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Age-induced changes in lung microenvironment: from melanoma dormancy to outgrowth

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Signal Transduction and Targeted Therapy 2023年第2期8卷 333-334页

作者： juan jin Li Li Caiyun Fu Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine College of Life Sciences and MedicineZhejiang Sci-Tech University310018HangzhouChina

In a recent study published in Nature,Mitchell *** et *** the critical role of the aged microenvironment in the reactivation of melanoma cells from dormancy.1 The authors found that age-induced lung fibroblast secretory changes promoted growth activation of dormant melanoma cells in the lung,and age-induced skin microenvironment changes suppressed melanoma growth but promoted melanoma cell dissemination(Fig.1).

关键词： melanoma lung microenvironment

Effect of Potassium on Ultrastructure of Maize Stalk Pith and Young Root and Their Relation to Stalk Rot Resistance

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Agricultural Sciences in China 2010年第10期9卷 1467-1474页

作者： LI Wen-juan HE Ping jin Ji-yun Key Laboratory of Plant Nutrition and Nutrient Cycling Institute of Agricultural Resources and Regional Planning Chinese Academy of Agricultural Sciences Beijing 100081 P.R. China

To study the mechanism of potassium （K） application on improvement of maize resistance to stalk rot at cellular level, scanning electron microscope and transmission electron microscope were used to observe the effect of K on the ultrastructure of maize stalk pith tissue and young root tip cell influenced by K and pathogen. In K deficient treatment, parenchyma cells of stalk pith had abnormal structure, and the cell wall between upper and lower adjacent cell was damaged, resulting in the loss of connections between vascular cells and insufficient supporting capacity. However, an improved K nutrition helped to keep a quite tight arrangement of root cell with thick cell wall, and prevent the invasion of pathogen effectively. Moreover, K treated root cell had abundant golgi apparatus, which could excrete large amount of secretions to degrade mycelium. Papillary and highly electronic intensity dot were accumulated at the invading point to prevent the deveJopment of the mycelium. Improved K nutrition could increase the resistant ability of maize plant to stalk rot, through keeping cell structure stability, preventing the expansion of intracellular space to reduce the chances of pathogen invasions, and through reinforcing cell wall and formation of intercellular and intracellular material to restrict further development of pathogen in host cell.

关键词： potassium (K) maize stalk rot ultrastructure disease resistance

Potential targeted therapy and diagnosis based on novel insight into growth factors,receptors,and downstream effectors in acute kidney injury and acute kidney injury-chronic kidney disease progression

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Signal Transduction and Targeted Therapy 2020年第1期5卷 2373-2383页

作者： Li Gao Xiang Zhong juan jin Jun Li Xiao-ming Meng The Key Laboratory of Major Autoimmune Diseases Anhui Institute of Innovative DrugsSchool of PharmacyAnhui Medical University230032 HefeiChina Department of Nephrology Sichuan Academy of Medical Sciences&Sichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of China610072 ChengduSichuanChina Department of Pharmacology Key Laboratory of Anti-inflammatory and ImmunopharmacologyMinistry of EducationAnhui Medical University230032 HefeiChina

Acute kidney injury(AKI)is defined as a rapid decline in renal function and is characterized by excessive renal inflammation and programmed death of resident *** shows high morbidity and mortality,and severe or repeated AKI can transition to chronic kidney disease(CKD)or even end-stage renal disease(ESRD);however,very few effective and specific therapies are available,except for supportive *** factors,such as epidermal growth factor(EGF),insulin-like growth factor(IGF),and transforming growth factor-β(TGF-β),are significantly altered in AKI models and have been suggested to play critical roles in the repair process of AKI because of their roles in cell regeneration and renal *** recent years,a series of studies have shown evidence that growth factors,receptors,and downstream effectors may be highly involved in the mechanism of AKI and may function in the early stage of AKI in response to stimuli by regulating inflammation and programmed cell ***,certain growth factors or correlated proteins act as biomarkers for AKI due to their sensitivity and ***,growth factors originating from mesenchymal stem cells(MSCs)via paracrine signaling or extracellular vesicles recruit leukocytes or repair intrinsic cells and may participate in AKI repair or the AKI-CKD *** addition,growth factor-modified MSCs show superior therapeutic potential compared to that of unmodified *** this review,we summarized the current therapeutic and diagnostic strategies targeting growth factors to treat AKI in clinical *** also evaluated the possibilities of other growth factorcorrelated molecules as therapeutic targets in the treatment of AKI and the AKI-CKD transition.

关键词： kidney diagnosis inflammation

Targeting methyltransferase-like 5-mediated sphingomyelin metabolism:A novel therapeutic approach in gastric cancer

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World Journal of Gastrointestinal Oncology 2024年第10期16卷 4060-4063页

作者： jin-juan Zhang Chang Yuan Sheng-Chun Dang Department of General Surgery The Affiliated Hospital of Jiangsu UniversityZhenjiang 212001Jiangsu ProvinceChina

Gastric cancer(GC)is a global health problem and a leading cause of cancerrelated deaths,with its mortality rate ranking third among all *** etiology and progression of GC are characterized by a complex interplay of genetic and epigenetic changes,which present challenges for its early diagnosis and effective *** the mechanisms underlying the occurrence and development of GC and identifying novel biomarkers for early detection and prognosis are crucial to improving patient *** editorial examines the role of methyltransferase-like 5(METTL5)in the progression of GC through sphingomyelin metabolism by considering an article published by Zhang et al in the World Journal of Gastrointestinal Oncology in 2024,which is entitled“METTL5 promotes GC progression via sphingomyelin metabolism”.These authors investigated the biological behavior of METTL5 in GC by examining its expression patterns,clinical relevance,functional effect,and potential mechanisms,as well as its response to *** editorial provides valuable insights into the role of METTL5 in the progression of GC and its potential as a therapeutic target.

关键词： Gastric cancer Methyltransferase-like 5 Sphingomyelin metabolism Biomarkers Chemotherapy response

Temperature-regulated self-assembly of lipids at free bubbles interface:A green and simple method to prepare micro/nano bubbles

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Nano Research 2020年第4期13卷 999-1007页

作者： juan jin Fang Yang Bin Li Dong Liu Lihong Wu Yan Li Ning Gu State Key Laboratory of Bioelectronics Jiangsu Key Laboratory for Biomaterials and DevicesSchool of Biological Sciences and Medical EngineeringSoutheast UniversityNanjing 210096China West Anhui University Luan 237012China Anhui Engineering Laboratory for Conservation and Sustainable Utilization of Traditional Chinese Medicine Resources Luan 237012China CSPC Zhongqi Pharmaceutical Technology(SJZ)Co. Ltd.Shijiazhuang 050035China

Micro/nanobubbles play an essential role in ultrasound-based biomedical ***,a green and simple method to fabricate micro/nanobubbles was developed by the temperature-regulated self-assembly of lipids in the presence of free *** self-assembly mechanism of lipids interacting with gas-water interfaces was investigated,and the ultrasound imaging of the obtained lipid-encapsulated bubbles(LBs)was further *** the phase transition temperature(Tm),fluid lipids transform from vesicles to micelles,and further assemble to the free bubbles interface to be a compressed monolayer,resulting in lipid shelled *** below 7m induces the lipid shell to glassy state and stables the ***,increasing the 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000](DSPE-PEG2K)content in lipids formulation can further manipulate the shell curvature and reduce the LBs size into *** with diameters of 1.68±0.11 pm,704±7 nm and 208±6 nm were successfully *** in vitro and in vivo ultrasound imaging results showed that all of the LBs had excellent *** nanosized LBs revealed elongated imaging duration time and greater microvascular details for the liver *** the organic solvent and complicated multiple preparation process,this method has great potential in construction of various multifunctional micro/nanobubbles with size control for theranostic applications.

关键词： lipid self-assembly gas-liquid interface microbubbles nanobubbles ultrasound imaging

Anti-oxidant and Anti-inflammatory Effects of Ethanol Extract from Polygala sibirica *** megalopha *** Lipopolysaccharide-Stimulated RAW264.7 Cells

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Chinese Journal of Integrative Medicine 2023年第10期29卷 905-913页

作者： YANG Cheng-liu WANG Shi-bo HE Wen-ping LIU jin-juan Key Laboratory of Biotechnology for Medicinal Plants of Jiangsu Province School of Life ScienceJiangsu Normal UniversityXuzhouJiangsu Province221116China

Objective To investigate the anti-oxidant and anti-inflammatory effects of ethanol extract of Polygala sibirica *** megalopha Fr.(EEP)on RAW264.7 mouse *** RAW264.7 cells were pretreated with 0–200µg/mL EEP or vehicle for 2 h prior to exposure to 1µg/mL lipopolysaccharide(LPS)for 24 *** oxide(NO)and prostaglandin(PGE2)production were determined by Griess reagent and enzyme-linked immunosorbent assay(ELISA),*** mRNA levels of inducible nitric oxide synthase(iNOS),cyclooxygenase-2(COX-2),tumor necrosis factorα(TNF-α),interleukin-1beta(IL-1β),and IL-6 were determined using reverse transcription polymerase chain reaction(RT-PCR).Western blot assay was used to determine the protein expressions of iNOS,COX-2,phosphorylation of extracellular regulated protein kinases(ERK1/2),c-Jun N-terminal kinase(JNK),inhibitory subunit of nuclear factor Kappa B alpha(IκB-α)and *** was used to observe the nuclear expression of nuclear factor-κB p65(NF-κB p65).Additionally,the anti-oxidant potential of EEP was evaluated by reactive oxygen species(ROS)production and the activities of catalase(CAT)and superoxide dismutase(SOD).The 2,2-diphenyl-1-picrylhydrazyl(DPPH),hydroxyl(OH),superoxide anion(O2−)radical and nitrite scavenging activity were also *** The total polyphenol and flavonoid contents of EEP were 23.50±2.16 mg gallic acid equivalent/100 g and 43.78±3.81 mg rutin equivalent/100 *** EEP treatment(100 and 150µg/mL),there was a notable decrease in NO and PGE2 production induced by LPS in RAW264.7 cells by downregulation of iNOS and COX-2 mRNA and protein expressions(P<0.01 or P<0.05).Furthermore,with EEP treatment(150µg/mL),there was a decrease in the mRNA expression levels of TNF-α,IL-1βand IL-6,as well as in the phosphorylation of ERK,JNK and p38 mitogen-activated protein kinase(MAPK,P<0.01 or P<0.05),by blocking the nuclear translocation of NF-κB p65 in LPS-stimulated *** addition,EEP(100 and 150µg/mL)led

关键词： Polygala sibirica L.var megalopha Fr. anti-inflammatory anti-oxidant RAW264.7 cells lipopolysaccharide Chinese medicine

Drug delivery system based on nanobubbles

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Interdisciplinary Materials 2022年第4期1卷 471-494页

作者： juan jin Li Yang Feng Chen Ning Gu School of Biomedical Engineering and Informatics Nanjing Medical UniversityNanjingP.R.China State Key Laboratory of Bioelectronics Jiangsu Key Laboratory for Biomaterials and DevicesSchool of Biological Sciences and Medical EngineeringSoutheast UniversityNanjingP.R.China

Ultrasound(US)medical technology is widely used due to its advantages of safety,speed,and low *** the rapid development of biomedical nanotechnology,micro/nanobubbles,as US contrast agents,are not only valuable in US imaging diagnosis but also show broad application prospects in drug ***(NBs)have more advantages as drug delivery systems(DDSs)due to their smaller size and longer circulation time compared with *** this review,the fundamentals of NBs,including classification,stability mechanism,and preparation methods are ***,the strategies of a DDS based on NBs,including direct delivery,codelivery,target delivery,and stimuli-responsive delivery are reviewed and *** three main applications of NBs-based DDSs,namely tumor theranostics,brain drug delivery,and vascular disease theranostics were *** challenges and future directions of the NBs-based DDSs are also considered and discussed.

关键词： drug delivery system nanobubbles theranostics ultrasound

An efficient method for the synthesis of thieno[3',2':2,3]pyrido-[4,5-d]-thiazolo[3,2-a]pyrimidinones

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Chinese Chemical Letters 2017年第3期28卷 579-582页

作者： Dao-Lin Wang Dong Wang jin-juan Xing Jian-Hua Qian College of Chemistry and Chemical Engineering Liaoning Key Laboratory of Synthesis and Application of Functional Compound Bahai University Jinzhou 121003 China

An efficient method for the preparation of thieno[3＇,2＇：2,3]pyrido[4,5-d]thiazolo[3,2-a] pyrimidin-5-ones 5 is described. The key intermediate, 7-（3-amino-4-cyano-5-phenyl aminothieno-2-yl）-5H-thiazolo-[80_TD$IF]3,2-a]pyrimidin-5-one（3）, was synthesized from 7-chloromethyl-5H-thiazolo[3,2-a]pyrimidin-5-one（1）with potassium-（2,2-dicyano-1-phenylaminoethen-1-yl）thiolate（2） by Thorpe–Ziegler *** reaction of the intermediate amine with aromatic aldehydes via Pictet–Spengler reaction provided thieno-pyridine fused thiazolo[3,2-a]pyrimidines under p-Ts OH as catalyst in good yields.

关键词： Thiazolo[3 2-a]pyrimidinone Thienopyridothiazolo[3 2-a]pyrimidinone Thorpe–Ziegler isomerization Pictet–Spengler reaction

Recent Progress in Ferroelectric Diodes: Explorations in Switchable Diode Effect

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Nano-Micro Letters 2013年第2期5卷 81-87页

作者： Chen Ge Can Wang Kui-juan jin Hui-bin Lu Guo-zhen Yang Beijing National Laboratory for Condensed Matter Physics Institute of Physics Chinese Academy of Sciences

Switchable diode effect in ferroelectric diodes has attracted much attention for its potential applications in novel nonvolatile memories. We briefly review recent investigations on the switchable diode effect in ferroelectric diodes both experimentally and theoretically. Many recent studies demonstrate that the interfacial barrier between the metal-ferroelectrics could be modulated by the polarization charges, and the ferroelectric polarization that can be reversed by an external electric field plays a dominant role in the switchable diode effect. Moreover, we review a self-consistent numerical model, which can well describe the switchable diode effect in ferroelectric diodes. Based on this model, it can be predicted that it is a better choice to select metals with a smaller permittivity, such as noble metals, to obtain a more pronounced switchable diode effect in ferroelectric diodes.

关键词： Ferroelectric diodes Switchable diode effect Metal/ferroelectrics/metal structure Self-consistent mode