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Hypothalamic-pituitary-adrenal axis function during perinatal depression

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Neuroscience Bulletin 2015年第3期31卷 338-350页

作者： Phillipe Leff Gelman Mónica Flores-Ramos Margarita López-Martínez carlos Cruz Fuentes juan Pablo Reyes Grajeda National Institute of Perinatology Mexico City National Council of Sciences and Technology (CONACy T) Mexico City National Institute of Psychiatry Mexico City National Institute of Genomic Medicine Mexico City

Abnormal function of the hypothalamic-pituitary-adrenal （HPA） axis is an important pathological finding in pregnant women exhibiting major depressive disorder. They show high levels of cortisol pro- inflammatory cytokines, hypothalamic-pituitary peptide hormones and catecholamines, along with low dehydroepiandrosterone levels in plasma. During pregnancy, the TH2 balance together with the immune system and placental factors play crucial roles in the development of the fetal allograft to full term. These factors, when altered, may generate a persistent dysfunction of the HPA axis that may lead to an overt transfer of cortisol and toxicity to the fetus at the expense of reduced activity of placental 1113-hydroxysteroid dehydrogenase type 2. Epigenetic modifications also may contribute to the dysregulation of the HPA axis. Affective disorders in pregnant women should be taken seriously, and therapies focused on preventing the deleterious effects of stressors should be implemented to promote the welfare of both mother and baby.

关键词： brain depression neuroendocrine pregnancy stress glucocorticoids

High prevalence of viable Mycobacterium avium subspecies paratuberculosis in Crohn's disease

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World Journal of Gastroenterology 2010年第36期16卷 4558-4563页

作者： juan L Mendoza Amparo San-Pedro Esther Culebras Raquel Cíes carlos Taxonera Raquel Lana Elena Urcelay Fernando de la Torre juan J Picazo Manuel Díaz-Rubio Department of Gastroenterology Hospital Clinico San Carlos28040 MadridSpain Department of Clinical Microbiology Hospital Clinico San Carlos28040 MadridSpain Department of Internal Medicine Hospital Clinico San Carlos28040 MadridSpain Department of Immunology Hospital Clinico San Carlos28040 MadridSpain

AIM:To examine the detection rate of viable Mycobacterium avium subspecies paratuberculosis(MAP) in patients with inflammatory bowel disease [Crohn's disease(CD) and ulcerative colitis(UC)].METHODS:Thirty patients with CD(15 with at least one NOD2/CARD15 mutation),29 with UC,and 10 with no inflammatory bowel disease(IBD).were tested for MAP by polymerase chain reaction(specific IS900 fragment) and blood ***:MAP DNA was detected in all original blood samples and 8-wk blood cultures(CD,UC and non-IBD).Positive MAP DNA status was confirmed by dot blot *** 69 cultures were negative by acid-fast Ziehl-Neelsen *** MAP,in spheroplast form,was isolated from the 18-mo blood cultures of all 30 CD patients,one UC patient,and none of the non-IBD *** association was found between positive MAP cultures and use of immunosuppressive drugs or CDassociated single nucleotide ***:MAP is widely present in our area and MAP DNA can be recovered from the blood of CD,UC and non-IBD ***,MAP spheroplasts were only found in CD patients.

关键词： Mycobacterium avium subspecies paratuberculosis Crohn’s disease Ulcerative colitis Inflammatory bowel disease Polymerase chain reaction Genetic susceptibility

Amphibians and Reptiles of Luzon Island, Philippines: the Herpetofauna of Pantabangan-Carranglan Watershed, Nueva Ecija Province, Caraballo Mountain Range

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Asian Herpetological Research 2018年第4期9卷 201-223页

作者： Paul Henric P. GOJO CRUZ Leticia E.AFUANG juan carlos T. GONZALEZ William SM.GRUEZO Faculty Department of Biological Sciences College of Arts and Sciences Central Luzon State University Faculty Animal Biology Division Institute of Biological Sciences College of Arts and Sciences University of the Philippines Los Ba?os Adjunct Faculty Graduate School University of the Philippines Los Ba?os

We present detailed species accounts for fifty-nine(59) species of amphibians and reptiles(17 frogs, 14 skinks, 3 agamids, 6 gekkonid lizards, 2 varanids, and 17 snakes) from Pantabangan-Carranglan Watershed, which lies within the Caraballo Mountain Range, whose biota is poorly-known. This was also the first extensive survey of herpetofauna within the watershed. Together with data from previous literature reviews, our records bring the total number of species of amphibians and reptiles for the Caraballo Mountain Range to 66. Forty-two(42) species from the area were Philippine endemics, with 25 species recorded only from Luzon faunal region. Seven species of herpetofauna are associated with unresolved taxonomic issues(new species and species complexes needing taxonomic partitioning, e.g. splitting of species groups). Two species recorded from the area were rarely represented in museum collections. Major distributional and elevational range extensions were recorded for several species. Comparison with Luzon’s other mountain ranges showed that the Caraballo Mountain Range is similar, in terms of species composition, to the northern Sierra Madre and Cordillera Mountain Ranges. The result of this survey showed the Caraballo Mountain Range and its mountains as a possible new center of herpetofaunal diversity and endemicity within Luzon. The importance of the Caraballo Mountain Range as an important biogeographic link merits further study.

关键词： Caraballo mountain range diversity ecology habitat herpetofauna

Sandy seepage faces as bioactive nitrate reactors:Biogeochemistry,microbial ecology and metagenomics

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Geoscience Frontiers 2023年第3期14卷 74-89页

作者： Shan Jiang Jie Jin Yongjun Wei Ying Wu Yixue Zhang carlos Rocha juan Severino Pino Ibánhez Guosen Zhang Jing Zhang State Key Laboratory of Estuarine and Coastal Research East China Normal UniversityShanghai 200241China School of Pharmaceutical Sciences Key Laboratory of State Ministry of EducationKey Laboratory of Henan Province for Drug Quality Control and EvaluationCollaborative Innovation Center of New Drug Research and Safety EvaluationZhengzhou UniversityZhengzhou 450001HenanChina Biogeochemistry Research Group School of Natural SciencesTrinity College DublinDublin 2Ireland Instituto de Investigacións Mariñas Consejo Superior de Investigaciones Científicas(IIM-CSIC)Eduardo Cabello 636208 VigoSpain School of Oceanography Shanghai Jiao Tong UniversityShanghai 200040China

Subterranean estuaries are highly dynamic in processing dissolved inorganic nitrogen(DIN).Here we investigate DIN turnover in surface sediments(0–20 cm depth)at the higher,medium and lower intertidal of a seepage face,i.e.,the outer “mouth”of the subterranean estuary,during four consecutive seasons in Sanggou Bay,*** the studied period,ammonium(NH_(4)^(+))and nitrite(NO_(2)^(-))concentrations in the sampled porewaters did not vary significantly with depth or *** contrast,peaks in porewater nitrate(NO_(3)^(-))concentration and decreases in δ^(15)N-NO_(3)^(-) and δ^(18)O-NO_(3)^(-) were observed in the 15–20 cm depth(bottom)sediment,particularly during summer and *** with NO_(3)^(-) production,the sediment total nitrogen was also markedly peaking in the bottom layer of the studied seepage *** with abundant heterotrophic microbes in the sediment,this NO_(3)^(-) accumulation was linked to a reaction chain including organic matter decomposition,ammonification and *** winter,porewater enrichment in total nitrogen occurred closer to the surface of the seepage face but triggered also active NO_(3)^(-) *** pattern reinforced the importance of pelagic organic matter supply on NO_(3)^(-) *** the shallower depths of the seepage face(<12 cm),active net NO3removal occurred except in *** isotopic fractionation(δ^(15)N-NO_(3)^(-) and δ^(18)O-NO_(3)^(-) and metagenomic results revealed denitrification as the main pathway for NO_(3)^(-) *** assimilation from benthic primary producers may also consume a fraction of NO_(3)^(-) at the sediment water *** NO_(3)^(-) production and removal significantly varied in magnitude with season(13.6 to 6.2 nmol cm^(-3)h^(-1)).Substrate supply was the key driver for nitrate cycling,as evidenced by the high NO3production rate in spring by comparison to *** highest NO_(3)^(-) turnover rates were found in summer,suggesting the comb

关键词： Benthic microbiota Nitrate Stable isotopes Subterranean estuary Denitrification

Biliary tract reconstruction using jejunal tube:an experimental study in dogs

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Hepatobiliary & Pancreatic Diseases International 2009年第2期8卷 179-185页

作者： Eliane Anrain Trentini Eduardo Crema juan carlos Llanos Mauro Masson Lerco Luiz Alberto Magna Luiz Sergio Leonardi State University of Campinas Faculty of Medical SciencesDepartment of Surgery Federal University of Triangulo Mineiro So Paulo State University "Júlio de Mesquita Filho" Faculty of Medicine of BotucatuDepartment of Surgery and Orthopedics

BACKGROUND:To physiologically reconstruct the biliary tract,Crema et al suggested the application of the Monti principle to the biliary tract,already used in humans for the urinary *** this technique,a jejunal segment is transversely *** study aimed to evaluate the efficacy of jejunal tube interposition between the common bile duct and duodenum in ***:Thirteen dogs underwent a laparoscopic common bile duct ligature,followed by a biliodigestive connection by jejunal tube interposition after one *** levels of glutamic-pyruvic and glutamic-oxalacetic transaminases,total bilirubins,alkaline phosphatase and gamma-glutamyltransferase were assessed before surgery and thereafter weekly until euthanasia,which was performed 6 weeks after biliodigestive ***:Data on 9 dogs were analyzed *** dogs presented with obstructive jaundice after common bile duct ligature,as confirmed by biochemical *** showed a statistically significant reduction in cholestasis after biliodigestive connection by jejunal tube interposition and were healthy until the end of the ***:A statistically significant reduction was seen in total bilirubin and canalicular enzymes(alkaline phosphatase and gamma-glutamyltransferase)in the 9 dogs 6 weeks after biliodigestive connetion by jejunal tube interposition.

关键词： biliary tract surgical procedures monti principle obstructive jaundice

Spectroscopic signatures of edge states in hexagonal boron nitride

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Nano Research 2019年第7期12卷 1663-1667页

作者： Chuang Gao Lei Tao Yu-Yang Zhang Shixuan Du Sokrates T. Pantelides juan carlos Idrobo Wu Zhou Hong-Jun Gao School of Physical Sciences and CAS Key Laboratory of Vacuum Physics University of Chinese Academy of SciencesBeijing 100049China Institute of Physics Chinese Academy of SciencesBeijing 100190China Department of Physics and Astronomy and Department of Electrical Engineering and Computer Science Vanderbilt UniversityNashvilleTN 37235USA CAS Centre for Excellence in Topological Quantum Computation University of Chinese Academy of SciencesBeijing 100049China Center for Nanophase Materials Sciences Oak Ridge National LaboratoryOak RidgeTN 37831USA

We use Z-contrast imaging and atomically resolved electron energy-loss spectroscopy on an aberration-corrected scanning transmission electron microscope to investigate the local electronic states of boron atoms at different edge structures in monolayer and bilayer *** find that edges with bonding unsaturated sp2 boron atoms have a unique spectroscopic signature with a prominent pre-peak at - 190.2 eV in the B K-edge fine ***-principles calculations reveal that the observed pre-peak arises from excitations to the in-plane lowest-energy empty sp2 boron dangling bonds at the B-terminated *** spectroscopic signature can serve as a fingerprint to explore new edge structures in h-BN.

关键词： h-BN edge structure spectroscopic signatures electron energy-loss near edge structure

“Naturalidad y sencillez,el sello de la poesía china”

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今日中国（西文版） 2022年第1期 74-75页

作者： juan carlos AGUILAR 不详

El mexicano Miguel Cuautle publicaráen chino su poemario El suicidio del *** el poeta mexicano Manuel Cuautle(1971),la poesía china tiene dos grandes cualidades que la hacen única:naturalidad y ***ás,dice,“es una... 详细信息

关键词： mex grande mode

45 Years of Diplomatic Relations with Mutual Benefits

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China Today 2016年第11期65卷 40-41页

作者： juan carlos CAPUNAY 不详

Afew months have passed since Pedro Pablo Kuczynski made his first foreign trip as president elect of Peru. He chose China for this maiden state visit in September to highlight the importance of bilateral relations be... 详细信息

关键词： Years of Diplomatic Relations with Mutual Benefits

China’s New Development Philosophy

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China Today 2021年第7期70卷 44-46页

作者： juan carlos CAPUNAY 不详

THIS year marks the first centenary of the founding of the Communist Party of China(CPC).The achievements made by China during the last 100 years are the result of the efforts of several generations of Chinese people under the leadership of the CPC,which has tasked itself with the mission to seek happiness for the Chinese people and rejuvenation for the Chinese nation since its birth.

关键词： founding Communist leadership