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Beyond wrecking a wall:revisiting the concept of blood–brain barrier breakdown in ischemic stroke

Neural Regeneration Research 2025年第7期20卷 1944-1956页

作者： julia Castillo-González Elena González-Rey Institute of parasitology and Biomedicine Lopez-Neyra(IpBLN) CSICPT SaludGranadaSpain

The blood–brain barrier constitutes a dynamic and interactive boundary separating the central nervous system and the peripheral *** tightly modulates the ion transport and nutrient influx,while restricting the entry of harmful factors,and selectively limiting the migration of immune cells,thereby maintaining brain *** the well-established association between blood–brain barrier disruption and most neurodegenerative/neuroinflammatory diseases,much remains unknown about the factors influencing its physiology and the mechanisms underlying its ***,the role of blood–brain barrier breakdown in the translational failure underlying therapies for brain disorders is just starting to be *** review aims to revisit this concept of“blood–brain barrier breakdown,”delving into the most controversial aspects,prevalent challenges,and knowledge gaps concerning the lack of blood–brain barrier *** moving beyond the oversimplistic dichotomy of an“open”/“bad”or a“closed”/“good”barrier,our objective is to provide a more comprehensive insight into blood–brain barrier dynamics,to identify novel targets and/or therapeutic approaches aimed at mitigating blood–brain barrier ***,in this review,we advocate for considering the diverse time-and location-dependent alterations in the blood–brain barrier,which go beyond tight-junction disruption or brain endothelial cell breakdown,illustrated through the dynamics of ischemic stroke as a case *** this exploration,we seek to underscore the complexity of blood–brain barrier dysfunction and its implications for the pathogenesis and therapy of brain diseases.

关键词： blood–brain barrier disruption drug delivery ischemic stroke neuroinflammation tight-junctions

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低空经济助推新质生产力的运行机理与路径选择

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新疆师范大学学报（哲学社会科学版） 2025年第1期46卷 118-131页

作者：欧阳日辉中央财经大学中国互联网经济研究院北京100081

低空经济是以低空飞行活动为牵引,以有人驾驶和无人驾驶航空器为主要载体,通过技术创新和模式创新推动相关产业融合发展的新型综合性经济形态。低空经济涉及领域和行业多、应用场景多、创新之处多、产业链条长、带动效应强,具有创新驱... 详细信息

低空经济是以低空飞行活动为牵引,以有人驾驶和无人驾驶航空器为主要载体,通过技术创新和模式创新推动相关产业融合发展的新型综合性经济形态。低空经济涉及领域和行业多、应用场景多、创新之处多、产业链条长、带动效应强,具有创新驱动性、空间依赖性、跨界融合性、辐射带动性等技术—经济特征。低空经济通过场景牵引、跨界融合、协同治理,聚焦应用场景,打造低空多场景应用,推动“低空+”物流配送、“低空+”城市空中交通、“低空+”旅游、“低空+”应急救援等规模化发展,在技术创新与制度创新相互嵌套、协同治理的基础上实现健康发展。当前,各地各部门积极抢占低空经济新赛道,通过建设智能互联高效的基础设施、加快低空智能互联航行技术创新、完善产业链增强低空产业韧性和安全等举措因地制宜打造融合创新的应用场景。为促进低空经济发展,应加强产业政策引导与支持,支持低空经济技术创新与研发,推动跨界融合与应用场景创新,完善产业链配套服务体系。

关键词：低空经济新质生产力应用场景科技创新产业创新

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De novo synthesis of atropisomeric benzofurans via Cu/SpDO complex catalyzed asymmetric formal [3 + 2] annulation

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Science China Chemistry 2025年第1期 174-180页

作者： Fan-Xiao Meng Xing-Yu Wang ka Lu Ju-Song Yang Fu-Min Zhang Ai-Jun Ma Bao Du Yong-Qiang Tu State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical Engineering Lanzhou University School of Chemistry and Chemical Engineering Shanghai Jiao Tong University School of Biotechnology and Health Sciences Wuyi University

Herein, the de novo synthesis of atropisomeric benzofurans through the Cu/spirocyclic-pyrrolidine-oxazoline(SpDO) complex catalyze asymmetric formal [3 + 2] cycloaddition between quinones and ynamides is explored, producing a range of structurally diverse axially chiral benzofurans in satisfactory yields with good to excellent enantioselectivities. Furthermore, density functional theory calculations were applied to explain the possible reaction mechanism.

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An effective round ball tool in electrochemistry process as novel reuse fabrication technology

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中国有色金属学会会刊：英文版 2012年第S3期22卷 825-830页

作者： p.S.pa Department of Digital Content Design Graduate School of Toy and Game DesignNational Taipei University of Education

A reuse fabrication module using micro electrochemistry (MECM) with a round-ball tool to remove the defective In2O3 SnO2 thin film from the surfaces of digital paper display was *** etching effect improves that the number of the round-balls decreases for promoting the concentration of electric power and increasing discharge *** a small size of the round-ball tool takes less time for the same amount of In2O3 SnO 2 layer removal since the effect of MECM is easily developed for supplying of sufficient electrochemical power.A higher feed rate of the poly ethylene terephthalate (pET) diaphragm combines with enough electric power to drive fast etching rate.A pulsed direct current can improve the effect of dreg discharge and is advantageous to couple this current with the fast feed rate of the *** the ultra-precise etching of In2O 3 SnO2,the optoelectronic semiconductor industry can effectively reuse the defective products,reducing production *** precision etching process is of high efficiency and requires only a short period of time to remove the In2O3 SnO2 nanostructures.

关键词： thin film round-ball tool In2O3SnO2 micro electrochemistry digital paper display

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Ultra-low temperature cofired ceramics based on Li_(2)WO_(4)as perspective substrate materials for terahertz frequencies

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Journal of Advanced Ceramics 2023年第3期12卷 526-538页

作者： Dorota Szwagierczak Beata Synkiewicz-Musialska Jan Kulawik Elżbieta Czerwińska Norbert pałka Kraków Division Łukasiewicz Research Network-Institute of Microelectronics and PhotonicsKraków 30-701Poland Institute of Optoelectronics Military University of TechnologyWarszawa 00-908Poland

With the development of low dielectric permittivity materials having an ultra-low sintering temperature,testing their dielectric properties at terahertz frequencies suitable for 6G communication systems and implementation of the fabricated materials in ultra-low temperature cofired ceramics(ULTCC)were the main goals of the *** tungstate Li_(2)WO_(4)was synthesized by a solid-state reaction and used for the preparation of green tapes and test structures with cofired internal conductive layers,which are destined for substrates of microwave and submillimeter wave *** behavior,thermal effects,and mass changes of the green tapes during heating were studied using a hot-stage microscope,differential thermal analysis,and thermogravimetry.A single-phase composition was revealed for being undoped and doped with AlF3–CaB_(4)O_(7)*** impact of frequency,temperature,the addition of AlF3–CaB_(4)O_(7)and CuBi_(2)O_(4)dopants,and sintering temperature was the subject of in-depth characterization of dielectric properties in a terahertz region.A glass-free composition,ultra-low sintering temperature of 590–630℃,low roughness of the green tapes,dense microstructure,compatibility with Ag conductors,low and stable dielectric permittivity of 5.0–5.8 in a broad range of 0.2–2 THz,and low dielectric loss of 0.008–0.01 at 1 THz are the main advantages of the developed ULTCC substrates.

关键词： Li_(2)WO_(4) ultra-low temperature cofired ceramics(ULTCC) tape casting dielectric properties terahertz frequency range

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Subject Area risk Assessment of Four Hungarian Universities with a View to the QS University Rankings by Subject

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Journal of Data and Information Science 2022年第4期7卷 61-80页

作者： péter Sasvári Anna Urbanovics public Governance and International Studies University of Public ServiceHungary University of Miskolc Hungary

purpose:The aim of our paper is to investigate the role of a mentor leading a research team in the overall scientific performance of an academic institution and the possible risks of their departure with a special attention to their publication ***/methodology/approach:By using SciVal subject area data,we composed a formula describing the level of vulnerability of any given university in the case of losing any of its leading mentors,identifying other risk factors by dividing their careers into separate ***:It turns out that the higher field-weighed citation impact is,the better position universities reach in the rankings by subject and the vulnerability of institutions highly depends on the mentors,especially in view of their contribution to the topic *** limitations:The analysis covers the publication output of leading researchers working at four Hungarian universities,the scope of the analysis is worth being *** implications:Our analysis has the potential to give an applicable systemic approach as well as a data collection scheme to university managements so as to formulate an inclusive and comprehensive research strategy involving the introduction of a reward system aimed at publications and further encouraging national and international research ***/value:The methodology and the principles of risk assessment laid down in our paper are not restricted to measuring the vulnerability level of a limited group of academic institutions,they can be appropriately used for investigating the role of mentors or leading researchers at every university across the globe.

关键词： QS Rankings by Subject Scientific Competitiveness risk Analysis Subject Area Exposure

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Assessing cooling energy reduction potentials by retrofitting traditional cavity walls into passively ventilated cavity walls

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Building Simulation 2021年第4期14卷 1295-1309页

作者： ri Na Zhigang Shen Department of Civil and Environmental Engineering University of DelawareNewarkDE19716USA The Durham School of Architecture Engineering and Construction University of Nebraska LincolnLincolnNE68588USA

A major roadblock in achieving substantial building energy reduction is the low performance of old buildings that account for a significant portion of the building energy *** low-cost energy retrofit solutions that do not disrupt occupants’daily life during the retrofitting is the key to successful building energy retrofit *** this paper,a novel and low-cost exterior wall retrofitting solution is introduced,and its performance in reducing space cooling load was quantitatively evaluated to demonstrate its feasibility and *** primary goal of this paper is to provide a quantitative assessment of the cooling-energy savings potential by using the proposed new wall *** intended retrofitting targets are the large amount of existing cavity-wall buildings located in hot climate *** quantification of the before-after heat-flux reduction was conducted through a 3-dimensional steady-state low turbulence computational fluid dynamics(CFD)model,which is validated by benchmarking its prediction against the published experimental case *** outcomes of the investigation suggest that this simple low-cost solution has great potentials in reducing buildings’summer cooling load in hot climate *** applicability of this solution is not limited to retrofitting existing *** energy-efficient building designs can also adopt this solution in their envelope systems.

关键词： low-cost energy retrofit building envelope cavity wall stack effect space cooling energy reduction CFD

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Outcompeted by an invader?Interference and exploitative competition between tropical house gecko(Hemidactylus mabouia)and Barbados leaf-toed gecko(phyllodactylus pulcher)for diurnal refuges in anthropogenic coastal habitats

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Integrative Zoology 2016年第3期11卷 229-238页

作者： Robert WILLIAMS Angelo p.pERNETTA julia A.HORROCKS Ecology and Conservation Research Group School of Pharmacy and Biomolecular SciencesUniversity of BrightonBrightonUK Ecology and Conservation Research Group University of BrightonHastingsUK Department of Biological and Chemical Sciences University of the West IndiesBarbadosWest Indies

House geckos in the genus Hemidactylus are highly successful colonizers of regions beyond their native range,with colonization often resulting in displacement of native gecko species through competitive interactions for daytime refuge(crevices)and prey *** report on data collected from nighttime surveys undertaken in April-May 2014 on Barbados,West Indies,that focused on the distribution and abundance of the endemic Barbados leaf-toed gecko(phyllodactylus pulcher)and the introduced tropical house gecko(Hemidactylus mabouia)along unlit coastal walls and among boulders in the grounds of a hotel *** contrast to patterns of displacement of native species by *** seen elsewhere,*** was more abundant than *** on coastal walls,whereas the latter was found in greater numbers using boulders at this *** and boulders differed with regard to availability of diurnal refugia suitable for geckos,with the walls having high frequency of small crevices with openingsring very little cover other than the underside of the boulder *** investigate whether this niche separation was a result of differences in diurnal refuge use between the species,we conducted experimental trials in which geckos were allowed to select between refugia with different *** species selected for narrower and warmer refugia,and refugia that had been previously occupied by the other *** shared preferences for refugia type suggest that other factors underlie the niche separation observed in the *** supporting high densities of ***,coastal walls could offer important secondary habitat by augmenting the natural cliff side habitat of this endemic gecko,a finding that could be exploited for the conservation of this candidate species for Critically Endangered classification.

关键词： Barbados leaf-toed gecko Hemidactylus island endemic phyllodactylus tropical house gecko

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A Remark on Leray's problem on Stationary Navier–Stokes Flows with Large Fluxes in Infinite Cylindrical Domains

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Acta Mathematica Sinica,English Series 2015年第10期31卷 1571-1581页

作者： Myong-Hwan ri Institute of Mathematics State Academy of SciencesPyongyang DPR Korea

We consider Leray＇s problem on stationary Navier Stokes flows with arbitrary large fluxes in an unbounded cylinder with several exits to infinity. For a stationary Navier Stokes flow with large fluxes in the unbounded cylinder, we prove that, if the difference between the pressure of the main flow and the pressure of the poiseuille flow with the same flux in a branch of the cylinder remains bounded at ｜x｜→∞, then the flow behaves at infinity of the branch like the poiseuille flow.

关键词： Leray's problem Navier-Stokes equations large flux unbounded cylindrical domains

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Regularity for 3D Navier–Stokes Equations Based on Energy Distribution at Wavenumber Bands

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Acta Mathematica Sinica,English Series 2019年第8期35卷 1377-1392页

作者： Myong-Hwan ri Institute of Mathematics State Academy of SciencesDPR Korea

We present some regularity criteria for the Leray–Hopf weak solutions to the Cauchy problem for 3D Navier–Stokes equations based on energy distribution at wavenumber bands. We show sufficient conditions for regularity based on the ratios of energy dissipation rates at sufficiently high wavenumber bands and neighboring medium wavenumber bands. Moreover, we give a regularity criterion based on relations between energy at high and low wavenumber bands.

关键词： Navier-Stokes equations global regularity energy transfer

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