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Neural Regeneration Research 2025年第6期20卷 1696-1698页

作者： Gonzalo Flores Leonardo Aguilar-Hernández Fernado García-Dolores Humberto Nicolini Andrea judith Vázquez-Hernández Hiram Tendilla-Beltrán Instituto de Fisiología Benemérita Universidad Autónoma de Puebla(BUAP)PueblaMexico Instituto de Ciencias Forenses(INCIFO) Tribunal Superior de Justicia de la Ciudad de México(TSJCDMX).Mexico CityMexico Instituto Nacional de medicina Genómica(INmEGEN) Mexico CityMexico

Recent reports suggest that aging is not solely a physiological process in living beings;instead, it should be considered a pathological process or disease(Amorim et al., 2022). Consequently, this process involves a wide range of factors, spanning from genetic to environmental factors, and even includes the gut microbiome(Gm)(mayer et al., 2022). All these processes coincide at some point in the inflammatory process, oxidative stress, and apoptosis, at different degrees in various organs and systems that constitute a living organism(mayer et al., 2022;AguilarHernández et al., 2023).

关键词： aging process stress

Label-free detection of single nanoparticles and biological molecules using microtoroid optical resonators

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Light(Science & Applications) 2016年第1期5卷 863-868页

作者： judith Su Alexander FG Goldberg Brian m Stoltz Division of Biology and Biological Engineering California Institute of TechnologyPasadenaCAUSA Divison of Chemistry and Chemical Engineering California Institute of TechnologyPasadenaCAUSA

Single-molecule detection is one of the fundamental challenges of modern *** experiments often use labels that can be expensive,difficult to produce,and for small analytes,might perturb the molecular events being *** size plays an important role in determining *** we use laser-frequency locking in the context of sensing to improve the signal-to-noise ratio of microtoroid optical resonators to the extent that single nanoparticles 2.5 nm in radius,and 15.5 kDa molecules are detected in aqueous solution,thereby bringing these detectors to the size limits needed for detecting the key macromolecules of the *** results,covering several orders of magnitude of particle radius(100 nm to 2 nm),agree with the‘reactive’model prediction for the frequency shift of the resonator upon particle *** confirms that the main contribution of the frequency shift for the resonator upon particle binding is an increase in the effective path length due to part of the evanescent field coupling into the adsorbed *** anticipate that our results will enable many applications,including more sensitive medical diagnostics and fundamental studies of single receptor–ligand and protein–protein interactions in real time.

关键词： biosensing frequency locking label-free microtoroid single molecule

Nanophotonics shines light on hyperbolic metamaterials

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Light(Science & Applications) 2022年第2期11卷 145-148页

作者： Andreas Aigner judith m.Dawes Stefan A.maier Haoran Ren Chair in Hybrid Nanosystems Nanoinstitute MunichFaculty of PhysicsLudwig-Maximilians-University MunichMunich 80539Germany mQ Photonics Research Centre Department of Physics and AstronomyMacquarie UniversityMacquarie ParkNSW 2109Australia.3Department of PhysicsImperial College LondonLondon SW72AZUK 不详

Hyperbolic metamaterials with a unique hyperbolic dispersion relation allow propagating waves with infinitely largewavevectors and a high density of states. Researchers from Korea and Singapore provide a comprehensive review ofhyperbolic metamaterials, including artificially structured hyperbolic media and natural hyperbolic materials. Theyexplain key nanophotonic concepts and describe a range of applications for these versatile materials.

关键词： materials. hyperbolic infinitely

A multi-strain probiotic administered via drinking water enhances feed conversion efficiency and meat quality traits in indigenous chickens

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Animal Nutrition 2019年第2期5卷 179-184页

作者： judith A.Atela Victor mlambo Caven m.mnisi Animal Nutrition Group Department of Animal SciencesEgerton UniversityPO Box 536Egerton20115Kenya School of Agricultural Sciences Faculty of Agriculture and Natural SciencesUniversity of MpumalangaP Bagx2046Mmabatho2735South Arica Department of Animal Science Faculty of Natural and Agricultural ScienceNorth-West UniversityP Bag x20462735South Africa Food Security and Safety Niche Area Faculty of Natural and Agricultural ScienceNorth West UniversityMafikeng 2745South Africa

Whereas the use of probiotics is commonplace in commercial production of improved chicken strains,little is known about the impact of these live microbial feed additives in indigenous chickens in South Africa. This study investigated the effect of a multi-strain probiotic(containing Bacillus safensis, Bacillus subtilis, Bacillus megaterium and Cupriavidus metallidurans, total bacteria number was 1.4 × 10~8 cfu/mL),administered via drinking water, on growth performance, blood parameters, and carcass and meat quality characteristics of Potchefstroom koekoek cockerels for a period of 12 weeks. A total of 140 fiveweek-old cockerels were randomly allocated to 4 experimental diets formulated to have similar energy and protein levels as follows: 1) negative control diet(CON;commercial chicken grower diet without both antibiotics and probiotics), 2) positive control diet(ANTIB;commercial chicken grower diet with antibiotics [0.05% Coxistac and 0.04% olaquindox] but no probiotics), 3) negative control diet plus 2.5 mL of probiotics per litre of water(PROB25) and 4) negative control with 5.0 mL of probiotics per litre of water(PROB50). There was a significant(P ments had no significant(P > 0.05) effect on overall feed intake, overall weight gain and haemato-biochemical parameters of cockerels. Gizzard and spleen weights were similar(P > 0.05) in PROB50, CON and PROB25 groups. Cockerels in PROB50 group had shorter(P mall intestine than those in CON and PROB25 groups. Cockerels in PROB50 group had larger(P < 0.05) breast weight than those in PROB25 *** in ANTIB and PROB50 groups had greater(P < 0.05) wing and thigh weight

关键词： Antibiotics Blood parameters Indigenous chickens meat Probiotic

Phylogenetic relationships of native and introduced Bemisia tabaci (Homoptera:Aleyrodidae) from China and India based on mtCOI DNA sequencing and host plant comparisons

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Progress in Natural Science:materials International 2007年第6期17卷 645-654页

作者： Susan A.Coats Ali m.Idris judith K.Brown Department of Plant Sciences The University of ArizonaTucsonAZ 85721USA

Phylogenetic relationships for Bemisia tabaci were reconstructed by analysis of a ～780 bp fragment of the mitochondrial cytochrome oxidase I (mtCOI) gene with an emphasis on geographic range and distribution among eight eudicot plant families that are common hosts of B. tabaci worldwide to elucidate key phylogeographic linkages between populations extant in China (n=31) and India (n=34). Bootstrap values for the maximum Parsimony tree were highly robust for all major nodes involving the major Asian clade, subgroups, and sister groups within, at 92%—100%. Between-clade distances for the Southeast Asia and three other major clades, e.g. from sub-Sahara Africa, North Africa-mediterranean, and the Americas, were approximately >16% divergent. Two major Asian subgroups (I, II) were resolved, which represented populations indigenous to the region, comprising two (I a, I b) and five (II a—e) sister groups, respectively, which diverged by 11%. Two distinct populations from sunflower in Hyderabad grouped separately within the two Asian subgroups. All other populations grouped uniquely within Asian subgroup II or I. The "B" biotype was identified in 23 collections from China at 97.3%—99.5% nucleotide identity with "B" biotype reference sequences; it was not identified in collections from India. The majority of haplotypes were associated with 3—4 plant families, with one exception that for sister group IId (sesame, India), it might be monophagous. Thus, B. tabaci from the southeastern and near eastern regions of the Asian continent comprise of a large number of ancestral, richly divergent, mostly polyphagous populations. This region is therefore hypothesized to constitute an important Old World center of diversification for the B. tabaci complex, together with sub-Saharan Africa.

关键词： Bemisia tabaci complex cytochrome oxidase I host range phylogenetic relationship

Ultra-high-Q free-space coupling to microtoroid resonators

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Light(Science & Applications) 2024年第4期13卷 682-695页

作者： Sartanee Suebka Euan mcLeod judith Su Wyant College of Optical Sciences University of ArizonaTucsonAZUSA Department of Biomedical Engineering University of ArizonaTucsonAZUSA

Whispering gallery mode(WGm)microtoroid resonators are one of the most sensitive biochemical sensors in existence,capable of detecting single *** main barrier for translating these devices out of the laboratory is that light is evanescently coupled into these devices though a tapered optical *** hinders translation of these devices as the taper is fragile,suffers from mechanical vibration,and requires precise ***,we eliminate the need for an optical fiber by coupling light into and out from a toroid via free-space coupling and monitoring the scattered resonant light.A single long working distance objective lens combined with a digital micromirror device(DmD)was used for light injection,scattered light collection,and *** obtain Q-factors as high as 1:6´108 with this *** induced transparency(EIT)-like and Fano resonances were observed in a single cavity due to indirect coupling in free *** enables improved sensing *** large effective coupling area(~10μm in diameter for numerical aperture=0.14)removes the need for precise *** performance was verified by combining the system with the frequency locked whispering evanescent resonator(FLOWER)approach to perform temperature sensing experiments.A thermal nonlinear optical effect was examined by tracking the resonance through FLOWER while adjusting the input *** believe that this work will be a foundation for expanding the implementation of WGm microtoroid resonators to real-world applications.

关键词： coupling scattered precise

Detecting white matter alterations in multiple sclerosis using advanced diffusion magnetic resonance imaging

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Neural Regeneration Research 2019年第1期14卷 114-123页

作者： Sourajit m.mustafi Jaroslaw Harezlak Chandana Kodiweera Jennifer S.Randolph James C.Ford Heather A.wishart Yu-Chien Wu Department of Radiology and Imaging Sciences Indiana University School of Medicine Department of Epidemiology and Biostatistics School of Public Health Indiana University Department of Psychological and Brain Sciences and Dartmouth Brain Imaging Center Dartmouth College Department of Psychiatry Geisel School of Medicine at Dartmouth

multiple sclerosis is a neurodegenerative and inflammatory disease, a hallmark of which is demyelinating lesions in the white matter. We hypothesized that alterations in white matter microstructures can be non-invasively characterized by advanced diffusion magnetic resonance imaging. Seven diffusion metrics were extracted from hybrid diffusion imaging acquisitions via classic diffusion tensor imaging, neurite orientation dispersion and density imaging, and q-space imaging. We investigated the sensitivity of the diffusion metrics in 36 sets of regions of interest in the brain white matter of six female patients(age 52.8 ± 4.3 years) with multiple sclerosis. Each region of interest set included a conventional T2-defined lesion, a matched perilesion area, and normal-appearing white matter. Six patients with multiple sclerosis(n = 5) or clinically isolated syndrome(n = 1) at a mild to moderate disability level were recruited. The patients exhibited microstructural alterations from normal-appearing white matter transitioning to perilesion areas and lesions, consistent with decreased tissue restriction, decreased axonal density, and increased classic diffusion tensor imaging diffusivity. The findings suggest that diffusion compartment modeling and q-spa ce analysis appeared to be sensitive for detecting subtle microstructural alterations between perilesion areas and normal-appearing white matter.

关键词： multiple sclerosis hybrid diffusion imaging NODDI diffusion tensor imaging q-space imaging

Solving traffic data occlusion problems in computer vision algorithms using DeepSORT and quantum computing

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Journal of Traffic and Transportation Engineering(English Edition) 2024年第1期11卷 1-15页

作者： Frank Ngeni judith mwakalonge Saidi Siuhi Department of Engineering South Carolina State UniversityOrangeburgSC 29117USA

Inaccuracies of traffic sensors during traffic counting and vehicle classification have persisted as transportation agencies have been prompted to calibrate sensors *** of multiple objects,heavy occlusions,and similar appearances in congested places are some causes of computer vision model *** paper used the YOLOv5 model for detection and the DeepSORT model for tracking *** to the nature of the reported problem caused by many misses and mismatches,the power of quantum computing with the alternating direction method of multipliers(ADmm)optimizer was leveraged.A basic Kalman filter and the Hungarian algorithm features were used in combination with a quantum optimizer to present robust multiple object tracking(mOT)*** hybrid combination of the classical and quantum model has fastened learning the occludes during frame matching of tracks and detections by generating minimum quantum cost function *** with the existing models indicated a significant increase in the primary mOT metric multiple object tracking accuracy(mOTA)by 16%more than the regular YOLOv5-DeepSORT model when using a quantum ***,a 6%multiple object tracking precision(mOTP)increases and a 6%identification metrics(F_(1))score increase were observed using the quantum optimizer with identity switching reduced from 6 to *** model is expected to assist transportation officials in improving the accuracy of traffic counts and vehicle classification and reduce the need for regular computer vision software calibration.

关键词： Traffic classification Traffic counting DeepSORT YOLOv5 Quantum computing

Natural regeneration responses to thinning and burning treatments in ponderosa pine forests and implications for restoration

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Journal of Forestry Research 2022年第3期33卷 741-753页

作者： Tzeidle N.Wasserman Amy E.m.Waltz John Paul Roccaforte judith D.Springer Joseph E.Crouse Ecological Restoration Institute Northern Arizona UniversityP.O.Box 15017FlagstaffAZ86011-5017USA

Understanding naturally occurring pine regeneration dynamics in response to thinning and burning treatments is necessary not only to measure the longevity of the restoration or fuels treatment,but also to assess how well regeneration meets forest sustainability guidelines and whether natural regeneration is sufficient for maintaining a sustainable forest structure and composition.A synthesis review was carried out on the effects of mechanical thinning and prescribed burn treatments on natural pine regeneration response in frequent-fire ponderosa pine forests across the western United *** focus was on site-specific variability in pine regeneration dynamics,temporal trends in regeneration presence and abundance,and response to treatment as described in the current literature using 29 studies that met our evidence-based review *** showed that the effects of thinning and burning treatments on regeneration depended on time since *** thinning,prescribed burning,and thinning plus burn treatments all increased seedling density,but there was high variability among sites and *** were mixed results in the short-term(m studies(>20 years)concluded that stands can return to pre-treatment densities in terms of total trees per hectare and forest floor duff levels when there are no maintenance treatments *** studies showed the average ponderosa pine seedling presence,survival and growth found in today’s forests to be at a high density;this combined with missed fire cycles could contribute to future fire risk and reduce the efficacy of maintaining fuel reduction goals.

关键词： Regeneration Ponderosa pine Frequent-fire Treatments Thinning Burning