检索结果-南通市图书馆

Coexistence of meningioma and other intracranial benign tumors in non-neurofibromatosis type 2 patients:A case report and review of literature

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2022年第13期10卷 4249-4263页

作者： Tian-Hao Hu Run Wang Hai-yun Wang Yi-Fu Song juan-han yu Zi-Xun Wang yu-Zhou Duan Ting Liu Sheng han Department of Neurosurgery The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Department of Pathology China Medical UniversityShenyang 110001Liaoning ProvinceChina Department of Radiology The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina

BACKGROUND The coexistence of meningioma and other intracranial primary benign tumors is rare,especially in non-neurofibromatosis type 2,and there is limited guidance for the management of such ***,we report a series of 5 patients with concomitant meningioma and other intracranial benign tumors,including subependymoma and pituitary *** SUMMARY Five non-neurofibromatosis type 2 patients with simultaneous occurrence of meningioma and other intracranial benign tumors were retrospectively *** patients had no history of previous *** clinical features,pre-and postoperative imaging,surgical procedure and pathological findings were extracted from electronic medical *** were 4 female patients(80%)and 1 male patient(20%).The mean age was 42.8 years(range:29-52 years).The coexisting tumors included subependymoma in 1 case(20%)and pituitary adenoma in 4 cases(80%).The most common clinical symptom was headache(3/5,60%).Four patients(80%)underwent *** patient(20%)underwent transsphenoidal surgery followed by transcranial *** tumor diagnoses were confirmed by histopathological *** mean follow-up was 38.8 mo(range:23-96 mo),and all 5 patients were in a stable condition at the last *** The simultaneous occurrence of meningioma and other intracranial benign tumors is a rare clinical *** examination is necessary for the accurate *** should select the appropriate surgical strategy according to the clinical features of each patient,which may provide a more favorable prognosis for individual patients.

关键词： Meningioma Sub-ependymoma Pituitary adenoma Coexisting tumors Case report

超深层油气藏石油地质特征及其成藏主控因素分析

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

石油实验地质 2016年第5期38卷 635-640页

作者：黄娟叶德燎韩彧中国石化石油勘探开发研究院无锡石油地质研究所江苏无锡214126

由于区域地质背景的不同,根据前人的研究成果,确定了超深层油气藏为大于6 km的埋深。对超深层油气藏的烃源岩、储集层、盖层和圈闭等的研究发现:与一般烃源岩相比,超深层油气藏的烃源岩成熟期晚、成熟度较高,生烃作用除了受温度和时间... 详细信息

由于区域地质背景的不同,根据前人的研究成果,确定了超深层油气藏为大于6 km的埋深。对超深层油气藏的烃源岩、储集层、盖层和圈闭等的研究发现:与一般烃源岩相比,超深层油气藏的烃源岩成熟期晚、成熟度较高,生烃作用除了受温度和时间的控制外,还受压力作用的影响,超压对有机质热演化和生烃过程有着强烈的抑制作用;储集层主要以次生孔隙为主,年代偏老,储集层岩性中,碳酸盐岩所占比例达33%;盖层主要为盐岩、泥质岩;圈闭类型主要为构造圈闭、岩性圈闭、礁和复合圈闭。超深层油气藏主要受地层异常压力分布和温度等因素的控制。对我国超深层油气藏的勘探,可集中于地温梯度较小的地区、超高压体系内的次生孔隙和裂缝发育带、深层海相碳酸盐岩区、盐下地层和东部海域的深水区等。

关键词：高温高压超深层油气成藏石油地质

Stiffness-tunable biomaterials provide a good extracellular matrix environment for axon growth and regeneration

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第5期20卷 1364-1376页

作者： Ronglin han Lanxin Luo Caiyan Wei Yaru Qiao Jiming Xie Xianchao Pan juan Xing Department of Pathophysiology School of Basic Medical SciencesSouthwest Medical UniversityLuzhouSichuan ProvinceChina Department of Medicinal Chemistry School of PharmacySouthwest Medical UniversityLuzhouSichuan ProvinceChina

Neuronal growth, extension, branching, and formation of neural networks are markedly influenced by the extracellular matrix—a complex network composed of proteins and carbohydrates secreted by cells. In addition to providing physical support for cells, the extracellular matrix also conveys critical mechanical stiffness cues. During the development of the nervous system, extracellular matrix stiffness plays a central role in guiding neuronal growth, particularly in the context of axonal extension, which is crucial for the formation of neural networks. In neural tissue engineering, manipulation of biomaterial stiffness is a promising strategy to provide a permissive environment for the repair and regeneration of injured nervous tissue. Recent research has fine-tuned synthetic biomaterials to fabricate scaffolds that closely replicate the stiffness profiles observed in the nervous system. In this review, we highlight the molecular mechanisms by which extracellular matrix stiffness regulates axonal growth and regeneration. We highlight the progress made in the development of stiffness-tunable biomaterials to emulate in vivo extracellular matrix environments, with an emphasis on their application in neural repair and regeneration, along with a discussion of the current limitations and future prospects. The exploration and optimization of the stiffness-tunable biomaterials has the potential to markedly advance the development of neural tissue engineering.

关键词： alginate axon growth biomaterials extracellular matrix neural repair neurons neuroregeneration polyacrylamide polydimethylsiloxane stiffness

Effects of Shenqi Xiangyi granules in advanced gastric cancer chemotherapy

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2025年第1期17卷 169-175页

作者： Xiao-Jing Shi yu Song Xue-Xue Liang Ting Chen Huang-yu Hao Xue han Ya-Nan Chen Department of Oncology Zhangjiagang First People's HospitalSuzhou 215600Jiangsu ProvinceChina

BACKGROUND Owing to the absence of specific symptoms in early-stage gastric cancer,most patients are diagnosed at intermediate or advanced *** a result,treatment often shifts from surgery to other therapies,with chemotherapy and targeted therapies being the primary options for advanced gastric cancer treatment.A total of 116 patients with advanced gastric cancer,admitted from January 2021 to December 2023,were selected and divided into two groups of 58 each using the random number table *** control group received FOLFOX4 chemothe-rapy(oxaliplatin+calcium+folinate+5-fluorouracil)combined with intravenous *** observation group received the same treatment as the control group,supplemented by oral administration of Senqi Shiyiwei *** groups underwent treatment cycles of 3 weeks,with a minimum of two *** therapeutic efficacy,immune mechanisms,and treatment-related toxicity and side effects were compared between the *** objective remission rate in the observation group(55.17%)was higher than that of the control group(36.21%)(P0.05).CONCLUSION Adjuvant therapy with Shenqixian granules may enhance the efficacy of simudizumab combined with FOLFOX4 chemotherapy in advanced gastric cancer and the immune function by increasing immune cell counts,making it a valuable option in clinical treatment.

关键词： Sindilizumab FOLFOX4 chemotherapy Advanced gastric cancer Ginseng Qi Xiangyi granule Clinic treatment

Prevalence of Helicobacter pylori infection in Chinese military personnel:A cross-sectional,multicenter-based study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2025年第3期31卷 42-49页

作者： han-Chen Min Chun-Yan Zhang Fang-yu Wang Xiao-Hui yu Shan-Hong Tang Hong-Wu Zhu Ya-Gang Zhao Ji-Luo Liu Jian Wang Jing-han Guo Xiao-Mei Zhang yun-Sheng Yang Chinese People’s Liberation Army Medical School Chinese People’s Liberation Army General HospitalBeijing 100853China Department of Gastroenterology and Hepatology The First Medical CenterChinese People’s Liberation Army General HospitalBeijing 100853China Sixth Healthcare Department The Second Medical CenterChinese People’s Liberation Army General HospitalBeijing 100853China Department of Gastroenterology The 940th Hospital of Joint Logistic Support Force of Chinese People’s Liberation ArmyLanzhou 730050Gansu ProvinceChina Department of Gastroenterology General Hospital of Western Theater CommandChengdu 610011Sichuan ProvinceChina Department of Gastroenterology General Hospital of Southern Theater CommandGuangzhou 510010Guangdong ProvinceChina Department of Epidemiology Naval Medical UniversityShanghai 200433China School of Medicine Nankai UniversityTianjin 300071China National Clinical Research Center for Geriatric Diseases Chinese People’s Liberation Army General HospitalBeijing 100853China

BACKGROUND Helicobacter pylori(***)infection is a prevalent disease encountered in military internal medicine and recognized as the main cause of dyspepsia,gastritis,and peptic ulcer,which are common diseases in military *** guidelines in China state all patients with evidence of active infection with *** are offered ***,the prevalence of *** infection and its regional distribution in the military population remain unclear,which hinders effective prevention and treatment *** the prevalence of *** infection in the military population will aid in the development of customized strategies to better manage this infectious *** To investigate the prevalence of *** infection in the Chinese military population in different geographic *** This multicenter,retrospective study included 22421 individuals from five tertiary hospitals located in north,east,southwest,and northwest cities of *** infection was identified using the urea breath test,which had been performed between January 2020 and December *** Of the 22421 military service members,7416(33.1%)were urea breath *** highest prevalence of *** was in the 30-39 years age group for military personnel,with an infection rate of 34.9%.The majority of infected subjects were younger than 40-years-old,accounting for 70.4%of the infected *** individuals serviced in Lanzhou and Chengdu showed a higher infection prevalence than those in Beijing,Nanjing,and Guangzhou,with prevalence rates of 44.3%,37.9%,29.0%,31.1%,and 32.3%,*** *** infection remains a common infectious disease among military personnel in China and has a relatively high prevalence rate in northwest China.

关键词： Helicobacter pylori Prevalence Military personnel Urea breath test Multicenter study

Development and prospect of near-infrared spectroscopy-assisted schizophrenia diagnosis based on bibliometrics

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Psychiatry 2025年第1期15卷 7-11页

作者： Yan Zhang Hao-yu Xing juan Yan Administration Office Lishui Second People’s HospitalLishui 323060Zhejiang ProvinceChina Department of Medical Engineering The Affiliated Mental Health Center&Hangzhou Seventh People's HospitalZhejiang University School of MedicineHangzhou 310013Zhejiang ProvinceChina Quality Control Office The Affiliated Mental Health Center&Hangzhou Seventh People's HospitalZhejiang University School of MedicineHangzhou 310013Zhejiang ProvinceChina

In this editorial,we comment on the recent article by Fei et al exploring the field of near-infrared spectroscopy(NIRS)research in schizophrenia from a bibliometrics *** recent years,NIRS has shown unique advantages in the auxiliary diagnosis of schizophrenia,and the introduction of bibliometrics has provided a macro perspective for research in this *** the opportunities brought about by these technological developments,remaining challenges require multidi-sciplinary approach to devise a reliable and accurate diagnosis system for ***,NIRS-assisted technology is expected to contribute to the division of methods for early intervention and treatment of schizophrenia.

关键词： Bibliometrics Schizophrenia Near-infrared spectroscopy Diagnostic technique Data analysis

Flexible Graphene Field‑Effect Transistors and Their Application in Flexible Biomedical Sensing

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano-Micro Letters 2025年第2期17卷 252-313页

作者： Mingyuan Sun Shuai Wang Yanbo Liang Chao Wang yunhong Zhang Hong Liu yu Zhang Lin han Institute of Marine Science and Technology Shandong UniversityQingdao 266237ShandongPeople’s Republic of China State Key Laboratory of Crystal Materials Shandong UniversityJinan 250100ShandongPeople’s Republic of China School of Integrated Circuits Shandong UniversityJinan 250100ShandongPeople’s Republic of China Shandong Engineering Research Center of Biomarker and Artificial Intelligence Application Jinan250100ShandongPeople’s Republic of China

Flexible electronics are transforming our lives by making daily activities more *** to this innovation are field-effect transistors(FETs),valued for their efficient signal processing,nanoscale fabrication,low-power consumption,fast response times,and ***,known for its exceptional mechanical properties,high electron mobility,and biocompatibility,is an ideal material for FET channels and *** combination of graphene and FETs has given rise to flexible graphene field-effect transistors(FGFETs),driving significant advances in flexible electronics and sparked a strong interest in flexible biomedical ***,we first provide a brief overview of the basic structure,operating mechanism,and evaluation parameters of FGFETs,and delve into their material selection and patterning *** ability of FGFETs to sense strains and biomolecular charges opens up diverse application *** specifically analyze the latest strategies for integrating FGFETs into wearable and implantable flexible biomedical sensors,focusing on the key aspects of constructing high-quality flexible biomedical ***,we discuss the current challenges and prospects of FGFETs and their applications in biomedical *** review will provide valuable insights and inspiration for ongoing research to improve the quality of FGFETs and broaden their application prospects in flexible biomedical sensing.

关键词： Flexible Graphene Field-effect transistor Wearable Implantable Biosensor

Computed tomography enterography-based radiomics for assessing mucosal healing in patients with small bowel Crohn's disease

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2025年第3期31卷 62-72页

作者： Hao Ding yuan-yuan Fang Wen-Jie Fan Chen-yu Zhang Shao-Fei Wang Jing Hu Wei han Qiao Mei Department of Gastroenterology The First Affiliated Hospital of Anhui Medical UniversityHefei 230022Anhui ProvinceChina Department of Radiation Oncology The First Affiliated Hospital of Anhui Medical UniversityHefei 230022Anhui ProvinceChina Department of Gastroenterology Suzhou First People's HospitalSuzhou 234099Anhui ProvinceChina

BACKGROUND Mucosal healing(MH)is the major therapeutic target for Crohn's disease(CD).As the most commonly involved intestinal segment,small bowel(SB)assessment is crucial for CD ***,it poses a significant challenge due to its limited accessibility through conventional endoscopic *** To establish a noninvasive radiomic model based on computed tomography enterography(CTE)for MH assessment in SBCD *** Seventy-three patients diagnosed with SBCD were included and divided into a training cohort(n=55)and a test cohort(n=18).Radiomic features were obtained from CTE images to establish a radiomic *** demographics were analysed to establish a clinical model.A radiomic-clinical nomogram was constructed by combining significant clinical and radiomic *** diagnostic efficacy and clinical benefit were evaluated via receiver operating characteristic(ROC)curve analysis and decision curve analysis(DCA),*** Of the 73 patients enrolled,25 patients achieved *** radiomic-clinical nomogram had an area under the ROC curve of 0.961(95%confidence interval:0.886-1.000)in the training cohort and 0.958(0.877-1.000)in the test cohort and provided superior clinical benefit to either the clinical or radiomic models alone,as demonstrated by *** These results indicate that the CTE-based radiomic-clinical nomogram is a promising imaging biomarker for MH and serves as a potential noninvasive alternative to enteroscopy for MH assessment in SBCD patients.

关键词： Crohn’s disease Computed tomography enterography Mucosal healing Nomogram Radiomics

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

眼科教学实践中的改革进展

教育教学论坛 2017年第35期 114-115页

作者：李文娟谭涵宇湖南中医药大学湖南长沙410208

在眼科教学过程中,模式已从传统的课堂讲授转化为以问题为基础的教学法,同时,多媒体计算机辅助教学、数据库系统、裂隙灯检眼镜显微镜示教系统、实验解剖等多种现代化的教育方法在眼科教学中也得到了广泛应用。

关键词：眼科教学教学改革 PBL教学循证医学