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A plant viral protein disrupts mitosis and contributes to host dwarfism by directly interrupting the conserved mitotic entry switch Wee1-Cdc25-Cdk1

A plant viral protein disrupts mitosis and contributes to ho...

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第十届全国小麦基因组学及分子育种大会

作者： Huaibing Jin Zhiqiang Du Yanjing Zhang judit antal Zongliang Xia Yan Wang Yang Gao Xiaoge Zhao Xinyun Han Yanjun Cheng Qianhua Shen Kunpu Zhang Robert E.Elder Zsigmond Benko Csaba Fenyvuesvolgyi Ge Li Dionne Rebello Richard Y.Zhao Daowen Wang State Key Laboratory of Plant Cell and Chromosome Engineering Institute of Genetics and Developmental BiologyChinese Academy of Sciences University of Chinese Academy of Sciences College of Agronomy and State Key Laboratory of Wheat and Maize Crop Science Henan Agricultural University Chicago Memorial Institute for Education and Research Northwestern University Feinberg School of Medicine Department of Pathology University of Maryland School of Medicine Department of Microbiology-Immunology Institute of Human Virologyand Institute of Global HealthUniversity of Maryland School of Medicine

Disruption of host mitosis plays an important role in viral pathogenesis However,the underlying molecular mechanisms are still not well ***,we report that the 17 K protein,conserved among the grass-infecting barley yellow dwarf viruses(BYDVs) and related poleroviruses,disrupts G2/M transition and inhibits cell growth in both host(barley) and nonhost(fission yeast and Arabidopsis thaliand)organisms through directly interrupting the mitotic entry switch Weel-Cdc25-Cdkl(CDKA in plant and Cdc2 in fission yeast).17 K binds to Cdc25 and CDKA/Cdc2 but not Weel,and decreases Cdc25’s phosphatase activity in ***,17 K expression up-regulates Weel *** alterations lead to abnormal accumulation of the CDKA/Cdc2 phosphorylated at critical mitosis-regulating residues,which impedes the function of CDKA/Cdc2 and results in G2/M ***,perturbing 17 K-CDKA interaction by silencing CDKA expression aggravates BYDV-induced dwarfing *** work suggests that the 17 K protein is an important contributor to BYDV-induced host *** the interaction between 17 K and Weel-Cdc25-CDKA may aid the control of cereal yellow dwarf ***,direct interruption of Weel-Cdc25-Cdkl is also being found for an increasing number of animal viral proteins,indicating commonality in the molecular mechanism underlying the disruption of mitosis by plant and animal viruses.

关键词： Barley yellow dwarf virus 17K mitosis disruption cyclin-dependent kinase Cdc25 Wee1

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Suicide signaling by GSDMA:a single-molecule mechanism for recognition and defense against SpeB-expressing GAS

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Signal Transduction and Targeted Therapy 2022年第6期7卷 1870-1871页

作者： judit Symmank Collin Jacobs Ulrike Schulze-Späte Department of Orthodontics University Hospital JenaLeutragraben 307743 JenaGermany Section of Geriodontics Department of Conservative Dentistry and PeriodonticsUniversity Hospital JenaAn der Alten Post 407743 JenaGermany

In a recent article published in Nature,1 Deng and colleagues uncovered a single-molecule mechanism for protection against the harmful human microbial pathogen Streptococcus *** Gram-positive Group A Streptococci(GAS)are responsible for a variety of acute infections ranging from noninvasive,mildly progressive to invasive infectious diseases with high mortality *** virulence factors thereby condition the invasion of the bloodstream and soft tissue,leading to invasive systemic dissemination.2 Deng et *** GSDMA not only as a sensor for intracellular streptopain(SpeB),an important GAS virulence factor,but also as an effector protein for host epithelial cell pyroptosis.

关键词： invasion mortality acute

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Long-term outcomes after endoscopic removal of malignant colorectal polyps:Results from a 10-year cohort

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World Journal of Gastrointestinal Endoscopy 2024年第4期16卷 193-205页

作者： Anna Fábián Renáta Bor Béla Vasas Mónika Szűcs Tibor Tóth Zsófia Bősze Kata judit Szántó Péter Bacsur Anita Bálint Bernadett Farkas Klaudia Farkas Ágnes Milassin Mariann Rutka Tamás Resál Tamás Molnár Zoltán Szepes Department of Internal Medicine University of SzegedSzent-Györgyi Albert Medical SchoolSzeged 6725Hungary Department of Pathology University of SzegedSzent-Györgyi Albert Medical SchoolSzeged 6725Hungary Department of Medical Physics and Medical Informatics University of SzegedSzent-Györgyi Albert Medical SchoolSzeged 6720Hungary USZ Translational Colorectal Research Group Hungarian Centre of Excellence for Molecular MedicineSzeged 6725Hungary

BACKGROUND Choosing an optimal post-polypectomy management strategy of malignant colorectal polyps is challenging,and evidence regarding a surveillance-only strategy is *** To evaluate long-term outcomes after endoscopic removal of malignant colorectal *** A single-center retrospective cohort study was conducted to evaluate outcomes after endoscopic removal of malignant colorectal polyps between 2010 and *** disease rate and nodal metastases after secondary surgery and local and distant recurrence rate for those with at least 1 year of follow-up were *** rates for categorical variables and means for continuous variables with 95%confidence intervals were calculated,and Fisher’s exact test and Mann-Whitney test were *** risk factors of adverse outcomes were RESULTS In total,135 lesions(mean size:22.1 mm;location:42%rectal)from 129 patients(mean age:67.7 years;56%male)were *** proportion of pedunculated and non-pedunculated lesions was similar,with en bloc resection in 82%and 47%of lesions,*** differentiation,distance from resection margins,depth of submucosal invasion,lymphovascular invasion,and budding were reported at 89.6%,45.2%,58.5%,31.9%,and 25.2%,*** tumor was found in 10 patients,and nodal metastasis was found in 4 of 41 patients who underwent secondary surgical *** analysis identified piecemeal resection as a risk factor for residual malignancy(odds ratio:1.74;P=0.042).At least 1 year of follow-up was available for 117 lesions from 111 patients(mean follow-up period:5.59 years).Overall,54%,30%,30%,11%,and 16%of patients presented at the 1-year,3-year,5-year,7-year,and 9-10-year surveillance *** outcomes occurred in 9.0%(local recurrence and dissemination in 4 patients and 9 patients,respectively),with no difference between patients undergoing secondary surgery and surveillance *** Reporting of histological featur

关键词： Malignant colorectal polyps T1 tumor Endoscopic removal Outcomes Long-term Surveillance

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Development of novel Gemini-cholesterol analogues for retinoid-related orphan receptors

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Organic Chemistry Frontiers 2022年第6期9卷 1522-1530页

作者： Uxía Gómez-Bouzó Alioune Fall judit Osz Yagamare Fall ORCID logo Natacha Rochel Hugo Santalla Departamento de Química Orgánica Facultade de QuímicaUniversity of VigoCampus Lagoas de Marcosende36310 VigoSpain Department of Integrative Structural Biology IGBMC-CNRS UMR7104-Inserm U9641rue Laurent Fries67400 IllkirchFrance

Retinoic-acid-related Orphan Receptors (RORs) regulate the maintenance of the circadian rhythm and immune response among others and are involved in increasing numbers of pathologies including autoimmune diseases, cancer and neurological disorders leading to huge interest in the development of ROR ligands. Here, we describe the synthesis of six novel Gemini cholesterol analogues and the binding mode of one of them to RORγ.

关键词： analogues synthesis numbers

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Regulation of neuronal survival by DNA methyltransferases

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Neural Regeneration Research 2017年第11期12卷 1768-1775页

作者： judit Symmank Geraldine Zimmer Institute of Human Genetics University Hospital JenaJenaGermany

The limited regenerative capacity of neuronal cells requires tight orchestration of cell death and survival regulation in the context of longevity, age-associated diseases as well as during the development of the nervous system. Subordinate to genetic networks epigenetic mechanisms like DNA methylation and histone modifications are involved in the regulation of neuronal development, function and aging. DNA methylation by DNA methyltransferases （DNMTs）, mostly correlated with gene silencing, is a dynamic and reversible process. In addition to their canonical actions performing cytosine methylation, DNMTs influence gene expression by interactions with histone modifying enzymes or complexes increasing the complexity of epigenetic transcriptional networks. DNMTs are expressed in neuronal progenitors, post-mi- totic as well as adult neurons. In this review, we discuss the role and mode of actions of DNMTs including downstream networks in the regulation of neuronal survival in the developing and aging nervous system and its relevance for associated disorders.

关键词： DNA methyltransferase I cortical interneurons PAK6 neuronal aging neuropsychiatric diseases neurodevelopment neuronal death

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Proteomics and the genetics of sperm chromatin condensation

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Asian Journal of Andrology 2011年第1期13卷 24-30页

作者： Rafael Oliva judit Castillo Human Genetics Research Group IDI BAPS Department of Ciencias Fisiologicas I Faculty of Medicine University of Barcelona Barcelona 08036 Spain Biochemistry and Molecular Genetics Service Hospital Clinic i Provincial Barcelona 08036 Spain

Spermatogenesis involves extremely marked cellular, genetic and chromatin changes resulting in the generation of the highly specialized sperm cell. Proteomics allows the identification of the proteins that compose the spermatogenic cells and the study of their function. The recent developments in mass spectrometry （MS） have markedly increased the throughput to identify and to study the sperm proteins. Catalogs of thousands of testis and spermatozoan proteins in human and different model species are becoming available, setting up the basis for subsequent research, diagnostic applications and possibly the future development of specific treatments. The present review intends to summarize the key genetic and chromatin changes at the different stages of spermatogenesis and in the mature sperm cell and to comment on the presently available proteomic studies.

关键词： epigenetic imprinting protamine proteome spermatozoa

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LHX1–a multifunctional regulator in preoptic area-derived interneuron development

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Neural Regeneration Research 2019年第7期14卷 1213-1214页

作者： judit Symmank Geraldine Zimmer-Bensch Polyclinic for Orthodontics University Hospital Jena Department of Functional Epigenetics in the Animal Model Institute for Biology ⅡRWTH Aachen University

In the cerebral cortex,local inhibition is achieved by different types of gamma-aminobutyric(GABA)-expressing interneurons,representing essential key players of cortical information processing(Marin,2012).Their development has to be highly orchestrated to ensure proper numbers and subtype composition in the adult cortex and defects in interneuron development contribute to the pathophysiology of psychiatric diseases(Marin,2012).

关键词： cerebral cortex different types gamma-aminobutyric

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Engineering polymer nanoparticles using cell membrane coating technology and their application in cancer treatments:Opportunities and challenges

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Nano Materials Science 2022年第4期4卷 295-321页

作者： Kai Guo Nanyang Xiao Yixuan Liu Zhenming Wang judit Tóth János Gyenis Vijay Kumar Thakur Ayako Oyane Quazi T.H.Shubhra Stomatology Hospital of Guangzhou Medical University Guangzhou Medical UniversityGuangzhou510140China Department of Microbiology The University of ChicagoChicagoIL60637USA Department of Pathology School of Basic Medical SciencesNanjing Medical UniversityNanjing21116China State Key Laboratory of Oral Diseases West China Hospital of StomatologySichuan UniversityChengdu610041China Research Centre for Natural Sciences Institute of Materials and Environmental Chemistry1117BudapestMagyar Tudósok Körútja 2Hungary University of Pannonia Egyetem u.10H-8200VeszprémHungary Nanomaterials Research Institute National Institute of Advanced Industrial Science and Technology(AIST)Tsukuba305-8565Japan School of Engineering University of Petroleum&Energy Studies(UPES)Dehradun 248007India

Nanotechnology has revolutionized cancer drug delivery,and recent research continues to focus on the development of“one-size-fits-all,”i.e.,“all-in-one”delivery *** nanomedicines can address significant shortcomings of conventional therapy,biological barriers remain a challenge in their delivery and accumulation at diseased *** achieve long circulation time,immune evasion,and targeted accumulation,conventional nanocarriers need modifications,e.g.,PEGylation,peptide/aptamer attachment,*** such modification is a biomimetic coating using cell membrane(CM),which can offer long circulation or targeting,or *** top-down CM coating process is facile and can provide some advantageous features over surface modification by synthetic ***,an overview is provided on the engineering of CM camouflaged polymer nanoparticles.A short section on CM and the development of CM coating technology has been *** description of the preparation and characterization of CM camouflaged polymer NPs and their applications in cancer treatment has been reported.A brief comparison between CM coating and PEGylation has been *** targeting approaches to achieve tumor-specific delivery of CM coated NPs have been summarized ***,this review will give the readers a nice picture of CM coated polymer NPs,along with their opportunities and challenges.

关键词： Cell membrane(CM) Nanoparticles(NPs) Cancer Camouflage Biomimetic coating Drug delivery

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The Effect of Reaction Conditions on the Synthesis of Thermoplastic Elastomers Containing Polyalloocimene, Polyisobutylene and Tapered Blocks

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Chinese Journal of Polymer Science 2019年第9期37卷 884-890页

作者： Jozsef Kantor judit E. Puskas Gabor Kaszas Department of Chemical and Biomolecular Engineering The University of Akron Akron OH 44325 USA Department of Food Agricultural and Biological Engineering (1/1/2019) The Ohio State University Wooster OH 44691 USA PolyFiberMatrix LLC 2295 W. Market St. Suite D. Akron OH 44313 USA

This work investigates the effect of reaction conditions on the copolymerization of isobutylene (IB) with alloocimene (Allo) in methyl chloride (MeCl) using AlCh and ethylaluminum dichloride (EtAlCh) as coinitiators and adventitious moisture as the initiator. Both AlCh and EtAlCb produced high molecular weight (Mn > 1.0 x 10^5 g/mol) thermoplastic elastomers (TPEs) with good mechanical properties in short reaction time (< 10 min). These unique TPEs have unsaturations in the end blocks, leading to easy functionalization and/or crosslinking.

关键词： Polyisobutylene Alloocimene Triblock copolymer Carbocationic polymerization

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Deactivation of Streptococcus mutans Biofilms on a Tooth Surface Using He Dielectric Barrier Discharge at Atmospheric Pressure

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Plasma Science and Technology 2013年第6期15卷 535-541页

作者： Imola MOLNAR judit PAPP Alpar SIMON Sorin Dan ANGHEL Babes-Bolyai University Faculty of Biology and GeologyCluj-Napoca 400015Romania Babes-Bolyai University Faculty of PhysicsCluj-Napoca 400084Romania

This paper presents a study of the effect of the low temperature atmospheric helium dielectric barrier discharge（DBD） on the Streptococcus mutans biofilms formed on tooth surface. Pig jaws were also treated by plasma to detect if there is any harmful effect on the *** plasma was characterized by using optical emission *** data indicated that the discharge is very effective in deactivating Streptococcus mutans *** can destroy them with an average decimal reduction time（D-time） of 19 s and about 98%of thein were killed after a treatment time of 30 *** to the survival curve kinetic an overall 32 s treatment time would be necessary to perform a complete *** experimental results presented in this study indicated that the helium dielectric barrier discharge,in plan-parallel electrode configuration,could be a very effective tool for deactivation of oral bacteria and might be a promising technique in various dental clinical applications.

关键词： Streptococcus mutans dielectric barrier discharge plasma treatment biofilm deactivation sterilization

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