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No significant association between dipeptidyl peptidase-4 inhibitors and adverse outcomes of COVID-19

World Journal of Clinical Cases 2020年第22期8卷 5576-5588页

作者： Jiang-Hua Zhou Bin Wu Wen-Xin Wang Fang Lei Xu Cheng juan-juan qin Jing-Jing Cai Xiao-Jing Zhang Feng Zhou Ye-Mao Liu Hao-Miao Li Li-Hua Zhu Zhi-Gang She Xin Zhang juan Yang Hong-Liang Li Department of Cardiology Renmin Hospital of Wuhan UniversityBasic Medical SchoolWuhan UniversityWuhan 430071Hubei ProvinceChina Basic Medical School Institute of Model AnimalWuhan UniversityWuhan 430071Hubei ProvinceChina Department of Cardiology the 3rd Xiangya HospitalCentral South UniversityChangsha 410013Hunan ProvinceChina Medical Science Research Center Zhongnan Hospital of Wuhan UniversityInstitute of Model AnimalWuhan UniversityWuhan 430072Hubei ProvinceChina Department of Cardiology Renmin Hospital of Wuhan UniversityInstitute of Model Animal of Wuhan UniversityWuhan 430071Hubei ProvinceChina Institute of Model Animal Wuhan UniversityDepartment of GastroenterologyWuhan Third HospitalTongren Hospital of Wuhan UniversityWuhan 430072Hubei ProvinceChina

BACKGROUND Dipeptidyl peptidase-4(DPP4)is commonly targeted to achieve glycemic control and has potent anti-inflammatory and immunoregulatory *** structural analyses indicated a potential tight interaction between DPP4 and severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),raising a promising hypothesis that DPP4 inhibitor(DPP4i)drugs might be an optimal strategy for treating coronavirus disease 2019(COVID-19)among patients with ***,there has been no direct clinical evidence illuminating the associations between DPP4i use and COVID-19 *** To illuminate the associations between DPP4i usage and the adverse outcomes of *** We conducted a multicenter,retrospective analysis including 2563 patients with type 2 diabetes who were hospitalized due to COVID-19 at 16 hospitals in Hubei Province,*** excluding ineligible individuals,142 patients who received DPP4i drugs and 1115 patients who received non-DPP4i oral anti-diabetic drugs were included in the subsequent *** performed a strict propensity score matching(PSM)analysis where age,sex,comorbidities,number of oral hypoglycemic agents,heart rate,blood pressure,pulse oxygen saturation(SpO2)<95%,CT diagnosed bilateral lung lesions,laboratory indicators,and proportion of insulin usage were ***,111 participants treated with DPP4i drugs were successfully matched to 333 non-DPP4i ***,a linear logistic model and mixed-effect Cox model were applied to analyze the associations between inhospital DPP4i use and adverse outcomes of *** After rigorous matching and further adjustments for imbalanced variables in the linear logistic model and Cox adjusted model,we found that there was no significant association between in-hospital DPP4i use(DPP4i group)and 28-d allcause mortality(adjusted hazard ratio=0.44,95%CI:0.09-2.11,P=0.31).Likewise,the incidences and risks of secondary outcomes,including septic shock,acute respiratory distress synd

关键词： COVID-19 SARS-CoV-2 DPP4 inhibitors Diabetes Glucose control Adverse effects

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Extracorporeal Membrane Oxygenation Therapy for Critically Ill Coronavirus Disease 2019 Patients in Wuhan,China:A Retrospective Multicenter Cohort Study

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Current Medical Science 2021年第1期41卷 1-13页

作者： Jing FANG Rui LI Yue CHEN juan-juan qin Ming HU Chao-lin HUANG Lin CHENG Yi HE Yi LI Qiang ZHOU Dai-xing ZHOU Fei HUANG Fang LEI Bo YANG Jun CHEN Hong-ping DENG Yu-feng YUAN Jia-hong XIA Song WAN Hong-liang LI Xiang WEI Division of Cardiothoracic and Vascular Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Key Laboratory of Organ Transplantation Ministry of EducationWuhan 430030China NHC Key Laboratory of Organ Transplantation Ministry of HealthWuhan 430030China Key Laboratory of Organ Transplantation Chinese Academy of Medical SciencesWuhan 430030China National Public Health Event Medical Center National Health Commission of the People’s Republic of ChinaWuhan 430030China Department of Cardiology Renmin Hospital of Wuhan UniversityWuhan 430060China Basic Medical School Wuhan UniversityWuhan 430071China Department of Critical Care Medicine Wuhan Pulmonary HospitalWuhan 430030China Wuhan Jinyintan Hospital Wuhan 430023China Division of Cardiology Department of Internal MedicineTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Intensive Critical Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Institute of Model Animal of Wuhan University Wuhan 430071China Department of Cardiac Surgery University of MichiganAnn ArborMI 48109USA Department of Vascular Surgery Renmin Hospital of Wuhan UniversityWuhan 430060China Department of Hepatobiliary and Pancreatic Surgery Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Cardiovascular Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Division of Cardiothoracic Surgery Department of Surgerythe Chinese University of Hong KongPrince of Wales HospitalHong Kong999077 China

Currently,little in-depth evidence is known about the application of extracorporeal membrane oxygenation(ECMO)therapy in coronavirus disease 2019(COVID-19)*** retrospective multicenter cohort study included patients with COVID-19 at 7 designated hospitals in Wuhan,*** patients were followed up until June 30,*** and multivariate logistic regression analyses were performed to identify the risk factors associated with unsuccessful ECMO *** score matching was used to match patients who received veno-venous ECMO with those who received invasive mechanical ventilation(IMV)-only *** 88 patients receiving ECMO therapy,27 and 61 patients were and were not successfully weaned from ECMO,***,15,15,and 65 patients were further weaned from IMV,discharged from hospital,or died during hospitalization,*** the multivariate logistic regression analysis,a lymphocyte count≤0.5×10^(9)/L and D-dimer concentration>4×the upper limit of normal level at ICU admission,a peak PaCO_(2)>60 mmHg at 24 h before ECMO initiation,and no tracheotomy performed during the ICU stay were independently associated with lower odds of ECMO *** the propensity scorematched analysis,a mixed-effect Cox model detected a lower hazard ratio for 120-day all-cause mortality after ICU admission during hospitalization in the ECMO *** presence of lymphocytopenia,higher D-dimer concentrations at ICU admission and hypercapnia before ECMO initiation could help to identify patients with a poor *** could facilitate weaning from *** relative to IMV-only therapy was associated with improved outcomes in critically ill COVID-19 patients.

关键词： coronavirus disease 2019 extracorporeal membrane oxygenation mechanical ventilation acute respiratory distress syndrome viral pneumonia

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An ultra-wideband circularly polarized microstrip patch antenna loaded with split-ring resonator

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Optoelectronics Letters 2025年

作者： WANG Shike XIA Dan Lü Lianrong qin juan WANG Meng REN Haiping School of Integrated Circuit Science and Engineering， Tianjin University of Technology

In this paper， the effect of a single-opening split-ring resonator （SRR） structure on the performance of ultra-wideband （UWB） microstrip patch antenna （MPA） is studied. Here a UWB MPA based on partial grounding is proposed， and the SRR structure is utilized to optimize other characteristics of the low-profile microstrip antenna while ensuring the bandwidth and gain remain unchanged. The proposed metamaterial structure， consisting of a 2 × 2 array of SRR， is loaded on the reverse side of the substrate. The volume of the proposed antenna is 61.6×67.6×1.5mm3. According to simulation and experimental results， the proposed microstrip antenna loaded with 2×2 SRRs performs better than that without SRR structure. It produces an operating band of 1.62 GHz-8 GHz while achieving circular polarization characteristics with an axial ratio （AR） bandwidth of 3.92 GHz-4.57 GHz. In addition， the performance of the proposed antenna is superior to relevant works of literature The antenna can be widely utilized in wireless communication systems.

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大中小学思政课区域一体化的价值意蕴、驱动要素与推进策略

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东北师大学报（哲学社会科学版） 2025年第1期 10-18页

作者：李爱琴师海娟东北林业大学马克思主义学院黑龙江哈尔滨150040

大中小学思政课区域一体化是大中小学思政课一体化的重要组成部分和重点建设方向,其核心要义在于区域教育主体突破学段和校际壁垒,以共同体成员的协作互动促进思想政治教育资源在区域间的有序流动和优化配置,实现大中小学思政课区域一... 详细信息

大中小学思政课区域一体化是大中小学思政课一体化的重要组成部分和重点建设方向,其核心要义在于区域教育主体突破学段和校际壁垒,以共同体成员的协作互动促进思想政治教育资源在区域间的有序流动和优化配置,实现大中小学思政课区域一体化的整体内涵式发展。新时代持续推进大中小学思政课区域一体化走深走实,可广泛凝聚区域多主体人才协同共培的价值共识,形成多模态纵横连贯式的区域教育网络生态系统,全面提升大中小学思想政治教育区域一体化的建设质量。学校思想政治教育政策要求、新时代思政课改革创新发展诉求和学生个人成长发展需求对大中小学思政课区域一体化具有正向驱动作用,牵动着大中小学思政课区域一体化建设的“时”和“序”、“质”和“量”、“道”和“术”。深化大中小学思政课区域一体化建设,要健全常态长效运行机制,畅通区域管理行动经络;补足协同推进短板弱项,统筹区域格局协调发展;建立多元主题合作网络,深化区域合作互联互通;优化教育资源服务供给,实现区域资源无界共享。

关键词：大中小学思政课区域一体化立德树人思想政治教育

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HMFI分子筛Bronsted酸性位点与碱性分子的作用机制

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原子与分子物理学报 2025年第4期42卷 1-7页

作者：郑健秦康秦玉才宋丽娟中石化石油化工科学研究院有限公司北京100083 辽宁石油化工大学辽宁省石油化工催化科学与技术重点实验室抚顺113001

采用密度泛函理论(DFT)方法,以单铝、双铝和三铝酸性位点HMFI分子筛为模型分子筛,计算去质子化能考察HMFI分子筛的本征酸性,以NH_(3)分子作为模型分子,计算NH_(3)分子在HMFI分子筛中的吸附能与去质子化能进行关联性分析,并进一步考察NH_... 详细信息

采用密度泛函理论(DFT)方法,以单铝、双铝和三铝酸性位点HMFI分子筛为模型分子筛,计算去质子化能考察HMFI分子筛的本征酸性,以NH_(3)分子作为模型分子,计算NH_(3)分子在HMFI分子筛中的吸附能与去质子化能进行关联性分析,并进一步考察NH_(3)分子与HMFI分子筛的作用机制.研究表明分子筛Bronsted酸(简称B酸)强度与B酸数量没有强相关性,在考虑B酸位数量的同时须考虑B酸位的分布.酸性位点数量和分布的差异均可以调控NH_(3)分子的吸附构象,并且可以通过调节HMFI分子筛孔道对分子施加相互作用的模式,解析分子的结构和电子性质,精准调控分子的进一步转化.此项工作可以为未来高效多孔材料有效物种活性位的构建提供新思路.

关键词：密度泛函理论 HMFI分子筛 Bronsted酸性质吸附性能

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腐植酸与纤维素的复合物对废水中重金属离子络合性能的研究

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山西师范大学学报（自然科学版） 2003年第1期17卷 69-71页

作者：王青蕾郭娟娟宋沁峰王怀亮山西师范大学化学与材料科学学院山西临汾041004

风化煤中提取的腐植酸类物质对废水中有害重金属离子具有一定的络合作用 ,但有沉积速度慢、时间长、沉积物不易分离等缺点 .本文用腐植酸钠与纤维素反应产生的复合物 ,对水中重金属离子的络合性能进行了研究 ,发现络合效果比单纯用腐植... 详细信息

风化煤中提取的腐植酸类物质对废水中有害重金属离子具有一定的络合作用 ,但有沉积速度慢、时间长、沉积物不易分离等缺点 .本文用腐植酸钠与纤维素反应产生的复合物 ,对水中重金属离子的络合性能进行了研究 ,发现络合效果比单纯用腐植酸钠效果要好 .因而腐植酸纤维素复合物有望成为重金属污水处理剂 .

关键词：重金属离子络合性能腐植酸钠纤维素重金属废水络合沉淀废水处理

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Focusing on the Focus： What Else beYOnd the Master Switches for Polar Cell Growth？

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Molecular Plant 2015年第4期8卷 582-594页

作者： Yuan qin juan Dong Center for Genomics and Biotechnology College of Crop Science Fujian Agriculture and Forestry University Fuzhou 350002 Fujian Province China Waksman Institute of Microbo ogy Rutgers the State University of New Jersey Piscataway NJ 08854 LISA The Department of Plant Biology and Pathology Burgers the State University of New Jersey New Brunswick NJ 08901 USA

Cell polarity, often associated with polarized cell expansion/growth in plants, describes the uneven distribution of cellular components, such as proteins, nucleic acids, signaling molecules, vesicles, cytoskeletal elements, and organelles, which may ultimately modulate cell shape, structure, and function. Pollen tubes and root hairs are model cell systems for studying the molecular mechanisms underlying sustained tip growth. The formation of intercalated epidermal pavement cells requires excitatory and inhibitory pathways to coordinate cell expansion within single cells and between cells in contact. Strictly controlled cell expansion is linked to asymmetric cell division in zygotes and stomatal lineages, which require integrated processes of pre-mitotic cellular polarization and division asymmetry. While small GTPase ROPs are recognized as fundamental signaling switches for cell polarity in various cellular and developmental processes in plants, the broader molecular machinery underpinning polarity establishment required for asymmetric division remains largely unknown. Here, we review the widely used ROP signaling pathways in cell polar growth and the recently discovered feedback loops with auxin signaling and PIN effluxers. We discuss the conserved phosphorylation and phospholipid signaling mechanisms for regulating uneven distribution of proteins, as well as the potential roles of novel proteins and MAPKs in the polarity establishment related to asymmetric cell division in plants.

关键词： cell expansion cytoskeleton polarity polarity determination signal transduction

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Improvement in Cr Nanoparticle Content in Ni-Cr Film by Co-deposition with Combined Surfactant HPB and CTAB

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Acta Metallurgica Sinica(English Letters) 2017年第10期30卷 999-1007页

作者： Li-juan qin Yuan-Chao Huang Laboratory for Corrosion and Protection Institute of Metal ResearchChinese Academy of Sciences College of Material Science and Engineering University of Science and Technology of China

The effects of single surfactant hexadecylpyridinium bromide（HPB） and cetyltrimethylammonium bromide（CTAB） and the combination of HPB and CTAB on the Cr nanoparticle content in the Ni-Cr film prepared by codeposition were investigated. Single HPB/CTAB addition inhibited the oxidation and amorphous transformation of the Cr nanoparticles in the plating bath and effectively stabilized the Cr nanoparticles content at approximately 10 mass% as a function of time. Moreover, the combination of HPB and CTAB formed a cylindrical micelle structure on the Cr nanoparticle surface, which prompted the formation of a layer of NiCr2O4. As a result, the Cr nanoparticle content increased sharply to 20 mass%.

关键词： Co-deposition Ni-Cr film Cr nanoparticle content HPB CTAB

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Seasonal variations of leaf traits and drought adaptation strategies of four common woody species in South Texas, USA

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Journal of Forestry Research 2019年第5期30卷 1715-1725页

作者： juan qin Zhouping Shangguan Weimin Xi School of Resources and Environment Anhui Agricultural UniversityHefei 230036AnhuiChina Department of Biological and Health Sciences Texas A&M University-KingsvilleKingsvilleTX 78363USA State Key Laboratory of Soil Erosion and Dryland Farming on the Loess Plateau Northwest A&F UniversityYangling 712100ShaanxiChina

Understanding physiological responses and drought adaptation strategies of woody plant leaf traits in sub-humid to semi-arid regions is of vital importance to understand the interplay between ecological processes and plant resource-allocation strategies of different tree *** variations of leaf morphological traits,stoichiometric traits and their relationships of two drought tolerant woody species,live oak(Quercus virginiana)and honey mesquite(Prosopis glandulosa)and two less drought tolerant species,sugarberry(Celtis laevigata)and white ash(Fraxinus americana)were analyzed in a sub-humid to semi-arid area of south Texas,*** findings demonstrate that for the two drought tolerant species,the leguminous *** had the highest specific leaf area,leaf N,P,and lowest leaf area and dry mass,indicating that *** adapts to an arid habitat by decreasing leaf area,thus reducing water loss,reflecting a resource acquisition *** the evergreen species *** exhibited higher leaf dry mass,leaf dry matter content,C content,C:N,C:P and N:P ratios,adapts to an arid habitat through increased leaf thickness and thus reduced water loss,reflecting a resource conservation strategy in south *** the two less drought tolerant deciduous species,the variations of leaf traits in *** and *** varied between *** and ***,reflecting a trade-off between rapid plant growth and nutrient maintenance in a semi-arid environment.

关键词： Drought adaptation strategies Leaf traits Seasonal variations South Texas Woody species

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Mode Ⅲ fracture analysis by Trefftz boundary element method

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Acta Mechanica Sinica 2007年第2期23卷 173-181页

作者： Yuhong Cui juan Wang Manicka Dhanasekar qinghua qin Department of Mechanics Tianjin UniversityTianjin 300072 China Centre for Railway Engineering Central Queensland UniversityNorth Rockhampton QLD 4702 Australia Department of Engineering Australian National UmversltyCanberra ACT 0200 Australia

This paper presents a hybrid Trefftz （HT） boundary element method （BEM） by using two indirect techniques for mode III fracture problems. Two Trefftz complete functions of Laplace equation for normal elements and a special purpose Trefftz function for crack elements are proposed in deriving the Galerkin and the collocation techniques of HT BEM. Then two auxiliary functions are introduced to improve the accuracy of the displacement field near the crack tips, and stress intensity factor （SIF） is evaluated by local crack elements as well. Furthermore, numerical examples are given, including comparisons of the present results with the analytical solution and the other numerical methods, to demonstrate the efficiency for different boundary conditions and to illustrate the convergence influenced by several parameters. It shows that HT BEM by usingthe Galerkin and the collocation techniques is effective for mode III fracture problems.

关键词： Hybrid Trefftz method. Galerkin technique .Point-collocation technique .Mode III fracture

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