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COMPLEX SYSTEMS In SPORTS:InTRODUCTIOn TO THE SPEciaL ISSUE

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Journal of Systems Science & Complexity 2013年第1期26卷 1-3页

作者： MERELO Juan julin MORA Antonio M COTTA Carlos Depto.ATC CITICUniversidad de Granada Depto.LCC Universidad de Malaga

1 Complex Systems in Sports Sport is one of the most important activities of *** relevance goes beyond the physical/psychological benefits that their practicing provides(an aspect that justifies in itself its importance in our current society).In fact,be it as actually playing some sport or just watching some games,it provides a huge means for socialization and *** to say,the economical viewpoint is also enormously relevant:events such as the Olympic games。

关键词：复杂系统运动教育手段社会化

nucleoside modified mRnA-lipid nanoparticles as a new delivery platform for the repair of the injured spinal cord

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neural Regeneration Research 2025年第8期20卷 2311-2312页

作者： Krisztián Pajer Tamás Bellák Antal nógrádi Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary

Spinal cord injury and treatment opportunities:The adult mammalian spinal cord has a very limited capacity for spontaneous regeneration due to various intrinsic molecular and cellular *** the spinal cord neurons have the capacity to regenerate their axons,the expression of growth inhibitory factors,lack or suppression of proper guidance cues,and profound inflammatory responses do not permit successful regeneration(Khyeam et al.,2021).

关键词： injured capacity modified

A nETWORK AnALYSIS OF THE 2010 FIFA WORLD CUP CHAMPIOn TEAM PLAY

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Journal of Systems Science & Complexity 2013年第1期26卷 21-42页

作者： COTTA Carlos MORA Antonio M MERELO Juan julin MERELO-MOLInA Cecilia Department of Computer Science University of Mlaga Department of Architecture and Computer Technology University of Granada

This paper analyzes the network of passes among the players of the Spanish team during the last FIFA World Cup 2010,where they emerged as the champion,with the objective of explaining the results obtained from the behavior at the complex network *** team is considered a network with players as nodes and passes as(directed) edges.A temporal analysis of the resulting passes network is also done,looking at the number of passes,length of the chain of passes,and to network measures such as player centrality and clustering *** of the last three matches(the decisive ones) indicate that the clustering coefficient of the pass network remains high,indicating the elaborate style of the Spanish *** effectiveness of the opposing team in negating the Spanish game is reflected in the change of several network measures over time,most importantly in drops of the clustering coefficient and passing length/speed,as well as in their being able in removing the most talented players from the central positions of the ***'s ability to restore their combinative game and move the focus of the game to offensive positions and talented players is shown to tilt the balance in favor of the Spanish team.

关键词： Complex network complex systems FIFA World Cup football La Roja network analysis soccer Spanish team sports.

A Review about Thermal Comfort in Aircraft

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Journal of Thermal Science 2019年第2期28卷 169-183页

作者： FAn juli ZHOU Qiongyao nanjing University of Aeronautics and Astronautics

Thermal comfort is an important factor which affects both work efficiency and life quality. On the basis of satisfying the normal life of the crew and reliable work of equipment, the thermal comfort is increasingly pursued through the design of the environmental control system of modern craft. Thus, a comprehensive survey of the thermal comfort in the cockpit is carried out. First of all, factors affecting the thermal comfort in aircraft cabin are summarized, including low relative humidity, mean radiant temperature, colored light, human metabolic rate and gender, among which the first three factors are environmental factors and the other two are human factors. Although noise is not a factor affecting thermal comfort, it is an important factor in the overall satisfaction of the aircraft cabin environment. Then the thermal comfort prediction models are introduced, including thermal comfort models suitable for steady state uniform environment and thermal comfort models suitable for transient non-uniform environment. Then the limitations of the typical thermal comfort models applied to aircraft are discussed. Since the concept of thermal adaptation has been gradually accepted in recent years, many field studies on thermal adaptation have been carried out. Therefore, the adaptive thermal comfort models are summarized and analyzed systematically in this paper. At present, mixing ventilation(MV) system is widely used in most commercial aircraft. However, the air quality under the MV system is very poor, and contaminants cannot be effectively eliminated. So a noticeable shift is the design of ventilation system for cabin drawing lessons from the surface buildings. Currently, the most interesting question is that whether the traditional mixing ventilation(MV) system in an aircraft can be replaced by or combined with displacement ventilation(DV) system without decreasing thermal comfort. A reduction of energy consumption is a valuable gain. Additionally, various seat persona

关键词： aircraft thermal comfort energy efficient ventilation system numerical simulation

cgaS-STInG signaling and function in metabolism and kidney diseases

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Journal of Molecular Cell Biology 2021年第10期13卷 728-738页

作者： juli Bai Feng Liu Department of Pharmacology University of Texas Health at San AntonioSan AntonioTX 78229USA national Clinical Research Center for Metabolic Diseases Metabolic Syndrome Research CenterKey Laboratory of Diabetes ImmunologyMinistry of Educationand Department of Metabolism and EndocrinologyThe Second Xiangya Hospital of Central South UniversityChangsha 410011China

The cyclic GMP-AMP synthase(cgaS)-stimulator of interferon genes(STInG)signaling pathway senses the presence of cytosolic DnA and,in turn,triggers downstream signaling to induce the expression of inflammatory and type I interferon genes in immune *** the innate immune function of the cgaS-STInG pathway is well studied over the past years,emerging evidence suggests that this signaling pathway may have additional functions beyond innate immune *** with this notion,dysregulation of the cgaS-STInG signaling pathway in adipocytes,hepatocytes,and renal proximal tubule epithelial cells are associated with metabolic dysfunction,impaired energy homeostasis,and kidney *** this review,we summarize current understanding of the cgaS-STInG pathway in several metabolic diseases such as obesity,insulin resistance,alcoholic and nonalcoholic fatty liver diseases,as well as acute kidney injury and chronic kidney *** also review the interaction between the cgaS-STInG pathway and lipid ***,we discuss potential mechanisms by which cgaS-STInG signaling regulates metabolism and point toward future avenues of research targeting the cgaS-STInG pathway as possible means to treat common metabolic disorders.

关键词： cgaS STInG obesity nAFLD nASH AKI CDK

nuclear cgaS: sequestration and beyond

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Protein & Cell 2022年第2期13卷 90-101页

作者： juli Bai Feng Liu Departments of Pharmacology University of Texas Health at San AntonioSan AntonioTXUSA national Clinical Research Center for Metabolic Diseases Metabolic Syndrome Research CenterKey Laboratory of Diabetes ImmunologyMinistry of Educationand Department of Metabolism and EndocrinologyThe Second Xiangya Hospital of Central South UniversityChangsha 410011China

The cyclic GMP-AMP(cgaMP)synthase(cgaS)has been identified as a cytosolic double stranded DnA sensor that plays a pivotal role in the type I interferon and inflammation responses via the STInG-dependent signaling *** the past several years,a growing body of evidence has revealed that cgaS is also localized in the nucleus where it is associated with distinct nuclear substructures such as nucleosomes,DnA replication forks,the double-stranded breaks,and centromeres,suggesting that cgaS may have other functions in addition to its role in DnA ***,while the innate immune function of cgaS is well established,the non-canonical nuclear function of cgaS remains poorly ***,we review our current understanding of the complex nature of nuclear cgaS and point to open questions on the novel roles and the mechanisms of action of this protein as a key regulator of cell nuclear function,beyond its well-established role in dsDnA sensing and innate immune response.

关键词： cgaS STInG innate immunity nuclear translocation DnA damage repair micronuclei

Impacts of PI3K/protein kinase B pathway activation in reactive astrocytes: from detrimental effects to protective functions

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neural Regeneration Research 2025年第4期20卷 1031-1041页

作者： Ramón Pérez-núñez María Fernanda González Ana María Avalos Lisette Leyton Cellular Communication Laboratory Programa de Biología Celular y MolecularCenter for Studies on ExerciseMetabolism and Cancer(CEMC)Instituto de Ciencias Biomédicas(ICBM)Facultad de MedicinaUniversidad de ChileSantiagoChile Advanced Center for Chronic Diseases(ACCDiS) Faculty of Chemical and Pharmaceutical Sciences&Faculty of MedicineUniversidad de ChileSantiagoChile Instituto de Ciencias Biomédicas Facultad de Ciencias de la SaludUniversidad Autónoma de ChileSantiagoChile

Astrocytes are the most abundant type of glial cell in the central nervous *** injury and inflammation,astrocytes become reactive and undergo morphological and functional *** on their phenotypic classification as A1 or A2,reactive astrocytes contribute to both neurotoxic and neuroprotective responses,***,this binary classification does not fully capture the diversity of astrocyte responses observed across different diseases and *** analysis has revealed that reactive astrocytes have a complex landscape of gene expression profiles,which emphasizes the heterogeneous nature of their *** actively participate in regulating central nervous system inflammation by interacting with microglia and other cell types,releasing cytokines,and influencing the immune *** phosphoinositide 3-kinase(PI3K)/protein kinase B(AKT)signaling pathway is a central player in astrocyte reactivity and impacts various aspects of astrocyte behavior,as evidenced by in silico,in vitro,and in vivo *** astrocytes,inflammatory cues trigger a cascade of molecular events,where nuclear factor-κB serves as a central mediator of the pro-inflammatory ***,we review the heterogeneity of reactive astrocytes and the molecular mechanisms underlying their *** highlight the involvement of various signaling pathways that regulate astrocyte reactivity,including the PI3K/AKT/mammalian target of rapamycin(mTOR),αvβ3 integrin/PI3K/AKT/connexin 43,and notch/PI3K/AKT *** targeting the inactivation of the PI3K/AKT cellular signaling pathway to control reactive astrocytes and prevent central nervous system damage,evidence suggests that activating this pathway could also yield beneficial *** dual function of the PI3K/AKT pathway underscores its complexity in astrocyte reactivity and brain function *** review emphasizes the importance of employing astrocyte-exclusive models to underst

关键词： inflammation integrins neuroprotective neurotoxic phosphatidylinositol 3-kinase reactive astrocytes signal transduction Thy-1(CD90)

Astrocytes, reactive astrogliosis, and glial scar formation in traumatic brain injury

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neural Regeneration Research 2025年第4期20卷 973-989页

作者： María Belén Cieri Alberto Javier Ramos Laboratorio de neuropatología Molecular IBCN UBA-CONICETFacultad de MedicinaUniversidad de Buenos AiresBuenos AiresArgentina

Traumatic brain injury is a global health crisis,causing significant death and disability *** that follows traumatic brain injury has serious consequences for neuronal survival and cognitive impairments,with astrocytes involved in this *** traumatic brain injury,astrocytes rapidly become reactive,and astrogliosis propagates from the injury core to distant brain *** astroglial proteins are downregulated near the traumatic brain injury core,while pro-inflammatory astroglial genes are *** altered gene expression is considered a pathological remodeling of astrocytes that produces serious consequences for neuronal survival and cognitive *** addition,glial scar formed by reactive astrocytes is initially necessary to limit immune cell infiltration,but in the long term impedes axonal reconnection and functional *** therapeutic strategies for traumatic brain injury are focused on preventing acute ***,cannabinoids,progesterone,beta-blockers,and cerebrolysin demonstrate neuroprotective benefits but most of them have not been studied in the context of *** this review,we discuss the cell signaling pathways activated in reactive astrocytes following traumatic brain injury and we discuss some of the potential new strategies aimed to modulate astroglial responses in traumatic brain injury,especially using cell-targeted strategies with miRnAs or lncRnA,viral vectors,and repurposed drugs.

关键词： astrocyte glial scar innate immunity neuroinflammation stab injury Toll-like receptors

Sex differences in aging and injured brain

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neural Regeneration Research 2025年第10期20卷 2901-2902页

作者： Jordan n.Williamson Yuan Yang University of Illinois Urbana-Champaign Grainger College of EngineeringDepartment of BioengineeringUrbanaILUSA Carle Foundation Hospital Stephenson Family Clinical Research InstituteClinical Imaging Research CenterUrbanaILUSA University of Illinois Urbana-Champaign Beckman Institute for Advanced Science and TechnologyUrbanaILUSA northwestern University Department of Physical Therapy and Human Movement SciencesChicagoILUSA

Background:The prevalence,age of onset,and symptomatology of traumatic brain injury,stroke,and neurodegenerative diseases(such as Alzheimer’s disease(AD),Parkinson’s disease,amyotrophic lateral sclerosis,and Huntington’s disease)differ substantially between males and *** higher prevalence of these brain disorders has been attributed to females having a greater longevity compared with *** one of the greatest risk factors of acquired brain injury(such as stroke,traumatic brain injury caused by fall)and neurodegenerative disease is age.

关键词： Huntington prevalence traumatic