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Transparency and reporting characteristics of randomized controlled trials with chinese herbal medicine formulas interventions

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FRONTIERS OF MEDIcINE 2024年第4期18卷 757-761页

作者： Wang, juan Shi, Dongni Wang, Yaochen Zhang, Xuanqi Li, Han Wang, Xihong Luo, Shufeng Hu, Lihan Deng, Jiashuai Zhang, Lin Lau, chung Tai cheng, chung Wah Han, Fei Li, Ji Wang, Ping Lyu, Aiping Bian, Zhaoxiang Zhang, Xuan Hong Kong Baptist Univ Inst Res & Continuing Educ Shenzhen 518057 Peoples R China Hong Kong Baptist Univ Chinese EQUATOR Ctr Hksar 999077 Peoples R China Hong Kong Baptist Univ Sch Chinese Med Hksar 999077 Peoples R China Hong Kong Baptist Univ Ctr Chinese Herbal Med Drug Dev Hksar 999077 Peoples R China Tianjin Univ Tradit chinese Med Sch Tradit Chinese Med Tianjin 301617 Peoples R China Beijing Univ chinese Med Sch Chinese Med Beijing 100105 Peoples R China china Acad chinese Med Sci Guanganmen Hosp Dept Pediat Beijing 100053 Peoples R China china Acad chinese Med Sci Xiyuan Hosp Beijing 100091 Peoples R China

Transparency and reporting characteristics of randomized controlled trials with chinese herbal medicine formulas interventions

关键词： Transparency reporting characteristics trials herbal medicine

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中国创新驱动水平测度、地区差异与动态演进

统计与决策 2024年第4期40卷 56-61页

作者：唐娟王华秦放鸣长沙民政职业技术学院商学院长沙417000 唐山师范学院海洋学院河北唐山063000 新疆大学经济与管理学院乌鲁木齐830046

创新驱动是高质量发展的第一动力,文章界定了创新驱动的内涵,明确其内在作用机制,在此基础上概括出认知基础、主体投入、成果产出和环境支撑四大维度。基于四大维度构建创新驱动水平评价指标体系,运用主成分分析法测算出创新驱动水平,... 详细信息

创新驱动是高质量发展的第一动力,文章界定了创新驱动的内涵,明确其内在作用机制,在此基础上概括出认知基础、主体投入、成果产出和环境支撑四大维度。基于四大维度构建创新驱动水平评价指标体系,运用主成分分析法测算出创新驱动水平,并借助Dagum基尼系数和Kernel密度估计方法揭示创新驱动水平的区域差异及演进趋势。结果表明:(1)虽然中国整体创新驱动水平大幅度提高,但是,地区之间的差异也越来越大,东部地区的创新驱动发展水平显著高于中西部地区;(2)各省份间的创新驱动水平差距较大,甚至部分省份的创新驱动水平在某些年份出现倒退的情况;(3)创新驱动的制度保障还不完善,地区之间的技术扩散和转移机制不畅,造成了不同的创新驱动发展路径。

关键词：创新驱动地区差异主成分分析 Kernel密度估计

Identification of the cytochrome P450s responsible for the biosynthesis of two types of aporphine alkaloids and their de novo biosynthesis in yeast

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Journal of Integrative Plant Biology 2024年第8期66卷 1703-1717页

作者： Qishuang Li Xiang Jiao Xinyi Li Wenlong Shi Ying Ma Xiangmei Tan Jingyi Gan Jimei Liu Jian Yang Jian Wang Baolong Jin Tong chen Ping Su Yujun Zhao Yifeng Zhang Jinfu Tang Guanghong cui Yun chen juan Guo Luqi Huang School of Traditional chinese Pharmacy China Pharmaceutical UniversityNanjing 211198China State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs National Resource Center for Chinese Materia MedicaChina Academy of Chinese Medical SciencesBeijing 100700China Department of Life Sciences Chalmers University of TechnologyGothenburg SE-41296Sweden State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijing 100191China State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaThe Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China

Aporphine alkaloids have diverse pharmacological activities;however,our understanding of their biosynthesis is relatively *** studies have classified aporphine alkaloids into two categories based on the configuration and number of substituents of the D-ring and have proposed preliminary biosynthetic pathways for each *** this study,we identified two specific cytochrome P450 enzymes(cYP80G6 and cYP80Q5)with distinct activities toward(S)-configured and(R)-configured substrates from the herbaceous perennial vine Stephania tetrandra,shedding light on the biosynthetic mechanisms and stereochemical features of these two aporphine alkaloid ***,we characterized two cYP719c enzymes(cYP719c3 and cYP719c4)that catalyzed the formation of the methylenedioxy bridge,an essential pharmacophoric group,on the A-and D-rings,respectively,of aporphine *** the functional characterization of these crucial cytochrome P450 enzymes,we reconstructed the biosynthetic pathways for the two types of aporphine alkaloids in budding yeast(Saccharomyces cerevisiae)for the de novo production of compounds such as(R)-glaziovine,(S)-glaziovine,and *** study provides key insight into the biosynthesis of aporphine alkaloids and lays a foundation for producing these valuable compounds through synthetic biology.

关键词： aporphine alkaloids biosynthesis cYP719c cYP80 engineered yeast

盆底康复治疗患者的分布及变化趋势分析:一项基于3033例患者的研究

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实用妇产科杂志 2024年第8期40卷 639-644页

作者：吴纯华刘娟广州医科大学附属第三医院妇产科、广东省产科重大疾病重点实验室、广东省妇产疾病临床医学研究中心、粤港澳母胎医学高校联合实验室广东广州510150

目的:分析接受盆底康复治疗患者的分布及变化特征,探讨其有临床症状的相关影响因素、就诊特征。方法:对2010年1月至2019年12月广州医科大学附属第三医院接受盆底康复治疗患者的年龄、分娩方式、产次、治疗时间等数据进行回顾性分析。结... 详细信息

目的:分析接受盆底康复治疗患者的分布及变化特征,探讨其有临床症状的相关影响因素、就诊特征。方法:对2010年1月至2019年12月广州医科大学附属第三医院接受盆底康复治疗患者的年龄、分娩方式、产次、治疗时间等数据进行回顾性分析。结果:①接受盆底康复治疗患者共3033例,无临床症状者72.8%(2209/3033),近十年呈下降趋势(P=0.000);有临床症状者27.2%(824/3033),呈上升趋势(P=0.000),8类临床症状中尿失禁症状的比例为72.5%(597/824)。②十年间盆底康复治疗患者中,40岁以上患者比例逐年增加(P=0.001);③经阴道分娩的妇女所占比例最高(70.3%),近十年趋势保持平稳(P=0.054)。④十年间盆底康复治疗患者中初产妇占比最高(73.1%),经产妇(产次≥2)的患者有增高趋势(P=0.000);⑤84.8%(2573/3033)患者进行盆底康复治疗距离末次分娩时间<1年,治疗距离末次分娩时间≥1年的患者呈增多的趋势(P=0.002,r=0.855)。⑥年龄≥40岁(OR 10.884,P<0.001)、孕次为3次(OR 1.634,P=0.001)、孕次≥4次(OR 1.908,P<0.001)、产次为2次(OR 1.305,P=0.038)、产次≥3次(OR 2.327,P=0.001)、经阴道分娩(OR 2.079,P<0.001)是已生育接受盆底康复治疗患者有临床症状的独立危险因素。结论:接受盆底康复治疗有临床症状患者中,以尿失禁症状为主,呈增加的趋势;强化对年龄≥40岁、有阴道分娩史、孕次≥3次、产次≥2次的女性早期筛查和干预,对年龄≥40岁、距离末次分娩≥1年的女性可考虑将治疗时间前移。

关键词：女性盆底功能障碍性疾病盆底康复治疗临床特点

Study on Detection of Antibiotic contents in Water around Landfill Sites

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Agricultural Biotechnology 2024年第2期13卷 33-37页

作者： Sha FENG Dandan LIU juan LUO Qing LI Tao MO Zheng LIU Xiaonan ZOU Guangzhou GRG Metrology&Test(Hunan)co. Ltd.Changsha 410007China Anhua Administration for Market Regulation Yiyang 413500China Guizhou Engineering Vocational college Tongren 565200China

[Objectives] An ultra performance liquid chromatography-tandem mass spectrometry (UPLc-MS/MS) method was established for simultaneous determination of 26 antibiotics in the water around landfills. [Methods] After an HLB solid-phase extraction column was activated, and a water sample, which was adjusted with phosphoric acid to a pH of (2±0.5) and added with 500 mg of disodium EDTA, was loaded, and 5 ml of water and 20% methanol water was added for washing. Next, 10 ml of elution solution was added for elution, and the collected eluate was evaporated under reduced pressure at 40 ℃ to near dryness, and 1 ml of reconstitution solution was added to a constant volume. An AcQUITY UPLc BEH c18 (100 mm×2.1 mm, 2.6 μm) chromatographic column was adopted for Lc separation by gradient elution with 0.1% formic acid aqueous solution-acetonitrile as the mobile phase. For MS detection, the MRM mode was adopted for collection, and the positive and negative ion modes were switched for simultaneous determination, and the internal standard method was used for quantification. [Results] The correlation coefficient R2 was greater than 0.99 in the linear range of each target substance. The limits of detection ranged from 0.15 to 3.00 ng/L, and the limits of quantitation were between 0.80 and 10.00 ng/L, and the recoveries ranged from 77.9% to 104.85%. [conclusions] The method has high sensitivity, good accuracy and strong practical value.

关键词： Landfill Antibiotics Ultra high performance liquid chromatography-tandem mass spectrometry

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基于传递熵的机场间延误传播关系网络

计算机应用与软件 2024年第9期41卷 377-382页

作者：王娟郗艳华江西机电职业技术学院车辆工程学院江西南昌330013 咸阳师范学院物理与电子工程学院陕西咸阳712000

为了刻画机场间延误传播的真实动力学过程并理解延误传播机制,建立基于传递熵的机场间延误传播关系网络并进行实例分析。由航班数据处理得到各个机场的延误时间序列,通过传递熵因果分析方法构建所有机场间的延误传播关系网络,使用复杂... 详细信息

为了刻画机场间延误传播的真实动力学过程并理解延误传播机制,建立基于传递熵的机场间延误传播关系网络并进行实例分析。由航班数据处理得到各个机场的延误时间序列,通过传递熵因果分析方法构建所有机场间的延误传播关系网络,使用复杂网络理论对该网络进行分析。实例分析结果表明,在机场间的日常延误传播交互中,小型机场尤其是4c级机场总是在向外传播延误;对于航空公司而言,较小型航空公司的航空系统更容易发生延误传播。这些分析结果可以为制定延误传播缓解措施提供理论支撑。

关键词：航空运输延误传播关系传递熵航班延误因果分析复杂网络

华泽兰内生真菌Septoriella phragmitis次级代谢产物及其生物活性研究

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天然产物研究与开发 2024年第6期36卷 986-992页

作者：张梦娇邝天浩赵金诺朱婷彭娟娟三峡大学生物与制药学院天然产物研究与利用湖北省重点实验室(中国轻工业功能酵母重点实验室) 宜昌443002

为研究华泽兰内生真菌Septoriella phragmitis的化学成分及其生物活性,运用硅胶柱柱色谱、半制备高效液相色谱等方法对其进行分离提纯,结合现代波谱技术鉴定化合物结构,从Septoriella phragmitis提取液中分离得到10个化合物,分别鉴定为... 详细信息

为研究华泽兰内生真菌Septoriella phragmitis的化学成分及其生物活性,运用硅胶柱柱色谱、半制备高效液相色谱等方法对其进行分离提纯,结合现代波谱技术鉴定化合物结构,从Septoriella phragmitis提取液中分离得到10个化合物,分别鉴定为腺苷(1)、cyclo-(S-Pro-S-Ile)(2)、5-羟基-2-羟甲基-4H-哌喃-4-酮(3)、3α-hydroxyartemisinic acid(4)、leptosphaerone c(5)、1-氨基四氢化萘(6)、泽兰素(7)、β-吲哚基丙氨酸(8)、环(丙氨酸-酪氨酸)二肽(9)、β-D-fructopyranocy-(2→6)-D-glucopyranose(10),所有化合物均为首次从华泽兰内生真菌Septoriella phragmitis中分离。对所得化合物采用对硝基苯基-β-吡喃半乳糖苷法测定α-葡萄糖苷酶抑制活性,对硝基苯磷酸盐法测定PTP1B抑制活性,MTT法测定胃癌细胞HGc-27抑制活性,标准精度对接法进行分子对接。化合物6和7有α-葡萄糖苷酶抑制活性,Ic_(50)值分别为8.1、8.6μg/mL;化合物6、7和9有PTP1B抑制活性,Ic_(50)值分别为6.5、8.2、0.5μg/mL;化合物5和6有胃癌细胞HGc-27抑制活性,Ic_(50)值分别为12.2、16.8μg/mL。分子对接显示化合物6和7与α-葡萄糖苷酶和PTP1B蛋白有较强关联性,可作抗糖尿病先导化合物进行后续研究。

关键词：华泽兰 Septoriella phragmitis 次级代谢产物生物活性

Organ Abscission in Plants: With Special Emphasis on Bell Pepper

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Phyton-International Journal of Experimental Botany 2024年第7期93卷 1467-1484页

作者： Ramiro Reyes-castro Héctor G.Núñez-Palenius juan I.Valiente-Banuet María E.Sosa-Morales Blanca E.Orosco-Alcalá Rafael Guzmán-Mendoza Graciela M.L.Ruiz-Aguilar Rogelio costilla-Salazar Life Sciences Division Universidad de GuanajuatoIrapuato36500México School of Engineering and Sciences Tecnologico de MonterreyQuerétaro76130México

Bell pepper(capsicum annuum L.),along with potato and tomato,is one of the three most cultivated vegetables in the *** pepper is worldwide accepted due to its characteristics of color,smell,ﬂavor,and *** pepper is also considered a nutritious food due to its vitamin and antioxidant *** Mexico,bell pepper production has a high value because it is grown for the international markets,particularly the United States of ***,the abscission ofﬂowers and fruits is a factor that limits the yield,hinders the planning of activities,and causes a variation in the prices of *** to the importance of this process,in this work we did a bibliometric analysis and literature review of scientiﬁc advances for the understanding of the abscission pro-cess in plants,and in particular for the bell ***,we introduce new perspectives that would help direct future research about organ abscission in ***,the lack of research that would further clarify abscis-sion process in the bell pepper plant is discussed.

关键词： capsicum annuum abscission zone plant growth regulators environmental factors

Impact of STAT-signaling pathway on cancer-associated fibroblasts in colorectal cancer and its role in immunosuppression

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1705-1724页

作者： Damián Sánchez-Ramírez Mónica G Mendoza-Rodríguez Omar R Alemán Fernando A candanedo-González Miriam Rodríguez-Sosa juan JoséMontesinos-Montesinos Mauricio Salcedo Ismael Brito-Toledo Felipe Vaca-Paniagua Luis I Terrazas Unidad de Investigacion en Biomedicina Facultad de Estudios Superiores IztacalaUniversidad Nacional Autonoma de MexicoTlalnepantla 54090Estado de MexicoMexico Department of Biology Facultad de QuimicaUniversidad Nacional Autonoma de MexicoCiudad UniversitariaMexico City 04510Mexico Department of Pathology National Medical Center Century XXIInstituto Mexicano del Seguro SocialMexico City 06720Mexico Laboratorio de células Troncales Mesenquimales Unidad de Investigación Médica en Enfermedades OncológicasHospital de Oncología Centro Medico Nacional Siglo XXIInstituto Mexicano del Seguro SocialMexico City 06720Mexico Unidad de Investigacion en Biomedicina y Oncologia Genomica Instituto Mexciano del Seguro SocialMexico City 07300Mexico Servicio de colon y Recto Hospital de Oncología Centro Medico Nacional Siglo XXIInstituto Mexicano del Seguro SocialMexico City 06720Mexico Laboratorio Nacional en Salud Facultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla 54090Estado de MexicoMexico

colorectal cancer(cRc)remains one of the most commonly diagnosed and deadliest types of cancer *** displays a desmoplastic reaction(DR)that has been inversely associated with poor prognosis;less DR is associated with a better *** reaction generates excessive connective tissue,in which cancer-associated fibroblasts(cAFs)are critical cells that form a part of the tumor *** are directly involved in tumorigenesis through different ***,their role in immunosuppression in cRc is not well understood,and the precise role of signal transducers and activators of transcription(STATs)in mediating cAF activity in cRc remains *** the myriad chemical and biological factors that affect cAFs,different cytokines mediate their function by activating STAT signaling ***,the harmful effects of cAFs in favoring tumor growth and invasion may be modulated using STAT ***,we analyze the impact of different STATs on cAF activity and their immunoregulatory role.

关键词： cancer-associated fibroblasts Signal transducer and activator of transcription signaling colorectal cancer Immunity Immunosuppression