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Hepatitis C virus-specific cytotoxic T cell response restoration after treatment-induced hepatitis C virus control

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World Journal of Gastroenterology 2015年第12期21卷 3480-3491页

作者： juan-Ramón Larrubia Elia moreno-Cubero Joaquín Miquel Eduardo Sanz-de-Villalobos Translational Hepatology Unit Guadalajara University Hospital University of Alcalá department of Medicine and Medical Specialties University of Alcalá department of Biology of Systems University of Alcalá

Hepatitis C virus(HCV)-specific cytotoxic T cell(CTL) response plays a major role in viral control during spontaneous infection resolution. These cells develop an exhausted and pro-apoptotic status during chronic onset, being unable to get rid of HCV. The role of this response in contributing to sustained viral response(SVR) after anti-HCV is controversial. Recent studies show that after successful interferon-based anti-HCV treatment, HCV traces are still detectable and this correlates with a peak of HCV-specific CTL response activation, probably responsible for maintaining SVR by subsequent complete HCV clearing. Moreover, SVR patients' serum is still able to induce HCV infection in na?ve chimpanzees, suggesting that the infection could be under the control of the immune system after a successful treatment, being transmissible in absence of this adaptive response. At least theoretically, treatmentinduced viral load decrease could allow an effective HCV-specific CTL response reestablishment. This effect has been recently described with anti-HCV interferonfree regimes, based on direct-acting antivirals. Nevertheless, this is to some extent controversial with interferon-based therapies, due to the detrimental immunoregulatory α-interferon effect on T cells. Moreover, HCV-specific CTL response features during anti-HCV treatment could be a predictive factor of SVR that could have clinical implications in patient management. In this review, the recent knowledge about the role of HCV-specific CTL response in the development of SVR after anti-HCV treatment is discussed.

关键词： Hepatitis C virus Chronic hepatitis Hepatitis C vi

Acute kidney injury in severely injured patients admitted to the Intensive Care Unit

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Military Medical Research 2021年第2期8卷 141-147页

作者： Alberto F.García Ramiro Manzano-Nunez juan G.Bayona Maria P.Naranjo dary Neicce Villa Manuel moreno Sebastian Ossa juan M.Martinez Nathalia Martinez juan C.Puyana division of Trauma and Acute Care Surgery Department of SurgeryFundación Valle del LiliCaliColombia Clinical Research Center Fundación Valle del LiliCaliColombia Escuela de Medicina Ciencias de la SaludUniversidad del RosarioCarrera 98#18-49760001BogotaColombia Méderi Hospital Universitario Mayor Colombia School of Medicine Universidad ICESI(ICESI University)CaliColombia department of Surgery University of PittsburghPittsburghPAUSA

Background:Our objective was to identify possible associations between clinical and laboratory variables and the risk of developing acute kidney injury(AKI)in severely injured patients admitted to the Intensive Care Unit(ICU)for whom creatine kinase(CK)levels were ***:For this retrospective observational study,we analyzed adult trauma patients admitted to the ICU from 2011 to 2015 at Fundación Valle del Lili(FVL)University *** primary outcome was the incidence of *** regression analysis was used to assess risk factors for this ***:A total of 315 patients were *** trauma mechanisms were blunt(n=130),penetrating(n=66)and blast(n=44)*** median[interquartile range,(IQR)of injury severity score(ISS)was 21(16–29).AKI developed in 75 patients(23.8%).Multivariate regression analysis revealed that the thoracic abbreviated injury scale(AIS)value(median(IQR)in the AKI group:3(0–4)],Acute Physiology and Chronic Health Evaluation(APACHE Ⅱ)score[median(IQR)in the AKI group:18(10–27)],CK greater than 5000 U/L,lactic acid concentration at admission,and dobutamine administration were independently associated with ***:We found that age,APACHE Ⅱ score,thoracic trauma,lactic acidosis,and dobutamine administration were independently associated with *** surgeons need to be aware of the increased odds of AKI if one of these factors is identified during the evaluation and treatment of injured patients.

关键词： Rhabdomyolysis Wounds and injuries Acute kidney injury Critical care Trauma

A Transactive Energy Model for Smart Metering Systems Using Blockchain

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CSEE Journal of Power and Energy Systems 2021年第5期7卷 943-953页

作者： juan C.Olivares-Rojas Enrique Reyes-Archundia Jose A.Gutierrez-Gnecchi Ismael Molina-moreno Jaime Cerda-Jacobo Arturo Mendez-Patino National Technological Institute of Mexico/Technological Institute of Morelia-division of Graduate Studies and Research MoreliaMichoacan 58120Mexico. School of Electrical Engineering Michoacan University of San Nicolas de HidalgoMorelia 58030.Mexico

The lowering cost of electricity generation technologies by renewable means has caused the role of end-users to change from being a simple consumer to a producer of their *** new role has been called a prosumer and has contributed to modifying electricity markets,by allowing prosumers to merchandize the energy surplus to electricity companies and other *** fundamental key to any economic transaction is trust between the ***,new technologies,such as blockchain,are transforming transaction security,and allowing decentralization of the smart power *** study presents the development of a transactional model of electrical energy using the infrastructure of smart metering and blockchain systems to allow the commercialization of electrical energy by *** results show that for the Mexican electricity market,they can he good alternatives hy reducing subsidies and being more profitable than current rates.

关键词： data visualization fault diagnosis IoT network photovoltaic system wireless remote monitoring

Scale dependency of Liolaemus lizards＇ home range in response to different environmental variables

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Current Zoology 2016年第6期62卷 521-530页

作者： Oscar Anibal STELLATELLI Carolina BLOCK debora Lina moreno-AZOCAR Laura Estela VEGA juan Pablo ISACCH Felix Benjamin CRUZ Laboratorio de Vertebrados Departamento de Biologia Instituto de Investigaciones Marinas y Costeras (IIMyC) CONICET-Facultad de Ciencias Exactas y Naturales Universidad Nacional de Mar del Plata. Defin Funes 3250 (B7602AYJ) Mar del Plata Buenos Aires Argentina Instituto de Investigaciones en Biodiversidad y Medioambiente (INIBIOMA) CONICET-Universidad Nacional del Comahue. Quintral 1250 (8400) San Carlos de Bariloche Rio Negro Argentina.

Animal habitat-use patterns cannot be isolated from scale issues. Consequently, multi-scale studies provide a complete characterization of ecological patterns that can further explain the observed variation. Liolaemus constitutes the world＇s second most speciose lizard genus. In this study, we assessed the relationships between home range size and environmental variables at 3 different spatial scales. The study at a local and regional scale was focused on the habitat specialist Liolaemus multimaculatus. The lizard＇s home range was calculated using the minimum convex polygon method in populations from grassland sites of the coastal sand dunes of the Argentinean Pampas under 2 different conditions, with or without forestations of Acacia Iongifolia. On the other hand, at a geographical scale we considered the evolutionary implications of 20 species of Liolaemus. Home range size, phylogeny, ecological, environmental, and climatic data were ob- tained from the literature and remote sensing. L. multimaculatus home range varied from 12.66 to 570.00 m. Regionally, this species had smaller home ranges in forested habitats （X： 94.02 m2） com- pared with the non-forested sites （X： 219.78m2）. Habitat structure, vegetation types, and food availability would explain the space use at finer scales. When the 20 species of Liolaernus were considered, high mean air temperature and broad thermal amplitudes showed an inverse relationship with home range size. Neither net primary productivity nor phylogeny was good predictors for home range variation at geographical scale. This study highlights the scale dependence of the explicative capability of a set of environmental and intrinsic variables on home range patterns.

关键词： environmental factors home range Liolaemus lizard scales

Three-dimensional acoustic propagation model for shallow waters based on an indirect boundary element method

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Chinese Physics B 2023年第5期32卷 485-495页

作者： Edmundo F.Lavia juan d.Gonzalez Silvia Blanc Acoustic Propagation department Argentinian Navy Research Office(DIIV)Buenos Aires 1638Argentina UNIdEF(National Council of Scientific and Technical Research/Ministry of defense) Buenos AiresArgentina

This work has a two-fold *** the one hand,the theoretical formulation of a three-dimensional(3d)acoustic propagation model for shallow waters with a constant sound speed is presented,based on the boundary element method(BEM),which uses a half-space Green function instead of the more conventional free-space Green *** the other hand,a numerical implementation is illustrated to explore the formulation in simple idealized cases,controlled by a few parameters,which provides necessary tests for the accuracy and performance of the *** half-space Green's function,which has been previously used in scattering and diffraction,adds terms to the usual expressions of the integral operators without altering their continuity *** against the wavenumber integration solution of the Pekeris waveguide suggest that the model allows an adequate prediction for the acoustic ***,numerical experiments in relation to the necessary mesh size for the description of the water-marine sediment interface lead to the conclusion that a transmission loss prediction with acceptable accuracy can be obtained with the use of a limited mesh around the desired evaluation region.

关键词： three-dimensional acoustic propagation boundary element method half-space Green function

Effectiveness of statins *** on reducing postprandial hypertriglyceridemia in dyslipidemic population:A systematic review and network meta-analysis

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Journal of Sport and Health Science 2022年第5期11卷 567-577页

作者： Laura Alvarez-Jimenez Alfonso moreno-Cabanas Miguel Ramirez-Jimenez Felix Morales-Palomo juan FOrtega Ricardo Mora-Rodriguez Exercise Physiology Lab at Toledo Sports Science DepartmentUniversity of Castilla-La ManchaToledo 45004Spain

Background:Individuals at risk of suffering cardiovascular disease(CVd) present with larger increases in blood trigyceride(TG) concentration after a high-fat meal than do healthy *** postprandial hypertriglyceride levels are an independent risk factor for *** of statins and a bout of prolonged exercise are both effective in lowering postprandial hypertriglyceride *** aimed to evaluate the comparative effectiveness of statins vs.a bout of aerobic exercise in reducing fasting and postprandial TG(PPTG) concentrations in indiv、duals at high nsk of developing ***:Thirty-seven sltudies from a systematic literature search of the PubMed,EMBASE,and Cochrane databases were included in this *** selected studies conducted trials involving statin therapy(n=20) or a bout of aerobic exercise(n=19) and measured their impact on PPTG levels as the *** studies analyzed both treatments and were included in *** meta-analysis was constructed using a random-effects model to calculate the mean difference(Md).The Student t test was used to compare the data sets for statins ***:Overall,statin and exercise interventions showed similar reductions in PPTG levels,with an Md of-0.65 mmol/L for statins(95% confidence interval(95%CI):-0.54 to-0.77;p d-0.46 mmol/L for exercise(95%CI:-0.21 to-0.71;p d fasting TG levels more than exercise(Md=-1.54 mmol/L,95%CI:-2.25 to-0.83;p=0.009).Conclusion:Although aerobic exercise is effective in lowering blood TG levels,statins seem to be more efficient,especially in the fasted state.A combination of exercise and statins might reveal a valuable approach to the treatment and prevention of *** studies are required to determine the underlying mechanisms and the possible additive effects of these interventions.

关键词： Aerobic exercise Cardiovascular disease Hydroxymethylglutaryl-CoA reductase inhibitor Meta-analysis Metabolic syndrome

In the era of rapid mRNA-based vaccines:Why is there no effective hepatitis C virus vaccine yet?

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World Journal of Hepatology 2021年第10期13卷 1234-1268页

作者： Natalia Echeverria Victoria Comas Fabian Aldunate Paula Perbolianachis Pilar moreno juan Cristina Laboratorio de Virologia Molecular Centro de Investigaciones NuclearesFacultad de CienciasUniversidad de la RepublicaMontevideo 11400Uruguay Laboratorio de Evolucion Experimental de Virus Institut PasteurMontevideo 11400Uruguay departamento de desarrollo Biotecnologico Instituto de HigieneFacultad de MedicinaUniversidad de la RepublicaMontevideo 11600Uruguay

Hepatitis C virus(HCV)is responsible for no less than 71 million people chronically infected and is one of the most frequent indications for liver transplanta-tion *** direct-acting antiviral therapies fuel optimism in controlling HCV infections,there are several obstacles regarding treatment accessibility and reinfection continues to remain a ***,the majority of new HCV infections in developed countries occur in people who inject drugs and are more plausible to get *** achieve global epidemic control of this virus the development of an effective prophylactic or therapeutic vaccine becomes a *** coronavirus disease 19(COVId-19)pandemic led to auspicious vaccine development against severe acute respiratory syndrome coronavirus-2(SARSCoV-2)virus,which has renewed interest on fighting HCV epidemic with *** aim of this review is to highlight the current situation of HCV vaccine candidates designed to prevent and/or to reduce HCV infectious cases and their *** will emphasize on some of the crossroads encountered during vaccine development against this insidious virus,together with some key aspects of HCV immunology which have,so far,ham-pered the progress in this *** main focus will be on nucleic acid-based as well as recombinant viral vector-based vaccine candidates as the most novel vaccine approaches,some of which have been recently and successfully employed for SARS-CoV-2 ***,some ideas will be presented on which methods to explore for the design of live-attenuated vaccines against HCV.

关键词： Hepatitis C virus Vaccine candidates Nucleic acid-based vaccines Recombinant vector-based vaccines Challenges COVId-19

Evaluation of drought indices to identify tolerant genotypes in common bean bush(Phaseolus vulgaris L.)

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Journal of Integrative Agriculture 2020年第1期19卷 99-107页

作者： Alefsi david SáNCHEZ-REINOSO Gustavo Adolfo LIGARRETO-moreno Hermann RESTREPO-díAZ departamento de Agronomía Universidad Nacional de Colombia

drought is one of the major abiotic stresses often causing negative impacts on bean crops in the Andean region in Colombia. An experiment under the greenhouse conditions was carried out to assess the effect of a prolonged drought period(15 days) at two different phenological stages(vegetative or reproductive) on grain yield and yield components of five bush bean cultivars(ICA-Cerinza, Bachue, NUA35, Bianca, and Bacatá). Nine tolerance indices including stress susceptibility index(SSI), tolerance(TOL), mean productivity(MP), geometric mean productivity(GMP), stress tolerance index(STI), yield stability index(YSI), yield index(YI), Harmonic mean(HM), and drought sensitivity index(dSI) were calculated based on grain yield under non-stressed(YP) and drought(YS) conditions. Based on the different drought indices, genotypes ICA-Cerinza and NUA35 had the best performance under drought conditions in both studied phases, which reflected in a reduction of grain yield ~≤40%. The biplot analysis also showed a clear superiority of these two genotypes at both phenological stages. Results also showed that SSI was more effective to identify genotypes less affected by drought. The above results allowed us to conclude that ICA-Cerinza and NUA35 may be considered for agricultural areas where long periods of water deficit are expected and can be used in breeding programs for drought tolerance.

关键词： yield components selection indices correlation biplot analysis

Lesser kestrels of the same colony do not overwinter together

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Current Zoology 2024年第4期70卷 505-512页

作者： Jorge Garcia-Macia Munir Chaouni Sara Morollon Javier Bustamante Lina Lopez-Ricaurte juan Martinez-dalmau Beatriz Rodriguez-moreno Vicente Urios Grupo de Investigacion Zoologia de Vertebrados Universidad de AlicanteApdo.99E-03080 AlicanteSpain department of Wetland Ecology Estacion Biologica de Donana(CSIC)C/Americo Vespucio 2641092SevillaSpain GREFA C/MontedelPilarS/NE-28220MajadahondaMadridSpain

Migratory connectivity describes the linkage between breeding and nonbreeding sites,having major ecological implications in birds:1 season influence the success of an individual or a population in the following *** studies on migratory connectivity have used large-scale approaches,often considering regional populations,but fine-scale studies are also necessary to understand colony *** lesser kestrel Falco naumanni,an insectivorous migratory raptor which form colonies during the breeding period,was considered to have strong connectivity based on regional ***,no small-scale studies on migratory connectivity have been ***,we GPS(Global Positioning System)-tracked 40 adult lesser kestrels from 15 different Spanish breeding colonies,estimating the overlap index between home ranges and the distance between their *** was found that lesser kestrels from the same breeding colony placed their nonbreeding areas at 347±281 km(mean±standard deviation)away from each other(range=23-990),and their home ranges over-lapped by 38.4±23.6%.No differences between intra-colony and inter-colony metrics were found,which suggests that lesser kestrels from the same breeding cluster do not overwinter together,but they spread out and mixed independently of the colony belonging throughout the nonbreeding range of the ***,this study highlights the importance of performing connectivity studies using fine-scale approaches.

关键词： Falco naumanni GPS telemetry migratory connectivity nonbreeding raptor spatial ecology wintering.