cell cycle arrest.The nuclease activity of the MRN complex is responsible for DNA end resection,which guides DNA repair to HR in the presence of sister chromatids.The MRN complex is also involved in NHEJ,and has a species-specific role in hairpin repair.This review focuses on the structure of the MRN complex and its function in DNA damage repair.

关键词： DNA damage repair MRE11-RAD50-NBS1(MRN)complex Homologous recombination Non-homologous end joining

An optimization model of parameter matching for aircraft catapult launch

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Chinese Journal of Aeronautics 2020年第1期33卷 191-204页

作者： Zeyang ZHOU Jun HUANG School of Aeronautic Science and Engineering Beihang UniversityBeijing 100083China

To efficiently and fully utilize aircraft carrier resources,an optimization model is presented to deal with parameter matching between aircraft and carrier in the process of aircraft catapult launch.Based on carrier aircraft longitudinal dynamic equations and theorem of kinetic energy in catapult launch course,the work characteristics of different forces are learned and a theory model of parameter matching is deduced.In view of the uncertainty of the model parameters of the theory model and the low matching accuracy of the approximate model,an optimization model of parameter matching is introduced in line with the structure of theory model and the approximate model and is generated by the proposed immune genetic algorithm.Compared with the original genetic algorithm and immune algorithm,the proposed algorithm has better calculation accuracy and convergence.The calculation results show that the optimization model occupies certain application value of engineering estimation from the comparison with the relevant literature data and has higher precision than the approximate models.The validity of the proposed approach is verified with numerical case study on a carrier based aircraft.

关键词： Aircraft catapult launch Approximate model Immune genetic algorithm Optimization model Parameter matching Theory model

Joint Sample Position Based Noise Filtering and Mean Shift Clustering for Imbalanced Classification Learning

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Tsinghua Science and Technology 2024年第1期29卷 216-231页

作者： Lilong Duan Wei Xue Jun HUANG Xiao Zheng School of Computer Science and Technology Anhui University of TechnologyMaanshan 243032China Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefei 230088China

The problem of imbalanced data classification learning has received much attention.Conventional classification algorithms are susceptible to data skew to favor majority samples and ignore minority samples.Majority weighted minority oversampling technique(MWMOTE)is an effective approach to solve this problem,however,it may suffer from the shortcomings of inadequate noise filtering and synthesizing the same samples as the original minority data.To this end,we propose an improved MWMOTE method named joint sample position based noise filtering and mean shift clustering(SPMSC)to solve these problems.Firstly,in order to effectively eliminate the effect of noisy samples,SPMsC uses a new noise filtering mechanism to determine whether a minority sample is noisy or not based on its position and distribution relative to the majority sample.Note that MWMOTE may generate duplicate samples,we then employ the mean shift algorithm to cluster minority samples to reduce synthetic replicate samples.Finally,data cleaning is performed on the processed data to further eliminate class overlap.Experiments on extensive benchmark datasets demonstrate the effectiveness of SPMsC compared with other sampling methods.

关键词： imbalanced data classification oversampling noise filtering clustering

Influence of stealth aircraft dynamic RCS peak on radar detection probability

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Chinese Journal of Aeronautics 2023年第3期36卷 137-145页

作者： Xiaoqiang LU Jun HUANG Yacong WU Lei SONG School of Aeronautic Science and Engineering Beihang UniversityBeijing 100191China

For modern stealth aircraft,it is important to analyze the influence of Radar Cross Section(RCS)peak exposure on penetration for guiding stealth design and penetration trajectory planning,which needs to reflect the RCS statistical uncertainty and the RCS difference with the change of incident angle.Based on the RCS characteristics of typical stealth aircraft,this paper established a simplified RCS dynamic fluctuation statistical model with the parameters log mean and log standard deviation.According to the detection probability algorithm in radar signal processing field,this paper built the algorithm of radar detection probability based on the RCS dynamic fluctuation statistical model.The analysis of examples concluded that the key to successful penetration is to shorten the RCS peak exposure time,which can be reduced by decreasing the RCS peak width or increasing velocity.Based on the conclusion,this paper proposed the method of turning maneuvering to reduce RCS peak exposure time dramatically.

关键词： Maneuver Penetration RCS RCS fluctuation statistical model RCS peak exposure time RCS peak width Stealth Trajectory planning

An explosive mud volcano origin for the pitted cones in southern Utopia Planitia,Mars

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中国科学:地球科学英文版 2023年第9期66卷 2045-2056页

作者： Le WANG Jiannan ZHAO Jun HUANG Long XIAO School of Earth Sciences China University of GeosciencesWuhan 430074China State Key Laboratory of Geological Processes and Mineral Resources Wuhan 430074China Key Laboratory of Geological Survey and Evaluation of Ministry of Education China University of GeosciencesWuhan 430074China

Pitted cones are cone-shaped structures,spanning from meters to kilometers in size,characterized by summit depressions.They are widely distributed on the surface of Mars with various origins,such as rootless cones,mud volcanoes,cinder or scoria cones,tuff rings or cones,pingos,and dirt cones.If the pitted cones identified in southern Utopia Planitia are mud volcanoes,as is speculated,they could be of particular interest due to the fact that mud volcanoes on Earth bring sediments from a depth of meters to kilometers to the surface.In this study,we have investigated the pitted cones near Zhurong rover’s landing site in southern Utopia Planitia,utilizing recent images and digital elevation models obtained from the High Resolution Imaging Camera instrument onboard China’s Tianwen-1 orbiter.By leveraging the high-resolution images and digital elevation models,we have conducted a geometric measurement to distinguish the origin of pitted cones in the vicinity of the Zhurong rover.The morphological characteristics of these pitted cones indicate an explosive mud volcano origin.These explosive mud volcanoes could have formed by the violent eruption of subsurface overpressurized sediments generated from the combined effect of overburden pressure and anomalous high heat flow.The sediments forming the pitted cones in the northern plains could be the remnants of an ancient ocean.With future in-situ observations of these pitted cones,we hope to gain further insights into the sediments of the putative northern ocean,as well as the physical and chemical properties of the Martian subsurface during the formation of the pitted cones.

关键词： Pitted cones Mud volcanoes Tianwen-l Mars

A novel proactive soft load balancing framework for ultra dense network

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Digital Communications and Networks 2023年第3期9卷 788-796页

作者： Miaona huang jun Chen School of Electrical Engineering and Intelligentization Dongguan University of TechnologyDongguanGuangdong523808China Huawei Technology Shenzhen518129China

A major challenge for the future wireless network is to design the self-organizing architecture.The reactive self-organizing model of traditional networks needs to be transformed into an active self-organizing network.Due to the user mobility and the coverage of small cells,the network load often becomes unbalanced,resulting in poor network performance.Mobility management has become an important issue to ensure seamless communication when users move between cells,and proactive mobility management is one of the important functions of the active Self-Organizing Network(SON).This paper proposes a proactive mobility management framework for active SON,which transforms the original reactive load balancing into a forward-aware and proactive load balancing.The proposed framework firstly uses the BART model to predict the users’temporal and spatial mobility based on a weekly cycle and then formulate the MLB optimization problem based on the soft load.Two solutions are proposed to solve the above MLB problem.The simulation results show that the proposed method can better optimize the network performance and realize intelligent mobile management for the future network.

关键词： 5G and beyond Proactive load balancing Heterogeneous network Soft load Location prediction

Parameter study on lateral moments of banked wings in ground effect

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Chinese Journal of Aeronautics 2022年第3期35卷 53-61页

作者： Jingfeng XIE Lei SONG Jun HUANG Jingcheng FU School of Aeronautics Science and Engineering Beihang UniversityBeijing 100083China

Ground effect dramatically improves the performance of the Wing-in-Ground(WIG)vehicles near the ground.However,making coordinate turnings in ground effect zone may raise complexity in flight control.The Angle of Attack(AOA)and height are believed to be important factors.To find the impact of these factors,three straight rectangular wings with different aspect ratios are simulated via CFD approach.The results show that in normal situations,the rolling moment tends to level the wing but less effective with the decreasing AOA and changes its direction when the AOA is less than a height dependent value.The yaw moment exhibits complex behavior because two different effects generate oppose moments.The rolling moment coefficient is more influenced by the ground if a wing has larger Aspect Ratio(AR)and works at low to medium AOA.The yawing coefficient is always more influenced if the wing has larger AR regardless AOAs.These findings can provide basic guidance for the design of control system and enable aircraft designers to reshape the crafts to avoid or utilize this effect.

关键词： Angle of attack CFD Ground effect Lateral moments

Morphometric changes in the cortex following acute mild traumatic brain injury

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Neural Regeneration Research 2022年第3期17卷 587-593页

作者： Meng-jun Li Si-Hong huang Chu-Xin huang jun Liu Department of Radiology the Second Xiangya Hospital of Central South UniversityChangshaHunan ProvinceChina

Morphometric changes in cortical thickness(CT),cortical surface area(CSA),and cortical volume(CV) can reflect pathological changes after acute mild traumatic brain injury(m TBI).Most previous studies focused on changes in CT,CSA,and CV in subacute or chronic m TBI,and few studies have examined changes in CT,CSA,and CV in acute m TBI.Furthermore,acute m TBI patients typically show transient cognitive impairment,and few studies have reported on the relationship between cerebral morphological changes and cognitive function in patients with m TBI.This prospective cohort study included 30 patients with acute m TBI(15 males,15 females,mean age 33.7 years) and 27 matched healthy controls(12 males,15 females,mean age 37.7 years) who were recruited from the Second Xiangya Hospital of Central South University between September and December 2019.High-resolution T1-weighted images were acquired within 7 days after the onset of m TBI.The results of analyses using Free Surfer software revealed significantly increased CSA and CV in the right lateral occipital gyrus of acutestage m TBI patients compared with healthy controls,but no significant changes in CT.The acute-stage m TBI patients also showed reduced executive function and processing speed indicated by a lower score in the Digital Symbol Substitution Test,and reduced cognitive ability indicated by a longer time to complete the Trail Making Test-B.Both increased CSA and CV in the right lateral occipital gyrus were negatively correlated with performance in the Trail Making Test part A.These findings suggest that cognitive deficits and cortical alterations in CSA and CV can be detected in the acute stage of m TBI,and that increased CSA and CV in the right lateral occipital gyrus may be a compensatory mechanism for cognitive dysfunction in acute-stage m TBI patients.This study was approved by the Ethics Committee of the Second Xiangya Hospital of Central South University,China(approval No.086) on February 9,2019.

关键词： acute mild brain trauma injury Alzheimer's disease cognitive function cortical surface area cortical thickness cortical volume Free Surfer surface-based morphometry