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Spatial and temporal patterns of sarcoptic mange in wombats using the citizen science tool,WomSAT

Integrative Zoology 2024年第3期19卷 387-399页

作者： Sujatha MAYADUNNAGE Hayley Jade STANNARD Peter WEST julie M.OLD School of Science Western Sydney UniversityHawkesburyNSWAustralia School of Agricultural Environmental and Veterinary SciencesCharles Sturt UniversityWagga WaggaNSWAustralia Department of Primary Industries Orange Agricultural InstituteOrangeNSWAustralia

There is currently limited information regarding the levels of infection and distribution of sarcoptic mange in the wombat population throughout *** analyzed cases of sarcoptic mange in bare-nosed wombats reported into WomSAT,a website and mobile phone application where citizen scientists can upload sightings of wombats,burrows,and sarcoptic mange *** used Maxent software to predict locations and the environmental factors associated with sarcoptic mange occurrence in bare-nosed wombats.A total of 1379 sarcoptic mange-infected and 3043 non-sarcoptic mange-infected wombats were reported by 674 and 841 citizen scientists,*** all the wombats reported to WomSAT from 2015 to 2019,31.2%were infected with sarcoptic *** mange in bare-nosed wombats was reported in 502 suburbs across four *** South Wales had the highest number of sarcoptic mange cases reported to *** was no statistically significant seasonal variation of sarcoptic mange levels in bare-nosed *** model showed that Euclidean distance to urban areas was the highest contributing factor for sarcoptic mange *** distance to urban areas decreased,the suitability for sarcoptic mange *** precipitation was the next contributing factor in the model,with higher rainfall of 400–700 mm correlating to an increase in sarcoptic mange *** the data collected to date have provided the largest-scale contemporary distribution of sarcoptic mange in wombats,data should continue to be collected by citizen scientists as it is an easy and low-cost method of collecting data over large *** suggest targeting the identified hotspot areas and more site-specific studies for studying and mitigating sarcoptic mange in bare-nosed wombats.

关键词： bare-nosed wombats habitat suitability Maxent modeling

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EGFR amplification induces sensitivity to antiEGFR therapy in pancreatic acinar cell carcinoma

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World Journal of Gastrointestinal Oncology 2018年第4期10卷 103-107页

作者： Corentin Richard julie Niogret Romain Boidot Francois Ghiringhelli Platform of Transfer in Oncology Center GF LeclercDijon 21000France INSERM U1231 Dijon 21000France University of Bourgogne Franche Comte Dijon 21000France Department of Medical Oncology Georges Francois Leclerc Cancer CenterDijon 21000France

Pancreatic acinar cell carcinoma(PACC) is a rare cancer. When the tumor is metastatic, few therapeutic options are available. Precision medicine using next-generation sequencing is defined by the administration of drugs based on the tumor genetic mutations. The usage of precision medicine for finding new therapeutic options for rare cancers is an emerging field. We have reported here the case of a patient bearing a multitreated metastatic PACC. This patient underwent somatic and constitutional exome analyses. The analyses revealed in the liver metastasis an amplification of the EGFR gene. Accordingly, the patient was treated with off-label usage of panitumumab. We observed rapid response with necrosis of the liver metastasis, while no efficacy was observed in the primary tumor. An exome analysis of the primary tumor revealed amplification of HER2 and MET with EGFR amplification. Such amplifications are known as a resistance mechanism to anti EGFR therapy. Our results suggest that exome analysis may be helpful to highlight targets in rare cancers, such as PACC. EGFR amplification in this pathology should be determined and could be used as a biomarker to propose anti EGFR therapy.

关键词： Pancreatic cancer Acinar cell carcinoma Exome Genetic mutations Precision medicine

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MicroRNA-155 expression suggests a sex disparity in innate lymphoid cells at the single-cell level

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Cellular & Molecular Immunology 2020年第5期17卷 544-546页

作者： Carina Malmhäll julie Weidner Madeleine Rådinger Krefting Research Centre Sahlgrenska AcademyUniversity of GothenburgGothenburgSweden

MicroRNAs(miRNAs)are small noncoding RNAs that control gene expression at the post-transcriptional level,thereby serving as important cellular regulators.1 However,miRNA expression in specific human cellular subtypes,especially at the single-cell level,remains largely *** this study,a novel method called the PrimeFlow^(TM) RNA Assay2 was used to directly monitor miRNA expression in the ***,we demonstrate for the first time that human innate lymphoid cells(ILCs)express *** further demonstrate a clear distinction between the sexes,with a significant increase in the number of ILCs expressing miR-155 in female-derived cells compared with male-derived cells upon in vitro stimulation.

关键词： lymphoid thereby expressing

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Assessment of diaphragmatic function by ultrasonography:Current approach and perspectives

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World Journal of Clinical Cases 2020年第12期8卷 2408-2424页

作者： Alain Boussuges Sarah Rives julie Finance Fabienne Brégeon Institut de Recherche Biomédicale des Armées ERRSOToulon 83800France Center for Cardiovascular and Nutrition Research(C2VN) Aix Marseille UniversitéINSERM(1260)INRAE(1263)Toulon 83800France Service d’Explorations Fonctionnelles Respiratoires CHU NordAssistance Publique des Hôpitaux de Marseille et Aix Marseille UniversitéIRDAPHMMEPHIIHU-Méditerranée InfectionMarseille 13015France

This article reports the various methods used to assess diaphragmatic function by *** excursions of the two hemidiaphragms can be measured using two-dimensional or M-mode ultrasonography,during respiratory maneuvers such as quiet breathing,voluntary sniffing and deep *** the zone of apposition to the rib cage for both hemidiaphragms,it is possible to measure the thickness on expiration and during deep breathing to assess the percentage of thickening during *** two approaches make it possible to assess the quality of the diaphragmatic function and the diagnosis of diaphragmatic paralysis or *** methods are particularly useful in circumstances where there is a high risk of phrenic nerve injury or in diseases affecting the contractility or the motion of the diaphragm such as neuro-muscular *** methods such as speckle tracking imaging and ultrasound shear wave elastography should provide more detailed information for better assessment of diaphragmatic function.

关键词： Ultrasound Hemidiaphragm Motion Thickness Paralysis Dysfunction Two-dimensional mode M-mode Speckle tracking imaging Ultrasound shear wave elastography

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Redox dysregulation as a driver for DNA damage and its relationship to neurodegenerative diseases

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Translational Neurodegeneration 2023年第1期12卷 604-637页

作者： Sina Shadfar Sonam Parakh Md Shafi Jamali julie D.Atkin Centre for Motor Neuron Disease Research Macquarie Medical SchoolMacquarie UniversitySydneyNSW 2109Australia La Trobe Institute for Molecular Science La Trobe UniversityBundooraMelbourneVIC 3086Australia

Redox homeostasis refers to the balance between the production of reactive oxygen species(ROS)as well as reactive nitrogen species(RNS),and their elimination by *** is linked to all important cellular activities and oxidative stress is a result of imbalance between pro-oxidants and antioxidant *** stress perturbs many cellular activities,including processes that maintain the integrity of *** acids are highly reactive and therefore particularly susceptible to *** DNA damage response detects and repairs these DNA *** DNA repair processes are therefore essential for maintaining cellular viability,but they decline considerably during *** damage and deficiencies in DNA repair are increasingly described in age-related neurodegenerative diseases,such as Alzheimer’s disease,Parkinson’s disease,amyotrophic lateral sclerosis and Huntington’s ***,oxidative stress has long been associated with these ***,both redox dysregulation and DNA damage increase significantly during aging,which is the biggest risk factor for neurodegenerative ***,the links between redox dysfunction and DNA damage,and their joint contributions to pathophysiology in these conditions,are only just *** review will discuss these associations and address the increasing evidence for redox dysregulation as an important and major source of DNA damage in neurodegenerative *** these connections may facilitate a better understanding of disease mechanisms,and ultimately lead to the design of better therapeutic strategies based on preventing both redox dysregulation and DNA damage.

关键词： Redox dysregulation DNA damage Neurodegeneration Reactive oxygen species Oxidative stress

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Mini-review:Plasticity of human menstrual blood stem cells derived from the endometrium

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第5期12卷 372-380页

作者： Jian LIN Dennis XIANG Jin-long ZHANG julie ALLICKSON Charlie XIANG State Key Laboratory for Diagnosis and Treatment of Infectious Diseases the First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 China Department of Chemical and Biomolecular Engineering Johns Hopkins University Baltimore MD 21218 USA Infectious Disease Unit Zhejiang Armed Police Hospital Jiaxing 314000 China Cryo-Cell International Inc. Oldsmar FL 34677 USA S-Evans Biosciences Hangzhou 311121 China J. Craig Venter Institute Rockville MD 20850 USA

Stem cells can be obtained from women's menstrual blood derived from the *** cells display stem cell markers such as Oct-4,SSEA-4,Nanog,and c-kit(CD117),and have the potent ability to differentiate into various cell types,including the heart,nerve,bone,cartilage,and *** has been no evidence of teratoma,ectopic formation,or any immune response after transplantation into an animal *** cells quickly regenerate after menstruation and secrete many growth factors to display recurrent *** plasticity and safety of the acquired cells have been demonstrated in many *** blood-derived stem cells(MenSCs) provide an alternative source of adult stem cells for research and application in regenerative *** we summarize the multipotent properties and the plasticities of MenSCs and other endometrial stem cells from recent studies conducted both in vitro and in vivo.

关键词： Menstrual blood-derived stem cells(MenSCs) Endometrium Multipotent Plasticity

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The impact of personality on the success of prospecting behavior in changing landscapes

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Current Zoology 2015年第3期61卷 557-568页

作者： John Curtis BURKHALTER Nina H. FEFFERMAN julie L. LOCKWOOD Graduate Program in Ecology and Evolution Department of Ecology Evolution and Natural Resources Rutgers University 14College Farm Rd. New Brunswick NJ 08901 USA

Personality can play a large role in dispersal decisions, influencing how each individual estimates and values ex- pected costs versus benefits of ventnring out to explore the unknown. We contrast the impact of persistence on fitness using deci- sion theory models to examine the relative success of prospecting movement （which is a widespread behavior used by animals to explore available breeding habitat before determining where to settle） in different landscapes among individuals with different personalities. While evaluating trends in the costs and benefits of movement we provide a quantifiable measure of the impacts of relative tenacity in prospecting behavior on fitness gains/losses. Our model results predict that, regardless of landscape composi- tion, individuals with greater tenacity in prospecting strategy have reduced fitness gains relative to individuals who are more willing to both initiate novel strategies, but then also abandon the new strategy rapidly if initial search does not seem fruitful. We show that fitness gains from choosing an appropriate prospecting strategy （i.e. abandoning poor habitat or staying in rich habitat） can be very high, indicating a potentially large influence from personality on fitness. Importantly, the model predicts that relative fitness gains are highly dependent on the availability of high quality habitat in the landscape, even if the difference under varying fitness outcomes between poor and rich habitat was substantial

关键词： Prospecting Tradeoff Movement Decision theory Personality Behavior

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Heritage and the COVID-19 pandemic:the meaning of visitation

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Built Heritage 2023年第2期7卷 50-60页

作者： Cut Dewi Matthew Rofe julie Nichols Izziah Izziah Architecture and Planning Department Universitas Syiah KualaJl.Syech Abdulrauf No.7DarussalamBanda AcehAceh 23111Indonesia UniSA Creative University of South AustraliaMagill Campus(B1-04)AdelaideSouth AustraliaSA 5072Australia UniSA Creative University of South AustraliaCity West Campus(K3-14)AdelaideSouth AustraliaSA 5000Australia

The onset of the COVID-19 pandemic has impacted global mobility.‘Lockdowns’and travel bans have been used as control measures by international ***,the ways that we use buildings have also been impacted by these ***,this paper explores the roles of heritage sites in a post-COVID-19 pandemic *** research is part of the Urban Heritage and Community Resilience:Conservation,Tourism,and Pandemic project,and it employs methods such as semistructured interviews,participant observations,archival research,and focus group discussions(FGDs).This paper is based on semistructured interviews conducted with one hundred eighteen participants across ten popular heritage sites in Banda Aceh and Aceh Besar,*** fndings confrm the debated claim in postdisaster studies asserting that some of these Acehnese heritage sites,especially those imbued with religious values,have become places of ***,during the pandemic,these sites have facilitated community resilience by helping people feel closer to *** practising Acehnese Muslims,prayer at home is culturally acceptable,but praying at the mosque,which is one of the essential heritages of the Acehnese,has contributed to and strengthened the sense of community ***,visitation and participation in heritage sites that include experiencing the sense of place and conducting religious and cultural activities is integral to community resilience.

关键词： Heritage Pandemic Visitation Resilience

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Targeting inflammation to reduce brain injury in growth restricted newborns:a potential treatment?

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Neural Regeneration Research 2017年第11期12卷 1804-1806页

作者： julie A Wixey Paul B Colditz Stella Tracey Bjorkman Centre for Clinical Research Faculty of MedicineThe University of QueenslandHerstonQueenslandAustralia

Introduction： Intrauterine growth restriction （IUGR） is commonly caused by placental insufficiency, resulting in a chronic hypoxic environment and subsequent abnormal fetal development. The developing brain is particularly vulnerable to IUGR conditions. Multiple causal factors associated with brain injury in fetal growth restriction include the timing of placental insufficiency, onset and subsequent severity of fetal compromise, fetal cerebrovascular response and the redistribution of brain blood flow. Although a significant proportion of IUGR infants exhibit adverse long-term neu- rological outcomes, relatively few studies have focused on the mechanisms of brain injury in the IUGR neonate. Clini- cal imaging studies of IUGR infants demonstrate alterations in grey matter and white matter volume and structure （Tolsa et al., 2004; Esteban et al., 2010; Padilla et al., 2015）. Cortical grey matter volume is reduced by up to 28% compared with control infants （Tolsa et al., 2004） and both white and grey matter show structural changes （Esteban et al., 2010）. These structural changes persist at 1 year of age and are associated with significant developmental disabilities （Tolsa et al., 2004;

关键词： Targeting inflammation brain injury

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A comparison of the ballistic behaviour of conventionally sintered and additively manufactured alumina

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Defence Technology（防务技术） 2020年第2期16卷 275-282页

作者： Gareth James Appleby-Thomas Kevin Jaansalu Amer Hameed Jonathan Painter James Shackel julie Rowley Centre for Defence Engineering Cranfield Defence and SecurityCranfield UniversityShrivenhamSwindonSN68LAUK Department of Chemistry and Chemical Engineering Royal Military College of CanadaPO Box 17000Station ForcesKingstonOntarioK7K 7B4Canada

Production of ceramic armour solutions on-demand/in-theatre would have significant logistical and military ***,even assuming that such technologies could be successfully deployed in the field,such near net-shape manufacturing technology is relatively immature compared to conventional sintering of *** this study,the ballistic performance of a series of additively manufactured(AM)/rapidly-prototyped(RP)alumina tiles of 97.2%of the density of Sintox FATM were investigated using both forward-and reverse-ballistic *** experiments,undertaken with compressed gasguns,employed the depth-of-penetration technique and flash X-ray as primary diagnostics to interrogate both efficiency of penetration and projectile-target interaction,*** RP alumina was found to exhibit useful ballistic properties,successfully defeating steel-cored(AP)7.62×39 mm BXN rounds at velocities of up-to c.a.850 m/s,while exhibiting comparable failure modes to conventionally sintered armour-grade Sintox ***,where a<1%by *** dopant was introduced into the RP material failure modes changed dramatically with performance dropping below that of conventionally sintered ***,the results from both sets of experiments were complimentary and clearly indicated the potential of such RP materials to play an active role in provision of real-world body armour solutions provided quality control of the RP material can be maintained.

关键词： Additive manufacture Rapidly prototyped Body armour Ballistics Ceramics

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