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世界显微外科大师——詹姆斯·史密斯

中华显微外科杂志 2022年第2期45卷 236-237页

作者： julia Kallipolitou Terzis 本刊编译组显微外科研究中心东弗吉尼亚医学院奥尔尼路700号路易斯大厅2055室尼尔福克弗吉尼亚州美国23501

julia Kallipolitou Terzis的话:在1990年和1991年的时候,我曾想让James把他的故事分享给我,但最终没能实现。众所周知James Smith和Kurtze在1964年分别独立发表关于利用显微镜进行神经修复的论文。Millesi教授曾说自己是在拜访了James ... 详细信息

julia Kallipolitou Terzis的话:在1990年和1991年的时候,我曾想让James把他的故事分享给我,但最终没能实现。众所周知James Smith和Kurtze在1964年分别独立发表关于利用显微镜进行神经修复的论文。Millesi教授曾说自己是在拜访了James Smith后才开始使用手术显微镜的,那是在1963年的纽约,在那里他见识到了如何使用显微镜修复周围神经。

关键词：手术显微镜神经修复显微外科周围神经 James 史密斯

Alcoholic liver disease and mast cells:What's your gut got to do with it?

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Liver Research 2019年第1期3卷 46-54页

作者： Julie Ann Tolefree Abigail Joy Garcia Jenee Farrell Vik Meadows Lindsey Kennedy Laura Hargrove Jennifer Demieville Nicole Francis julia Mirabel Heather Francis Department of Medical Physiology College of MedicineTexas A&M Health Science CenterTempleTXUSA Division of Research Central Texas Veterans Health Care SystemTempleTXUSA Department of Medicine Indiana UniversityIndianapolisINUSA

Alcoholic liver disease(ALD)remains one of the leading causes of liver injury and death when left *** gut microbiota has been recognized as a key regulator of a number of pathologies,including *** role of mast cells(MCs)during liver disease progression has been demonstrated in a number of animal models and in human liver *** interaction between the gut microbiota and MCs has been investigated,and links between the gut and these immune cells are being *** interplay between the gut microbiota and MCs during ALD has been evaluated and studies suggest that there could be an important link between MCs,their mediators and gut inflammation during the progression of ALD.

关键词： Alcoholic liver disease(ALD) Alcoholic steatohepatitis(ASH) Cirrhosis Steatosis Mast cells(MCs) Microbiota Gut

The incorporation of emotion-regulation skills into couple-and family-based treatments for post-traumatic stress disorder

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Military Medical Research 2017年第4期4卷 218-228页

作者： Deborah A.Perlick Frederic J.Sautter julia J.Becker-Cretu Danielle Schultz Savannah C.Grier Alexander V.Libin Manon Maitland Schladen Shirley M.Glynn JJPeters Department of Veterans Affairs Medical Center and VISN2 South Mental Illness Research Education and Clinical Center130 West Kingsbridge RdBronxNY 10468USA Department of Psychiatry Icahn School of Medicine at Mount Sinai1 Gustave L.Levy PINew YorkNY 10029USA Southeast Louisiana Veterans Health Care System 1601 Perdido StNew OrleansLA 70112USA Tulane University School of Medicine 1430 Tulane AveNew OrleansLA 70112USA Research and Development Washington DC VA Medical Center50 Irving St NWWashingtonDC 20422USA. Georgetown University Medical Center 3800 Reservoir Rd NWWashingtonDC 20007USA va Greater Los Angeles Healthcare System 11301 Wilshire BlvdLos AngelesCA 90073USA David Geffen School of Medicine UCLA10833 LeConte Ave#12138Los AngelesCA 90095USA

Post-traumatic stress disorder(PTSD) is a disabling, potentially chronic disorder that is characterized by re-experience and hyperarousal symptoms as well as the avoidance of trauma-related stimuli. The distress experienced by many veterans of the Vietnam War and their partners prompted a strong interest in developing conjoint interventions that could both alleviate the core symptoms of PTSD and strengthen family bonds. We review the evolution of and evidence base for conjoint PTSD treatments from the Vietnam era through the post-911 era. Our review is particularly focused on the use of treatment strategies that are designed to address the emotions that are generated by the core symptoms of the disorder to reduce their adverse impact on veterans, their partners and the relationship. We present a rationale and evidence to support the direct incorporation of emotion-regulation skills training into conjoint interventions for PTSD. We begin by reviewing emerging evidence suggesting that high levels of emotion dysregulation are characteristic of and predict the severity of both PTSD symptoms and the level of interpersonal/marital difficulties reported by veterans with PTSD and their family members. In doing so, we present a compelling rationale for the inclusion of formal skills training in emotional regulation in couple–/family-based PTSD treatments. We further argue that increased exposure to trauma-related memories and emotions in treatments based on learning theory requires veterans and their partners to learn to manage the uncomfortable emotions that they previously avoided. Conjoint treatments that were developed in the last 30 years all acknowledge the importance of emotions in PTSD but vary widely in their relative emphasis on helping participants to acquire strategies to modulate them compared to other therapeutic tasks such as learning about the disorder or disclosing the trauma to a loved one. We conclude our review by describing two recent innovative treatmen

关键词： couples family post-traumatic stress disorder emotional regulation

Weight Gain: A Modifiable Risk Factor for Primary Cesarean Delivery

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Open Journal of Obstetrics and Gynecology 2017年第5期7卷 525-531页

作者： Annelee Boyle julia Timofeev Sameer Desale Rita W. Driggers Donald J. Dudley Department of Obstetrics and Gynecology MedStar Washington Hospital Center Washington DC USA Department of Gynecology and Obstetrics Johns Hopkins University School of Medicine Baltimore MD USA MedStar Health Research Institute Hyattsville MD USA Department of Obstetrics and Gynecology University of Virginia School of Medicine Charlottesville VA USA

Objective: To evaluate the relationship between weight gain and primary cesarean delivery. Methods: This was a retrospective cohort study of women 5442 who delivered a singleton from 2009-2013. Women were classified as normal weight [pre-pregnancy body mass index (BMI) 18.5 - 24.9 kg/m2], overweight (pre-pregnancy BMI 25.0 - 29.9 kg/m2), obese (pre-pregnancy BMI 30.0 - 39.9 kg/m2), and extremely obese (pre-pregnancy BMI ≥ 40.0 kg/m2). Each BMI group was subdivided by weight gain—low, recommended, or excessive, as defined by the 2009 Institute of Medicine guidelines—and rates of primary cesarean delivery were compared. Results: The overall primary cesarean delivery rate was 27.3%, but this varied based on pre-pregnancy BMI. The primary cesarean delivery rate among women of normal weight was 22.3%, overweight women 27.5%, obese women 35.3%, and extremely obese women 45.7%. Among normal-weight, obese, and extremely obese women, the risk of primary cesarean delivery increased with excessive weight gain [normal weight odds ratio (OR) 1.63, (95% confidence interval 1.32 - 2.01);obese OR 1.55 (1.12 - 2.15);extremely obese OR 2.19 (1.18 - 4.08)] compared to recommended weight gain. More than half of women (53.2%) had excessive weight gain. Conclusion: Adherence to guidelines may decrease a woman’s risk of primary cesarean delivery.

关键词： Primary Cesarean Weight Gain Pre-Pregnancy BMI Obese Obesity

精神医学中的生物统计学(6):对观察性研究治疗效果的估计(英文)

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上海精神医学 2011年第6期23卷 380-382页

作者： julia Y.LIN US Department of Veterans Affairs Cooperative Studies Program Coordinating Center Palo Alto VA Health Care SystemPalo AltoCAUSA

In randomized treatment studies the randomization of subjects to the different treatment conditions ensures that the treatment groups are comparable in their baseline characteristics-measured or unmeasured-so we can confidently attribute differences in treatment outcomes to the assigned *** contrast, subjects in observational studies are not randomly assigned to the treatment groups so differences in treatment outcomes could be due to differences in baseline characteristics between the treatment groups.

关键词：精神医学生物统计学观察性研究治疗效果 studies treatment outcomes differences assigned mental health primary care high different contrast treated factors type two

从研究设计角度考虑如何避免数据缺失以及由此带来的问题(英文)

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上海精神医学 2012年第3期24卷 181-184页

作者： julia Y. LIN US Department of Veterans Affairs Cooperative Studies Program Coordinating Center Palo Alto VA Health Care System

One of the most common challenges in biomedical and psychosocial research is missing data, which occurs when respondents refuse to provide answers to sensitive questions and when study subjects are lost to follow-up during the repeated assessments of longitudinal trials. This paper is the first in a 3-part series focusing on this important topic; it describes different types of missing data and their differential effects on model estimates, focusing on study design strategies that can be used to prevent or minimize missing data and, thus, maintain the scientific integrity of the research. The second paper in the series will discuss implementation strategies

关键词：研究设计 missing longitudinal focusing estimates maintain repeated challenges minimize integrity

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建立临床试验的数据监测委员会（英文）

上海精神医学 2014年第1期26卷 54-56页

作者： julia Y. LIN Ying LU US Department of Veterans Affairs Cooperative Studies Program Coordinating Center Palo Alto VA Health Care System Department of Health Research and Policy Stanford University School of Medicine

数据监测委员会是由研究赞助者指定的一组临床医生和生物统计学家,对临床试验的安全性、科学有效性和完整性进行独立评估。在美国,食品和药物管理局要求在评估所有新的干预时在要成立数据监测委员会。在其他临床研究中,如果存在重大的... 详细信息

数据监测委员会是由研究赞助者指定的一组临床医生和生物统计学家,对临床试验的安全性、科学有效性和完整性进行独立评估。在美国,食品和药物管理局要求在评估所有新的干预时在要成立数据监测委员会。在其他临床研究中,如果存在重大的安全问题、实施双盲治疗分配或者预期对临床实践会产生重大影响,也强烈建议成立数据监测委员会。因为数据监测委员会对经常参加此类研究的弱势群体提供了一层额外的保护,所以他们在精神病学临床研究中是非常重要的。本报告描述了数据监测委员会的作用,组建和运作。

关键词：临床试验数据监测委员会安全问题生物统计学 DMC 临床医生临床实践

Estimating treatment effects in observational studies

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上海精神医学 2011年第6期23卷 380-382页

作者： julia Y. LIN Ying LU US Department of Veterans Affairs Cooperative Studies Program Coordinating Center Palo Alto VA Health Care System Palo Alto CA USA Department of Health Research and Policy Stanford University Palo Alto CA USA

关键词：精神医学精神病学临床诊断

精神医学中的生物统计学(16) 把握度分析在横断面研究和纵向研究设计中的应用(英文)

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上海精神医学 2013年第4期25卷 259-262页

作者： Naiji LU Yu HAN Tian CHEN Douglas David GUNZLER Yinglin XIA julia LIN Xin Ming TU Department of Biostatistics University of Rochester Medical CenterRochesterNYUSA Veterans Integrated Service Network 2 Center of Excellence for Suicide Prevention Canandaigua VA Medical CenterCanandaiguaNYUSA Department of Biostatistics University of Rochester Medical CenterRochester NYUSA School of Medicine Case Western Reserve UniversityCenter for Health Care Research&Policy MetroHealth Medical Center ClevelandOHUSA US Department of Veterans Affairs Cooperative Studies Program Coordinating Center Palo Alto VA Health Care SystemPalo AltoCAUSA Department of Biostatistics University of Rochester Medical Center RochesterNYUSA Department of Psychiatry University of Rochester Medical CenterRochesterNYUSA

*** Power and sample size estimation constitutes an important component of designing and planning modern scientific *** provides information for assessing the feasibility of a study to detect treatment effects and for estimating the resources needed to conduct the *** tutorial discusses the basic concepts of power analysis and the major differences between hypothesis testing and power *** also

关键词：功率分析横断面设计组成部分现代科学治疗效果假设检验功耗分析