MicroRNA-155 expression suggests a sex disparity in innate lymphoid cells at the single-cell level

作     者：Carina Malmhäll Julie Weidner Madeleine Rådinger 

作者机构：Krefting Research CentreSahlgrenska AcademyUniversity of GothenburgGothenburgSweden 

出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)

年 卷 期：2020年第17卷第5期

页      面：544-546页

核心收录：

学科分类：1001[医学-基础医学(可授医学、理学学位)] 100102[医学-免疫学] 10[医学] 

基　　金：by the Herman Krefting Foundation,the Swedish Heart and Lung Foundation the Swedish Research Council an ALF/LUA research grant from Sahlgrenska University Hospital 

主　　题：lymphoid thereby expressing 

摘      要：MicroRNAs(miRNAs)are small noncoding RNAs that control gene expression at the post-transcriptional level,thereby serving as important cellular regulators.1 However,miRNA expression in specific human cellular subtypes,especially at the single-cell level,remains largely *** this study,a novel method called the PrimeFlow^(TM) RNA Assay2 was used to directly monitor miRNA expression in the ***,we demonstrate for the first time that human innate lymphoid cells(ILCs)express *** further demonstrate a clear distinction between the sexes,with a significant increase in the number of ILCs expressing miR-155 in female-derived cells compared with male-derived cells upon in vitro stimulation.