检索结果-南通市图书馆

A scoping review on the field validation and implementation of rapid diagnostic tests for vector-borne and other infectious diseases of poverty in urban areas

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Infectious Diseases of Poverty 2018年第1期7卷 879-896页

作者： Lyda Osorio Jonny Alejandro garcia Luis Gabriel Parra Victor garcia Laura Torres Stephanie Degroote Valery Ridde Epidemiology and Population Health Research Group School of Public HealthUniversidad del ValleCalle 4B No.36-00 Edif 118 Escuela de Salud PúblicaUniversidad del Valle Campus San FernandoCaliColombia School of Medicine Universidad del ValleCaliColombia University of Montreal Public Health Research Institute(IRSPUM) MontrealCanada French Institute for Research on Sustainable Development(IRD) Paris Descartes UniversityPopulation and Development Center(CEPED)UniversiteParis Sorbonne CiteNational Institute of Health and Medical Research(INSERM)HealthVulnerabilities and Gender Relations South(SAGESUD)ParisFrance

Background:Health personnel face challenges in diagnosing vector-borne and other diseases of poverty in urban *** is a need to know what rapid diagnostic technologies are available,have been properly assessed,and are being implemented to improve control of these diseases in the urban *** paper characterizes evidence on the field validation and implementation in urban areas of rapid diagnostics for vector-borne diseases and other diseases of *** body:A scoping review was ***-reviewed and grey literature were searched using terms describing the targeted infectious diseases,diagnostics evaluations,rapid tests,and urban *** review was limited to studies published between 2000 and 2016 in English,Spanish,French,and *** and exclusion criteria were refined post hoc to identify relevant literature regardless of study design and geography.A total of 179 documents of the 7806 initially screened were included in the ***(n=100)and tuberculosis(n=47)accounted for the majority of studies that reported diagnostics performance,impact,and implementation *** studies,assessing mainly performance,were identified for visceral leishmaniasis(n=9),filariasis and leptospirosis(each n=5),enteric fever and schistosomiasis(each n=3),dengue and leprosy(each n=2),and Chagas disease,human African trypanosomiasis,and cholera(each n=1).Reported sensitivity of rapid tests was variable depending on several ***,specificities were high(>80%),except for schistosomiasis and *** and implementation outcomes,mainly acceptability and cost,followed by adoption,feasibility,and sustainability of rapid tests are being evaluated in the *** to implementing rapid tests range from cultural to technical and administrative ***:Rapid diagnostic tests for vector-borne and other diseases of poverty are being used in the urban context with demonstrated impact on case ***

关键词： Communicable diseases Diagnostic services Point-of-care testing Field evaluation Sensitivity and specificity Implementation Evaluation studies Urban health

Use of a lyophilized bovine pericardium graft to repair tunical defect in patients with Peyronie＇s disease： experience in a clinical setting

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2017年第3期19卷 316-320页

作者： Javier Romero Otero Borja garcia Gomez Jose Medina Polo Carlos Pascual Mateoe Silvia garcia Barreras Eduard garcia Cruz Javier de la Riva de la Vifia Alfredo Rodriguez Antolin 12 de Octubre University Hospital Department of Urology Madrid Spain Monteprincipe University Hospital Department of Urology Madrid Spain Clinic Hospital Department of Urology Barcelona Spain

Many different materials are available for grafting during surgery for Peyronie＇s disease （PD）. To study the outcomes associated with the use of a lyophilized bovine pericardium graft （Peri-Guard） to repair tunical defects in patients with PD, descriptive study of 43 patients with disabling penile curvature was performed. Curvature was measured before and after the intervention using a standardized procedure. Surgical technique was plaque excision and grafting of the tunical defect carried out by a single surgeon. A lyophilized bovine pericardium patch was used for grafting. We measured the change in penile curvature and length, the ability to perform successful sexual intercourse without further pharmacological or surgical treatment, and the satisfaction with treatment. Follow-up data were available for a total of 41 patients. Median age was 50 years （IQR 48-52）; mean follow-up time was 14 ± 6 months. Complete penile straightening was achieved in 33 patients （80.5%） and five patients （12.2%） had curvature under 20. Three months after surgery and stretching therapy, mean （s.d.） flaccid penile length increased from 11.2 ± 2.8 cm to 12.1 ± 2.9 cm （P = 0.062）. Seventy-five percentage of patients reported being able to achieve successful intercourse without further treatment. Eighty-five percentage of patients reported to be satisfied with the treatment. There was no evidence of tissue rejection or infection, and only four patients suffered an adverse event. Plaque excision and grafting of the tunical defect with lyophilized bovine pericardium seems to be a safe and effective treatment for patients with PD.

关键词： penile curvature pericardium patch Peyronie's disease surgical treatment

Induced pluripotent stem cells from Huntington's disease patients:a promising approach to define and correct disease-related alterations

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2019年第5期14卷 769-770页

作者： Azra Fatima Ricardo Gutiérrez-garcia David Vilchez Institute for Genetics and Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases(CECAD) University of Cologne

Adult somatic cells such as skin or blood cells from either health donors or patients can be reprogrammed into induced pluripotent stem cells(iPSCs).Given their unlimited self-renewal and differentiation capacities,iPSCs are an invaluable resource to generate terminally differentiated ***,iPSCs can facilitate the study of human diseases and drug screening,holding great promise for regenerative *** significant advantage of iPSC disease-modeling is that normal and mutant proteins are expressed at endogenous *** addition,subtle phenotypes and the effects of genetic background variations can be assessed by comparison between iPSC lines obtained from different patients and healthy donors as well as isogenic lines,in which disease-related mutations are corrected.

关键词： Adult somatic cells skin or blood cells Huntington’s disease patients

On SIR epidemic models with generally distributed infectious periods： Number of secondary cases and probability of infection

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

International Journal of Biomathematics 2017年第2期10卷 157-169页

作者： A. Gomez-Corral M. Lopez-garcia Instituto de Ciencias Matemdticas CSIC- UAM- UC3M- UCM Calle Nicolds Cabrera 13-15 Madrid 28049 Spain Department of Applied Mathematics School of Mathematics University of Leeds Leeds LS29JT UK

Recently, Clancy [SIR epidemic models with general infectious period distribution, Statist. Prob. Left. 85 （2014） 1-5] has shown how SIR epidemics in which individuals＇ infection periods are not necessarily exponentially distributed may be modeled in terms of a piecewise-deterministic Markov process （PDMP）. In this paper, we present a more detailed description of the underlying PDMP, from which we analyze the population transmission number and the infection probability of a certain susceptible individual.

关键词： Number of secondary cases piecewise-deterministic Markov process proba-bility of infection SIR epidemic model.

ADAM17/TACE:a key molecule in brain injury regeneration

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2019年第8期14卷 1378-1379页

作者： Samuel Dominguez-garcia Carmen Castro Noelia Geribaldi-Doldan Area de Fisiologia Facultad de Medicina Universidad de Cadiz Cadiz Spain Instituto de Investigacion e Innovacion Biomedica de Cadiz (INIBICA) Universidad de Cadiz Cadiz Spain

It has been many years since "the tumor necrosis factor-a-converting enzyme”,also known as ADAM17/TACE, was described as "the enzyme that does it all” because of its role in neurodegenerative diseases and in several physiological processes including proteolysis, adhesion, intracellular signaling, migration and proliferation. ADAM17/TACE is an integral membrane protein that belongs to the disintegrin and metalloprotease (ADAM) family. Several years ago, Romero-Grimaldi et al.

关键词： ADAM17/TACE key molecule injury regeneration

Mitochondrial Sulfide Detoxification Requires a Functional Isoform O-Acetylserine（thiol）lyase C in Arabidopsis thaliana

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Molecular Plant 2012年第6期5卷 1217-1226页

作者： Consolacien Alvarez Irene garcia Luis C Romero Cecilia Gotor Instituto de Bioquimica Vegetal y Fotosintesis Consejo Superior de Investigaciones Cientificas y Universidad de Sevilla Avda. Am~rico Vespucio 49 41092Sevilla Spain

In non-cyanogenic species, the main source of cyanide derives from ethylene and camalexin biosyntheses. In mitochondria, cyanide is a potent inhibitor of the cytochrome c oxidase and is metabolized by the β-cyanoalanine synthase CYS-C1, catalyzing the conversion of cysteine and cyanide to hydrogen sulfide and β-cyanoalanine. The hydrogen sulfide released also inhibits the cytochrome c oxidase and needs to be detoxified by the O-acetylserine（thiol）lyase mitochondrial isoform, OAS-C, which catalyzes the incorporation of sulfide to O-acetylserine to produce cysteine, thus generating a cyclic pathway in the mitochondria. The loss of functional OAS-C isoforms causes phenotypic characteristics very similar to the loss of the CYS-C1 enzyme, showing defects in root hair formation. Genetic complementation with the OAS-Cgene rescues the impairment of root hair elongation, restoring the wild-type phenotype. The mitochondria compromise their capacity to properly detoxify cyanide and the resulting sulfide because the latter cannot re-assimilate into cysteine in the oas-c null mutant. Consequently, we observe an accumulation of sulfide and cyanide and of the alternative oxidase, which is unable to prevent the production of reactive oxygen species probably due to the accumulation of both toxic molecules. Our results allow us to suggest that the significance of OAS-C is related to its role in the proper sulfide and cyanide detoxification in mitochondria.

关键词： alternative oxidase Arabidopsis thaliana cysteine cyanide β-cyanoalanine synthase O-acetylserine(thiol)-lyase reactive oxygen species root hair sulfide.

Intense pulsed light‑based treatment for the improvement of symptoms in glaucoma patients treated with hypotensive eye drops

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Eye and Vision 2024年第2期10卷 12-21页

作者： Jose Maria Martinez‑de‑la‑Casa Carlos Oribio‑Quinto Almudena Milans‑del‑Bosch Pilar Perez‑garcia Laura Morales‑Fernandez Javier garcia‑Bella Jose Manuel Benitez‑del‑Castillo Julian garcia‑Feijoo David P.Pinero Ophthalmology Unit Department of Ophthalmology and ORLFaculty of MedicineHospital Clinico San-CarlosUniversidad Complutense de MadridInstituto de Investigacion Sanitaria del Hospital Clinico San-Carlos(IdISSC)28040 MadridSpain Department of Immunology Ophthalmology and ORLSchool of MedicineInstituto de Investigaciones Oftalmologicas Ramon CastroviejoUniversidad Complutense de MadridMadridSpain Department of Optics Pharmacology and AnatomyUniversity of AlicanteAlicanteSpain

Background:Ocular surface disease in glaucoma patients is a significant ocular co-morbidity that can affect 40%to 59%of these patients *** current study was aimed at evaluating the potential clinical benefit of an intense pulsed light(IPL)-based treatment in glaucomatous patients with ocular surface disease due to prolonged hypotensive eyedrop *** our knowledge,this is the first series analyzing the therapeutic effect of this treatment option in this type of ***:This non-comparative prospective case series study enrolled a total of 30 glaucoma patients ranging in age from 57 to 94 years old and treated with hypotensive eyedrops for years with dry eye *** patients received four sessions of IPL treatment using the Optima IPL system(Lumenis,Yokneam,Israel)adjusted to the official optimized Lumenis *** in symptomatology,corneal staining,conjunctival hyperemia,non-invasive break-up time(NIBUT),tear osmolarity,tear meniscus height(TMH),meiboscore and meibomian gland expressibility was analyzed after ***:Statistically significant reductions were observed after IPL treatment in the symptomatology scores measured with different questionnaires[ocular surface disease index(OSDI),standard patient evaluation of eye dryness(SPEED)and symptom assessment questionnaire in dry eye(SANDE)]as well as with the visual analogue scale(P<0.001).Mean change in OSDI was−15.0±11.3.A significant reduction was found after treatment in the corneal staining score(P<0.001).A significant reduction was found in tear film meniscus height(P=0.012),as well as in tear film osmolarity(P=0.001).A significant reduction was also found in meibomian gland expressibility(P=0.003),changing the percentage of grade 3 eyes from 44.4%before IPL to 17.2%after ***:IPL therapy combined with meibomian gland expression(MGX)seems to be an effective option to improve symptomatology in glaucomatous patients with ocular surface diseas

关键词： Glaucoma Intense pulsed light Dry eye Meibomian glands

Li2SnO3 branched nano- and microstructures with intense and broadband white-light emission

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2019年第2期12卷 441-448页

作者： Miguel garcia-Tecedor Javier Bartolome David Maestre Achim Trampert Ana Cremades Dpt. Fisica de Materials Facultad de CC. Fisicas Universidad Complutense de Madrid Madrid 28040 Spain Paul-Drude-Institut fur Festkorperelektronik Hausvogteiplatz 5-7 Berlin 10117 Germany Institute of Advanced Materials (INAM) Universitat Jaume I Castello 12006 Spain Dpt. Fisica de Materiales Facultad de CC. Ftsicas Universidad Complutense de Madrid Madrid 28040 Spain

Exploiting the synergy between microstructure, morphology and dimensions by suitable nanomaterial engineeri ng, can effectively upgrade the physical properties and material performances. Li2SnO3 elongated nano- and microstructures in form of belts, wires, rods and branched structures have been fabricated by a vapor-solid method at temperatures ranging from 700 to 900℃ using metallic Sn and Li2CO3 as precursors. The achievement of these new morphologies can face challenging applications for Li2SnO3, not only in the field of energy storage, but also as building blocks in optoelectronic devices. The micro? and nanostructures grown at 700 and 800℃ correspond to monoclinic Li2SnO3, while at 900℃ complex Li2S nO/SnO2 core-shell microstructures are grow n, as con firmed by X-ray diffractio n and Rama n spectroscopy. Transmission electron microscopy reveals structural disorder related to stacking faults in some of the branched structures, which is associated with the prese nee of the low-temperature phase of L12S nO3. The luminescent resp onse of these structures is domi nated by in tense emissi ons at 2, 2.5 and 3 eV, almost completely covering the whole range of the visible light spectrum. As a result, white-light emission is obtained without the need of phosphors or complex quantum well heterostructures. Enhanced functionality in applications such as in light-emitting devices could be exploited based on the high luminescenee intensity observed in some of the analysed Li2SnO3 structures.

关键词： lithium oxides white light emitters nanostructures luminescenee

Gibbs sampling based distributed OFDMA resource allocation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Information Sciences) 2014年第4期57卷 18-29页

作者： garcia Virgile CHEN Chung Shue ZHOU YiQing SHI JingLin Wireless Technology Research Center Institute of Computing Technology Chinese Academy of Sciences Beijing Key Laboratory of Mobile Computing and Pervasive Device

In this article,we present a distributed resource and power allocation scheme for multiple-resource wireless cellular *** global optimization of multi-cell multi-link resource allocation problem is known to be NP-hard in the general *** use Gibbs sampling based algorithms to perform a distributed optimization that would lead to the global optimum of the *** objective of this article is to show how to use the Gibbs sampling(GS)algorithm and its variant the Metropolis-Hastings(MH)*** also propose an enhanced method of the MH algorithm,based on a priori known target state distribution,which improves the convergence speed without increasing the ***,we study different temperature cooling strategies and investigate their impact on the network optimization and convergence *** results have also shown the effectiveness of the proposed methods.

关键词： radio resource allocation power control interference management distributed optimization Gibbs sampling Metropolis-Hastings