An efficient method for the synthesis of thieno[3',2':2,3]pyrido-[4,5-d]-thiazolo[3,2-a]pyrimidinones

作     者：Dao-Lin Wang Dong Wang Jin-Juan Xing Jian-Hua Qian 

作者机构：College of Chemistry and Chemical Engineering Liaoning Key Laboratory of Synthesis and Application of Functional Compound Bahai University Jinzhou 121003 China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2017年第28卷第3期

页      面：579-582页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：partially supported by innovation team project of Liaoning Province Education Department(No.2015001) 

主　　题：Thiazolo[3 2-a]pyrimidinone Thienopyridothiazolo[3 2-a]pyrimidinone Thorpe–Ziegler isomerization Pictet–Spengler reaction 

摘      要：An efficient method for the preparation of thieno[3＇,2＇：2,3]pyrido[4,5-d]thiazolo[3,2-a] pyrimidin-5-ones 5 is described. The key intermediate, 7-（3-amino-4-cyano-5-phenyl aminothieno-2-yl）-5H-thiazolo-[80_TD$IF]3,2-a]pyrimidin-5-one（3）, was synthesized from 7-chloromethyl-5H-thiazolo[3,2-a]pyrimidin-5-one（1）with potassium-（2,2-dicyano-1-phenylaminoethen-1-yl）thiolate（2） by Thorpe–Ziegler *** reaction of the intermediate amine with aromatic aldehydes via Pictet–Spengler reaction provided thieno-pyridine fused thiazolo[3,2-a]pyrimidines under p-Ts OH as catalyst in good yields.