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Involvement of glycated albumin in adipose-derived-stem cellmediated interleukin 17 secreting T helper cell activation

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World Journal of Stem Cells 2020年第7期12卷 621-632页

作者： julien pestel Maud Robert Sara Corbin Hubert Vidal Assia Eljaafari INSERM U1060 CarMen Batiment CENS-ELICentre Hospitalier Lyon SudPierre Bénite 69310France Faculty of Medicine UniversitéClaude Bernard Lyon 1Batiment CENS-ELICentre Hospitalier Lyon SudPierre Bénite 69310France Department of Surgery in Gastro-enterology Edouard Herriot HospitalLyon 69003France Public Health Department Hospices Civils de Lyon1 quai des célestins Lyon 69002France DO-IT Research Team Hospices Civils de Lyon1 quai des célestinsLyon 69002France

BACKGROUND Advanced glycation end products(AGE)are a marker of various diseases including diabetes,in which they participate to vascular damages such as retinopathy,nephropathy and *** those vascular complications,AGE are involved in altered metabolism in many tissues,including adipose tissue(AT)where they contribute to reduced glucose uptake and attenuation of insulin *** are known to contribute to type 1 diabetes(T1D)through promotion of interleukin(IL)-17 secreting T helper(Th17)*** To investigate whether lean adipose-derived stem cells(ASC)could be able to induce IL-17A secretion,with the help of *** As we have recently demonstrated that ASC are involved in Th17 cell promotion when they are harvested from obese AT,we used the same co-culture model to measure the impact of glycated human serum albumin(G-HSA)on human lean ASC interacting with blood mononuclear ***-17A and pro-inflammatory cytokine secretion were measured by *** of AGE(RAGE)together with intercellular adhesion molecule 1(ICAM-1),human leukocyte Antigen(HLA)-DR,cluster of differentiation(CD)41,and CD62P surface expressions were measured by ***-RAGE specific monoclonal antibody was added to co-cultures in order to evaluate the role of RAGE in IL-17A *** Results showed that whereas 1%G-HSA only weakly potentiated the production of IL-17A by T cells interacting with ASC harvested from obese subjects,it markedly increased IL-17A,but also interferon gamma and tumor necrosis factor alpha production in the presence of ASC harvested from lean *** was associated with increased expression of RAGE and HLA-DR molecule by cocultured ***,RAGE blockade experiments demonstrated RAGE specific involvement in lean ASC-mediated Th-17 cell ***,platelet aggregation and ICAM-1,which are known to be induced by AGE,were not involved in these *** Thus,our results demonstrated tha

关键词： Interleukin 17 secreting T helper cells Lean adipose tissue Type 1 diabetes Advanced glycation end products Adipose-derived stem cells

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