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Exploring challenges ahead of nanotechnology for biomedicine

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Bioactive Materials 2017年第3期2卷 119-120页

作者： julietta v.rau Roberto De Santis Gianni Ciofani Istituto di Struttura della Materia(ISM-CNR) Consiglio Nazionale delle Ricerchevia del Fosso del Cavaliere 10000133 RomaItaly IPCB-CNR Institute for Polymers Composites and Biomaterials-National Research Council of ItalyVia J.F.Kennedy54 Mostra D'Oltremare Pad.2080125 NaplesItaly Politecnico di Torino Department of Mechanical and Aerospace EngineeringCorso Duca degli Abruzzi 2410129 TorinoItaly Istituto Italiano di Tecnologia Smart Bio-InterfacesViale Rinaldo Piaggio 3456025 PontederaPisaItaly

This special issue is dedicated to the selected papers of the 1st biennial International Conference BioMaH-BioMaterials for Healthcare“Biomaterials for Tissue and Genetic Engineering and the Role of Nanotechnology”held in Rome(Italy)in October 17-20,*** special issue is focused on the new frontiers of bioactive materials facing challenges and embracing opportunities in the field of tissue regeneration and *** focus includes a wide range of chemical,physical,and biological aspects,with the scope of exploring emerging technologies for a large variety of engineered materials,their combinations,and interfaces with specific biofunctionality.

关键词： frontier challenges ahead

A review on current research status of the surface modification of Zn-based biodegradable metals

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Bioactive Materials 2022年第1期7卷 192-216页

作者： Wei Yuan Dandan Xia Shuilin Wu Yufeng Zheng Zhenpeng Guan julietta v.rau School of Materials Science and Engineering Peking UniversityBeijing100871China National Engineering Laboratory for Digital and Material Technology of Stomatology National Clinical Research Center for Oral DiseasesBeijing Key Laboratory of Digital StomatologyNational Medical Products Administration Key Laboratory for Dental MaterialsResearch Center of Engineering and Technology for Digital DentistryMinistry of HealthBeijing100081China School of Materials Science&Engineering The Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of ChinaTianjin UniversityTianjin300072China Orthopedics Department Peking University Shougang HospitalNo.9 Jinyuanzhuang RdShijingshan DistrictBeijing100144China Istituto di Struttura della Materia Consiglio Nazionale delle Ricerche(ISM-CNR)Via del Fosso del Cavaliere100-00133RomeItaly Sechenov First Moscow State Medical University Institute of PharmacyDepartment of AnalyticalPhysical and Colloid ChemistryTrubetskaya 8build.2119991MoscowRussia

Recently,zinc and its alloys have been proposed as promising candidates for biodegradable metals(BMs),owning to their preferable corrosion behavior and acceptable biocompatibility in cardiovascular,bone and gastrointestinal environments,together with Mg-based and Fe-based ***,there is the desire for surface treatment for Zn-based BMs to better control their biodegradation ***,the implantation of some Zn-based BMs in cardiovascular environment exhibited intimal activation with mild ***,for orthopedic applications,the biodegradation rates of Zn-based BMs are relatively slow,resulting in a long-term retention after fulfilling their ***,excessive Zn2+release during degradation will cause in vitro cytotoxicity and in vivo delayed *** this review,we firstly summarized the current surface modification methods of Zn-based alloys for the industrial *** we comprehensively summarized the recent progress of biomedical bulk Zn-based BMs as well as the corresponding surface modification *** but not least,the future perspectives towards the design of surface bio-functionalized coatings on Zn-based BMs for orthopedic and cardiovascular applications were also briefly proposed.

关键词： Zn-based biodegradable metals Surface modification Corrosion behavior Biocompatibility Osseointegration

In vitro characterization of novel nanostructured collagen-hydroxyapatite composite scaffolds doped with magnesium with improved biodegradation rate for hard tissue regeneration

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Bioactive Materials 2021年第10期6卷 3383-3395页

作者： Iulian v.Antoniac Aurora Antoniac Eugeniu vasile Camelia Tecu Marco Fosca viktoriya G.Yankova julietta v.rau University Politehnica of Bucharest 313 Splaiul Independentei StreetDistrict 6060042BucharestRomania Academy of Romanian Scientists 54 Splaiul Independentei StreetDistrict 5050094BucharestRomania Istituto di Struttura della Materia Consiglio Nazionale delle Ricerche(ISM-CNR)Via del Fosso del Cavaliere10000133RomeItaly Sechenov First Moscow State Medical University Institute of PharmacyDepartment of AnalyticalPhysical and Colloid ChemistryTrubetskaya 8Build.2Moscow119991Russia

New materials are required for bone healing in regenerative medicine able to temporarily substitute damaged bone and to be subsequently resorbed and replaced by endogenous *** inspiration from basic composition of the mammalian bones,composed of collagen,apatite and a number of substitution ions,among them magnesium(Mg2+),in this work,novel composite scaffolds composed of collagen(10%)-hydroxyapatite(HAp)(90%)and collagen(10%)-HAp(80%)-Mg(10%)were *** lyophilization was used for composites *** insight into the nanostructural nature of the developed scaffolds was performed by Scanning Electron Microscopy coupled with Energy Dispersive X-Ray and Transmission Electron Microscopy coupled with Energy Dispersive *** HAp nanocrystallite clusters and Mg nanoparticles were homogeneously distributed within the scaffolds and adherent to the collagen *** samples were tested for degradation in Simulated Body Fluid(SBF)solution by soaking for up to 28 *** release of Mg from collagen(10%)-HAp(80%)-Mg(10%)composite during the period of up to 21 days was attested,this composite being characterized by a decreased degradation rate with respect to the composite without *** developed composite materials are promising for applications as bone substitute materials favouring bone healing and regeneration.

关键词： Composite Collagen Hydroxyapatite Magnesium Scaffold Hard tissue regeneration Scaffold degradation

Ionized jet deposition of antimicrobial and stem cell friendly silver-substituted tricalcium phosphate nanocoatings on titanium alloy

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Bioactive Materials 2021年第8期6卷 2629-2642页

作者： Gabriela Graziani Katia Barbaro Inna v.Fadeeva Daniele Ghezzi Marco Fosca Enrico Sassoni Gianluca vadalà Martina Cappelletti Francesco valle Nicola Baldini julietta v.rau IRCSS Istituto Ortopedico Rizzoli Laboratory of NanoBiotechnologyvia di Barbiano 1/1040136BolognaItaly Istituto Zooprofilattico Sperimentale Lazio e Toscana“M.Aleandri” Via Appia Nuova 1411-00178RomeItaly A.A.Baikov Institute of Metallurgy and Materials Science Russian Academy of SciencesLeninsky prospect 49119334MoscowRussia Istituto di Struttura della Materia Consiglio Nazionale delle Ricerche(ISM-CNR)Via del Fosso del Cavaliere100-00133RomeItaly University of Bologna Department of CivilChemicalEnvironmental and Materials Engineeringvia Terracini 2840131BolognaItaly UniversitàCampus Bio-Medico di Roma Research Unit of Orthopaedic SurgeryFaculty of Medicine and SurgeryVia Alvaro del Portillo 2100128RomeItaly University of Bologna Department of Pharmacy and Biotechnologyvia Irnerio 4240126BolognaItaly Institute of Nanostructured Materials National Research Council(ISMN-CNR)Via Piero Gobetti10140129BolognaItaly IRCSS Istituto Ortopedico Rizzoli BST Biomedical Science and Technologies Labvia di Barbiano 1/1040136BolognaItaly University of Bologna Department of Biomedical and Neuromotor SciencesVia Massarenti940128BolognaItaly Sechenov First Moscow State Medical University Institute of PharmacyDepartment of AnalyticalPhysical and Colloid ChemistryTrubetskaya 8build.2119991MoscowRussia

Orthopedic infections pose severe societal and economic burden and interfere with the capability of the implanted devices to integrate in the host bone,thus significantly increasing implants failure *** address infection and promote integration,here nanostructured antibacterial and bioactive thin films are proposed,obtained,for the first time,by Ionized Jet Deposition(IJD)of silver-substituted tricalcium phosphate(Ag-TCP)targets on *** morphology,composition and mechanical properties are characterized and proof-of-concept of biocompatibility is *** efficacy is investigated against four Gram positive and Gram negative bacterial strains and against *** fungus,by investigating the modifications in planktonic bacterial growth in the absence and presence of ***,for all bacterial strains,the capability of the film to inhibit bacterial adhesion is also *** indicate that IJD permits a fine control over films composition and morphology and deposition of films with suitable mechanical *** studies show a good efficacy against Escherichia coli,Staphylococcus aureus,Pseudomonas aeruginosa,Enterococcus faecalis and against fungus Candida albicans,with evidences of efficacy against planktonic growth and significant reduction of bacterial cell *** cytotoxic effects are evidenced for equine adipose tissue derived mesenchymal stem cells(ADMSCs),as no reductions are caused to cells viability and no interference is assessed in cells differentiation towards osteogenic lineage,in the presence of ***,thanks to nanostructuration and biomimetic composition,tricalcium phosphate(TCP)coatings favor cells viability,also when *** findings show that silver-substituted nanostructured coatings are promising for orthopedic implant applications.

关键词： Tricalcium phosphate Silver Nanostructured coatings Antibacterial coatings Orthopedics Antibacterial ceramics

Modification of titanium surface via Ag-,Sr-and Si-containing micro-arc calcium phosphate coating

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Bioactive Materials 2019年第1期4卷 224-235页

作者： Mariya B.Sedelnikova Ekaterina G.Komarova Yurii P.Sharkeev Anna v.Ugodchikova Tatiana v.Tolkacheva julietta v.rau Evgeny E.Buyko vladimir v.Ivanov vladimir v.Sheikin Institute of Strength Physics and Materials Science of SB RAS Academicheskii Prospect 2/4Tomsk634055Russia National Research Tomsk Polytechnic University Lenina Prospect 30Tomsk634050Russia Istituto di Struttura della Materia Consiglio Nazionale delle Ricerche(ISM-CNR)Via del Fosso del Cavaliere 10000133 RomaItaly Siberian State Medical University Moscovskii Tract 2Tomsk634050Russia

The current research is devoted to the study of the modification of the titanium implants by the micro-arc oxidation with bioactive calcium phosphate coatings containing Ag or Sr and Si *** coatings’microstructure,phase composition,morphology,physicochemical and biological properties were examined by scanning electron microscopy(SEM),transmission electron microscopy(TEM),energy-dispersive X-ray spectroscopy(EDX)and X-ray diffraction(XRD).Ag-containing and Sr-Si-incorporated coatings were formed in alkaline and acid electrolytes,*** formation of the coatings occurred at different ranges of the applied voltages,which led to the significant difference in the coatings *** trace elements Ag,Sr and Si participated intensively in the plasma-chemical reactions of the micro-arc coatings ***-containing coatings demonstrated strong antibacterial effect against Staphylococcus aureus AТСС*** in vitro test with 3T3-L1 fibroblasts showed no cytotoxicity appearance on Sr-Si-incorporated coatings.

关键词： Trace elements Biocoatings Micro-arc oxidation Titanium substrate Antibacterial activity

Quality control methods in musculoskeletal tissue engineering:from imaging to biosensors

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Bone Research 2021年第4期9卷 473-493页

作者： Daniele Zuncheddu Elena Della Bella Andrea Schwab Dalila Petta Gaia Rocchitta Silvia Generelli Felix Kurth Annapaola Parrilli Sophie verrier julietta v.rau Marco Fosca Margherita Maioli Pier Andrea Serra Mauro Alini Heinz Redl Sibylle Grad valentina Basoli AC Research Institute Davos Clavadelerstrasse 87270 DavosSwitzerland Regenerative Medicine Technologies Lab Ente Ospedaliero Cantonale(EOC)Via Tesserete 466900 LuganoSwitzerland Department of Medical Surgical and Experimental SciencesUniversity of SassariViale San Pietro 43/b07100 SassariItaly Centre Suisse d'Electronique et de Microtechnique Bahnhofstrasse 17302 LandquartSwitzerland Center for X-ray Analytics Empa-Swiss Federal Laboratories for Materials Science and TechnologyUberlandstrasse 1298600 DubendorfSwitzerland lstituto di Struttura della Materia Consiglio Nazionale delle Ricerche(ISM-CNR)Via del Fosso del Cavaliere100-00133 RomeItaly Sechenov First Moscow State Medical University Trubetskaya 8build.2119991 MoscowRussian Federation Department of Biomedical Sciences University of SassariViale San Pietro 43/b07100 SassariItaly Ludwig Boltzmann Institute for Experimental and Clinical Traumatology in AUvA trauma research center DonaueschingenstraBe 131200 ViennaAustria Austrian Cluster for Tissue Regeneration ViennaAustria

Tissue engineering is rapidly progressing toward clinical *** the musculoskeletal field,there has been an increasing necessity for bone and cartilage *** the promising translational potential of tissue engineering approaches,careful attention should be given to the quality of developed constructs to increase the real applicability to *** a general introduction to musculoskeletal tissue engineering,this narrative review aims to offer an overview of methods,starting from classical techniques,such as gene expression analysis and histology,to less common methods,such as Raman spectroscopy,microcomputed tomography,and biosensors,that can be employed to assess the quality of constructs in terms of viability,morphology,or matrix deposition.A particular emphasis is given to standards and good practices(GXP),which can be applicable in different ***,a classification of the methods into destructive,noninvasive,or conservative based on the possible further development of a preimplant quality monitoring system is *** in musculoskeletal tissue engineering have not yet been used but have been proposed as a novel technology that can be exploited with numerous advantages,including minimal invasiveness,making them suitable for the development of preimplant quality control systems.

关键词： skeletal starting spite

Severe acute pancreatitis: Clinical course and management

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World Journal of Gastroenterology 2007年第38期13卷 5043-5051页

作者： Hans G Beger Bettina M rau Department of General Surgery Department of Viszeralsurgery University of Ulm (1982-2001) Donau-Klinikum Neu-Ulm Germany Department of General Viszeral Vascular and Pediatric Surgery Universit?tsklinikum des Saarlandes Homburg/ Saar Germany

Severe acute pancreatitis (SAP) develops in about 25% of patients with acute pancreatitis (AP). Severity of AP is linked to the presence of systemic organ dysfunctions and/or necrotizing pancreatitis pathomorphologically. Risk factors determining independently the outcome of SAP are early multi-organ failure, infection of necrosis and extended necrosis (> 50%). Up to one third of patients with necrotizing pancreatitis develop in the late course infection of necroses. Morbidity of SAP is biphasic, in the first week strongly related to early and persistence of organ or multi-organ dysfunction. Clinical sepsis caused by infected necrosis leading to multi-organ failure syndrome (MOFS) occurs in the later course after the first week. To predict sepsis, MOFS or deaths in the first 48-72 h, the highest predictive accuracy has been objectified for procalcitonin and IL-8; the Sepsis- Related Organ Failure Assessment (SOFA)-score predicts the outcome in the first 48 h, and provides a daily assessment of treatment response with a high positive predictive value. Contrast-enhanced CT provides the highest diagnostic accuracy for necrotizing pancreatitis when performed after the first week of disease. Patients who suffer early organ dysfunctions or at risk of developing a severe disease require early intensive care treatment. Early vigorous intravenous fluid replacement is of foremost importance. The goal is to decrease the hematocrit or restore normal cardiocirculatory functions. Antibiotic prophylaxis has not been shown as an effective preventive treatment. Early enteral feeding is based on a high level of evidence, resulting in a reduction of local and systemic infection. Patients suffering infected necrosis causing clinical sepsis, pancreatic abscess or surgical acute abdomen are candidates for early intervention. Hospital mortality of SAP after interventional or surgical debridement has decreased in high volume centers to below 20%.

关键词： Severe acute pancreatitis Multiorgan failure syndrome Infected necrosis Fluid replacement Enteral feeding Surgical and interventional debridement

Colloidal forming of macroporous calcium pyrophosphate bioceramics in 3D-printed molds

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Bioactive Materials 2020年第2期5卷 309-317页

作者： Ya.Yu Filippov E.D.Orlov E.S.Klimashina P.v.Evdokimov T.v.Safronova v.I.Putlayev J.v.rau Department of Materials Science Lomonosov Moscow State UniversityMoscowRussia Institute of Mechanics Research Lomonosov Moscow State UniversityMoscowRussia Department of Chemistry Lomonosov Moscow State UniversityMoscowRussia Istituto di Struttura della Materia Consiglio Nazionale delle Ricerche(ISM-CNR)Via del Fosso del Cavaliere 10000133RomeItaly

A technique for colloidal forming of Ca2P2O7 macroporous bioceramics,based on low-pressure injection molding(LPIM)of a glycerol-water slip containing Ca2P2O7 and Ca(Н2PO4)2 into a plastic mold fabricated via FDM 3Dprinting,was *** reaction between the solid phases of the water containing slip-Ca2P2O7 and Ca(Н2PO4)2,resulting in brushite(CaHPO4·2H2O)formation,led to consolidation of the casting and preserved its complex architecture in the course of mold *** ceramics of Kelvin structure(70%macropores with the sizes from 2 up to 4 mm),based on a pre-defined composition with 10 wt%Ca(PO3)2 and sintered in liquid-phase regime,demonstrated a compressive strength of 1.4±0.1 MPa at a density of 22±2%.In vitro tests on bioactivity in SBF solution,as well as on resorption of the ceramics in model solution of citric acid,were carried out.

关键词： Bioceramics Calcium pyrophosphate Calcium metaphosphate Colloidal forming 3D-printing Kelvin structure

Screening for nonalcoholic fatty liver disease-when,who and how?

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World Journal of Gastroenterology 2021年第35期27卷 5803-5821页

作者： Christoph G Dietrich Monika rau Andreas Geier Department of Internal Medicine Bethlehem Health CenterStolberg 52222Germany Department of Internal Medicine II University Hospital WürzburgWürzburg 97080Germany Department of Medicine II University Hospital WürzburgWürzburg 97080Germany

Nonalcoholic fatty liver disease(NAFLD)is becoming a frequent liver disease,especially in patients with metabolic syndrome and especially in Western *** of NAFLD comprise progressive fibrosis,cirrhosis and hepatocellular *** also represents an independent risk factor for cardiovascular disease,extrahepatic neoplasia and other organ damage,such as renal *** the epidemiological importance of the disease,new developments in specific treatment of the disease and the wide availability of noninvasive techniques in estimating steatosis and fibrosis,NAFLD should be subject to screening programs,at least in countries with a high prevalence of the *** review discusses prerequisites for screening,cost-effectiveness,current guideline recommendations,suitability of techniques for screening and propositions for the following questions:Who should be screened?Who should perform screening?How should screening be performed?It is time for a screening program in patients at risk for NAFLD.

关键词： Screening Nonalcoholic fatty liver disease Diabetes Liver fibrosis Cirrhosis