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Central role of the LEAFY COTYLEDON1 transcription factor in seed development

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Journal of Integrative Plant Biology 2019年第5期61卷 564-580页

作者： Leonardo Jo julie M.Pelletier John J.harada Department of Plant Biology and Plant Biology Graduate Group University of CaliforniaDavis USA

Seed development is a complex period of the flowering plant life *** fertilization,the three main regions of the seed,embryo,endosperm and seed coat,undergo a series of developmental processes that result in the production of a mature seed that is developmentally arrested,desiccated,and metabolically *** processes are highly coordinated,both temporally and spatially,to ensure the proper growth and development of the *** transcription factor,LEAFY COTYLEDON1(LEC1),is a central regulator that controls several aspects of embryo and endosperm development,including embryo morphogenesis,photosynthesis,and storage reserve ***,LEC1 regulates distinct sets of genes at different stages of seed *** its critical importance for seed development,an understanding of the mechanisms underlying LECi's multifunctionality is only beginning to be *** studies describe the roles of specific transcription factors and the hormones,gibberellic acid and abscisic acid,in controlling the activity and transcriptional specificity of LEC1 across seed ***,studies indicate that LEC1 acts as a pioneer transcript!on factor to promote epigenetic reprogramming during *** this review,we discuss the mechanisms that enable LEC1 to serve as a central regulator of seed development.

关键词： Seed development flowering plant seed development

Anti-methanogenic potential of seaweeds and seaweed-derived compounds in ruminant feed:current perspectives,risks and future prospects

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Journal of Animal Science and Biotechnology 2024年第2期15卷 463-489页

作者： Ailbhe McGurrin julie Maguire Brijesh K.Tiwari Marco Garcia-Vaquero Section of Food and Nutrition School of Agriculture and Food ScienceUniversity College DublinDublin 4BelfieldIreland TEAGASC Food Research CentreDublin 15AshtownIreland Bantry Marine Research Station Ltd BantryCo.CorkP75 AX07GearhiesIreland

With methane emissions from ruminant agriculture contributing 17%of total methane emissions worldwide,there is increasing urgency to develop strategies to reduce greenhouse gas emissions in this *** of the proposed strategies is ruminant feed intervention studies focused on the inclusion of anti-methanogenic compounds which are those capable of interacting with the rumen microbiome,reducing the capacity of ruminal microorganisms to produce ***,seaweeds have been investigated for their ability to reduce methane in ruminants in vitro and in vivo,with the greatest methane abatement reported when using the red seaweed Asparagopsis taxiformis(attributed to the bromoform content of this species).From the literature analysis in this study,levels of up to 99%reduction in ruminant methane emissions have been reported from inclusion of this seaweed in animal feed,although further in vivo and microbiome studies are required to confirm these results as other reports showed no effect on methane emission resulting from the inclusion of seaweed to basal *** review explores the current state of research aiming to integrate seaweeds as anti-methanogenic feed additives,as well as examining the specific bioactive compounds within seaweeds that are likely to be related to these *** effects of the inclusion of seaweeds on the ruminal microbiome are also reviewed,as well as the future challenges when considering the largescale inclusion of seaweeds into ruminant diets as anti-methanogenic agents.

关键词： Asparagopsis Bromoform Methanogenesis Phlorotannin Saponin Tannin

hypoxia-ischemia in the immature rodent brain impairs serotonergic neuronal function in certain dorsal raphé nuclei

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Neural Regeneration Research 2020年第3期15卷 457-463页

作者： hanna E.Reinebrant julie A.Wixey Kathryn M.Buller UQ Centre for Clinical Research Faculty of Medicine The University of Queensland

Neonatal hypoxia-ischemia(hI) results in losses of serotonergic neurons in specific dorsal raphé nuclei. however, not all serotonergic raphé neurons are lost and it is therefore important to assess the function of remaining neurons in order to understand their potential to contribute to neurological disorders in the hI-affected neonate. The main objective of this study was to determine how serotonergic neurons, remaining in the dorsal raphé nuclei after neonatal hI, respond to an external stimulus(restraint stress). On postnatal day 3(P3), male rat pups were randomly allocated to one of the following groups:(i) control + no restraint(n = 5),(ii) control + restraint(n = 6),(iii) P3 hI + no restraint(n = 5) or(iv) P3 hI + restraint(n = 7). In the two hI groups, rat pups underwent surgery to ligate the common carotid artery and were then exposed to 6% O2 for 30 minutes. Six weeks after P3 hI, on P45, rats were subjected to restraint stress for 30 minutes. Using dual immunolabeling for Fos protein, a marker for neuronal activity, and serotonin(5-hydroxytrypamine; 5-hT), numbers of Fos-positive 5-hT neurons were determined in five dorsal raphé nuclei. We found that restraint stress alone increased numbers of Fos-positive 5-hT neurons in all five dorsal raphé nuclei compared to control animals. however, following P3 hI, the number of stress-induced Fos-positive 5-hT neurons was decreased significantly in the dorsal raphé ventrolateral, interfascicular and ventral nuclei compared with control animals exposed to restraint stress. In contrast, numbers of stress-induced Fos-positive 5-hT neurons in the dorsal raphé dorsal and caudal nuclei were not affected by P3 hI. These data indicate that not only are dorsal raphé serotonergic neurons lost after neonatal hI, but also remaining dorsal raphé serotonergic neurons have reduced differential functional viability in response to an external stimulus. Procedures were approved by the University of Queensland Animal Ethics Committee(

关键词： dorsal raphé nuclei Fos hypoxia-ischemia neonate newborn brain injury preterm restraint stress serotonin

Mesenchymal stem cells in the treatment of osteogenesis imperfecta

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Cell Regeneration 2023年第1期12卷 386-406页

作者： Erica Lang julie A.Semon Department of Biological Sciences Missouri University of Science and Technology400 W 11th St.RollaMOUSA

Osteogenesis imperfecta(OI)is a disease caused by mutations in different genes resulting in mild,severe,or lethal *** no cure,researchers have investigated the use of cell therapy to correct the underlying molecular defects of *** stem cells(MSCs)are of particular interest because of their differentiation capacity,immunomodulatory effects,and their ability to migrate to sites of *** can be isolated from different sources,expanded in culture,and have been shown to be safe in numerous clinical *** review summarizes the preclinical and clinical studies of MSCs in the treatment of ***,the culmination of these studies show that MSCs from different sources:1)are safe to use in the clinic,2)migrate to fracture sites and growth sites in bone,3)engraft in low levels,4)improve clinical outcome but have a transient effect,5)have a therapeutic effect most likely due to paracrine mechanisms,and 6)have a reduced therapeutic potential when isolated from patients with OI.

关键词： Osteogenesis imperfecta Mesenchymal stem cells Cell therapy Transplantation

Insights into the 2023 multidisciplinary surgical treatment guidelines for hepatocellular carcinoma:perspectives from Italian Professional Associations

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hepatobiliary Surgery and Nutrition 2024年第5期13卷 861-864页

作者： Mohamed Bouattour julie Devictor Clemence hollande AP-hP Hôpital BeaujonLiver Cancer and Innovative Therapy UnitClichyFrance UniversitéParis Cité Centre de Recherche sur l’Inflammation(CRI)INSERMU1149ParisFrance UniversitéParis Cité ECEVEINSERM UMR 1123ParisFrance

The collaboration among various Italian scientific societies to establish recommendations for the surgical management of hepatocellular carcinoma(hCC),recently published in Digestive and Liver Disease(1),is a worthy *** multidisciplinary approach,which includes input from different disciplines such as surgery,hepatology,gastroenterology,oncology,pathology,radiology,and patient associations,underscores the commitment to placing patients at the center of *** a holistic and inclusive approach enhances the relevance and applicability of these guidelines in clinical *** several scientific associations have previously issued guidelines for managing hCC,the Italian colleagues have adopted a comprehensive methodology.

关键词： Multidisciplinary patient-centered surgery recommendation

Spatial and temporal patterns of sarcoptic mange in wombats using the citizen science tool,WomSAT

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Integrative Zoology 2024年第3期19卷 387-399页

作者： Sujatha MAYADUNNAGE hayley Jade STANNARD Peter WEST julie M.OLD School of Science Western Sydney UniversityHawkesburyNSWAustralia School of Agricultural Environmental and Veterinary SciencesCharles Sturt UniversityWagga WaggaNSWAustralia Department of Primary Industries Orange Agricultural InstituteOrangeNSWAustralia

There is currently limited information regarding the levels of infection and distribution of sarcoptic mange in the wombat population throughout *** analyzed cases of sarcoptic mange in bare-nosed wombats reported into WomSAT,a website and mobile phone application where citizen scientists can upload sightings of wombats,burrows,and sarcoptic mange *** used Maxent software to predict locations and the environmental factors associated with sarcoptic mange occurrence in bare-nosed wombats.A total of 1379 sarcoptic mange-infected and 3043 non-sarcoptic mange-infected wombats were reported by 674 and 841 citizen scientists,*** all the wombats reported to WomSAT from 2015 to 2019,31.2%were infected with sarcoptic *** mange in bare-nosed wombats was reported in 502 suburbs across four *** South Wales had the highest number of sarcoptic mange cases reported to *** was no statistically significant seasonal variation of sarcoptic mange levels in bare-nosed *** model showed that Euclidean distance to urban areas was the highest contributing factor for sarcoptic mange *** distance to urban areas decreased,the suitability for sarcoptic mange *** precipitation was the next contributing factor in the model,with higher rainfall of 400–700 mm correlating to an increase in sarcoptic mange *** the data collected to date have provided the largest-scale contemporary distribution of sarcoptic mange in wombats,data should continue to be collected by citizen scientists as it is an easy and low-cost method of collecting data over large *** suggest targeting the identified hotspot areas and more site-specific studies for studying and mitigating sarcoptic mange in bare-nosed wombats.

关键词： bare-nosed wombats habitat suitability Maxent modeling

EGFR amplification induces sensitivity to antiEGFR therapy in pancreatic acinar cell carcinoma

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World Journal of Gastrointestinal Oncology 2018年第4期10卷 103-107页

作者： Corentin Richard julie Niogret Romain Boidot Francois Ghiringhelli Platform of Transfer in Oncology Center GF LeclercDijon 21000France INSERM U1231 Dijon 21000France University of Bourgogne Franche Comte Dijon 21000France Department of Medical Oncology Georges Francois Leclerc Cancer CenterDijon 21000France

Pancreatic acinar cell carcinoma(PACC) is a rare cancer. When the tumor is metastatic, few therapeutic options are available. Precision medicine using next-generation sequencing is defined by the administration of drugs based on the tumor genetic mutations. The usage of precision medicine for finding new therapeutic options for rare cancers is an emerging field. We have reported here the case of a patient bearing a multitreated metastatic PACC. This patient underwent somatic and constitutional exome analyses. The analyses revealed in the liver metastasis an amplification of the EGFR gene. Accordingly, the patient was treated with off-label usage of panitumumab. We observed rapid response with necrosis of the liver metastasis, while no efficacy was observed in the primary tumor. An exome analysis of the primary tumor revealed amplification of hER2 and MET with EGFR amplification. Such amplifications are known as a resistance mechanism to anti EGFR therapy. Our results suggest that exome analysis may be helpful to highlight targets in rare cancers, such as PACC. EGFR amplification in this pathology should be determined and could be used as a biomarker to propose anti EGFR therapy.

关键词： Pancreatic cancer Acinar cell carcinoma Exome Genetic mutations Precision medicine

Assessment of diaphragmatic function by ultrasonography:Current approach and perspectives

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World Journal of Clinical Cases 2020年第12期8卷 2408-2424页

作者： Alain Boussuges Sarah Rives julie Finance Fabienne Brégeon Institut de Recherche Biomédicale des Armées ERRSOToulon 83800France Center for Cardiovascular and Nutrition Research(C2VN) Aix Marseille UniversitéINSERM(1260)INRAE(1263)Toulon 83800France Service d’Explorations Fonctionnelles Respiratoires CHU NordAssistance Publique des Hôpitaux de Marseille et Aix Marseille UniversitéIRDAPHMMEPHIIHU-Méditerranée InfectionMarseille 13015France

This article reports the various methods used to assess diaphragmatic function by *** excursions of the two hemidiaphragms can be measured using two-dimensional or M-mode ultrasonography,during respiratory maneuvers such as quiet breathing,voluntary sniffing and deep *** the zone of apposition to the rib cage for both hemidiaphragms,it is possible to measure the thickness on expiration and during deep breathing to assess the percentage of thickening during *** two approaches make it possible to assess the quality of the diaphragmatic function and the diagnosis of diaphragmatic paralysis or *** methods are particularly useful in circumstances where there is a high risk of phrenic nerve injury or in diseases affecting the contractility or the motion of the diaphragm such as neuro-muscular *** methods such as speckle tracking imaging and ultrasound shear wave elastography should provide more detailed information for better assessment of diaphragmatic function.

关键词： Ultrasound hemidiaphragm Motion Thickness Paralysis Dysfunction Two-dimensional mode M-mode Speckle tracking imaging Ultrasound shear wave elastography

MicroRNA-155 expression suggests a sex disparity in innate lymphoid cells at the single-cell level

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Cellular & Molecular Immunology 2020年第5期17卷 544-546页

作者： Carina Malmhäll julie Weidner Madeleine Rådinger Krefting Research Centre Sahlgrenska AcademyUniversity of GothenburgGothenburgSweden

MicroRNAs(miRNAs)are small noncoding RNAs that control gene expression at the post-transcriptional level,thereby serving as important cellular regulators.1 however,miRNA expression in specific human cellular subtypes,especially at the single-cell level,remains largely *** this study,a novel method called the PrimeFlow^(TM) RNA Assay2 was used to directly monitor miRNA expression in the ***,we demonstrate for the first time that human innate lymphoid cells(ILCs)express *** further demonstrate a clear distinction between the sexes,with a significant increase in the number of ILCs expressing miR-155 in female-derived cells compared with male-derived cells upon in vitro stimulation.

关键词： lymphoid thereby expressing