检索结果-南通市图书馆

Biomaterial engineering strategies for modeling the Bruch's membrane in age-related macular degeneration

neural Regeneration Research 2024年第12期19卷 2626-2636页

作者： Blanca Molins Andrea Rodríguez Víctor Llorenç Alfredo Adán Group of Ocular Inflammation:Clinical and Experimental Studies Institut d’Investigacions Biomèdiques AgustíPi I Sunyer(IDIBAPS)BarcelonaSpain Institut Clínic d’Oftalmologia(ICOF) Hospital Clínic BarcelonaSpain

Age-related macular degeneration,a multifactorial inflammatory degenerative retinal disease,ranks as the leading cause of blindness in the ***,there is a scarcity of curative therapies,especially for the atrophic advanced form of age-related macular degeneration,likely due to the lack of models able to fully recapitulate the native structure of the outer blood retinal barrier,the prime to rget tissue of age-related macular *** in vitro systems rely on 2D monocultures unable to adequately reproduce the structure and function of the outer blood retinal barrier,integrated by the dynamic interaction of the retinal pigment epithelium,the Bruch's membrane,and the underlying *** Bruch's membrane provides structu ral and mechanical support and regulates the molecular trafficking in the outer blood retinal barrier,and therefo re adequate Bruch's membrane-mimics are key for the development of physiologically relevant models of the outer blood retinal barrie *** the last years,advances in the field of biomaterial engineering have provided novel approaches to mimic the Bruch's membrane from a variety of *** review provides a discussion of the integrated properties and function of outer blood retinal barrier components in healt hy and age-related macular degeneration status to understand the requirements to adequately fabricate Bruch's membrane biomimetic ***,we discuss novel materials and techniques to fabricate Bruch's membrane-like scaffolds for age-related macular degeneration in vitro modeling,discussing their advantages and challenges with a special focus on the potential of Bruch's membrane-like mimics based on decellularized tissue.

关键词： age-related macular degeneration Bruch's membrane decellularization retinal pigment epithelium scaffold

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

阅读目标和阅读任务对读者眼动的影响(中文)

引用

心理与行为研究 2011年第1期9卷 24-34页

作者： jukka hy.n? Johanna K.Kaakinen University of Turku

We review two studies examining task effects on eye guidance during reading. The first study investigated effects of reading perspective on eye behavior in reading. It demonstrated that both the initial encoding of words as well as the later integration stage of wrapping up the sentence meaning are influenced by the reading perspective. Early effects of reading perspective were observed both in saccadic programming and in fixation times and were primarily seen when reading a text of familiar content. In the second study, effects of reading task were examined by comparing eye movements between proofreading and reading for comprehension. Task effects appeared very early in the processing time line; both temporal and spatial aspects of eye movements were affected. Taking together, the two studies demonstrate that readers make a global adjustment to eye behavior on the basis of reading task or goal.

关键词：心理学行为研究理论

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Biochar as adsorbent in purification of clear-cut forest runoff water:adsorption rate and adsorption capacity

引用

Biochar 2020年第2期2卷 227-237页

作者： Taija Saarela Elham Kakaei Lafdani Ari Laurén jukka Pumpanen Marjo Palviainen Department of Environmental and Biological Sciences University of Eastern FinlandYliopistonranta 1 EFI-70210 KuopioFinland School of Forest Sciences University of Eastern FinlandYliopistokatu 7FI-80101 JoensuuFinland Department of Forest Sciences University of HelsinkiLatokartanonkaari 7FI-00014 HelsinkiFinland

Forest management practices in boreal peatlands increase nutrient export and suspended solids to watercourses calling for development of new water protection *** potential solution could be adsorption-based purification of runoff water using *** aim of this study was to determine the adsorption rate and capacity for norway spruce and silver birch biochars to design a biochar-filled reactor for a ditch *** a 10-day laboratory experiment,biochar was stirred with runoff water from a clear-cut peatland forest,and changes in water pH,total nitrogen,nitrate nitrogen,ammonium nitrogen,phosphorus,and total organic carbon concentrations were *** on the concentration changes,adsorption was quantified and adsorption model containing the adsorption rate and capacity was fitted to the *** results indicate that biochar effectively adsorbs both inorganic and organic nitrogen from runoff *** biochar had higher adsorption capacity of nitrogen than spruce *** study demonstrates that the adsorption of nitrogen compounds onto biochar surfaces increases with increasing initial ***,aquatic ecosystems exposed to high nutrient loads from fertile peatlands would particularly benefit from biochar-based water purification.

关键词： Adsorption Ammonium Biochar nitrate nutrients Total nitrogen Water quality

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

What Eye Movements Tell About Identifying Compound Words in Reading and Top-Down Effects in Reading Long Texts

引用

心理与行为研究 2004年第3期2卷 497-504页

作者： jukka hy.n? Department of Psychology University of Turku FIN-20014 Turku Finland

Two lines of research on eye movements in reading are summarized. One line of research examines how adult readers identify compound words during reading. The other line of research deals with how a specific reading goal influences the way long expository texts are read. Both lines of research are conducted using Finnish as the source language. With respect to the first research question, it is demonstrated that compound words are recognized either holistically or via their components, depending on the length of the compound word. Readers begin to process whatever information is readily available in the foveal vision(i.e., either the whole-word form or the initial component). The second line of research demonstrates that(1)a specific reading goal is capable of exerting an early effect on readers’ eye fixation patterns,(2)time course analyses based on eye movement patterns can reveal interesting individual differences, and(3)working memory capacity is linked to the efficiency to strategically allocate attention as well as to encode information to and retrieve it from the long-term memory. It is concluded that the eye-tracking technique is an excellent research tool to tap into the workings of the human mind during the comprehension of written texts.

关键词： eye movements word recognition compound words text comprehension working memory capacity.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Synthesis and mesomorphic properties of n-butyl-4- [4-((4-n-alkoxyl-tetrafluorophenyl)ethynyl)benzyloxy]benzoates

引用

Chinese Journal of Chemistry 1995年第6期13卷 515-519页

作者： Wen, JX Yin, hy Chen, Q CHInESE ACAD SCI SHANGHAI INST ORGAN CHEMSHANGHAI 200032PEOPLES R CHINA

A homologous series of n-butyl-4-[4-((4-n-alkoxyl-tetrafluorophenyl)ethynyl)benzyloxy] benzoates have been synthesized. Their phase transition temperatures have also measured by polarizing textural observation and con... 详细信息

关键词： liquid crystal synthesis mesomorphic properties

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

An Algorithm for the Stochastic Simulation of Gene Expression and Heterogeneous Population Dynamics

引用

Communications in Computational Physics 2011年第1期9卷 89-112页

作者： Daniel A.Charlebois jukka Intosalmi Dawn Fraser Mads Kærn Department of Physics University of Ottawa150 Louis PasteurOttawaOntarioK1N 6N5Canada Ottawa Institute of Systems Biology University of Ottawa451 Symth RoadOttawaOntarioK1H 8M5Canada Department of Mathematics Tampere University of TechnologyP.O.Box 55333101 TampereFinland Department of Signal Processing Tampere University of TechnologyP.O.Box 55333101 TampereFinland Department of Cellular and Molecular Medicine University of Ottawa451 Symth RoadOttawaOntarioK1H 8M5Canada.

We present an algorithm for the stochastic simulation of gene expression and heterogeneous population *** algorithm combines an exact method to simulate molecular-level fluctuations in single cells and a constant-number Monte Carlo method to simulate time-dependent statistical characteristics of growing cell *** benchmark performance,we compare simulation results with steadystate and time-dependent analytical solutions for several scenarios,including steadystate and time-dependent gene expression,and the effects on population heterogeneity of cell growth,division,and DnA *** comparison demonstrates that the algorithm provides an efficient and accurate approach to simulate how complex biological features influence gene *** also use the algorithm to model gene expression dynamics within"bet-hedging"cell populations during their adaption to environmental *** simulations indicate that the algorithm provides a framework suitable for simulating and analyzing realistic models of heterogeneous population dynamics combining molecular-level stochastic reaction kinetics,relevant physiological details and phenotypic variability.

关键词： Constant-number Monte Carlo stochastic simulation algorithm gene expression heterogeneous population dynamics

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

人脸表情对视觉追踪的影响

人脸表情对视觉追踪的影响

引用

第十七届全国心理学学术会议

作者：李杰 Lauri Oksama jukka hy.n?? 北京体育大学心理教研室

人通常需要在动态的环境中保持追踪多个客体。视觉系统如何实现这种追踪,其底层机制如何,一直是近年来研究关注的重点问题。经典理论认为多目标追踪完全由底层视觉系统完成,借助前注意的视觉索引实现对多个运动客体的追踪,而后期的认知... 详细信息

人通常需要在动态的环境中保持追踪多个客体。视觉系统如何实现这种追踪,其底层机制如何,一直是近年来研究关注的重点问题。经典理论认为多目标追踪完全由底层视觉系统完成,借助前注意的视觉索引实现对多个运动客体的追踪,而后期的认知加工不能渗透和影响到这种底层的追踪过程。本研究考查人脸表情这种带有丰富社会信息需要经过认知加工的属性是否影响视觉追踪,以及不同类型的表情的是否对视觉追踪产生不同的影响。研究采用多身份追踪(Multiple-Identity Tracking)范式,呈现多张不断运动的人脸,要求被试追踪其中的几张目标人脸并忽略另外一些干扰子人脸;人脸运动一段时间后停止并被掩蔽,要求被试点出每张目标人脸最终停止的位置。实验分别独立操纵了目标人脸和干扰子人脸的表情。实验1中,目标人脸和干扰人脸可能是高兴表情或中性表情;实验2中,目标人脸和干扰子人脸可能是愤怒表情或中性表情。实验结果显示,当干扰子为高兴表情时,视觉追踪的绩效低于干扰子为中性表情时;当目标人脸为愤怒表情时,追踪绩效高于目标人脸为中性表情时。此结果说明视觉追踪并非是完全由底层视觉系统完成的、认知不可渗透的过程,人脸表情这类社会信息也可影响视觉追踪,而且不同类型的表情对追踪产生不同的影响。人的视觉系统可能对高兴表情较为敏感,不需中央凹注视,边缘视野中的高兴表情即可被加工和觉察,觉察到的高兴表情即使与当前任务完全无关,仍可自动捕获注意,干扰当前任务的执行。愤怒表情则更容易锁定人的注意,当愤怒表情与观察者主体有关时,人能更有效地保持对其的动态追踪。

关键词：视觉注意表情多身份追踪

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

注意追踪漂亮人脸:男性与女性有何差异

注意追踪漂亮人脸:男性与女性有何差异

引用

心理学与创新能力提升——第十六届全国心理学学术会议

作者：李杰 Lauri Oksama jukka hy.n?)n() 北京体育大学心理教研室 Department of Behavioral Sciences National Defence University Department of Psychology University of Turku

面孔吸引力在人类的求偶行为中具有重要影响。日常经验以及实验结果都表明人们通常会更加注意漂亮的脸,并更长时间地注视漂亮的脸。本研究进一步考查当漂亮的人脸与当前任务无关,且当前任务要求人的注意高度投入的时候,人的注意是否会... 详细信息

面孔吸引力在人类的求偶行为中具有重要影响。日常经验以及实验结果都表明人们通常会更加注意漂亮的脸,并更长时间地注视漂亮的脸。本研究进一步考查当漂亮的人脸与当前任务无关,且当前任务要求人的注意高度投入的时候,人的注意是否会被漂亮人脸所干扰。本研究采用了多身份追踪(Multiple-Identity Tracking)范式。多张人脸不断运动,被试被要求追踪一些目标人脸并忽略另外一些干扰人脸,然后在人脸停止运动并被掩蔽后,指出每张目标人脸最终停止的位置。目标人脸可能是漂亮人脸或不漂亮人脸,干扰子人脸也可能是漂亮人脸或不漂亮人脸。结果显示当干扰子是漂亮的女性人脸时,相比于干扰子是不漂亮的女性人脸条件,男性被试的任务绩效显著降低。而女性被试的任务绩效并不受到干扰子人脸漂亮程度的影响。另外,女性对于男性目标人脸的追踪绩效高于女性目标人脸;而男性被试追踪男性与女性目标人脸的追踪绩效无显著差异。从进化心理学角度分析,这一实验结果体现了男性与女性在进化历史中的不同求偶策略。为了成功的繁殖,男性的策略是接触更多的女性,尤其是外表漂亮的女性,因为这表明她们可能具有更佳的繁殖能力。因此男性的认知系统可能也进化成为适宜追踪更多漂亮女性的状态。而在进化历史中,女性的繁殖成功率主要不受接触的男性个数的影响,而是受拥有的养育后代的资源量的影响,所以其认知系统可能更适宜保持当前可获得的男性。

关键词：面孔吸引力多身份追踪求偶策略

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Regulation of embryo implantation by nitric oxide in mouse

引用

Chinese Science Bulletin 2002年第17期47卷 1461-1465页

作者： Zhang, X Wang, HM Lin, hy Li, QL Liu, DL Qian, D Liu, GY Zhu, C Chinese Acad Sci State Key Lab Reprod Biol Inst Zool Beijing 100080 Peoples R China

Intrauterine injection and zymography were used to investigate the effect of nitric oxide (nO) on embryo implantation in mice. On day 3, one uterine horn of female pregnant mice was injected intraluminally with various doses of nitric oxide synthase (nOS) inhibitor, n-nitro-L-arginine methyl ester (L-nAME), while the contralateral horn served as control. Animals were sacrificed by cervical dislocation on day 7 of gestation, and the number of implanted embryos in each horn was calculated. The results showed that lower doses (0.05mg L-nAME) did not inhibit implantation significantly (P > 0.05), but high doses (0.2 mg L- nAME) resulted in a significant reduction in the number of implanted embryos (P nistration of SnP, a generator of nO, with L-nAME would reverse the anti-implantation effect of L-nAME. To further understand the precise mechanism of nO in implantation, matrix metallo-proteinase (MMPs) activities were detected by gelatin zymography. The reduction in the number of implanted

关键词： mouse nitric oxide nitric oxide synthase embryo im-plantation matrix metalloproteinases.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The impact of family history of hepatocellular carcinoma on its patients' survival

引用

Hepatobiliary & Pancreatic Diseases International 2012年第2期11卷 160-164页

作者： Wing Chiu Dai Sheung Tat Fan Tan To Cheung Kenneth SH Chok Albert CY Chan Simon hy Tsang Ronnie TP Poon Chung Mau Lo Department of Surgery The University of Hong Kong 102 Pokfulam Road Hong Kong China State Key Laboratory for Liver Research The University of Hong Kong 102 Pokfulam Road Hong Kong China

BACKGROUnD:Family history of hepatocellular carcinoma(HCC) has been identified as a risk factor for the development of the *** aim of this study is to evaluate the impact of such a history on HCC patients’ ***:Data of all HCC patients(n=4532) managed at our center from 1989 to 2008 were prospectively *** patients were quizzed on their various characteristics including family HCC ***:Totally 475(10.48%) patients had a family history of *** presented the disease at a significantly earlier age(median 53 vs 59 years,Pnd at an earlier stage(the United network for Organ Sharing staging system).They had significantly better liver function in terms of ChildPugh classification and serum albumin and bilirubin *** more of them presented the disease without symptoms(44.0% vs 29.4%,Pnificantly better overall survival under these specifications:patients in the whole study cohort,patients who had minor hepatectomy,patients with stage I disease,patients with stage II disease,and patients with stage III ***:Contrary to what is generally believed,we found in this study cohort that patients with a family history of HCC had better overall survival than those without such a *** believe this was in part due to earlier diagnosis of the disease and better liver function in this group of ***,the effects of genetic factors on the risk of HCC cannot be overlooked and are yet to be identified.

关键词： hepatocellular carcinoma family history resection survival risk factor

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：