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Asian Journal of Andrology 2006年第4期8卷 463-467,516-517页

作者： t.Pushpalatha P.RamachandraReddy P.SreenivasulaReddy Department of Biotechnology Sri Venkateswara University Tirupati 517502India

Aim:to investigate the effect of in utero exposure to hydroxyprogesterone(HP)on liver metabolism in adult male albino ***:Pregnant Wistar strain albino rats were exposed to supra-normal levels(10 mg/kg and 25 mg/kg)of HP on days 1,7 and 14 of *** male pups were maintained under controlled conditions and the rats were killed 90 days after *** liver tissue was immediately excised,weighed and used for biochemical assays. Results:the activity levels of succinate dehydrogenase(SDH),glutamate dehydrogenase(GDH),glucose-6-phosphate dehydrogenase(G-6-PDH),malate dehydrogenase(MDH)and aminotransaminases were significantly increased in the livers of rats exposed to HP during embryonic *** lactate dehydrogenase(LDH)activity level was significantly decreased in the liver of experimental ***,there was a significant elevation of activity levels of antioxidant enzymes(glutathione S-transferase[GSt] and catalase[CAt])with an increased lipid peroxidation in the hepatic tissue of experimental rats compared with the control ***:the results of the present study suggest that there is an increase in the oxidative metabolism,antioxidative mechanism and levels of lipid peroxidation in rats exposed to HP during embryonic *** increased aminotransaminase activities in these rats reveal tissue damage and disruption of mitochondrial integrity.(Asian J Androl 2006 jul;8:463-467)

关键词： hydroxyprogesterone liver oxidative enzymes antioxidants lipid peroxidation embryonic development

Expression of Neuropeptide Y gene in mouse testes during testicular development

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Asian Journal of Andrology 2006年第4期8卷 443-449,515页

作者： M.terado M.Nomura K.Mineta N.Fujimoto t.Matsumoto Department of Urology University of Occupational and Environmental HealthSchool of MedicineKitakyushu 807-8555Japan

Aim:to elucidate the distribution and regulation of Neuropeptide Y(NPY)gene expression in testes under physiologi- cal and pathophysiological conditions,such as testicular development,fasting and experimental cryptorchidism. Methods:In the first experiment,C57BL/6J male mice at the ages of 3 days as well as 2,3,5 and 8 weeks were used. In the second and third experiments,adult C57BL/6J male mice were subjected to fasting for 48 h and experimental cryptorchidism for 72 *** NPY transcripts were detected by isotopic in situ hybridization ***: the NPY transcripts were exclusively expressed in the interstitial cells regardless of the age groups and experimental *** NPY mRNA levels were found to increase significantly with age(from the neonatal to prepubertal period [Pthe prepubetal to postpubertal period [Ption for 48 h resulted in a significant increase in the NPY mRNA levels in the arcuate nucleus of the hypothalamus(Pt not in the *** cryptorchidism for 72 h failed to regulate the NPY gene expression in the ***: NPY gene expression is distributed in Leydig cells and increases in line with testicular *** regulation of testicular NPY is different from that of hypothalamic NPY.(Asian J Androl 2006 jul;8:443-449)

关键词： Neuropeptide Y testes in situ hybridization histochemistry steroidogenesis androgen testicular development cryptorchidism

甲状腺功能正常的2型糖尿病甲状腺激素与嘌呤代谢和体重的相关性

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昆明医科大学学报 2016年第11期37卷 82-85页

作者：韩文菊牛奔梁赟段晓燕苏恒薛元明德宏州芒市人民医院内科云南德宏678400 云南省第一人民医院内分泌代谢科云南昆明650032

目的探讨甲状腺功能正常的2型糖尿病患者甲状腺激素与尿酸(UA)和体重指数(BMI)的关系.方法选取确诊的甲功正常的2型糖尿病患者313例,入院后测BMI、空腹血糖(FBG)、血脂、甲状腺激素和UA等代谢指标,分析甲状腺激素和BMI及UA的相关性.结果... 详细信息

目的探讨甲状腺功能正常的2型糖尿病患者甲状腺激素与尿酸(UA)和体重指数(BMI)的关系.方法选取确诊的甲功正常的2型糖尿病患者313例,入院后测BMI、空腹血糖(FBG)、血脂、甲状腺激素和UA等代谢指标,分析甲状腺激素和BMI及UA的相关性.结果 (1)根据性别分为2组,男性Ft3、Ft4、UA显著高于女性(PtSH、SBP、HDL-C显著高于男性(PtSH)、三碘甲腺原氨酸(tt3)、游离三碘甲状腺原氨酸(Ft3)、UA、FBG均高于体重正常组(PtSH水平分为2组,tSH>2.5μIU/L组血清尿酸、tt3、Ft3、空腹胰岛素高于tSHtSH及Ft3高于正常尿酸组,PtSH高于正常尿酸组(P<0.05).结论甲状腺激素对评估2型糖尿病患者的体重和尿酸有重要的临床意义.

关键词： 2型糖尿病甲状腺激素体重指数尿酸

Prostate androgen-regulated gene:a novel potential target for androgen-independent prostate cancer therapy

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Asian Journal of Andrology 2006年第4期8卷 455-462,516页

作者： Xu, XF Zhou, SW Zhang, X Ye, ZQ Zhang, JH Ma, X Zheng, t Li, HZ Huazhong Univ Sci & technol Dept Urol Surg Tongji Hosp Tongji Med Coll Wuhan 430030 Peoples R China

Aim:to investigate the involvement of the prostate androgen-regulated(PAR)gene in the androgen receptor(AR) signaling pathway and the malignant phenotype of androgen-independent prostate cancer(PCa)***:the difference in PAR expression between LNCaP and PC3 cells was detected by reverse transcription-polymerase chain reaction(Rt-PCR).Androgen and anti-androgen effects on PAR expression were evaluated by Rt-PCR in LNCaP,PC3 cells and PC3 cells stably transfected with vector containing wild-type *** determine the importance of PAR in the malignant proliferation of androgen-independent PCa cells,we used small interfering RNA(siRNA)transfection to knock down the expression of the gene in PC3 *** changes in the malignant phenotype of PCa cells after transfection were analyzed by cell count,colony formation in soft agar and flow ***:PAR expression was 3-fold higher in PC3 cells than that in LNCaP ***(DHt)regulated PAR mRNA expression in LNCaP cells and the effect was inhibited by the AR antagonist,*** contrast,DHt did not affect PAR expression in PC3 *** reintroduction of AR into PC3 cells by stable transfection restored the androgen effect on PAR upregulation. After the knockdown of the PAR gene by siRNA,PC3 cells exhibited a reversal of the malignant ***: Because of the possibility that PAR is downstream from the AR,and because of its contribution to malignant proliferation in androgen-independent PCa cells,the gene could be a potential therapeutic target for androgen-independent PCa with AR signaling pathway alteration.(Asian J Andro12006 jul;8:455-462)

关键词： prostate androgen-regulated gene prostate cancer androgen receptor dihydrotestosterone small interfering RNA