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Evaluation of hypoxia inducible factor targeting pharmacological drugs as antileishmanial agents

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Asian Pacific Journal of Tropical Medicine 2016年第7期9卷 633-638页

作者： Marina Dal’Bo Pelegrini juliana Biar pereira Solange dos Santos Costa Myriam Janeth Salazar Terreros Adriana Degrossoli Selma Giorgio Department of Animal Biology Biology InstituteUniversidade Estadual de CampinasCampinasSao PauloBrazil

Objective:To evaluate whether hypoxia inducible factor(HIF-1α) targeting pharmacological drugs,echinomycin,resveratrol and CdCl_2 which inhibit HIF-1α stimulation,and mimosine,which enhances the stability of HIF-1α present antileishmanial ***:The leishmanicidal effect of drugs was evaluated in mouse macrophages and Balb/c mouse model for cutaneous ***:Resveratrol and CdCl_2 reduced the parasite load [IC50,(27.3±2.25) μM and(24.8±0.95) μM,respectively].The IC50 value of echinomycin was(22.7±7.36) nM and mimosine did not alter the parasite load in primary *** macrophage viability IC50 values for resveratrol,echinomycin and CdCl_2 and mimosine were >40 μM,>100 nM,> 200 μM and>2 000 μM,*** vivo no differences between cutaneous lesions from control,resveratrol-and echinomycin-treated Balb/c mice were ***:Resveratrol,echinomycin and CdCl_2 reduce parasite survival in *** HIF-1α targeting pharmacological drugs require further study to more fully determine their anti-Leishmania potential and their role in therapeutic strategies.

关键词： Leishmaniosis Hypoxia inducible factor Resveratrol Echinomycin CdCl2 Mimosine

Analysis of Radium Isotopes in Surface Waters nearby a Phosphate Mining with NORM at Santa Quiteria,Brazil

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Journal of Environmental Protection 2014年第3期5卷 193-199页

作者： Wagner de S.pereira Alphonse Kelecom juliana R.de S.pereira Multidisciplinary Group of Radioprotection(GMR) Servico de RadioprotecaoUnidade de Tratamento de MinerioIndustrias Nucleares do BrasilCaldasBrazil Laboratory of Radiobiology and Radiometry Pedro Lopes dos Santos(LARARA-PLS) Group of Environmental Themes Assessment(GETA)Universidade Federal Fluminense(UFF)NiteroiBrazil Interdisciplinary Under-Graduation in Science and Technology Universidade Federal de AlfenasPocos de CaldasBrazil

The radium isotopes 226Ra and 228Ra were analyzed in surface water at six points in the neighborhood of a mine of phosphate, associated with uranium, in the region of Santa Quitéria, state of Ceará, Brazil. Water samples were collected during twenty months, filtered and the concentrations of activity determined in the soluble and particulate phases. The results were analyzed using the Principal Component Analysis (PCA) for ordination of environmental data, and also by ANOVA, Tukey and Z tests to compare sets of data considering the radionuclides, the two analyzed phases and the six collecting points. The PCA identified four groups that included all collecting points, using aggregation features such as radionuclide and analyzed phase. The first group is composed by the samples of 226Ra in the soluble phase;the second group by samples of 226Ra in the particulate phase;the third one by 228Ra in the soluble phase, and finally, the fourth group by 228Ra in the particulate phase. This last group has two discrepant points (01 and 06). Statistical analysis identified differences between the concentrations of activity of radionuclides (228Ra higher than 226Ra) and in analyzed phases (soluble phase higher than the particulate one) but showed no differences between sampled points.

关键词： Radioecology Environmental Radioprotection NORM Mining Radium Isotopes PCA

Can dietary flavonoids be useful in the personalized treatment of colorectal cancer?

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World Journal of Gastrointestinal Oncology 2022年第6期14卷 1115-1123页

作者： Cristina pereira-Wilson Department of Biology Centre of Biological EngineeringLABBELS Associate LaboratoryUniversity of MinhoBraga 4710-057Portugal

Activating mutations in the oncogenes KRAS,BRAF and PI3K define molecular colorectal cancer(CRC)subtypes because they play key roles in promoting CRC development and in determining the efficacy of chemotherapeutic agents such as 5-fluorouracil and anti-epidermal growth factor receptor monoclonal *** of patients with cancers displaying these molecular profiles is *** the limited efficacy of therapeutic strategies for CRC presenting mutational activations in mitogen-activated protein kinase and/or PI3K pathways,developing combination therapies with natural flavonoids or other phytochemicals with demonstrated effects on these pathways(and little or no toxic effects)may constitute a valuable path *** has been published on the anticancer effects of dietary ***,even an exhaustive characterization of potential beneficial effects produced by in vitro studies cannot be extrapolated to effects in *** far,the available data constitute a good starting *** results show quercetin and curcumin as possibly the best candidates to be further explored in the context of adjuvant CRC therapy either as part of dietary prescriptions or as purified compounds in combination regimens with the drugs currently used in CRC *** trial data is still largely missing and is urgently needed to verify relevant effects and for the development of more personalized treatment approaches.

关键词： Colorectal cancer Personalized treatment Quercetin Curcumin KRAS BRAF

Developing an integrated urban ecological efficiency framework for spatial ecological planning:A case on a tropical mega metropolitan area of the global south

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Geoscience Frontiers 2023年第1期14卷 298-309页

作者： Manob Das Arijit Das Paulo pereira Department of Geography University of Gour BangaMaldaWest BengalIndia Environmental Management Laboratory Mykolas Romeris University VilniusLithuania

Rapid urbanization has emerged as one of the most critical challenges to ecological sustainability in urban *** developing countries,the degradation of the ecosystem is more prominent due to the lack of urban ***,it has become urgent for researchers to identify the ecological efficiency(EE)changes imposed by urban expansion and promote sustainable land use *** study aims to develop a comprehensive urban ecological efficiency(UEE)framework in the Kolkata Metropolitan Area(KMA),India,from 2000 to *** component analysis(PCA)was used to develop a remote sensing-based UEE index(UEEI)based on five effective ecological parameters(Greenness,Dryness,Heat,Wetness and vegetation health.A single sensitivity parameter was also calculated to determine the role of a single parameter based on which management strategies can be carried *** findings showed that(i)there were substantial deteriorations of UEE in the last 20 *** 2000 the areas with good EE were about 65.5%which declined to 53.72%in 2010 and 20.87%in *** areas with good UEE decreased 68%and 61%from 2000 to 2020 and 2010 to 2020,respectively;(ii)the areas with good UEE were 52%in 2000,while 38%in *** urban centres(Bhadreshwar,Champdani,Srirampur,Bally,Howrah,Kamarhati,Baranagar,Dum Dum,South Dum Dum,Rajarhat,Bidhannagar)located around the Kolkata megacity are characterized by poor and very poor EE(ranges of 0.60-1.00).Thus,spatiotemporal pattern of UEE could assist to clarify the administrative responsibilities as well as *** addition to this,the UEE framework can help for scientific guidance of urban ecosystem protection and restoration through comprehensive spatial landscape planning.

关键词： Urban ecological efficiency Kolkata metropolitan area Ecosystem services Urban ecological management Urbanization

Effect of pre-and post-wildfire management practices on plant recovery after a wildfire in Northeast Iberian Peninsula

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Journal of Forestry Research 2020年第5期31卷 1647-1661页

作者： Marcos Francos Paulo pereira Xavier Ubeda GRAM(Grup de Recerca Ambiental Mediterrania) Department of GeographyUniversity of BarcelonaMontalegre608001 BarcelonaSpain Environmental Management Centre Mykolas Romeris UniversityVilniusLithuania

Fire and pre-or post-fire management practices shape the distribution and richness of plant ***,the effects of pre-and post-fire management on vegetation recovery were studied at different times,up to 18 months after a *** months after a 2015 wildfire,18 study plots were established(three 4-m^2 plots for each treatment),vegetation regrowth was monitored and vegetal species richness(S),evenness(IT),density(D),diversity(H0)and maximum diversity(HMax)after 2,10 and 18 *** treatments were(1)control,unaffected by 2015 wildfire;(2)no treatment(NT),burned in 2015 wildfire and not managed;(3)managed in 2005 and burned in 2015(M05B);(4)managed in 2015,2 months before wildfire(M15B);(5)cut and manual removal after the 2015 wildfire(CR);(6)cut and no trunk removal randomly deposited on topsoil after the 2015 wildfire(CL).All the treatments were carried out in a Pinus halepensis Miller *** 10 and 18 months after the wildfire,vegetation recovery was greater in NT,CR and CL plots than in M05B and M15B the *** 18 months after the wildfire,Brachypodium retusum(Pers.)*** Rosmarinus officinalis *** still dominant,especially in M15B,corroborating the belief that pre-fire treatment reduced ecosystem resilience and vegetal recovery compared to the NT and post-fire managed *** was significantly lower 10 months after wildfire in control plots,and IT was significantly higher in that inventory than previously in *** months after the wildfire,H0 was significantly lower in *** months post-wildfire,HMax was significantly lower in the control *** months after the wildfire,HMax,was significantly higher in CR,CL and M05B than in the control and M15B ***,pre-fire management was detrimental to post-fire vegetation recovery,while manual post-fire management proved beneficial.

关键词： Forest management Vegetation recovery Diversity Richness Evenness

Long-term forest management after wildfire(Catalonia,NE Iberian Peninsula)

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Journal of Forestry Research 2020年第1期31卷 269-278页

作者： Marcos Francos Xavier Ubeda Paulo pereira GRAM(Grup de Recerca Ambiental Mediterrania) Department of GeographyUniversity of BarcelonaMontalegre608001 BarcelonaSpain Environmental Management Centre Mykolas Romeris UniversityVilniusLithuania

Studies of post-fire soil status in Mediterranean ecosystems are common;however,few have examined the effects of long-term forest management after a wildfire on physicochemical soil ***,we analyzed differences in soil properties attributable to long-term postfire management and assessed the sustainability of these management practices in relation to the soil *** study area is located in Odena in the northeast region of the Iberian Peninsula consisted of the control forest(burned more than 30 years ago),low density forest(LD;burned in a wildfire in 1986 and managed in 2005)and high density forest(HD;burned in a wildfire in 1986 and no managed).For soils from each plot,we measured soil water repellency,aggregate stability,total nitrogen(TN),soil organic matter(SOM),inorganic carbon(IC),pH,electrical conductivity,extractable calcium,magnesium,sodium,potassium(K),phosphorus,aluminum(Al),manganese(Mn),iron(Fe),zinc,copper,boron,chrome,silicon and sulfur and calculated the ratios of C/N,Ca+Mg/(Na+K)^1/2,Ca/Al and Ca/*** differences were found in TN,IC,SOM,pH,K,Al,Mn,Fe and C/N ratio(p<0.05).All soil properties were found to have largely recovered their pre-fire *** were affected by the post-fire management practices implemented 20 years after the fire,as reflected in their respective physicochemical properties,so that soil properties at the control and LD sites are more similar today than those at the control and HD ***,sustainable forest management can overcome soil degradation in areas affected by wildfire in the medium-and long-term by improving soil properties.

关键词： Soil chemical properties Aggregate stability Post-fire management Wildfire risk Vegetal density

GEM... The new IUGS Commission on Geoscience for Environmental Management

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Episodes 2005年第1期28卷 65-66页

作者： pereira, J Univ Kebangsaan Malaysia LESTARI Inst Environm & Dev Bangi 43600 Malaysia

At the International Geological Congress held in Florence, Italy in August 2004 the IUGS Council approved the formation of a new Commission on Geoscience for Environmental Management. This new Commission was formed to continue IUGS activities in the environment following the closure of the IUGS Commission on Geological Sciences for Environmental Planning(COGEOENVIRONMENT) which had completed its term (refer to separate article in this issue).

关键词： IUGS 地质学环境规划发展目标工作思路

The IUGS Commission on Geological Sciences for Environmental Planning （COGEOENVIRONMENT） completes its term

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Episodes 2005年第1期28卷 64-65页

作者： Joy pereira Institute for Environment and Development LESTARI Universiti Kebangsaan Malaysia

During the last 2 years the IUGS has reviewed its Organisation and Operations to allow more efficient and effective administration into the future. Among the items reviewed was the life of Commissions which have now been defined at a maximum of 8 years. As a consequence COGEOENVIRONMENT, which has been in existence since early 1990, was formally closed down at the IGC in Florence in August 2004. The decision by the IUGS Council to close COGEOENVIRONMENT did not in any way imply that the role of the IUGS in promoting geoscience in environment matters was completed.

关键词：地质学环境规划 IUGS 工作思路发展目标

Cork and Sustainability:Discussing the Sustainable Use of the Material from a Design Perspective

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Journal of Shanghai Jiaotong university(Science) 2012年第3期17卷 360-363页

作者： ANA CARINA pereira HAN Brezet HELENA pereira JOOST Vogtlnder Design for Sustainability Faculty Industrial Design EngineeringDelft University of Technology2628 CE DelftThe Netherlands Forest Research Centre School of AgronomyTechnical University of LisbonLisbon 1349-017Portugal

There is the challenge to use materials in a more sustainable *** though cork has an interesting eco-profile as a material,other aspects contributing to an enhanced sustainable use of the resource are discussed:addres... 详细信息

关键词： sustainability design and materials cork products and materials eco-materials