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Tumor microenvironment involvement in colorectal cancer progression via Wnt/β-catenin pathway:Providing understanding of the complex mechanisms of chemoresistance

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World Journal of Gastroenterology 2022年第26期28卷 3027-3046页

作者： María Belén novoa Díaz María julia martín Claudia Gentili Departamento de Biología Bioquímica y FarmaciaUniversidad Nacional del Sur(UNS)-INBIOSUR(CONICET-UNS)Bahía Blanca 8000Argentina Departamento de Química Universidad Nacional del Sur(UNS)-INQUISUR(CONICET-UNS)Bahía Blanca 8000Argentina

Colorectal cancer(CRC)continues to be one of the main causes of death from cancer because patients progress unfavorably due to resistance to current *** of the Wnt/β-catenin pathway plays a fundamental role in the genesis and progression of several types of cancer,including *** many subtypes of CRC,hyperactivation of theβ-catenin pathway is associated with mutations of the adenomatous polyposis coli ***,it can also be associated with other *** recent years,studies of the tumor microenvironment(TME)have demonstrated its importance in the development and progression of *** this tumor nest,several cell types,structures,and biomolecules interact with neoplastic cells to pave the way for the spread of the ***-communications between tumor cells and the TME are then established primarily through paracrine factors,which trigger the activation of numerous signaling *** advances in the field of oncology have been made in the last *** Minireview aims to actualize what is known about the central role of the Wnt/β-catenin pathway in CRC chemoresistance and aggressiveness,focusing on crosscommunication between CRC cells and the *** this analysis,our main objective was to increase the understanding of this complex disease considering a more global *** many treatments for advanced CRC fail due to mechanisms involving chemoresistance,the data here exposed and analyzed are of great interest for the development of novel and effective therapies.

关键词： Colorectal cancer β-catenin pathway Tumor stroma Tumor microenvironment factors Cancer progression Drug resistance

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Involvement of parathyroid hormone-related peptide in the aggressive phenotype of colorectal cancer cells

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World Journal of Gastroenterology 2021年第41期27卷 7025-7040页

作者： María Belén novoa Díaz Pedro Matías Carriere María julia martín natalia Calvo Claudia Gentili Departamento de Biología Bioquímica y FarmaciaUniversidad Nacional del Sur(UNS)-INBIOSUR(CONICET-UNS)Bahía Blanca 8000Buenos AiresArgentina Departamento de Química Universidad Nacional del Sur(UNS)-INQUISUR(CONICET-UNS)Bahía Blanca 8000Buenos AiresArgentina

Colorectal cancer(CRC)remains one of the leading causes of mortality from malignant diseases *** general terms,CRC presents high heterogeneity due to the influence of different genetic and environmental factors;also,the neoplastic cells are strongly influenced by the extracellular matrix and several surrounding cells,known together as the tumor microenvironment(TME).Bidirectional communication takes place between the tumor and the TME through the release of autocrine and paracrine *** hormone-related peptide(PTHrP)is a cytokine secreted by a wide variety of tissues and is able to regulate several cellular functions both in physiological as well as in pathological *** exerts its effects as a paracrine/autocrine factor,although its mode of action is mainly *** has been shown that this peptide is expressed by several tumors and that the tumor secretion of PTHrP is responsible for the malignant humoral *** years ago,when our research group started studying PTHrP effects in the experimental models derived from intestinal tumors,the literature available at the time addressing the effects of PTHrP on colorectal tumors was limited,and no articles had been published regarding to the paracrine action of PTHrP in CRC *** on this and on our previous findings regarding the role of PTH in CRC cells,our purpose in recent years has been to explore the role of PTHrP in *** analyzed the behavior of CRC cells treated with exogenous PTHrP,focalizing in the study of the following events:Survival,cell cycle progression and proliferation,migration,chemoresistance,tumor-associated angiogenesis,epithelial to mesenchymal transition program and other events also associated with invasion,such us the induction of cancer stem cells *** work summarizes the major findings obtained by our investigation group using in vitro and in vivo CRC models that evidence the participation of PTHrP in the acquisition of an aggressiv

关键词： Parathyroid hormone-related protein Colorectal cancer Tumor biomarkers neoplastic processes Drug resistance Tumor microenvironment

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Hepatotoxicity induced by acute and chronic paracetamol overdose in children: Where do we stand?

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World Journal of Pediatrics 2017年第1期13卷 76-83页

作者： Hoi Yan Tong nicolás Medrano Alberto Manuel Borobia JoséAntonio Ruiz Ana María martínez julia martín Manuel Quintana Santos Garcfa Antonio Jos6 Carcas Elena Ramirez Department of Clinical Pharmacology Hospital Universitario La PazIdiPAZSchool of MedicineUniversidad Autónoma de MadridMadridSpain Pediatric Emergency Department Hospital Universitario La PazIdiPAZMadridSpain General Emergency Department Hospital Universitario La PazIdiPAZMadridSpain

Background:There are few data Oll hepatotoxicity induced by acute or chronic paracetamol poisoning in the pediatric *** poisoning data can reveal the weakn嗍ofparacetamol poisoning management ***:We retrospectively studied the patients of less than 18 years old with measurable paracetamol levels,who were brought to the emergency department(ED)of La Paz University Hospital,Madrid,Spain,for suspected paracetamol overdoses between 2005 and 2010.

关键词： acute liver failure hepatotoxicity paracetamol poisoning

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Mycobacterium tuberculosis in the aorta of a patient with takayasu’s arteritis. extra pulmonary tuberculosis

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Health 2011年第3期3卷 159-161页

作者： María Elena Soto Virgilia Soto julia Isela martín Sandría Ricardo Gamboa Claudia Huesca 不详

Takayasu’s arteritis (TA), of unknown etiology, has been related with Mycobacterium tuberculosis infection. The published cases are controversial. A 29- year-old man died, prolapse of the aortic valve and unspecific arteritis were demonstrated at necropsy. Our objective was to search in the fresh aortic tissues, the infectious agent of tuberculosis through culture, as well as by performing histopathology and searching by the molecular study, sequences of genes associated to micobacteria and Ziehl’s stain. Results. The bacillus of tuberculosis was observed by the Ziehl’s stain and the sequences of insertion IS6110 gene were identified. Our findings support the relation of TA with possible tuberculosis ***. The possibility that Takayasu’s arteritis is an extra pulmonary tu-berculosis must be explored.

关键词： Takayasu’s arteritis extrapulmonary tuberculosis IS6110 and HupB sequences

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Beta-blocker therapy in elderly patients with renal dysfunction and heart failure

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Journal of Geriatric Cardiology 2021年第1期18卷 20-29页

作者： Juan martínez-Milla Marcelino Cortés García julia Anna Palfy Mikel Taibo Urquía marta López Castillo Ana Devesa Arbiol Ana Lucía Rivero Monteagudo María Luisa martín Mariscal Inés Jiménez-Varas Sem Briongos Figuero Juan Antonio Franco-Pelaéz JoséTuñón Department of Cardiology Hospital Universitario Fundación Jiménez Díaz-Quirónsalud Centro nacional de Investigaciones Cardiovasculares MadridSpain Department of Cardiology Hospital Central de Asturias Department of Cardiology Hospital Universitario Ruber-Quirónsalud Department of Cardiology Hospital Universitario Infanta Leonor Department of Endocrinology Hospital Clínico San Carlos Universidad Autónoma de Madrid CIBERCV MadridSpain

OBJECTIVE To assess the role of beta-blockers(BB)in patients with chronic kidney disease(CKD)aged≥75 *** AnD RESULTS From January 2008 to July 2014,we included 390 consecutive patients≥75 years of age with ejection fraction≤35%and glomerular filtration rate(GFR)≤60 m L/min per 1.73 m^*** analyzed the relationship between treatment with BB and mortality or cardiovascular *** mean age of our population was 82.6±4.1 *** ejection fraction was 27.9%±6.5%.GFR was 60-45 m L/min per 1.73 m^2 in 50.3%of patients,45-30 m L/min per 1.73 m^2 in 37.4%,andn per 1.73 m^2 in 12.3%.At the conclusion of follow-up,67.4%of patients were receiving *** median follow-up was28.04(IR:19.41-36.67)*** the study period,211 patients(54.1%)died and 257(65.9%)had a major cardiovascular event(death or hospitalization for heart failure).BB use was significantly associated with a reduced risk of death(HR=0.51,95%CI:0.35-0.74;Pnts receiving BB consistently showed a reduced risk of death across the different stages of CKD:stage IIIa(GFR=30-45 m L/min per 1.73 m^2;HR=0.47,95%CI:0.26-0.86,Pn per 1.73 m^2;HR=0.55,95%CI:0.26-1.06,P=0.007),and stages IV and V(GFRn per 1.73 m~2;HR=0.29,95%CI:0.11-0.76;P=0.047).COnCLUSIOnS The use of BB in elderly patients with HFr EF and renal impairment was associated with a better *** of BB should be encouraged when possible.

关键词： CKD GFR Beta-blocker therapy in elderly patients with renal dysfunction and heart failure

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文化浸入在旅游业中的应用研究 ——以文化浸入旅行社TripDeep为例

文化浸入在旅游业中的应用研究 ——以文化浸入旅行社TripDeep为例

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作者： julia nú(?)ez martínez 上海外国语大学

学位级别：硕士

本论文以一家文化浸入旅行社TripDeep为例,探究了文化浸入在旅游业中的应用。本研究结合了目前西班牙市场的两个社会趋势:客户体验和国家文化遗产。本研究的对象为一家浸入式旅行社,该旅行社的第一阶段重点为西班牙市场。TripDeep希望... 详细信息

本论文以一家文化浸入旅行社TripDeep为例,探究了文化浸入在旅游业中的应用。本研究结合了目前西班牙市场的两个社会趋势:客户体验和国家文化遗产。本研究的对象为一家浸入式旅行社,该旅行社的第一阶段重点为西班牙市场。TripDeep希望借助西班牙的历史、音乐、体育、习惯、建筑、美食等文化遗产,提供在西班牙旅行的多种可能性。TripDeep旅行社不会采用常规旅行社通常提供的巴士旅行或常规旅游路线,它的目标客户是希望能体验不同的旅行方式、享受特殊旅行体验、对西班牙特色感兴趣的人群。旅行项目将由西班牙当地传统行业的相关从业者提供,涉及内容包括:缝制传统服装、弹奏传统乐器或从事摘橄榄等。本项目的成功基于对其可以满足市场真实需求的预期。此外,目前业内没有任何一家机构能够提供类似的旅游服务。在这样一个消费者需求日益增长的行业,TripDeep将提供一项全新的浸入式体验。

关键词：文化浸入体验经济营销策略旅游业

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Autoantibodies against beta cells to predict early insulin requirements in pediatric patients with clinically diagnosed type 2 diabetes

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World Journal of Diabetes 2024年第8期15卷 1717-1725页

作者： Jorge M Molina Patricia G Medina Rita A Gomez julia R Herrera nancy L martínez Brenda Hernández Yesenia García Department of Endocrinology Children’s Hospital Federico GomezMexico 06720Mexico national Medical Center"Siglo XXI" UMAE Hosp EspecialidadesUnidad Invest Med Epidemiol ClinMexican Social Security InstituteMexico 06720Mexico Research Division UMAE Hospital de EspecialidadesCentro Médico Nacional Siglo XXIMexican Institute of Social SecurityMexico 06720Mexico Epidemiology Research Unit in Endocrinology and nutrition Federico Gómez Children’s HospitalMexico 06720Mexico Department of Endocrinology Comprehensive Health Unit for Trans PersonsMexico 11340Mexico

BACKGROUnD Autoimmunity has emerged as a probable disease modifier in patients with clinically diagnosed type 2 diabetes mellitus(T2DM),that is,patients who have insulin resistance,obesity,and other cardiovascular risk factors,suggesting that the presence of glutamic acid decarboxylase(anti-GAD65),islet antigen 2(anti-IA2),and zinc transporter 8(anti-Zn8T)antibodies could have deleterious effects on beta cell function,causing failure and earlier requirement for insulin *** To evaluate anti-GAD65,anti-IA2 and anti-Zn8T as predictors of early insulin requirement in adolescents with a clinical diagnosis of *** This was a case–control study in patients with clinically diagnosed with T2DM(68 cases and 64 controls with and without early insulin dependence respectively),male and female,aged 12–18 ***,blood pressure,glucose,insulin,C-peptide,glycated hemoglobin A1c,and lipid profiles were *** was used to measure anti-GAD65,anti-IA2,and anti-Zn8T *** statistics,Pearson'sχ2 test,Student's t test,and logistic regression was performed.Pnsidered statistically *** There were 132 patients(53.8%female),with a mean age was 15.9±1.3 years,and there was a disease evolution time of 4.49±0.88 *** presence of anti-GAD65,anti-IA2,and anti-Zn8T positivity was found in 29.5%,18.2%,and 15.9%,*** the groups by early or no insulin dependence showed that the group with insulin had a higher frequency of antibody positivity:anti-GAD65 odds ratio(OR):2.42(1.112–5.303,P=0.026);anti-IA2:OR:1.55(0.859–2.818,P=0.105);and anti-Zn8T:OR:7.32(2.039–26.279,P=0.002).COnCLUSIOn Anti-GAD65 positivity was high in our ***-GAD65 and anti-Zn8T positivity showed a significantly depleted beta cell reserve phenotype,leading to an increased risk of early insulin dependence.

关键词： Diabetes Obesity Adolescents Autoimmunity Beta cell Insulin requirements

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Hepatic flow is an intraoperative predictor of early allograft dysfunction in whole-graft deceased donor liver transplantation: An observational cohort study

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World Journal of Hepatology 2019年第9期11卷 689-700页

作者： Pablo Lozano Lominchar Maitane Igone Orue-Echebarria Lorena martín Cristina julia Lisbona María Magdalena Salcedo Luis Olmedilla Hemant Sharma Jose Manuel Asencio JoséAngel López-Baena General Surgery Department Liver Transplant UnitHospital General Universitario Gregorio MaranonMadrid 28007Spain Anesthesiology Department Liver Transplant UnitHospital General Universitario Gregorio MaranonMadrid 28007Spain Hepatology Department Liver Transplant UnitHospital General Universitario Gregorio MaranonMadrid 28007Spain Department of Transplant Surgery Oschner Medical CenterNew OrleansLA 70816United States

BACKGROUnD Early allograft dysfunction(EAD)after liver transplantation(LT)is an important cause of morbidity and *** ensure adequate graft function,a critical hepatocellular mass is required in addition to an appropriate blood *** hypothesized that intraoperative measurement of portal venous and hepatic arterial flow may serve as a predictor in the diagnosis of *** To study whether hepatic flow is an independent predictor of EAD following *** This is an observational cohort study in a single *** arterial blood flow and portal venous blood flow were measured intraoperatively by transit *** was defined using the Olthoff *** and multivariate analyses were used to determine the intraoperative predictors of *** analysis and prognostic factor analysis were performed using the Kaplan-Meier and Cox regression *** A total of 195 liver transplant procedures were performed between January 2008 and December 2014 in 188 patients.A total of 54(27.7%)patients developed *** median follow-up was 39 *** venous flow,hepatic arterial flow(HAF)and total hepatic arterial flow were associated with EAD in both the univariate and multivariate *** is an independent prognostic factor for 30-d patient *** Intraoperative measurement of blood flow after reperfusion appears to be a predictor of EAD;Moreover,HAF should be considered a predictor of 30-d patient mortality.

关键词： Hepatic flow Early allograft dysfunction Liver transplant

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Diabetic gastroenteropathy:An underdiagnosed complication

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World Journal of Diabetes 2021年第6期12卷 794-809页

作者： Marcio JoséConcepción Zavaleta Jhean Gabriel Gonzáles Yovera Diego martín Moreno Marreros Luciana del Pilar Rafael Robles Kely Roxana Palomino Taype Karen nohelly Soto Gálvez Luis Fernando Arriola Torres julia Cristina Coronado Arroyo Luis Alberto Concepción Urteaga Division of Endocrinology Hospital Nacional Guillermo Almenara IrigoyenLima 12590Peru Division of Gastroenterology Hospital Nacional Guillermo Almenara IrigoyenLima 12590Peru Division of Medicine Universidad Nacional de TrujilloTrujillo 13011Peru Division of Endocrinology Hospital Nacional Dos de MayoLima 150101Peru Division of Endocrinology Instituto de Neurología y Endocrinología AvanzadaAndahuaylas 03700Peru Clinical Management Unit Hospital Nacional Guillermo Almenara IrigoyenLima 12590Peru Division of neurology Instituto de Neurología y Endocrinología AvanzadaAndahuaylas 03700Peru Division of Obstetrics and Gynaecology Clínica VesalioLima 15036Peru Division of neumology Hospital Regional Docente de TrujilloTrujillo 13011Peru

This article is an extensive review that provides an update on the pathophysiology,symptoms,diagnosis,and treatment of diabetic *** is no reported prevalence,but it has been described that patients with type 1 diabetes have a cumulative incidence at 10 years of 5.2%,and type 2 patients,1%.Also,in the group of type 1 diabetes,it has been observed that women are more likely to present this condition(5.8%vs 3.5%).Many factors are associate with its development(e.g.,hyperglycemia,vagal dysfunction,loss of expression of neural nitric oxide synthase in the myenteric plexus,alterations in the Cajal interstitial cell network,and oxidative stress).Gastrointestinal discomfort could be perceived 70% higher in diabetic patients,describing that 25%of diabetic patients experience gastrointestinal *** enteropathy could affect any portion of the gastrointestinal tract,but esophageal alterations were described in more than 60% of diabetic patients,also 60% of them present constipation,and 20%,*** emptying scintigraphy is useful to evaluate gastroparesis,therefore,gastric retention of more than 60%at 2 h has a sensitivity of 100% and specificity of 20% for diagnosis;however,other studies such as breath tests,with a sensitivity of 89% and a specificity of 80%,or the endoscopic capsule contribute to the *** is no cure;however,management must be multidisciplinary,focused on slowing the progression of diabetic gastroenteropathy,reducing symptoms,and restoring function;that includes nutritional recommendation,maintain glucose levels kept below 180 mg/dL,use of prokinetics,anti-emetics;nowadays,it has been special interest in surgical treatment,such as pyloroplasty,also gastric electrical stimulation appears to be another alternative.

关键词： Gastroenteropathy Gastroparesis Diabetes mellitus Complication Gastrointestinal disease Treatment

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An egg-shell bifunctional CeO_(2)-modified niPd/Al_(2) O_(3) catalyst for petrochemical processes involving selective hydrogenation and hydroisomerization

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Journal of Rare Earths 2021年第11期39卷 1382-1388,I0003页

作者： Franklin J.Mendez Javier A.Alves Yahse Rojas-Challa Oscar Corona Yanet Villasana julia Guerra German Garcia-Colli Osvaldo M.martinez Joaquin L.Brito Centro de Quimica Instituto Venezolano de Invesdgaciones CientfficasCarretera PanamericanaKm 11 Altos de PipeCaracas1020AVenezuela Departamento de Estado Solido Instituto de FisicaUniversidad Nacional Autonoma de MexicoCiudad UniversitariaCiudad de Mexico04510Mexico Departamento de Ingenieria Quimica Facultad de Ingenieria(UNLP)and Centro de Investigacion y Desarrollo en Ciencias Aplicadas"Dr.J.J.Ronco"(CINDECA)CCT-La Plata-CONICET-UNLPLa Plata1900Argentina Departamento de Quimica Analitica Facultad de QufmicaUniversidad Nacional Autonoma de MexicoCiudad UniversitariaCiudad de Mexico04510Mexico Instituto Tecnoldgico Venezolano Del Petroleo SA. Petrole os de Venezuela SA.Urb.Santa Rosa-Sector El TamborLos Teques1201Venezuela Instituto Superior de Formacion Docente Salome Urena Esquina Leonardo D'VinciSanto Domingo10114Republica Dominicana Biomass to Resources Group Universidad Regional Amazonica IkiamKm 7 via MuyunaTena150150Ecuador Departamento de Termodinamica y Fenomenos de Transferencia Universidad Simon BolivarValle de SartenejasCaracas1086Venezuela

The catalytic performance during the 1-butyne hydrogenation using two reduced Al_(2) O_(3)-supported Pdbased catalysts was carried out in a total recirculation system with an external fixed-bed *** lab-prepared egg-shell niPd/CeO_(2)-Al_(2) O_(3) catalyst(niPdCe) with Pd loading=0.5 wt%,ni/Pd atomic ratio=1 and CeO_(2) loading=3 wt% was synthesized and characterized,and it was compared with an egg-shell Al_(2) O_(3)-supported Pd based commercial catalyst(PdCC).The reduced catalysts were characterized by X-ray diffraction,X-ray photoelectron spectroscopy,and high-resolution transmission electron *** textural characteristics and ammonia temperature-programmed desorption profiles of the fresh(unreduced) catalysts were also *** catalysts show high 1-butyne conversion and selectivity to 1-butene,but the catalysts also present important differences between hydroisomerizing and hydrogenating *** catalyst shows higher capability for hydroisomerization reactions,while the PdCC catalyst exhibits higher hydrogenating *** observed catalytic performances can be interesting for some industrial processes and can provide a guideline for the development of a Pd-based catalyst with specific catalytic properties.

关键词： 1-Butyne Bifunctional catalyst Egg-shell Hydrogenation Hydroisomerization niPd catalyst

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