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Nephroprotective effect of Croton zamhesicus root extract against gentimicin-induced kidney injury

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Asian Pacific Journal of Tropical Medicine 2011年第12期4卷 969-972页

作者： jude e okokon Paul A Nwafor Kufre Noah Department of Pharmacology and Toxicology Faculty of PharmacyUniversity Of UyoUyo.Nigeria

Objective:To evaluate the kidney protective effect of ethanolic root extract of Croton zambesicus (***) against gentimicin-induced kidney injury in ***:The root extract(27 -81 mg/kg) was administered to rats for eight days with concurrent administration of gentimicin (100 mg/kg) daily for the same period of *** effect of the extract was evaluated in serum levels of creatinine,urea,and uric acid as well as some ions like sodium,potassium and *** examination of the kidneys from different treatment groups were also carried ***:Administration of the root extract significantly reduced histopathological changes in the kidneys of the extract-treated rats especially in the rats treated with lower doses of the extract(27 and 54 mg/kg).The levels of serum urea and creatinine were also reduced significantly(Pese doses with no observable effect on the levels of uric acid and ions. Conclusions:The kidney - protective activity of this extract could be due to its antioxidant and free radical scavenging activities.

关键词： Crolon zambesicus Nephroproteotive Gentimicin

Antiplasmodial and analgesic activities of Clausena anisata

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Asian Pacific Journal of Tropical Medicine 2012年第3期5卷 214-219页

作者： jude e okokon ette O etebong John A Udobang Grace e essien Department of Pharmacology and Toxicology Faculty of PharmacyUniversity of UyoUyoNigeria

Objective:Antiplasmodial and analgesic activities of the leaf extract and fractions of Clausena anisata(***) were evaluated for antimalarial and analgesic ***:The crude leaf extract(39-117mg/kg) and fractions(chloroform and acqeous;78mg/kg) of C. anisata were investigated for antiplasmodial activity against chloroquine-sensitive Plasmodium berghei(***) infections in mice using suppressive,prophylactic and curative models and analgesic activity against acetic acid,formalin and heat-induced ***,5 mg/kg and pyrimethamine,1.2mg/kg were used as positive *** films made from tail blood of each mouse were used to assess the level of parasitaemia of the ***:The extract and its fractions dose-dependently reduced parasitaemia induced by chloroquine-sensitive *** in prophylactic,suppressive and curative models in *** reductions were statistically significant(Pey also improved the mean survival time(MST) from 17 to 21 days relative to control(Pemically and thermally-induced pains,the extract inhibited acetic acid and formalin-induced inflammation as well as hot plate-induced pain in *** inhibitions were statistically significant(Pe-dependent fashion. Conclusions:The antiplasmodial and analgesic effects of this plant may in part be mediated through its chemical constituents and it can be concluded that the *** possess significant antimalarial and analgesic properties.

关键词： Clausena anisata antiplasmodial antimalarial analgesic

Antidiabetic and hypolipidemic activities of ethanolic leaf extract and fractions of Melanthera scandens

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Asian Pacific Journal of Tropical Biomedicine 2012年第7期2卷 523-527页

作者： enomfon J Akpan jude e okokon emem Offong Department of Biochemistry Faculty of Basic Medical SciencesUniversity of Uyo Department of Pharmacology and Toxicology Faculty of PharmacyUniversity of Uyo

Objective:To evaluate the antidiabetic and hypolipidemie activities of ethanolic leaf extract and Fraction of Melanthera scandens(***) in alloxan-induced diabetic ***:*** leaf extract/fractions(37-111 mg/kg) were administered to alloxan-induced diabetic rats for 14 days and blood glucose levels(BGL) of the diabetic rats were monitored at intervals of 7 hours for acute study and 14 days lor prolonged *** profiles of the treated diabetic rats were determined after the period of ***:Treatment of alloxan-induced diabetic rats with the extract/fractions caused a significant(Peduction in lasting bloodglucose levels(BGL) ol the diabetic rats both in acute study and prolonged Irealnient(2weeks).The activities of the extract and fractions were more than that of the reference drug,*** extract/fractions exerted a significant reduction in the levels of serum total cholesterol,triglycerides,LDL and VLDL of extract with increases in *** of the diabetic ***:These results suggest that the leaf extract/fractions(*** possesses antidiabetic effect on alloxan induced diabetic rats and this justifies its use in ethno medicine and can be exploited in the management of diabetes.

关键词： Antidiabetic Hypolididemic Melanthera scandens

Antiplasmodial and antiulcer activities of Melanthera scadens

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Asian Pacific Journal of Tropical Biomedicine 2012年第1期2卷 16-20页

作者： jude e okokon ette O etebong John A Udobang Jackson Obot Department of Pharmacology and Toxicology Faculty of PharmacyUniversity of Uyo

Objective:To evaluate the antimalarial and antiulcerogenic activities ofleaf exlracl and fractions of Melanthera scandens(***).Methods:The crude leaf extract(37-111 mg/kg)and fractions(chloroform,ethylacetale and methanol;78 mg/kg)of *** were investigated for antiplasmodial activity against chloroquine-sensitive Plasmodium berghei infections in mice and for antiulcer activity against experimentally-induced *** antimalarial activity during early and established infections as well as prophylactic was ***(5 mg/kg)and pyrimethamine(1.2 mg/kg)were used as positive *** films made from tail blood of each mouse were used to assess the level of parasitaemia of the *** activity of the crude extract was also evaluated against indomethacin,ethanol and histamine induced ***:The extract and its fractions dose-dependently reduced parasitaemia induced by chloroquine-sensitive Plasmodium berghei infection in prophylactic,suppressive and curative models in *** reductions were statistically significant(Pey also improved the mean survival time(MST)from 9.28 to 17.73 days as compared with the control(Pe activities of extract/fractions were incomparable to that of the standard drugs *** and *** experimentally-induced ulcers,the extract inhibited indomethacin,ethanol and histamine induced *** inhibitions were statistically significant(Pe-dependent ***:The antiplasmodial and antiulcerogenic effects of this plant may in part be mediated through the chemical constituents of the plant.

关键词： Melanthera scadens Antiplasmodial activity Antiulcer activity Antimalarial activity Antiulcerogenic activity Chemical constituent Parasitaemia Plasmodium berghei Artesunate Indomethacin Pyrimethamine

Anti-inflammatory and analgesic activities of Melanthera scandens

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Asian Pacific Journal of Tropical Biomedicine 2012年第2期2卷 144-148页

作者： jude e okokon Anwanga e Udoh Samuel G Frank Louis U Amazu Department of Pharmacology and Toxicology Faculty of PharmacyUniversity of Uyo Department of Science Technology Akwa Ibom State PolytechnicIkot Osurua Department of Pharmacology and Therapeutice.College of Medicine Evans Enwerem University

Objective:To evaluate the anti-inflammatory and analgesic activities of leaf extract of Melanthera scandens(***).Methods:The crude leaf extract(39-111 mg/kg)of *** was investigated for anti-inflammatory and analgesic activities using various experimental *** anti-inflammatory activity was investigated using carragenin,egg-albumin induced oedema models,while acetic acid,formalin-induced paw licking and thermal-induced pain models were used to evaluate the antinociceptive ***:The extract caused a significant(Pe-dependent reduction of inflammation and pains induced by different agents ***:The leaf extract possesses anti-inflammatory and analgesic effects which may be mediated through the phytochemical constituents of the plant.

关键词： Melanthera scandens Anti-inflammatory Analgesic

Antidiabetic activities of ethanolic extract and fraction of Anthocleista djalonensis

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Asian Pacific Journal of Tropical Biomedicine 2012年第6期2卷 461-464页

作者： okokon jude e Antia Bassey S Udobang John A Department of Pharmacology and Toxicology Faculty of Pharmacy University of Uyo Department of Chemistry Faculty of Science University of Uyo

Objective:To evaluate the antidiabetic activities of ethanolic root extract/fraction of Anthocleista djalonensis(A. djalonensis) in alloxan-induced diabetic ***: A. djalonensisroot extract/fractions(37-111 mg/kg) were administered to alloxan-induced diabetic rats for 14 days and blood glucose levels(BGLs) of the diabetic rats were monitored at intervals of hours and days throughout the duration of the ***:Treatment of alloxan-induced diabetic rats with the extract/fractions caused a significant(Peduction in fasting BGLs of the diabetic rats both in acute study and prolonged treatment(2 weeks). The activities of the extract and fractions were more than that of the reference drug, glibenclam ***:These results suggest that the root extract/fractions of A. djalonensispossess antidiabetic effect on alloxan-induced diabetic rats and this justifies its use in ethnomedicine and can be exploited in the management of diabetes.

关键词： Antidiabetic Alloxan Anthocleista djalonensis

Antibacterial and antibiofi lm activity of peptide PvGBP2 against pathogenic bacteria that contaminate Auricularia auricular culture bags

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Food Science and Human Wellness 2022年第6期11卷 1607-1613页

作者： Shen Yang Zijin Yuan jude Juventus Aweya Shanggui Deng Wuyin Weng Yueling Zhang Guangming Liu College of Food and Biological engineering Xiamen Key Laboratory of Marine Functional FoodJimei UniversityXiamen 361021China Department of Biology Guangdong Provincial Key Laboratory of Marine BiotechnologyShantou UniversityShantou 515063China College of Food and Pharmacy Zhejiang Ocean UniversityZhoushan 316000China

Bacteria contamination in Auricularia auricular culture bags reduces yield and increases the risk of food *** this study,5 species of bacteria,mainly gram-positive bacteria including three species of Bacillus spp.,Arthrobacter arilaitensis and Staphylococcus warneri,were isolated and identifi ed from bacteria-contaminated *** culture *** in silico predicted antimicrobial peptide from theβ-1,3-glucan-binding protein sequence of Penaeus vannamei,designated Pv GBP2(FLKLGRKSRYGMLKL),was screened and its antibacterial effect and mechanism of action on the isolated Bacillus *** minimal inhibitory concentrations(MIC)of Pv GBP2 on Bacillus *** 15.6–31.25μg/m *** Pv GBP2 could inhibit Bacillus subtilis in *** culture bags to maintain growth and yield of *** electron microscopy(TeM)revealed that Pv GBP2 kills bacteria by perforating the cell wall,destroying membrane integrity and resulting in the leakage of intracellular *** addition,Pv GBP2 inhibits biofi lm formation by *** by 90.6%at 1×***,peptide Pv GBP2 could be potentially applied as an antibacterial agent to control bacterial infection of *** cultivation and the spread of foodborne pathogens.

关键词： Auricularia auricular Antimicrobial peptide Penaeus vannamei β-1,3-Glucan-binding protein Bacillus spp.e

The Implication of TALC to Tourism Planning and Development in the Global South:examples from Nigeria

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Journal of Tourism and Hospitality Management 2020年第2期8卷 68-86页

作者： Chigozie jude Odum University of Nigeria NsukkaNigeria

Application of Tourist Area Life Cycle(TALC)in tourism destinations in the global south(i.e.,Nigeria)is limited despite its predictive *** study evaluates ecotourism destinations in southeastern Nigeria using the TALC model and its implications to tourism planning and *** Group Discussions(FGDs)and in-depth interviews were used in the study,and the results were discussed based on variables in the *** results showed the following:“Instant resorts”were developed near lakes;limited development and stagnations,the uncertainty of destination growth,stages over-lap,among others were characteristics of tourism destinations in southeastern Nigeria due to socio-political landscape shaping tourism in *** destinations in the region fall between exploration and development stages;this is not unconnected to government“slapdash attitude”to ***,the status of these destinations offers the opportunity for community involvement for sustainability *** qualitative means used to gauge tourism destinations’stages is novel and worthy of academic attention;it is invaluable where numeric data are *** study is suggestive of theoretical underpinning in tourism studies in developing ***:Anambra,Butler,destination,ecotourism,enugu,Tourism Area Life Cycle(TALC)

关键词： Anambra Butler destination ecotourism enugu Tourism Area Life Cycle(TALC)

Determination of Natural Logarithm of Diffusion Coefficient and Activation energy of Thin Layer Drying Process of Ginger Rhizome Slices

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World Journal of engineering and Technology 2024年第1期12卷 213-228页

作者： Austin Ikechukwu Gbasouzor Sam Nna Omenyi Sabuj Mallik jude e. Njoku Department of Agricultural and Biological engineering College of Engineering Purdue University West Lafayette IN USA Department of Mechanical engineering Nnamdi Azikiwe University Awka Nigeria Department of Mechanical and Manufacturing and Built environment School of Engineering University of Derby Derby UK Faculty of engineering and Science University of Greenwich Kent UK

This study is an extension of the previous work done with ARS-680 environmental Chamber. Drying is a complex operation that demands much energy and time. Drying is essentially important for preservation of ginger rhizome. Drying of ginger was modeled, and then the effective diffusion coefficient and activation energy were determined. For this purpose, the experiments were done at six levels of varied temperatures: 10°C, 20°C, 30°C, 40°C, 50°C and 60°C. The values of effective diffusion coefficients obtained in this work for the variously treated ginger rhizomes closely agreed with the average effective diffusion coefficients of other notable authors who determined the drying kinetics and convective heat transfer coefficients of ginger slices.

关键词： Activation energy Diffusion Coefficients Ginger Rhizomes Drying Model Drying Time Moisture Ratio Thin Layer